RU2446166C2 - Гетероциклические соединения, имеющие сродство к мускариновым рецепторам - Google Patents

Гетероциклические соединения, имеющие сродство к мускариновым рецепторам Download PDF

Info

Publication number
RU2446166C2
RU2446166C2 RU2009143353/04A RU2009143353A RU2446166C2 RU 2446166 C2 RU2446166 C2 RU 2446166C2 RU 2009143353/04 A RU2009143353/04 A RU 2009143353/04A RU 2009143353 A RU2009143353 A RU 2009143353A RU 2446166 C2 RU2446166 C2 RU 2446166C2
Authority
RU
Russia
Prior art keywords
pyrazol
compound
methylpyridine
tetrahydro
mmol
Prior art date
Application number
RU2009143353/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2009143353A (ru
Inventor
Аксел СТОЙТ (NL)
Аксел Стойт
Хейн К.А.С. КОЛЕН (NL)
Хейн К.А.С. Колен
Корнелис Г. Крюсе (NL)
Корнелис Г. Крюсе
Ян Х. РЕЙНДЕРС (NL)
Ян Х. РЕЙНДЕРС
Original Assignee
Солвей Фармасьютикалс Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Солвей Фармасьютикалс Б.В. filed Critical Солвей Фармасьютикалс Б.В.
Publication of RU2009143353A publication Critical patent/RU2009143353A/ru
Application granted granted Critical
Publication of RU2446166C2 publication Critical patent/RU2446166C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
RU2009143353/04A 2007-04-24 2008-04-23 Гетероциклические соединения, имеющие сродство к мускариновым рецепторам RU2446166C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US91358407P 2007-04-24 2007-04-24
US60/913,584 2007-04-24
EP07106814.2 2007-04-24
EP07106814 2007-04-24

Publications (2)

Publication Number Publication Date
RU2009143353A RU2009143353A (ru) 2011-05-27
RU2446166C2 true RU2446166C2 (ru) 2012-03-27

Family

ID=38510408

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2009143353/04A RU2446166C2 (ru) 2007-04-24 2008-04-23 Гетероциклические соединения, имеющие сродство к мускариновым рецепторам

Country Status (8)

Country Link
EP (1) EP2150543A2 (zh)
JP (1) JP2010525020A (zh)
CN (1) CN101939311A (zh)
AU (1) AU2008240704A1 (zh)
CA (1) CA2682994A1 (zh)
MX (1) MX2009011499A (zh)
RU (1) RU2446166C2 (zh)
WO (1) WO2008129054A2 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8084473B2 (en) 2007-04-24 2011-12-27 Solvay Pharmaceuticals B.V. Heterocyclic compounds with affinity to muscarinic receptors
EP2427432A2 (en) * 2009-05-07 2012-03-14 Torrent Pharmaceuticals Limited Novel heterocyclic compounds
EP2593447B1 (de) 2010-07-15 2016-08-17 Bayer Intellectual Property GmbH 3-pyridyl-heteroarylcarboxamidverbindungen als schädlingsbekämpfungsmittel
CN104640850A (zh) 2012-10-26 2015-05-20 霍夫曼-拉罗奇有限公司 3,4-二取代的1h-吡唑和4,5-二取代的噻唑的syk抑制剂
AR121893A1 (es) 2020-04-22 2022-07-20 Sumitomo Chemical Co Compuesto de fenilo y método para controlar enfermedades vegetales

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0259621A2 (en) * 1986-09-08 1988-03-16 Novo Nordisk A/S Piperidine compounds and their preparation and use
EP0296721A2 (en) * 1987-06-24 1988-12-28 H. Lundbeck A/S Heterocyclic compounds
EP0316718A2 (en) * 1987-11-13 1989-05-24 Novo Nordisk A/S Azacyclic compounds and their preparation and use
RU2004110717A (ru) * 2001-10-17 2005-10-20 Юсиби, С.А. (Be) Производные хинуклидина, способы их получения и их применение в качестве и нгибиторов м2- и/или м3- мускариновых рецепторов

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2332957A1 (en) * 1998-06-05 1999-12-09 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents
US6861440B2 (en) * 2001-10-26 2005-03-01 Hoffmann-La Roche Inc. DPP IV inhibitors
US20100160324A1 (en) * 2004-12-30 2010-06-24 Astex Therapeutics Limited Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0259621A2 (en) * 1986-09-08 1988-03-16 Novo Nordisk A/S Piperidine compounds and their preparation and use
EP0296721A2 (en) * 1987-06-24 1988-12-28 H. Lundbeck A/S Heterocyclic compounds
EP0316718A2 (en) * 1987-11-13 1989-05-24 Novo Nordisk A/S Azacyclic compounds and their preparation and use
RU2004110717A (ru) * 2001-10-17 2005-10-20 Юсиби, С.А. (Be) Производные хинуклидина, способы их получения и их применение в качестве и нгибиторов м2- и/или м3- мускариновых рецепторов

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MARIA ROSARIA DEL GLUDICE et al. Synthesis of 1-Methyl-5-(Pyrazol-3-and 5-yl- and 1,2,4-triazol-3- and 5-yl)-1,2,3,6-tetrahydropyridine Derivatives and Tyeir Evuluation as Muscarinic Recehtor Ligands", Frch. Pharm. Pharm. Med. Chem., 2003, 336, p.p.143-154. PLATE RALF et al. Synthesis and Muscarinic Activities of 3-(Pyrazolyl)-1,2,5,6-tetrahydropyridine Derivatives// Bioorganic & Medicinal Chemistry, 1996, Vol.4, N2, p.p.227-237. ZLOTOS DARIUS P. et al. Muscarinic recehtor agonists and antagonists// Expert Opinion on Therareutic Patents, 1999, 9(8), p.p.1029-1053. PLATE RALF et al. Synthesis and In Vitro Muscarinic Activities of Series of 3-(Pyrazolyl-3-yl)-1-azabicyclo[2.2.2]octanes// Bioorganic & Medicinal Chemistry, 2000, 8, p.p.449-454. *
STN Online, соединение с Beilstein Registry Number 15155. *
WARD JOHN S. et al. Novel Functional M1 Muscarinic Agonists. 2. Synthesis and Structure-Activity Relanionchips of 3-Pyrazinyl-1,2,5,6-tetrahydro-1-methylpyridines. Construction of a Molecular Model for the M1 Pharmocophore// J. Med. Chem., 1992, 35, p.p.4011-4019. SAUUERBERG PER et al. Novel Functional M1 Muscarinic Agonists. 2. Synthesis and Structure-Activity Relanionchips of 3-(1,2,5-Thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines// J. Med. Chem., 1992, 35, p.p.2274-2283. *

Also Published As

Publication number Publication date
CN101939311A (zh) 2011-01-05
WO2008129054A2 (en) 2008-10-30
RU2009143353A (ru) 2011-05-27
CA2682994A1 (en) 2008-10-30
MX2009011499A (es) 2009-11-09
AU2008240704A1 (en) 2008-10-30
WO2008129054A3 (en) 2009-02-05
EP2150543A2 (en) 2010-02-10
JP2010525020A (ja) 2010-07-22

Similar Documents

Publication Publication Date Title
JP6453231B2 (ja) ウレア誘導体、またはその薬理学的に許容される塩
JP5680101B2 (ja) Ｏｒｌ−１受容体アンタゴニストとしてのスピロピペリジン化合物
AU2017263361A1 (en) Cyclopropyl-amide compounds as dual LSD1/HDAC inhibitors
AU2006298164A1 (en) Novel fused pyrrole derivative
JP2018524338A (ja) 複素環化合物
JPH09507484A (ja) 置換モルホリン誘導体およびその治療剤としての使用
CA2787248C (en) Piperazine compound having a pgds inhibitory effect
AU2013243353B2 (en) Fused cyclopentyl antagonists of CCR2
JP2022525885A (ja) Ｒａｆキナーゼの阻害剤
RU2446166C2 (ru) Гетероциклические соединения, имеющие сродство к мускариновым рецепторам
EP1940823A2 (fr) Dérivés de la 1-amino-phtalazine substituee, leur préparation et leur application en thérapeutique
JPWO2017155050A1 (ja) 芳香環化合物
WO2018181345A1 (ja) 複素環化合物
JP2015157836A (ja) キノロン化合物及び医薬組成物
EP3455212B1 (en) Inhibitors of protease-activated receptor-2
WO2019151269A1 (ja) 複素環化合物
JP3916092B2 (ja) イミダゾリジノン誘導体とその酸付加塩及び老年性痴呆症の治療薬
US8735388B2 (en) Heterocyclic compounds with affinity to muscarinic receptors
JP7140915B2 (ja) ムスカリンｍ１受容体陽性アロステリックモジュレーターとしてのピロロ－ピリダジン誘導体
KR20080089461A (ko) 무스카린 수용체 길항제
JPH04112868A (ja) 置換ヘテロ環を有するフェニルカルボン酸誘導体
JP2024517465A (ja) ジアゼパン誘導体、それらの調製のための方法、並びに精神的及び神経学的疾患の寛解、防止及び／又は処置のためのその使用
WO2021020362A1 (ja) 複素環化合物
JP2008523027A (ja) ドーパミン−ｄ２受容体に関する親和力およびセロトニン再吸収部位の組み合わせを有するテトラヒドロピリジン−４−イルインドール類
JPH04321666A (ja) １−アリールスルホニル−２−ピロリドン誘導体、それらの製造法及び得られる新規な中間体、それらの薬剤としての使用並びにそれらを含む製薬組成物

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20130424