RU2464024C2 - Композиции и способы лечения мукормикоза и других грибковых заболеваний - Google Patents

Композиции и способы лечения мукормикоза и других грибковых заболеваний Download PDF

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Publication number
RU2464024C2
RU2464024C2 RU2009104961/15A RU2009104961A RU2464024C2 RU 2464024 C2 RU2464024 C2 RU 2464024C2 RU 2009104961/15 A RU2009104961/15 A RU 2009104961/15A RU 2009104961 A RU2009104961 A RU 2009104961A RU 2464024 C2 RU2464024 C2 RU 2464024C2
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RU
Russia
Prior art keywords
mucormycosis
iron
deferasirox
iron chelating
oryzae
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RU2009104961/15A
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English (en)
Russian (ru)
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RU2009104961A (ru
Inventor
Эшраф С. ИБРАХИМ (US)
Эшраф С. ИБРАХИМ
Брэд Дж. СПЕЛЛБЕРГ (US)
Брэд Дж. СПЕЛЛБЕРГ
Джон Э. ЭДВАРДЗ (US)
Джон Э. ЭДВАРДЗ
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Лос-Анджелес Биомедикал Рисерч Инститьют Эт Харбор-Юкла Медикал Сентер
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2009104961/15A 2006-07-13 2007-07-13 Композиции и способы лечения мукормикоза и других грибковых заболеваний RU2464024C2 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US83109906P 2006-07-13 2006-07-13
US60/831,099 2006-07-13
US89762007P 2007-01-26 2007-01-26
US60/897,620 2007-01-26
US90407507P 2007-02-27 2007-02-27
US60/904,075 2007-02-27

Publications (2)

Publication Number Publication Date
RU2009104961A RU2009104961A (ru) 2010-08-20
RU2464024C2 true RU2464024C2 (ru) 2012-10-20

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RU2009104961/15A RU2464024C2 (ru) 2006-07-13 2007-07-13 Композиции и способы лечения мукормикоза и других грибковых заболеваний

Country Status (18)

Country Link
US (1) US20100129434A1 (https=)
EP (2) EP2412371A1 (https=)
JP (2) JP2009543788A (https=)
KR (1) KR20090036587A (https=)
AU (1) AU2007272781B2 (https=)
BR (1) BRPI0714221A2 (https=)
CA (1) CA2657634A1 (https=)
CL (1) CL2007002026A1 (https=)
IL (1) IL196389A0 (https=)
MA (1) MA30625B1 (https=)
MX (1) MX2009000506A (https=)
NO (1) NO20090565L (https=)
NZ (1) NZ574862A (https=)
RU (1) RU2464024C2 (https=)
SG (1) SG177122A1 (https=)
TN (1) TN2009000004A1 (https=)
TW (1) TWI448285B (https=)
WO (1) WO2008008537A2 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ614255A (en) * 2009-03-19 2015-03-27 Los Angeles Biomed Res Inst Vaccine compositions and methods for treatment of mucormycosis and other fungal diseases
US8980876B2 (en) 2010-10-28 2015-03-17 The Procter & Gamble Company Inhibition of microbial growth by aconitase inhibition
MX2015003729A (es) * 2012-11-12 2015-06-15 Cipla Ltd Composiciones farmaceuticas de dosis fija que comprende deferasirox y deferiprona.
US11229685B2 (en) 2013-01-29 2022-01-25 Case Western Reserve University Fungal iron acquisition inhibitors and uses thereof
WO2015026852A1 (en) * 2013-08-19 2015-02-26 Rutgers, The State University Of New Jersey Method of inducing an anti-retroviral immune response by counter-acting retro-virus induced anti-apoptosis
US20170239182A1 (en) * 2014-08-13 2017-08-24 Mark E. Hayes Pharmaceutical formulations of and methods to prepare chelating agents for efficient metal removal treatment systems
WO2016025611A2 (en) * 2014-08-13 2016-02-18 Zoneone Pharma, Inc. Pharmaceutical formulations of chelating agents as a metal removal treatment system
EP3344246A4 (en) * 2015-08-31 2019-04-10 The University of Adelaide METHOD AND PRODUCTS FOR THE PREVENTION AND / OR TREATMENT OF MICROORGANISM INFECTIONS WITH IRON-CHELATORS AND IRON-FREE PORPHYRINE
US10960002B2 (en) 2016-05-13 2021-03-30 The Brigham And Women's Hospital, Inc. Volatile metabolite profiles for the diagnosis and treatment of Mucorales fungi
FR3095755A1 (fr) * 2019-05-10 2020-11-13 Balmes Transplantation Nouveaux médicaments cytoprotecteurs
CN113905715B (zh) 2019-06-28 2025-04-15 宝洁公司 光增强处理方法
JP2023057423A (ja) * 2021-10-11 2023-04-21 国立大学法人 熊本大学 ムコール症治療薬

Citations (3)

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RU2118899C1 (ru) * 1993-09-30 1998-09-20 Жансен Фармасетика Н.В. Пероральные противогрибковые композиции
WO2004045609A2 (en) * 2002-11-19 2004-06-03 Relivia Srl Hydroxypyridinones for the local treatment of skin microcirculatory disorders
WO2004060903A2 (en) * 2002-12-31 2004-07-22 Nektar Therapeutics Aerosolizable pharmaceutical formulation for fungal infection therapy

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GB8329043D0 (en) * 1983-10-31 1983-11-30 Hider R C Pharmaceutical compositions
US4698431A (en) * 1985-11-12 1987-10-06 The United States Of America As Represented By The United States Department Of Energy Hydroxypyridonate chelating agents
MY129541A (en) 1996-06-25 2007-04-30 Novartis Ag Substituded 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators
WO1999009997A1 (en) * 1997-08-26 1999-03-04 Board Of Regents, The University Of Texas System Edta and other chelators with or without antifungal antimicrobial agents for the prevention and treatment of fungal infections
EP1223308B1 (de) * 2000-12-16 2007-01-24 ALSTOM Technology Ltd Komponente einer Strömungsmaschine
GB0223978D0 (en) 2002-10-15 2002-11-20 Novartis Ag Organic compound
WO2004108114A2 (en) * 2003-03-31 2004-12-16 Dinesh Shantilal Patel Anti-fungal composition and a process for its manufacture
DE10356409B4 (de) * 2003-11-28 2006-12-28 Biofrontera Discovery Gmbh Neues Arzneimittel Oxachelin und Derivate

Patent Citations (3)

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RU2118899C1 (ru) * 1993-09-30 1998-09-20 Жансен Фармасетика Н.В. Пероральные противогрибковые композиции
WO2004045609A2 (en) * 2002-11-19 2004-06-03 Relivia Srl Hydroxypyridinones for the local treatment of skin microcirculatory disorders
WO2004060903A2 (en) * 2002-12-31 2004-07-22 Nektar Therapeutics Aerosolizable pharmaceutical formulation for fungal infection therapy

Non-Patent Citations (3)

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Eucker J. et al. Mucormycoses. Mycoses. 2001; 44(7-8), p.253-260. Найдено из БД PubMed, PMID: 11714058. *
Weiss H.Markus et al. «In vitro blood distribution and plasma protein binding of the iron chelator deferasirox (ICL670) and its iron complex FE-ICL670 2 for rat, marmoset, rabbit, mouse, dog, and human». Drag metabolism and disposition, v.34, №6, June 2006 (2006-06), p.971-975. Abstract. *
Климко H.H. и Колбина А.С. Перспективы использования новых системных противогрибковых препаратов в педиатрии (Обзор литературы). Проблемы медицинской микологии. 2005, т.7, №3, с.3-11. Kattamis et al. Iron chelation treatment with combined therapy with deferiprone and deferioxamine: A 12-monht trial. Blood Cells, molecules and diseases, Lajolla, us. v.36, №1, January 2006 (2006-01), p.21-25. Abstract. Медицинские термины. 2000. Найдено из Интернет: http://dic.academic.ru/dic.nsf/medic/545). *

Also Published As

Publication number Publication date
US20100129434A1 (en) 2010-05-27
NZ574862A (en) 2012-02-24
MX2009000506A (es) 2009-05-20
JP2009543788A (ja) 2009-12-10
TW200816994A (en) 2008-04-16
AU2007272781A1 (en) 2008-01-17
WO2008008537A3 (en) 2008-04-24
JP2013040212A (ja) 2013-02-28
EP2412371A1 (en) 2012-02-01
BRPI0714221A2 (pt) 2013-01-01
IL196389A0 (en) 2009-09-22
TN2009000004A1 (en) 2010-08-19
TWI448285B (zh) 2014-08-11
EP2043636A2 (en) 2009-04-08
MA30625B1 (fr) 2009-08-03
CL2007002026A1 (es) 2008-06-06
AU2007272781B2 (en) 2012-10-18
WO2008008537A2 (en) 2008-01-17
RU2009104961A (ru) 2010-08-20
KR20090036587A (ko) 2009-04-14
NO20090565L (no) 2009-03-30
CA2657634A1 (en) 2008-01-17
SG177122A1 (en) 2012-01-30

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Effective date: 20140714