RU2460516C2 - Офтальмические эмульсии масло-в-воде, содержащие простагландины - Google Patents
Офтальмические эмульсии масло-в-воде, содержащие простагландины Download PDFInfo
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- RU2460516C2 RU2460516C2 RU2009143324/15A RU2009143324A RU2460516C2 RU 2460516 C2 RU2460516 C2 RU 2460516C2 RU 2009143324/15 A RU2009143324/15 A RU 2009143324/15A RU 2009143324 A RU2009143324 A RU 2009143324A RU 2460516 C2 RU2460516 C2 RU 2460516C2
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- Prior art keywords
- oil
- water emulsion
- emulsion according
- component
- prostaglandin
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- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 229920003086 cellulose ether Polymers 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 239000008139 complexing agent Substances 0.000 description 1
- 210000000795 conjunctiva Anatomy 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 229940061607 dibasic sodium phosphate Drugs 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-M dihydrogenphosphate Chemical compound OP(O)([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-M 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 229960002390 flurbiprofen Drugs 0.000 description 1
- SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 229960005015 local anesthetics Drugs 0.000 description 1
- 229920001684 low density polyethylene Polymers 0.000 description 1
- 239000004702 low-density polyethylene Substances 0.000 description 1
- 229940112534 lumigan Drugs 0.000 description 1
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- 150000004667 medium chain fatty acids Chemical class 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229940045641 monobasic sodium phosphate Drugs 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229940125702 ophthalmic agent Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 239000008389 polyethoxylated castor oil Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000056 polyoxyethylene ether Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229940068984 polyvinyl alcohol Drugs 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000003334 potential effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 description 1
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
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- 229940113006 travatan Drugs 0.000 description 1
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- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000000733 zeta-potential measurement Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07008357.1 | 2007-04-24 | ||
| EP07008357A EP1985298A1 (en) | 2007-04-24 | 2007-04-24 | Ophtalmic oil-in-water emulsions containing prostaglandins |
| US94269107P | 2007-06-08 | 2007-06-08 | |
| US60/942,691 | 2007-06-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2009143324A RU2009143324A (ru) | 2011-05-27 |
| RU2460516C2 true RU2460516C2 (ru) | 2012-09-10 |
Family
ID=38924841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009143324/15A RU2460516C2 (ru) | 2007-04-24 | 2008-04-24 | Офтальмические эмульсии масло-в-воде, содержащие простагландины |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8414904B2 (enExample) |
| EP (2) | EP1985298A1 (enExample) |
| JP (1) | JP5452472B2 (enExample) |
| CN (1) | CN101674804B (enExample) |
| AU (1) | AU2008240964B2 (enExample) |
| CA (1) | CA2683672C (enExample) |
| ES (1) | ES2425593T3 (enExample) |
| MX (1) | MX2009011391A (enExample) |
| NZ (1) | NZ579954A (enExample) |
| RU (1) | RU2460516C2 (enExample) |
| WO (1) | WO2008128779A1 (enExample) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10905695B2 (en) | 2016-11-09 | 2021-02-02 | Taejoon Pharmaceutical Co., Ltd. | Ophthalmic composition for lowering intraocular pressure |
| RU2746083C2 (ru) * | 2015-03-05 | 2021-04-06 | Аллерган, Инк. | Самоэмульгирующиеся системы доставки лекарств (sedds) для доставки офтальмологического лекарства |
| US11090356B2 (en) | 2015-01-15 | 2021-08-17 | Newport Research, Inc. | Aqueous suspensions of cyclosporin |
| US11324800B2 (en) | 2015-01-15 | 2022-05-10 | Wellspring Ophthalmics, Inc. | Aqueous suspensions of cyclosporin |
| RU2772230C2 (ru) * | 2016-11-09 | 2022-05-18 | Таедзоон Фармасьютикал Ко., Лтд. | Композиция в форме глазных капель для снижения внутриглазного давления |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1985298A1 (en) * | 2007-04-24 | 2008-10-29 | Azad Pharma AG | Ophtalmic oil-in-water emulsions containing prostaglandins |
| JP2009040727A (ja) * | 2007-08-09 | 2009-02-26 | Towa Yakuhin Kk | ラタノプロストを有効成分とする安定な点眼液剤 |
| FR2934955B1 (fr) * | 2008-08-14 | 2011-07-08 | Commissariat Energie Atomique | Encapsulation d'agents therapeutiques lipophiles ou amphiphiles dans des nanoemulsions |
| FR2934954B1 (fr) | 2008-08-14 | 2011-07-22 | Commissariat Energie Atomique | Emulsion fluorescente de vert d'indocyanine |
| FR2938757B1 (fr) * | 2008-11-27 | 2010-12-31 | Octalia Technologies | Vehicule sous forme d'une emulsion huile-dans-eau notamment destine a une utilisation cosmetique ou dermatologique |
| EP2228058A1 (en) * | 2009-03-04 | 2010-09-15 | Novagali Pharma S.A. | Anionic oil-in-water emulsion containing prostaglandins and uses thereof |
| DE102009021372A1 (de) * | 2009-05-14 | 2010-11-18 | Ursapharm Arzneimittel Gmbh | Phosphatfreie pharmazeutische Zusammensetzung zur Glaukombehandlung |
| AU2014250656B2 (en) * | 2009-06-02 | 2016-05-05 | Johnson & Johnson Surgical Vision, Inc. | Omega-3 oil containing ophthalmic emulsions |
| US9480645B2 (en) * | 2009-06-02 | 2016-11-01 | Abbott Medical Optics Inc. | Omega-3 oil containing ophthalmic emulsions |
| US20100305046A1 (en) | 2009-06-02 | 2010-12-02 | Abbott Medical Optics Inc. | Stable cyclosporine containing ophthalmic emulsion for treating dry eyes |
| US20100303915A1 (en) * | 2009-06-02 | 2010-12-02 | Abbott Medical Optics Inc. | Therapeutic opthalmic emulsions |
| KR20170095402A (ko) * | 2009-11-09 | 2017-08-22 | 알러간, 인코포레이티드 | 모발 성장을 촉진하기 위한 조성물 및 방법 |
| EP2389939A1 (en) | 2010-05-28 | 2011-11-30 | Novagali Pharma S.A. | Use of prostaglandins F2alpha and analogues for the healing of corneal and conjunctival lesions |
| SG187770A1 (en) | 2010-08-12 | 2013-03-28 | Univ Nanyang Tech | A liposomal formulation for ocular drug delivery |
| DE102011108948A1 (de) * | 2011-07-29 | 2013-01-31 | Achim Göpferich | Wässrige, kolloidale Lösungen von lipophilen Substanzen,insbesondere Arzneistofflösungen |
| US9278132B2 (en) | 2012-02-13 | 2016-03-08 | Bausch & Lomb Incorporated | Ophthalmic pharmaceutical compositions and methods of making and using same |
| EP2664329A1 (de) * | 2012-05-15 | 2013-11-20 | F. Holzer GmbH | Ophthalmologisches Vehikelsystem |
| US9956195B2 (en) | 2014-01-07 | 2018-05-01 | Nanyang Technological University | Stable liposomal formulations for ocular drug delivery |
| KR101848124B1 (ko) * | 2015-03-31 | 2018-04-11 | 단국대학교 천안캠퍼스 산학협력단 | 타크로리무스의 경구용 과포화성 마이크로에멀젼 조성물 |
| CN105748415B (zh) * | 2016-03-18 | 2019-05-07 | 上海方予健康医药科技有限公司 | 一种前列地尔冻干微乳组合物及其制备方法 |
| FR3064002B1 (fr) | 2017-03-14 | 2021-07-02 | Prevor Int | Melange liquide pour nettoyer les deversements de peinture, vernis, colorant et/ou lasure |
| JP7569336B2 (ja) | 2019-06-11 | 2024-10-17 | サイファイ エス．ピー．エー． | マイクロエマルション組成物 |
| US20210000910A1 (en) | 2019-07-03 | 2021-01-07 | Jysk Skin Solutions Pte Ltd | Topical compositions |
| WO2021056106A1 (en) * | 2019-09-23 | 2021-04-01 | Dds Research Inc. | Lipid vesicle compositions with penetration enhancing agents |
| MX2022014226A (es) * | 2020-05-13 | 2023-04-14 | Follicle Pharma Ltd | Composiciones para la administracion de agentes bioactivos en foliculos pilosos. |
| EP3919047A1 (en) * | 2020-06-03 | 2021-12-08 | AZAD Pharma AG | Microemulsion for the treatment of dry eye syndrome |
| KR20230124625A (ko) * | 2020-12-24 | 2023-08-25 | 산텐 세이야꾸 가부시키가이샤 | 에피나스틴 또는 그의 염과 황계 항산화제를 함유하는경피 투여용 의약 조성물 |
| KR20240035939A (ko) | 2021-03-24 | 2024-03-19 | 글로 파마, 인크. | 피부 색소침착을 감소시키기 위한 펩타이드 및 방법 |
| ES2944784B2 (es) | 2021-12-23 | 2025-11-24 | Univ Madrid Complutense | Microemulsión oftálmica, procedimiento de obtención y uso dado a la misma |
| US12083204B2 (en) | 2022-06-02 | 2024-09-10 | L'oreal | Topical composition for homeostatic delivery of nitric oxide and uses thereof |
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-
2007
- 2007-04-24 EP EP07008357A patent/EP1985298A1/en not_active Withdrawn
-
2008
- 2008-04-24 NZ NZ579954A patent/NZ579954A/en unknown
- 2008-04-24 RU RU2009143324/15A patent/RU2460516C2/ru active
- 2008-04-24 CN CN2008800132624A patent/CN101674804B/zh active Active
- 2008-04-24 CA CA2683672A patent/CA2683672C/en active Active
- 2008-04-24 AU AU2008240964A patent/AU2008240964B2/en active Active
- 2008-04-24 US US12/597,528 patent/US8414904B2/en active Active
- 2008-04-24 ES ES08749111T patent/ES2425593T3/es active Active
- 2008-04-24 JP JP2010504543A patent/JP5452472B2/ja active Active
- 2008-04-24 EP EP08749111.4A patent/EP2136782B1/en active Active
- 2008-04-24 WO PCT/EP2008/003317 patent/WO2008128779A1/en not_active Ceased
- 2008-04-24 MX MX2009011391A patent/MX2009011391A/es active IP Right Grant
-
2013
- 2013-03-14 US US13/804,794 patent/US20130195936A1/en not_active Abandoned
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2131266C1 (ru) * | 1994-07-12 | 1999-06-10 | Скотиа Липидтекник АБ | Эмульсия типа "масло в воде", носитель на ее основе и фармацевтическая композиция |
| US5849792A (en) * | 1994-12-22 | 1998-12-15 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
| RU2164134C2 (ru) * | 1995-09-12 | 2001-03-20 | Астра Актиеболаг | Микроэмульсия для применения в качестве носителя для введения активных соединений и способ ее получения |
| US6417228B1 (en) * | 1998-11-02 | 2002-07-09 | Alcon Manufacturing, Ltd.. | 13-Aza prostaglandins for the treatment of glaucoma and ocular hypertension |
| EP1681059A1 (en) * | 2003-11-07 | 2006-07-19 | Senju Pharmaceutical Co., Ltd. | Pharmaceutical composition containing prostaglandin |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11090356B2 (en) | 2015-01-15 | 2021-08-17 | Newport Research, Inc. | Aqueous suspensions of cyclosporin |
| US11324800B2 (en) | 2015-01-15 | 2022-05-10 | Wellspring Ophthalmics, Inc. | Aqueous suspensions of cyclosporin |
| RU2746083C2 (ru) * | 2015-03-05 | 2021-04-06 | Аллерган, Инк. | Самоэмульгирующиеся системы доставки лекарств (sedds) для доставки офтальмологического лекарства |
| US10905695B2 (en) | 2016-11-09 | 2021-02-02 | Taejoon Pharmaceutical Co., Ltd. | Ophthalmic composition for lowering intraocular pressure |
| RU2772230C2 (ru) * | 2016-11-09 | 2022-05-18 | Таедзоон Фармасьютикал Ко., Лтд. | Композиция в форме глазных капель для снижения внутриглазного давления |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2136782B1 (en) | 2013-06-05 |
| CA2683672C (en) | 2015-10-06 |
| US20100112016A1 (en) | 2010-05-06 |
| HK1133598A1 (en) | 2010-04-01 |
| CA2683672A1 (en) | 2008-10-30 |
| WO2008128779A1 (en) | 2008-10-30 |
| AU2008240964B2 (en) | 2013-03-07 |
| US20130195936A1 (en) | 2013-08-01 |
| CN101674804B (zh) | 2013-02-13 |
| JP2010524992A (ja) | 2010-07-22 |
| RU2009143324A (ru) | 2011-05-27 |
| EP1985298A1 (en) | 2008-10-29 |
| NZ579954A (en) | 2011-04-29 |
| EP2136782A1 (en) | 2009-12-30 |
| CN101674804A (zh) | 2010-03-17 |
| ES2425593T3 (es) | 2013-10-16 |
| MX2009011391A (es) | 2010-02-09 |
| JP5452472B2 (ja) | 2014-03-26 |
| AU2008240964A1 (en) | 2008-10-30 |
| US8414904B2 (en) | 2013-04-09 |
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