RU2451015C2 - Производные 1,2,4-триазола в качестве ингибиторов сигма рецептора - Google Patents
Производные 1,2,4-триазола в качестве ингибиторов сигма рецептора Download PDFInfo
- Publication number
- RU2451015C2 RU2451015C2 RU2009122197/04A RU2009122197A RU2451015C2 RU 2451015 C2 RU2451015 C2 RU 2451015C2 RU 2009122197/04 A RU2009122197/04 A RU 2009122197/04A RU 2009122197 A RU2009122197 A RU 2009122197A RU 2451015 C2 RU2451015 C2 RU 2451015C2
- Authority
- RU
- Russia
- Prior art keywords
- methyl
- triazol
- dichlorophenyl
- ylthio
- ethyl
- Prior art date
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- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 26
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- 238000000034 method Methods 0.000 claims abstract description 24
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 23
- 150000002367 halogens Chemical class 0.000 claims abstract description 23
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 19
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06380291A EP1921073A1 (en) | 2006-11-10 | 2006-11-10 | 1,2,4-Triazole derivatives as sigma receptor inhibitors |
| EP06380291.2 | 2006-11-10 |
Publications (2)
| Publication Number | Publication Date |
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| RU2009122197A RU2009122197A (ru) | 2010-12-20 |
| RU2451015C2 true RU2451015C2 (ru) | 2012-05-20 |
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| RU2009122197/04A RU2451015C2 (ru) | 2006-11-10 | 2007-11-07 | Производные 1,2,4-триазола в качестве ингибиторов сигма рецептора |
Country Status (13)
| Country | Link |
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| US (2) | US8039497B2 (enExample) |
| EP (2) | EP1921073A1 (enExample) |
| JP (1) | JP2010509280A (enExample) |
| KR (1) | KR20090087031A (enExample) |
| CN (1) | CN101595098B (enExample) |
| AU (1) | AU2007316605B2 (enExample) |
| BR (1) | BRPI0718587A2 (enExample) |
| CA (1) | CA2668994A1 (enExample) |
| ES (1) | ES2453497T3 (enExample) |
| MX (1) | MX2009004746A (enExample) |
| NZ (1) | NZ577557A (enExample) |
| RU (1) | RU2451015C2 (enExample) |
| WO (1) | WO2008055932A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2718049C2 (ru) * | 2015-01-30 | 2020-03-30 | Ньюрокрайн Байосайенсиз, Инк. | Замещенные триаозлы и способы, касающиеся их |
| RU2805308C2 (ru) * | 2017-12-29 | 2023-10-13 | Байомарин Фармасьютикал Инк. | Ингибиторы гликолатоксидазы для лечения заболеваний |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0507602D0 (en) * | 2005-04-14 | 2005-05-18 | Glaxo Group Ltd | Compounds |
| EP2116539A1 (en) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof |
| US20100273805A1 (en) * | 2009-04-23 | 2010-10-28 | Astrazeneca Ab | Sulphide bridged derivatives as modulators of mglur5 733 |
| EP2353598A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for use in the prevention and/or treatment of postoperative pain |
| EP2353591A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof |
| EP2388005A1 (en) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy |
| EP2415471A1 (en) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in opioid-induced hyperalgesia |
| EP2524694A1 (en) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in diabetes type-2 associated pain |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2014047413A1 (en) * | 2012-09-21 | 2014-03-27 | Uwm Research Foundation, Inc. | Novel gabaa agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma |
| EP2752411A1 (en) | 2013-01-07 | 2014-07-09 | Laboratorios Del Dr. Esteve, S.A. | 1,2,3-triazole-4-amine derivatives for the treatment of sigma receptor related diseases and disorders |
| EP2989105B1 (en) | 2013-04-23 | 2020-03-11 | Esteve Pharmaceuticals, S.A. | Pyrazino[1,2-a]indole compounds, their preparation and use in medicaments |
| MA38569A1 (fr) | 2013-04-23 | 2017-03-31 | Esteve Labor Dr | Composés pyrazino[1,2-a]indole, leur préparation et utilisation dans des médicaments |
| EP2832720A1 (en) | 2013-07-30 | 2015-02-04 | Laboratorios Del. Dr. Esteve, S.A. | 1,2-disubstituted cyclobutyl compounds |
| SG11201604480PA (en) | 2013-12-17 | 2016-07-28 | Esteve Labor Dr | SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITORS (SNRIs) AND SIGMA RECEPTOR LIGANDS COMBINATIONS |
| MA41177A (fr) * | 2014-12-15 | 2017-10-24 | Esteve Labor Dr | Utilisation de ligands des récepteurs sigma dans l'arthrose |
| US10118904B2 (en) | 2015-06-05 | 2018-11-06 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of Demyelinating Diseases |
| CN111432813B (zh) | 2017-11-14 | 2024-01-09 | 爱思开生物制药株式会社 | 用于预防、减轻、或治疗精神分裂症的包含氨基甲酸酯化合物的共混物 |
| CN111432814B (zh) * | 2017-11-14 | 2024-05-14 | 爱思开生物制药株式会社 | 用于减轻或治疗包括脆性X染色体综合征、Angelman综合征或Rett综合征的发育障碍的氨基甲酸酯化合物的用途 |
| ES3027977T3 (en) | 2017-11-14 | 2025-06-17 | Sk Biopharmaceuticals Co Ltd | Use of a carbamate compound to prevent, alleviate or treat visceralgia or pain arising from visceral disease |
| EP3711756A4 (en) | 2017-11-14 | 2021-11-24 | SK Biopharmaceuticals Co., Ltd. | USE OF A CARBAMATE COMPOUND TO PREVENT, RELAX, OR TREAT MYOTONIA |
| WO2020123847A1 (en) * | 2018-12-12 | 2020-06-18 | Rutgers, The State University Of New Jersey | Organic compounds |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1343497A1 (en) * | 2000-11-02 | 2003-09-17 | K and K Biosciences, Inc. | $g(D)?2 ,-1,2,3-TRIAZOLINE ANTICONVULSANTS AND THEIR ACTIVE METABOLITE ANALOGUES, THE AMINOALKYLPYRIDINES, ARE EXCITATORY AMINO ACID ANTAGONISTS AND ANTIISCHEMIC AGENTS, USEFUL IN THE TREATMENT OF CEREBRAL ISCHEMIA RESULTING FROM STROKE |
| RU2007134401A (ru) * | 2005-02-17 | 2009-03-27 | Мерк Патент ГмбХ (DE) | Производные триазола |
Family Cites Families (7)
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|---|---|---|---|---|
| DE1547640A1 (de) * | 1967-04-10 | 1969-12-04 | Agfa Gevaert Ag | Verbessertes photographisches Material |
| WO1991009594A1 (en) | 1989-12-28 | 1991-07-11 | Virginia Commonwealth University | Sigma receptor ligands and the use thereof |
| US6797722B2 (en) | 2002-05-03 | 2004-09-28 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Use of 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole for the treatment of autoimmune diseases |
| SE0301232D0 (sv) | 2003-04-25 | 2003-04-25 | Astrazeneca Ab | Novel use |
| CA2542682A1 (en) | 2003-10-18 | 2005-05-06 | Bayer Healthcare Ag | 5-substituted 2-(phenylmethyl) thio-4-phenyl-4h-1,2,4-triazole derivatives and related compounds as gaba-agonists for the treatment of urinary incontinence and related diseases |
| WO2005039550A2 (en) | 2003-10-24 | 2005-05-06 | Solvay Pharmaceuticals Gmbh | Novel medical uses of compounds showing cb1-antagonistic activity and combination treatment involving said compounds |
| GB0504556D0 (en) | 2005-03-04 | 2005-04-13 | Pfizer Ltd | Novel pharmaceuticals |
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2006
- 2006-11-10 EP EP06380291A patent/EP1921073A1/en not_active Withdrawn
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2007
- 2007-11-07 EP EP07847122.4A patent/EP2097394B1/en not_active Not-in-force
- 2007-11-07 KR KR1020097011466A patent/KR20090087031A/ko not_active Ceased
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- 2007-11-07 JP JP2009535719A patent/JP2010509280A/ja active Pending
- 2007-11-07 CA CA002668994A patent/CA2668994A1/en not_active Abandoned
- 2007-11-07 AU AU2007316605A patent/AU2007316605B2/en not_active Ceased
- 2007-11-07 WO PCT/EP2007/062006 patent/WO2008055932A1/en not_active Ceased
- 2007-11-07 US US12/514,202 patent/US8039497B2/en not_active Expired - Fee Related
- 2007-11-07 ES ES07847122.4T patent/ES2453497T3/es active Active
- 2007-11-07 CN CN2007800418720A patent/CN101595098B/zh not_active Expired - Fee Related
- 2007-11-07 RU RU2009122197/04A patent/RU2451015C2/ru not_active IP Right Cessation
- 2007-11-07 NZ NZ577557A patent/NZ577557A/en not_active IP Right Cessation
- 2007-11-07 BR BRPI0718587-1A2A patent/BRPI0718587A2/pt not_active IP Right Cessation
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2011
- 2011-09-12 US US13/229,917 patent/US8349878B2/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1343497A1 (en) * | 2000-11-02 | 2003-09-17 | K and K Biosciences, Inc. | $g(D)?2 ,-1,2,3-TRIAZOLINE ANTICONVULSANTS AND THEIR ACTIVE METABOLITE ANALOGUES, THE AMINOALKYLPYRIDINES, ARE EXCITATORY AMINO ACID ANTAGONISTS AND ANTIISCHEMIC AGENTS, USEFUL IN THE TREATMENT OF CEREBRAL ISCHEMIA RESULTING FROM STROKE |
| US6638954B2 (en) * | 2000-11-02 | 2003-10-28 | K And K Biosciences, Inc. | Δ2-1,2,3-triazoline anticonvulsants and their active metabolite analogues, the aminoalkylpyridines, are excitatory amino acid antagonists and antiischemic agents, useful in the treatment of cerebral ischemia resulting from stroke |
| RU2007134401A (ru) * | 2005-02-17 | 2009-03-27 | Мерк Патент ГмбХ (DE) | Производные триазола |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2718049C2 (ru) * | 2015-01-30 | 2020-03-30 | Ньюрокрайн Байосайенсиз, Инк. | Замещенные триаозлы и способы, касающиеся их |
| US10738017B2 (en) | 2015-01-30 | 2020-08-11 | Neurocrine Biosciences, Inc. | Substituted triazoles and methods relating thereto |
| US11021449B2 (en) | 2015-01-30 | 2021-06-01 | Neurocrine Biosciences, Inc. | Substituted triazoles and methods relating thereto |
| RU2805308C2 (ru) * | 2017-12-29 | 2023-10-13 | Байомарин Фармасьютикал Инк. | Ингибиторы гликолатоксидазы для лечения заболеваний |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2009122197A (ru) | 2010-12-20 |
| US8349878B2 (en) | 2013-01-08 |
| AU2007316605A1 (en) | 2008-05-15 |
| EP2097394B1 (en) | 2013-12-25 |
| US20120004211A1 (en) | 2012-01-05 |
| US8039497B2 (en) | 2011-10-18 |
| US20100004224A1 (en) | 2010-01-07 |
| EP2097394A1 (en) | 2009-09-09 |
| JP2010509280A (ja) | 2010-03-25 |
| BRPI0718587A2 (pt) | 2014-03-11 |
| NZ577557A (en) | 2011-12-22 |
| CN101595098A (zh) | 2009-12-02 |
| WO2008055932A1 (en) | 2008-05-15 |
| AU2007316605B2 (en) | 2012-02-09 |
| MX2009004746A (es) | 2009-05-22 |
| EP1921073A1 (en) | 2008-05-14 |
| CA2668994A1 (en) | 2008-05-15 |
| KR20090087031A (ko) | 2009-08-14 |
| CN101595098B (zh) | 2012-07-18 |
| ES2453497T3 (es) | 2014-04-08 |
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