RU2451015C2 - Производные 1,2,4-триазола в качестве ингибиторов сигма рецептора - Google Patents
Производные 1,2,4-триазола в качестве ингибиторов сигма рецептора Download PDFInfo
- Publication number
- RU2451015C2 RU2451015C2 RU2009122197/04A RU2009122197A RU2451015C2 RU 2451015 C2 RU2451015 C2 RU 2451015C2 RU 2009122197/04 A RU2009122197/04 A RU 2009122197/04A RU 2009122197 A RU2009122197 A RU 2009122197A RU 2451015 C2 RU2451015 C2 RU 2451015C2
- Authority
- RU
- Russia
- Prior art keywords
- methyl
- triazol
- dichlorophenyl
- ylthio
- ethyl
- Prior art date
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- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 26
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- 238000000034 method Methods 0.000 claims abstract description 24
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 23
- 150000002367 halogens Chemical class 0.000 claims abstract description 23
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 19
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06380291A EP1921073A1 (en) | 2006-11-10 | 2006-11-10 | 1,2,4-Triazole derivatives as sigma receptor inhibitors |
| EP06380291.2 | 2006-11-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2009122197A RU2009122197A (ru) | 2010-12-20 |
| RU2451015C2 true RU2451015C2 (ru) | 2012-05-20 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| RU2009122197/04A RU2451015C2 (ru) | 2006-11-10 | 2007-11-07 | Производные 1,2,4-триазола в качестве ингибиторов сигма рецептора |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8039497B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP1921073A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2010509280A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20090087031A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101595098B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2007316605B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0718587A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2668994A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2453497T3 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2009004746A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ577557A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2451015C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008055932A1 (cg-RX-API-DMAC7.html) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2718049C2 (ru) * | 2015-01-30 | 2020-03-30 | Ньюрокрайн Байосайенсиз, Инк. | Замещенные триаозлы и способы, касающиеся их |
| RU2805308C2 (ru) * | 2017-12-29 | 2023-10-13 | Байомарин Фармасьютикал Инк. | Ингибиторы гликолатоксидазы для лечения заболеваний |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0507602D0 (en) * | 2005-04-14 | 2005-05-18 | Glaxo Group Ltd | Compounds |
| EP2116539A1 (en) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof |
| US20100273805A1 (en) * | 2009-04-23 | 2010-10-28 | Astrazeneca Ab | Sulphide bridged derivatives as modulators of mglur5 733 |
| EP2353598A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for use in the prevention and/or treatment of postoperative pain |
| EP2353591A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof |
| EP2388005A1 (en) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy |
| EP2415471A1 (en) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in opioid-induced hyperalgesia |
| EP2524694A1 (en) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in diabetes type-2 associated pain |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| CA2885148A1 (en) * | 2012-09-21 | 2014-03-27 | Uwm Research Foundation, Inc. | Novel gabaa agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma |
| EP2752411A1 (en) | 2013-01-07 | 2014-07-09 | Laboratorios Del Dr. Esteve, S.A. | 1,2,3-triazole-4-amine derivatives for the treatment of sigma receptor related diseases and disorders |
| CN105339369B (zh) | 2013-04-23 | 2017-12-22 | 埃斯蒂维实验室股份有限公司 | 一种吡嗪并[1,2‑a]吲哚化合物及其制备方法和在药物中的应用 |
| WO2014173901A1 (en) | 2013-04-23 | 2014-10-30 | Laboratorios Del Dr. Esteve, S.A. | PYRAZINO[1,2-a]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS |
| EP2832720A1 (en) | 2013-07-30 | 2015-02-04 | Laboratorios Del. Dr. Esteve, S.A. | 1,2-disubstituted cyclobutyl compounds |
| JP2016540771A (ja) | 2013-12-17 | 2016-12-28 | ラボラトリオス・デル・ドクトル・エステベ・ソシエダッド・アノニマ | セロトニン−ノルアドレナリン再取り込み阻害薬（ｓｎｒｉ）およびシグマ受容体リガンドの組み合わせ |
| MA41177A (fr) * | 2014-12-15 | 2017-10-24 | Esteve Labor Dr | Utilisation de ligands des récepteurs sigma dans l'arthrose |
| AU2016270373A1 (en) * | 2015-06-05 | 2018-01-04 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
| US11666554B2 (en) | 2017-11-14 | 2023-06-06 | Sk Biopharmaceuticals Co., Ltd. | Use of a carbamate compound to prevent, alleviate or treat visceralgia or pain arising from visceral disease |
| WO2019098632A1 (ko) * | 2017-11-14 | 2019-05-23 | 에스케이바이오팜 주식회사 | 근긴장증의 예방, 경감 또는 치료를 위한 카바메이트 화합물의 용도 |
| EP3711761A4 (en) * | 2017-11-14 | 2021-11-24 | SK Biopharmaceuticals Co., Ltd. | USE OF A CARBAMATE COMPOUND TO REDUCE OR TREAT DEVELOPMENTAL DISORDERS, INCLUDING FRAGILE X SYNDROME, ANGELMAN'S SYNDROME, OR RETT'S SYNDROME |
| JP7355747B2 (ja) * | 2017-11-14 | 2023-10-03 | エスケー バイオファーマスティカルズ カンパニー リミテッド | カルバメート化合物を含む統合失調症の予防、軽減又は治療用配合物 |
| EP3893892A4 (en) * | 2018-12-12 | 2022-09-14 | Rutgers, the State University of New Jersey | Organic compounds |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP1343497A1 (en) * | 2000-11-02 | 2003-09-17 | K and K Biosciences, Inc. | $g(D)?2 ,-1,2,3-TRIAZOLINE ANTICONVULSANTS AND THEIR ACTIVE METABOLITE ANALOGUES, THE AMINOALKYLPYRIDINES, ARE EXCITATORY AMINO ACID ANTAGONISTS AND ANTIISCHEMIC AGENTS, USEFUL IN THE TREATMENT OF CEREBRAL ISCHEMIA RESULTING FROM STROKE |
| RU2007134401A (ru) * | 2005-02-17 | 2009-03-27 | Мерк Патент ГмбХ (DE) | Производные триазола |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DE1547640A1 (de) * | 1967-04-10 | 1969-12-04 | Agfa Gevaert Ag | Verbessertes photographisches Material |
| CA2071897A1 (en) | 1989-12-28 | 1991-06-29 | Richard A. Glennon | Sigma receptor ligands and the use thereof |
| US6797722B2 (en) | 2002-05-03 | 2004-09-28 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Use of 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole for the treatment of autoimmune diseases |
| SE0301232D0 (sv) | 2003-04-25 | 2003-04-25 | Astrazeneca Ab | Novel use |
| JP2007509045A (ja) | 2003-10-18 | 2007-04-12 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 尿失禁および関連疾患の処置用のｇａｂａアゴニストとしての５−置換２−（フェニルメチル）チオ−４−フェニル−４ｈ−１，２，４−トリアゾール誘導体および関連化合物 |
| JP2007513872A (ja) | 2003-10-24 | 2007-05-31 | ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ１拮抗作用を示す化合物の新規の医学的用途および前記化合物を伴う組み合わせ治療 |
| GB0504556D0 (en) | 2005-03-04 | 2005-04-13 | Pfizer Ltd | Novel pharmaceuticals |
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2006
- 2006-11-10 EP EP06380291A patent/EP1921073A1/en not_active Withdrawn
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2007
- 2007-11-07 NZ NZ577557A patent/NZ577557A/en not_active IP Right Cessation
- 2007-11-07 EP EP07847122.4A patent/EP2097394B1/en not_active Not-in-force
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- 2007-11-07 WO PCT/EP2007/062006 patent/WO2008055932A1/en not_active Ceased
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- 2007-11-07 CA CA002668994A patent/CA2668994A1/en not_active Abandoned
- 2007-11-07 RU RU2009122197/04A patent/RU2451015C2/ru not_active IP Right Cessation
- 2007-11-07 BR BRPI0718587-1A2A patent/BRPI0718587A2/pt not_active IP Right Cessation
- 2007-11-07 CN CN2007800418720A patent/CN101595098B/zh not_active Expired - Fee Related
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1343497A1 (en) * | 2000-11-02 | 2003-09-17 | K and K Biosciences, Inc. | $g(D)?2 ,-1,2,3-TRIAZOLINE ANTICONVULSANTS AND THEIR ACTIVE METABOLITE ANALOGUES, THE AMINOALKYLPYRIDINES, ARE EXCITATORY AMINO ACID ANTAGONISTS AND ANTIISCHEMIC AGENTS, USEFUL IN THE TREATMENT OF CEREBRAL ISCHEMIA RESULTING FROM STROKE |
| US6638954B2 (en) * | 2000-11-02 | 2003-10-28 | K And K Biosciences, Inc. | Δ2-1,2,3-triazoline anticonvulsants and their active metabolite analogues, the aminoalkylpyridines, are excitatory amino acid antagonists and antiischemic agents, useful in the treatment of cerebral ischemia resulting from stroke |
| RU2007134401A (ru) * | 2005-02-17 | 2009-03-27 | Мерк Патент ГмбХ (DE) | Производные триазола |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2718049C2 (ru) * | 2015-01-30 | 2020-03-30 | Ньюрокрайн Байосайенсиз, Инк. | Замещенные триаозлы и способы, касающиеся их |
| US10738017B2 (en) | 2015-01-30 | 2020-08-11 | Neurocrine Biosciences, Inc. | Substituted triazoles and methods relating thereto |
| US11021449B2 (en) | 2015-01-30 | 2021-06-01 | Neurocrine Biosciences, Inc. | Substituted triazoles and methods relating thereto |
| RU2805308C2 (ru) * | 2017-12-29 | 2023-10-13 | Байомарин Фармасьютикал Инк. | Ингибиторы гликолатоксидазы для лечения заболеваний |
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0718587A2 (pt) | 2014-03-11 |
| NZ577557A (en) | 2011-12-22 |
| MX2009004746A (es) | 2009-05-22 |
| CN101595098A (zh) | 2009-12-02 |
| US20100004224A1 (en) | 2010-01-07 |
| EP2097394A1 (en) | 2009-09-09 |
| CA2668994A1 (en) | 2008-05-15 |
| RU2009122197A (ru) | 2010-12-20 |
| US8039497B2 (en) | 2011-10-18 |
| CN101595098B (zh) | 2012-07-18 |
| AU2007316605B2 (en) | 2012-02-09 |
| KR20090087031A (ko) | 2009-08-14 |
| AU2007316605A1 (en) | 2008-05-15 |
| WO2008055932A1 (en) | 2008-05-15 |
| EP1921073A1 (en) | 2008-05-14 |
| US8349878B2 (en) | 2013-01-08 |
| JP2010509280A (ja) | 2010-03-25 |
| ES2453497T3 (es) | 2014-04-08 |
| EP2097394B1 (en) | 2013-12-25 |
| US20120004211A1 (en) | 2012-01-05 |
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