RU2455021C2 - Композиции легочных сурфактантов и способы их применения, содействующие очищению от слизи - Google Patents

Композиции легочных сурфактантов и способы их применения, содействующие очищению от слизи Download PDF

Info

Publication number
RU2455021C2
RU2455021C2 RU2009114825/15A RU2009114825A RU2455021C2 RU 2455021 C2 RU2455021 C2 RU 2455021C2 RU 2009114825/15 A RU2009114825/15 A RU 2009114825/15A RU 2009114825 A RU2009114825 A RU 2009114825A RU 2455021 C2 RU2455021 C2 RU 2455021C2
Authority
RU
Russia
Prior art keywords
surfactant
pulmonary
amino acid
polypeptide
acid residues
Prior art date
Application number
RU2009114825/15A
Other languages
English (en)
Russian (ru)
Other versions
RU2009114825A (ru
Inventor
Марк И. ДЖОНСОН (US)
Марк И. ДЖОНСОН
Роберт СИГАЛ (US)
Роберт СИГАЛ
Томас ХОФМАНН (US)
Томас ХОФМАНН
Роберт Дж. КЕЙПИТОЛА (US)
Роберт Дж. КЕЙПИТОЛА
Original Assignee
Дискавери Лабораториз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дискавери Лабораториз, Инк. filed Critical Дискавери Лабораториз, Инк.
Publication of RU2009114825A publication Critical patent/RU2009114825A/ru
Application granted granted Critical
Publication of RU2455021C2 publication Critical patent/RU2455021C2/ru

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/10Expectorants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/12Mucolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
RU2009114825/15A 2006-09-19 2007-09-19 Композиции легочных сурфактантов и способы их применения, содействующие очищению от слизи RU2455021C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84599106P 2006-09-19 2006-09-19
US60/845,991 2006-09-19

Publications (2)

Publication Number Publication Date
RU2009114825A RU2009114825A (ru) 2010-10-27
RU2455021C2 true RU2455021C2 (ru) 2012-07-10

Family

ID=38921793

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2009114825/15A RU2455021C2 (ru) 2006-09-19 2007-09-19 Композиции легочных сурфактантов и способы их применения, содействующие очищению от слизи

Country Status (11)

Country Link
US (1) US8221772B2 (enExample)
EP (1) EP2063903A1 (enExample)
JP (1) JP2010503731A (enExample)
KR (1) KR20090060348A (enExample)
AU (1) AU2007297691B2 (enExample)
BR (1) BRPI0717177A2 (enExample)
CA (1) CA2663795A1 (enExample)
MX (1) MX2009003002A (enExample)
RU (1) RU2455021C2 (enExample)
WO (1) WO2008036293A1 (enExample)
ZA (1) ZA200902487B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8669418B2 (en) 2005-12-22 2014-03-11 Vib Vzw Means and methods for mediating protein interference
AU2008310734B2 (en) 2007-10-10 2014-06-05 Parion Sciences, Inc. Delivering osmolytes by nasal cannula
EP3581197A1 (de) 2009-07-31 2019-12-18 ethris GmbH Rna mit einer kombination aus unmodifizierten und modifizierten nucleotiden zur proteinexpression
MX2013001936A (es) 2010-08-23 2013-03-08 Takeda Gmbh Particulas humidificadas que comprenden una sustancia terapeuticamente activa.
CN103732213A (zh) 2011-06-07 2014-04-16 帕里昂科学公司 治疗方法
US8945605B2 (en) 2011-06-07 2015-02-03 Parion Sciences, Inc. Aerosol delivery systems, compositions and methods
WO2015061412A1 (en) * 2013-10-22 2015-04-30 The Scripps Research Institute Methods and compositions for promoting bronchioli dilatation
GB201406225D0 (en) * 2014-04-07 2014-05-21 Hall Roderick L Treatment for respiratory disease
NZ728487A (en) * 2014-08-08 2021-07-30 Shenzhen Hightide Biopharmaceutical Ltd Liquid formulation compositions, medicament delivery devices, and methods of preparation and use thereof
US20190380977A1 (en) * 2016-05-23 2019-12-19 University Of Iowa Research Foundation Method of treating cystic fibrosis airway disease
US20190231686A1 (en) * 2016-07-16 2019-08-01 Lauranell Harrison BURCH Methods for treating cystic fibrosis and other diseases affecting mucosal surfaces
WO2018064529A1 (en) * 2016-09-29 2018-04-05 The Uab Research Foundation Methods and compositions for increasing mucus clearance
CN110621688A (zh) 2017-05-09 2019-12-27 非营利性组织佛兰芒综合大学生物技术研究所 用于治疗细菌感染的手段和方法
EP3727353A4 (en) * 2017-12-21 2021-10-13 Civitas Therapeutics, Inc. SURFACTANT FORMULATIONS FOR INHALATION
US12427273B1 (en) 2020-05-15 2025-09-30 John E. Boyd Methods for treating respiratory distress and compositions for use in the same
GB202202297D0 (en) 2022-02-21 2022-04-06 Verona Pharma Plc Formulation production process
US12194045B1 (en) 2023-06-26 2025-01-14 Verona Pharma Plc Particulate composition
KR20250153517A (ko) 2024-04-18 2025-10-27 민현홍 신생아 호흡 곤란 증후군을 앓고 있는 조산아의 폐 전달을 개선하기 위한 미세기포 함유 에어로졸
WO2025231023A1 (en) * 2024-04-29 2025-11-06 Virginia Commonwealth University Aerosol surfactant therapy (ast) for respiratory distress syndrome (rds)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840527A (en) * 1984-12-11 1998-11-24 Byk Gulden Lomberg Chemische Fabrik Gmbh Recombinant alveolar surfactant protein
RU2149015C1 (ru) * 1999-07-01 2000-05-20 Центральный научно-исследовательский рентгенорадиологический институт Способ лечения постнатальных пневмоний у новорожденных
RU2149014C1 (ru) * 1999-07-01 2000-05-20 Центральный научно-исследовательский рентгенорадиологический институт Способ лечения острых бронхопневмоний, осложненных ателектазом
RU2198670C1 (ru) * 2002-02-19 2003-02-20 ООО "Биосурф" Способ получения сурфактанта из легких крупного рогатого скота
RU2213746C1 (ru) * 2002-02-15 2003-10-10 Научно-исследовательский институт физико-химической медицины Компонент, обеспечивающий поверхностно-активные свойства композиций - аналогов препаратов для заместительной сурфактантной терапии легочных заболеваний

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659805A (en) 1984-12-11 1987-04-21 California Biotechnology, Inc. Recombinant alveolar surfactant protein
US4918161A (en) 1985-09-26 1990-04-17 Genetics Institute, Inc. Low molecular weight pulmonary surfactant proteins
IT1203873B (it) 1987-04-08 1989-02-23 Chiesi Farma Spa Composizioni farmaceutiche che lo surfattante polmonare naturale, contengono. metodo di preparazione e
JP2602968B2 (ja) 1987-11-04 1997-04-23 カリフォルニア バイオテクノロジー インコーポレイテッド 肺胞の界面活性タンパク類
US6013619A (en) 1988-01-06 2000-01-11 The Scripps Research Institute Pulmonary surfactants and therapeutic uses, including pulmonary lavage
US5260273A (en) 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US6613734B2 (en) 1988-01-06 2003-09-02 The Scripps Research Institute Peptides-containing liposomal surfactants
US5164369A (en) * 1988-01-06 1992-11-17 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US4861756A (en) 1988-03-08 1989-08-29 Merrell Dow Pharmaceuticals Inc. Synthetic pulmonary surfactant
SE8803713D0 (sv) 1988-10-18 1988-10-18 Kabigen Ab Biologically active lipoprotein and its use
US5006343A (en) 1988-12-29 1991-04-09 Benson Bradley J Pulmonary administration of pharmaceutically active substances
US5238920A (en) 1989-08-22 1993-08-24 Abbott Laboratories Pulmonary surfactant protein fragments
DE69125750D1 (de) 1990-05-21 1997-05-28 Abbott Lab Fettsäure-Oberflächenaktives-Lungenprotein Konjate
US5272252A (en) 1991-11-04 1993-12-21 Merrell Dow Pharmaceuticals Inc. Synthetic lung surfactant having antioxidant properties
WO1993021221A1 (en) 1992-04-10 1993-10-28 Abbott Laboratories Pulmonary surfactant protein fragments
US5302481A (en) 1993-06-07 1994-04-12 Xerox Corporation Toner compositions with negative charge enhancing complexes
CA2178345A1 (en) 1993-12-08 1995-06-15 Tsunetomo Takei Novel synthetic peptide, lung surfactant containing the same, and remedy for respiratory distress syndrome
DE4418936A1 (de) 1994-05-31 1996-02-08 Byk Gulden Lomberg Chem Fab Polypeptid
DE4434629C1 (de) 1994-09-28 1996-06-27 Byk Gulden Lomberg Chem Fab Zusammensetzungen zur Behandlung von IRDS und ARDS
US5508269A (en) 1994-10-19 1996-04-16 Pathogenesis Corporation Aminoglycoside formulation for aerosolization
US5767068A (en) 1997-02-13 1998-06-16 Pathogenesis Corporation Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections
US5925334A (en) 1997-08-27 1999-07-20 Rubin; Bruce K. Use of surface active agents to promote mucus clearance
US7198635B2 (en) * 2000-10-17 2007-04-03 Asthmatx, Inc. Modification of airways by application of energy
US6926911B1 (en) 1998-12-22 2005-08-09 The University Of North Carolina At Chapel Hill Compounds and methods for the treatment of airway diseases and for the delivery of airway drugs
DK1140150T3 (da) * 1998-12-22 2004-03-22 Bayer Ag Fremgangsmåde til accelerering af hastigheden af mucociliær clearance under anvendelse af en serinproteaseinhibitor af Kunitz-type
DE10006179A1 (de) * 2000-02-11 2001-08-23 Byk Gulden Lomberg Chem Fab Neue Verwendung von Lungensurfactant zur Prophylaxe und Behandlung von chronischen Lungenerkrankungen
US6660833B1 (en) 2000-02-29 2003-12-09 Harbor-Ucla Research And Education Institute Respiratory distress syndrome therapy with peptide analogs of human SP-B
US7422743B2 (en) * 2000-05-10 2008-09-09 Schering Corporation Mammalian receptor protein DCRS5;methods of treatment
PT1280520E (pt) * 2000-05-10 2014-12-16 Novartis Ag Pós à base de fosfolípidos para administração de fármacos
DE60101451T2 (de) 2001-03-05 2004-10-21 Pera Ivo E Inhaliergerät zur Verteilung von in einer Kapsel enthaltenen Medikamenten in Pulverform durch die Atemwege
CA2445516C (en) 2001-04-26 2007-11-20 New England Pharmaceuticals, Inc. Metered dose delivery device for liquid and powder agents
GB0327723D0 (en) * 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
AU2004296206A1 (en) * 2003-12-04 2005-06-23 The Scripps Research Institute Treatment and preventions of asthma
JP2007537833A (ja) 2004-05-20 2007-12-27 ディスカバリー ラボラトリーズ,インコーポレイテッド 非侵襲的な肺吸入のための方法、システム、及び装置
CA2575513C (en) * 2004-08-06 2014-09-16 Altana Pharma Ag Composition comprising a pulmonary surfactant and a tnf-derived peptide
AU2005280281A1 (en) 2004-08-27 2006-03-09 Discovery Laboratories, Inc. Methods, systems and devices for noninvasive pulmonary delivery
US7582312B2 (en) 2004-11-15 2009-09-01 Discovery Laboratories, Inc. Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
US8337815B2 (en) * 2004-12-23 2012-12-25 Discovery Laboratories, Inc. Pulmonary surfactant formulations
SI1841458T1 (sl) * 2005-01-06 2012-04-30 Discovery Lab Inc Zdravljenje s predpisanim odmerjanjem surfaktanta za zdravljenje ali preprečevanje bronhopulmonalne displazije

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840527A (en) * 1984-12-11 1998-11-24 Byk Gulden Lomberg Chemische Fabrik Gmbh Recombinant alveolar surfactant protein
RU2149015C1 (ru) * 1999-07-01 2000-05-20 Центральный научно-исследовательский рентгенорадиологический институт Способ лечения постнатальных пневмоний у новорожденных
RU2149014C1 (ru) * 1999-07-01 2000-05-20 Центральный научно-исследовательский рентгенорадиологический институт Способ лечения острых бронхопневмоний, осложненных ателектазом
RU2213746C1 (ru) * 2002-02-15 2003-10-10 Научно-исследовательский институт физико-химической медицины Компонент, обеспечивающий поверхностно-активные свойства композиций - аналогов препаратов для заместительной сурфактантной терапии легочных заболеваний
RU2198670C1 (ru) * 2002-02-19 2003-02-20 ООО "Биосурф" Способ получения сурфактанта из легких крупного рогатого скота

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Ferzli G et al. Surfactant protein В deficiency: a rare cause of respiratory failure in a Lebanese newbom. Ann Saudi Med. 2006 Jan-Feb; 26(1):69-70. [он-лайн] [найдено 2011-06-21] Найдено из базы данных PubMed PMID: 16521884. Serrano AG et al. Intrinsic structural and functional determinants within the amino acid sequence of mature pulmonary surfactant protein SP-B. Biochemistry. 2005 Jan 11; 44(1):417-30. Реферат [он-лайн] [найдено 2011-06-21] Найдено из базы данных PubMed PMID: 1568884. *
МИХАЙЛОВ И.Б. Настольная книга врача по клинической фармакологии. - СПб.: Фолиант, 2001, с.378-381. *

Also Published As

Publication number Publication date
BRPI0717177A2 (pt) 2013-10-08
US8221772B2 (en) 2012-07-17
ZA200902487B (en) 2010-07-28
CA2663795A1 (en) 2008-03-27
JP2010503731A (ja) 2010-02-04
US20080199410A1 (en) 2008-08-21
MX2009003002A (es) 2009-06-01
WO2008036293A1 (en) 2008-03-27
RU2009114825A (ru) 2010-10-27
EP2063903A1 (en) 2009-06-03
AU2007297691B2 (en) 2013-12-19
KR20090060348A (ko) 2009-06-11
AU2007297691A1 (en) 2008-03-27

Similar Documents

Publication Publication Date Title
RU2455021C2 (ru) Композиции легочных сурфактантов и способы их применения, содействующие очищению от слизи
JP5666569B2 (ja) サーファクタントタンパク質b(sp−b)およびサーファクタントタンパク質c(sp−c)の類似体を含有する改善された再構築サーファクタント組成物
US8337815B2 (en) Pulmonary surfactant formulations
WO2015138423A1 (en) Prostacylin compositions and methods for using the same
JP2007513180A (ja) 喘息の処置および予防
CN102448498A (zh) 包括肺表面活性物质和类固醇的治疗组合
EP3558376B1 (en) A therapeutic combination comprising a pulmonary surfactant and a steroid for the treatment of evolving bpd
US10124015B2 (en) Surfactant composition
EP1340506B1 (en) Compositions comprising pulmonary surfactants and a polymyxin having improved surface properties
TW201208690A (en) Lipid formulations
RU2748417C2 (ru) Стабильная фармацевтическая композиция, включающая восстановленную композицию легочного сурфактанта
JP4559731B2 (ja) 肺サーファクタントの新規使用
KR101721309B1 (ko) 계면활성 단백질 b(sp-b) 및 계면활성 단백질 c(sp-c)의 유사체를 포함하는 합성 폐 계면활성제 조성물
HK1109077B (en) Pulmonary surfactant formulations
RS20170169A1 (sr) Poboljšana rekonstituisana kompozicija sufraktanta koja sadrži analoge sufraktanta proteina b (sp-b) i surfaktanta proteina c (sp-c)
HK1058155A (en) Lung surfactant compositions with dynamic swelling behaviour

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20160920