AU2008240964B2 - Ophthalmic oil-in-water emulsions containing prostaglandins - Google Patents

Ophthalmic oil-in-water emulsions containing prostaglandins Download PDF

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Publication number
AU2008240964B2
AU2008240964B2 AU2008240964A AU2008240964A AU2008240964B2 AU 2008240964 B2 AU2008240964 B2 AU 2008240964B2 AU 2008240964 A AU2008240964 A AU 2008240964A AU 2008240964 A AU2008240964 A AU 2008240964A AU 2008240964 B2 AU2008240964 B2 AU 2008240964B2
Authority
AU
Australia
Prior art keywords
oil
water emulsion
emulsion
prostaglandin
polyoxyethylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
AU2008240964A
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English (en)
Other versions
AU2008240964A1 (en
Inventor
Mihran Baronian
Fabio Carli
Elisabetta Chiellini
Rene Schmid
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Azad Pharma AG
Original Assignee
Azad Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Azad Pharma AG filed Critical Azad Pharma AG
Publication of AU2008240964A1 publication Critical patent/AU2008240964A1/en
Application granted granted Critical
Publication of AU2008240964B2 publication Critical patent/AU2008240964B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2008240964A 2007-04-24 2008-04-24 Ophthalmic oil-in-water emulsions containing prostaglandins Active AU2008240964B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP07008357.1 2007-04-24
EP07008357A EP1985298A1 (en) 2007-04-24 2007-04-24 Ophtalmic oil-in-water emulsions containing prostaglandins
US94269107P 2007-06-08 2007-06-08
US60/942,691 2007-06-08
PCT/EP2008/003317 WO2008128779A1 (en) 2007-04-24 2008-04-24 Ophthalmic oil-in-water emulsions containing prostaglandins

Publications (2)

Publication Number Publication Date
AU2008240964A1 AU2008240964A1 (en) 2008-10-30
AU2008240964B2 true AU2008240964B2 (en) 2013-03-07

Family

ID=38924841

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008240964A Active AU2008240964B2 (en) 2007-04-24 2008-04-24 Ophthalmic oil-in-water emulsions containing prostaglandins

Country Status (11)

Country Link
US (2) US8414904B2 (enExample)
EP (2) EP1985298A1 (enExample)
JP (1) JP5452472B2 (enExample)
CN (1) CN101674804B (enExample)
AU (1) AU2008240964B2 (enExample)
CA (1) CA2683672C (enExample)
ES (1) ES2425593T3 (enExample)
MX (1) MX2009011391A (enExample)
NZ (1) NZ579954A (enExample)
RU (1) RU2460516C2 (enExample)
WO (1) WO2008128779A1 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1985298A1 (en) * 2007-04-24 2008-10-29 Azad Pharma AG Ophtalmic oil-in-water emulsions containing prostaglandins
JP2009040727A (ja) * 2007-08-09 2009-02-26 Towa Yakuhin Kk ラタノプロストを有効成分とする安定な点眼液剤
FR2934955B1 (fr) * 2008-08-14 2011-07-08 Commissariat Energie Atomique Encapsulation d'agents therapeutiques lipophiles ou amphiphiles dans des nanoemulsions
FR2934954B1 (fr) 2008-08-14 2011-07-22 Commissariat Energie Atomique Emulsion fluorescente de vert d'indocyanine
FR2938757B1 (fr) * 2008-11-27 2010-12-31 Octalia Technologies Vehicule sous forme d'une emulsion huile-dans-eau notamment destine a une utilisation cosmetique ou dermatologique
EP2228058A1 (en) * 2009-03-04 2010-09-15 Novagali Pharma S.A. Anionic oil-in-water emulsion containing prostaglandins and uses thereof
DE102009021372A1 (de) 2009-05-14 2010-11-18 Ursapharm Arzneimittel Gmbh Phosphatfreie pharmazeutische Zusammensetzung zur Glaukombehandlung
US20100305046A1 (en) 2009-06-02 2010-12-02 Abbott Medical Optics Inc. Stable cyclosporine containing ophthalmic emulsion for treating dry eyes
AU2014250656B2 (en) * 2009-06-02 2016-05-05 Johnson & Johnson Surgical Vision, Inc. Omega-3 oil containing ophthalmic emulsions
US20100303915A1 (en) * 2009-06-02 2010-12-02 Abbott Medical Optics Inc. Therapeutic opthalmic emulsions
US9480645B2 (en) 2009-06-02 2016-11-01 Abbott Medical Optics Inc. Omega-3 oil containing ophthalmic emulsions
EP3421030A1 (en) * 2009-11-09 2019-01-02 Allergan, Inc. Compositions and methods for stimulating hair growth
EP2389939A1 (en) 2010-05-28 2011-11-30 Novagali Pharma S.A. Use of prostaglandins F2alpha and analogues for the healing of corneal and conjunctival lesions
WO2012021107A2 (en) 2010-08-12 2012-02-16 Nanyang Technological University A liposomal formulation for ocular drug delivery
DE102011108948A1 (de) * 2011-07-29 2013-01-31 Achim Göpferich Wässrige, kolloidale Lösungen von lipophilen Substanzen,insbesondere Arzneistofflösungen
US9278132B2 (en) * 2012-02-13 2016-03-08 Bausch & Lomb Incorporated Ophthalmic pharmaceutical compositions and methods of making and using same
EP2664329A1 (de) * 2012-05-15 2013-11-20 F. Holzer GmbH Ophthalmologisches Vehikelsystem
US9956195B2 (en) 2014-01-07 2018-05-01 Nanyang Technological University Stable liposomal formulations for ocular drug delivery
US11324800B2 (en) 2015-01-15 2022-05-10 Wellspring Ophthalmics, Inc. Aqueous suspensions of cyclosporin
US20200237859A1 (en) 2019-01-25 2020-07-30 Newport Research, Inc. Aqueous suspensions of cyclosporin
AU2016226224B2 (en) * 2015-03-05 2021-07-08 Allergan, Inc. Self-emulsifying drug delivery system (SEDDS) for ophthalmic drug delivery
KR101848124B1 (ko) * 2015-03-31 2018-04-11 단국대학교 천안캠퍼스 산학협력단 타크로리무스의 경구용 과포화성 마이크로에멀젼 조성물
CN105748415B (zh) * 2016-03-18 2019-05-07 上海方予健康医药科技有限公司 一种前列地尔冻干微乳组合物及其制备方法
KR101770324B1 (ko) 2016-11-09 2017-08-22 주식회사태준제약 안압 강하용 점안 조성물
FR3064002B1 (fr) 2017-03-14 2021-07-02 Prevor Int Melange liquide pour nettoyer les deversements de peinture, vernis, colorant et/ou lasure
CN114245737A (zh) 2019-06-11 2022-03-25 司斐股份有限公司 微乳剂组合物
US20210000910A1 (en) 2019-07-03 2021-01-07 Jysk Skin Solutions Pte Ltd Topical compositions
KR20220070246A (ko) 2019-09-23 2022-05-30 디디에스 리서치 인크. 침투 증진제를 갖는 지질 소포 조성물
KR20230011997A (ko) * 2020-05-13 2023-01-25 폴리클 파마 리미티드 모낭으로 생물활성제를 전달하기 위한 조성물
EP3919047A1 (en) * 2020-06-03 2021-12-08 AZAD Pharma AG Microemulsion for the treatment of dry eye syndrome
US20240058356A1 (en) * 2020-12-24 2024-02-22 Santen Pharmaceutical Co., Ltd. Pharmaceutical composition for transdermal administration containing epi-nastine or salt thereof and containing sulfur-based antioxidant
MX2023011157A (es) 2021-03-24 2024-01-25 Glo Pharma Inc Peptidos y metodos para reducir la pigmentacion de la piel.
ES2944784B8 (es) * 2021-12-23 2026-04-21 Univ Madrid Complutense Microemulsión oftálmica, procedimiento de obtención y uso dado a la misma
US12083204B2 (en) 2022-06-02 2024-09-10 L'oreal Topical composition for homeostatic delivery of nitric oxide and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849792A (en) * 1994-12-22 1998-12-15 Alcon Laboratories, Inc. Storage-stable prostaglandin compositions
US6417228B1 (en) * 1998-11-02 2002-07-09 Alcon Manufacturing, Ltd.. 13-Aza prostaglandins for the treatment of glaucoma and ocular hypertension
WO2006050836A2 (en) * 2004-11-09 2006-05-18 Novagali Pharma Sa Ophthalmic emulsions containing prostaglandins
EP1681059A1 (en) * 2003-11-07 2006-07-19 Senju Pharmaceutical Co., Ltd. Pharmaceutical composition containing prostaglandin

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3608073A (en) 1968-07-16 1971-09-21 Barnes Hind Pharm Inc Emulsion of pilocarpine for ophthalmic use
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US5171566A (en) 1986-05-16 1992-12-15 The Green Cross Corporation Flurbiprofen derivative ophthalmic preparation
JP2597629B2 (ja) 1988-02-26 1997-04-09 株式会社 上野製薬応用研究所 １３，１４−ジヒドロ−１５−ケトプロスタグランジン類の安定化
CA2031469A1 (en) 1989-12-28 1991-06-29 Larry A. Wheeler Use of inclusion complexes of prostaglandins with cyclodextrins in the treatment of ocular hypertension
DE69105349T2 (de) 1990-05-22 1995-04-06 Ueno Seiyaku Oyo Kenkyujo Kk Behandlung von intraocularem Druck mit einer synergistischen Kombination zur ophthalmischen Verwendung.
IL98747A0 (en) 1991-07-05 1992-07-15 Yissum Res Dev Co Ophthalmic compositions
IL101241A (en) 1992-03-16 1997-11-20 Yissum Res Dev Co Pharmaceutical or cosmetic composition comprising stabilized oil-in-water type emulsion as carrier
SE518823C2 (sv) 1994-07-12 2002-11-26 Karlshamns Lipidteknik Ab Olja-i-vatten-emulsioner
ES2094688B1 (es) 1994-08-08 1997-08-01 Cusi Lab Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion.
US5827835A (en) 1994-08-30 1998-10-27 Alcon Laboratories, Inc. Thermally-gelling emulsions
US6294563B1 (en) * 1994-10-27 2001-09-25 Allergan Sales, Inc. Combinations of prostaglandins and brimonidine or derivatives thereof
SE9503143D0 (sv) 1995-09-12 1995-09-12 Astra Ab New preparation
US6770675B2 (en) 1997-03-17 2004-08-03 Novartis Ag Compositions and methods for reducing ocular hypertension
CA2422031C (en) * 2000-09-13 2011-11-15 Santen Pharmaceutical Co., Ltd. Ophthalmic solutions comprising difluoroprostaglandin f2 alpha
US7095714B2 (en) 2000-11-28 2006-08-22 Kabushiki Kaisha Toshiba Ring interconnection network system, node equipment, network management equipment, and path setting method
US20030215471A1 (en) 2001-01-31 2003-11-20 Wilmott James M. Surfactant free topical compositions and method for rapid preparation thereof
WO2002096367A2 (en) * 2001-05-30 2002-12-05 Targesome, Inc. Targeted multivalent macromolecules
KR100446960B1 (ko) * 2001-12-04 2004-09-01 김종국 프로스타글란딘 ｅ1을 포함하는 온도감응성 에멀젼 외용제조성물
US20040076678A1 (en) 2002-08-21 2004-04-22 Sucampo Ag Opthalmic solution
AU2003262268A1 (en) 2002-08-23 2004-04-30 Santen Pharmaceutical Co., Ltd. Stable eye drops containing latanoprost as the active ingredient
CA2707067C (en) 2002-09-09 2013-07-16 Santen Pharmaceutical Co., Ltd. Clear ophthalmic solution comprising latanoprost as active ingredient
US20040185068A1 (en) * 2003-03-18 2004-09-23 Zhi-Jian Yu Self-emulsifying compositions, methods of use and preparation
US20050196370A1 (en) 2003-03-18 2005-09-08 Zhi-Jian Yu Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye
WO2005011633A1 (ja) * 2003-08-01 2005-02-10 National Institute Of Advanced Industrial Science And Technology 標的指向性リポソームを含む炎症性疾患治療薬または診断薬
US20060182781A1 (en) 2004-04-30 2006-08-17 Allergan, Inc. Methods for treating ocular conditions with cyclic lipid contraining microparticles
EP1655021B1 (en) 2004-11-09 2008-10-29 Novagali Pharma SA Oil-in-water type emulsion with low concentration of cationic agent and positive zeta potential
PT1937212E (pt) * 2005-10-10 2010-11-30 Novagali Pharma Sa Emulsões oftálmicas contendo prostaglandinas
EP1985298A1 (en) * 2007-04-24 2008-10-29 Azad Pharma AG Ophtalmic oil-in-water emulsions containing prostaglandins

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849792A (en) * 1994-12-22 1998-12-15 Alcon Laboratories, Inc. Storage-stable prostaglandin compositions
US6417228B1 (en) * 1998-11-02 2002-07-09 Alcon Manufacturing, Ltd.. 13-Aza prostaglandins for the treatment of glaucoma and ocular hypertension
EP1681059A1 (en) * 2003-11-07 2006-07-19 Senju Pharmaceutical Co., Ltd. Pharmaceutical composition containing prostaglandin
WO2006050836A2 (en) * 2004-11-09 2006-05-18 Novagali Pharma Sa Ophthalmic emulsions containing prostaglandins

Also Published As

Publication number Publication date
RU2460516C2 (ru) 2012-09-10
EP2136782B1 (en) 2013-06-05
CN101674804A (zh) 2010-03-17
JP2010524992A (ja) 2010-07-22
HK1133598A1 (en) 2010-04-01
EP2136782A1 (en) 2009-12-30
US20100112016A1 (en) 2010-05-06
MX2009011391A (es) 2010-02-09
US20130195936A1 (en) 2013-08-01
US8414904B2 (en) 2013-04-09
RU2009143324A (ru) 2011-05-27
CN101674804B (zh) 2013-02-13
WO2008128779A1 (en) 2008-10-30
AU2008240964A1 (en) 2008-10-30
CA2683672C (en) 2015-10-06
CA2683672A1 (en) 2008-10-30
ES2425593T3 (es) 2013-10-16
EP1985298A1 (en) 2008-10-29
NZ579954A (en) 2011-04-29
JP5452472B2 (ja) 2014-03-26

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