RU2440822C2 - Способы и фармацевтические композиции для лечения и профилактики инфекции гепатита с - Google Patents

Способы и фармацевтические композиции для лечения и профилактики инфекции гепатита с Download PDF

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Publication number
RU2440822C2
RU2440822C2 RU2008117157/15A RU2008117157A RU2440822C2 RU 2440822 C2 RU2440822 C2 RU 2440822C2 RU 2008117157/15 A RU2008117157/15 A RU 2008117157/15A RU 2008117157 A RU2008117157 A RU 2008117157A RU 2440822 C2 RU2440822 C2 RU 2440822C2
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Russia
Prior art keywords
cyclosporin
agent
hcv
compound
pharmaceutically acceptable
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RU2008117157/15A
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English (en)
Russian (ru)
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RU2008117157A (ru
Inventor
Дэвид Ренвик ХОУК (US)
Дэвид Ренвик ХОУК
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Скайнексис, Инк
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Publication of RU2008117157A publication Critical patent/RU2008117157A/ru
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
RU2008117157/15A 2005-09-30 2006-10-02 Способы и фармацевтические композиции для лечения и профилактики инфекции гепатита с RU2440822C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72267905P 2005-09-30 2005-09-30
US60/722,679 2005-09-30
US78754906P 2006-03-29 2006-03-29
US60/787,549 2006-03-29

Publications (2)

Publication Number Publication Date
RU2008117157A RU2008117157A (ru) 2009-11-10
RU2440822C2 true RU2440822C2 (ru) 2012-01-27

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Family Applications (1)

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RU2008117157/15A RU2440822C2 (ru) 2005-09-30 2006-10-02 Способы и фармацевтические композиции для лечения и профилактики инфекции гепатита с

Country Status (13)

Country Link
US (1) US7754685B2 (enExample)
EP (1) EP1933859A2 (enExample)
JP (1) JP5517454B2 (enExample)
KR (1) KR20080059270A (enExample)
CN (1) CN105169369B (enExample)
AU (1) AU2006299426B2 (enExample)
BR (1) BRPI0616476A2 (enExample)
CA (1) CA2623865A1 (enExample)
IL (1) IL190478A0 (enExample)
NZ (1) NZ567262A (enExample)
RU (1) RU2440822C2 (enExample)
WO (1) WO2007041632A2 (enExample)
ZA (1) ZA200803493B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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RU2639388C1 (ru) * 2016-10-11 2017-12-21 Федеральное государственное бюджетное учреждение "Государственный научный центр "Институт иммунологии" Федерального медико-биологического агентства России Композиция для терапии вирусного гепатита С

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SI1802650T1 (sl) * 2004-10-01 2012-03-30 Scynexis Inc Eter in tioeter substituirani ciklosporinski derivati za zdravljenje in preventivo pred infekcijami s hepatitisom c
CA2623864C (en) 2005-09-30 2014-12-16 Scynexis, Inc. Arylalkyl and heteroarylalkyl derivatives of cyclosporine a for the treatment and prevention of viral infection
CN105169369B (zh) 2005-09-30 2019-10-18 中美华世通生物医药科技（武汉）有限公司 治疗和预防丙型肝炎感染的方法和药物组合物
EP2023918B1 (en) 2006-05-19 2011-03-23 Scynexis, Inc. Cyclosporins for the treatment and prevention of ocular disorders
KR101089112B1 (ko) * 2006-06-02 2011-12-06 피씨 제스띠옹 에스.아.에스. 활성 전자 관리
AU2007286754A1 (en) * 2006-08-25 2008-02-28 Viropharma Incorporated Identification and characterization of HCV replicon variants with reduced susceptibility to HCV-796, and methods related thereto
US7576057B2 (en) 2006-11-20 2009-08-18 Scynexis, Inc. Cyclic peptides
WO2008127613A1 (en) * 2007-04-11 2008-10-23 Scynexis, Inc. New pharmaceutical compositions
EP2494991A1 (en) 2007-05-04 2012-09-05 Vertex Pharmaceuticals Incorporated Combination therapy for the treatment of HCV infection
EP2116602A1 (en) 2008-05-07 2009-11-11 Institut Gustave Roussy Combination products for treating cancer
JP5820722B2 (ja) * 2008-06-06 2015-11-24 スシネキス インク シクロスポリン類似体及びｈｃｖ感染の治療におけるその使用
WO2009148615A1 (en) * 2008-06-06 2009-12-10 Scynexis, Inc. Cyclosporin analogs and their use in the treatment of hcv infections
KR101068160B1 (ko) * 2008-12-30 2011-09-27 건국대학교 산학협력단 Ｃ형 간염 바이러스 ｒｎａ핵산 중합효소의 활성을 저해하는 신규 플라보놀 유도체
CA2748389A1 (en) * 2008-12-31 2010-07-08 Scynexis, Inc. Derivatives of cyclosporin a
AU2010203660A1 (en) * 2009-01-07 2011-07-28 Scynexis, Inc Combination of a cyclosporine derivative and nucleosides for treating HCV
CN102869775A (zh) 2009-09-30 2013-01-09 哈佛大学校长及研究员协会 通过调节自噬抑制基因产物调节自噬的方法
JP2014520835A (ja) 2011-07-15 2014-08-25 ビーエーエスエフ ソシエタス・ヨーロピア 動物有害生物を駆除するための置換３−ピリジルチアゾール化合物および誘導体ｉを使用した有害生物防除方法
WO2020037530A1 (en) * 2018-08-22 2020-02-27 Waterstone Pharmaceuticals (Wuhan) Co., Ltd. Crystalline form of compound and uses thereof in medicine
AU2021256222A1 (en) * 2020-04-15 2022-10-06 Farsight Medical Technology (Shanghai) Co., Ltd. Prevention and treatment of organ injuries

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WO2005021028A1 (en) * 2003-09-03 2005-03-10 Novartis Ag Use of modified cyclosporins for the treatment of hcv disorders
WO2006039668A2 (en) * 2004-10-01 2006-04-13 Scynexis, Inc 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis c infection

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CA2623864C (en) * 2005-09-30 2014-12-16 Scynexis, Inc. Arylalkyl and heteroarylalkyl derivatives of cyclosporine a for the treatment and prevention of viral infection
EP2023918B1 (en) 2006-05-19 2011-03-23 Scynexis, Inc. Cyclosporins for the treatment and prevention of ocular disorders
US7576057B2 (en) * 2006-11-20 2009-08-18 Scynexis, Inc. Cyclic peptides
WO2008127613A1 (en) 2007-04-11 2008-10-23 Scynexis, Inc. New pharmaceutical compositions
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US5994299A (en) * 1996-12-24 1999-11-30 Rhone-Poulenc Rorer, S.A. Cyclosporin compounds, their preparation and the pharmaceutical compositions which contain them
RU2178293C2 (ru) * 1998-08-18 2002-01-20 Панацея Биотек Лимитед Фармацевтическая композиция, содержащая циклоспорин, способ получения мягких желатиновых капсул
WO2005021028A1 (en) * 2003-09-03 2005-03-10 Novartis Ag Use of modified cyclosporins for the treatment of hcv disorders
WO2006039668A2 (en) * 2004-10-01 2006-04-13 Scynexis, Inc 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis c infection

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2639388C1 (ru) * 2016-10-11 2017-12-21 Федеральное государственное бюджетное учреждение "Государственный научный центр "Институт иммунологии" Федерального медико-биологического агентства России Композиция для терапии вирусного гепатита С

Also Published As

Publication number Publication date
WO2007041632A3 (en) 2007-12-13
RU2008117157A (ru) 2009-11-10
US20070173440A1 (en) 2007-07-26
IL190478A0 (en) 2008-11-03
NZ567262A (en) 2011-12-22
BRPI0616476A2 (pt) 2011-06-21
CN105169369B (zh) 2019-10-18
AU2006299426A1 (en) 2007-04-12
WO2007041632A2 (en) 2007-04-12
AU2006299426B2 (en) 2012-07-26
KR20080059270A (ko) 2008-06-26
ZA200803493B (en) 2009-12-30
JP5517454B2 (ja) 2014-06-11
US7754685B2 (en) 2010-07-13
JP2009510129A (ja) 2009-03-12
CN105169369A (zh) 2015-12-23
CA2623865A1 (en) 2007-04-12
EP1933859A2 (en) 2008-06-25

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20161003