RU2430727C2 - Комбинация производных пиримидиламинобензамида и иматиниба для лечения или профилактики пролиферативных заболеваний - Google Patents

Комбинация производных пиримидиламинобензамида и иматиниба для лечения или профилактики пролиферативных заболеваний Download PDF

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Publication number
RU2430727C2
RU2430727C2 RU2007147957/15A RU2007147957A RU2430727C2 RU 2430727 C2 RU2430727 C2 RU 2430727C2 RU 2007147957/15 A RU2007147957/15 A RU 2007147957/15A RU 2007147957 A RU2007147957 A RU 2007147957A RU 2430727 C2 RU2430727 C2 RU 2430727C2
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RU
Russia
Prior art keywords
ness
combination
acid
alkyl
phenyl
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RU2007147957/15A
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English (en)
Russian (ru)
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RU2007147957A (ru
Inventor
Лила ОЛЛАНД (US)
Лила ОЛЛАНД
Пол У. МАНЛИ (CH)
Пол У. Манли
Юрген МЕСТАН (DE)
Юрген МЕСТАН
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Новартис Аг
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Publication of RU2007147957A publication Critical patent/RU2007147957A/ru
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Publication of RU2430727C2 publication Critical patent/RU2430727C2/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
RU2007147957/15A 2005-06-03 2006-06-02 Комбинация производных пиримидиламинобензамида и иматиниба для лечения или профилактики пролиферативных заболеваний RU2430727C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68775805P 2005-06-03 2005-06-03
US60/687,758 2005-06-03

Publications (2)

Publication Number Publication Date
RU2007147957A RU2007147957A (ru) 2009-07-20
RU2430727C2 true RU2430727C2 (ru) 2011-10-10

Family

ID=36968749

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2007147957/15A RU2430727C2 (ru) 2005-06-03 2006-06-02 Комбинация производных пиримидиламинобензамида и иматиниба для лечения или профилактики пролиферативных заболеваний

Country Status (26)

Country Link
US (2) US7767688B2 (https=)
EP (1) EP1893213B1 (https=)
JP (2) JP5281887B2 (https=)
KR (1) KR101276425B1 (https=)
CN (1) CN101180060B (https=)
AT (1) ATE457727T1 (https=)
AU (1) AU2006255559B2 (https=)
BR (1) BRPI0611506A2 (https=)
CA (1) CA2608814C (https=)
CY (1) CY1110027T1 (https=)
DE (1) DE602006012313D1 (https=)
DK (1) DK1893213T3 (https=)
ES (1) ES2339593T3 (https=)
HR (1) HRP20100265T1 (https=)
IL (1) IL187408A0 (https=)
MA (1) MA29565B1 (https=)
MX (1) MX2007015159A (https=)
NO (1) NO20080037L (https=)
NZ (1) NZ563446A (https=)
PL (1) PL1893213T3 (https=)
PT (1) PT1893213E (https=)
RU (1) RU2430727C2 (https=)
SI (1) SI1893213T1 (https=)
TN (1) TNSN07453A1 (https=)
WO (1) WO2006132930A1 (https=)
ZA (1) ZA200709473B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006255559B2 (en) * 2005-06-03 2009-12-17 Novartis Ag Combination of pyrimidylaminobenzamide compounds and imatinib for treating or preventing proliferative diseases
TW201102068A (en) * 2009-06-02 2011-01-16 Novartis Ag Treatment of ophthalmologic disorders mediated by alpha-carbonic anhydrase isoforms
EP2382976A1 (en) 2010-04-30 2011-11-02 Hiroshima University Use of pdgf-r inhibitors for the treatment of lymph node metastasis of gastric cancer
CN102719530B (zh) * 2012-05-07 2013-11-06 厦门艾德生物医药科技有限公司 一种用于检测PDGFRα基因突变的引物、探针及试剂盒
KR101386697B1 (ko) * 2012-06-18 2014-04-18 아주대학교산학협력단 이매티닙 또는 이의 약학적으로 허용되는 염을 유효성분으로 포함하는 혈관 투과성 관련 질환의 치료 또는 예방용 조성물
AU2018306149B2 (en) 2017-07-26 2021-09-16 Ftf Pharma Private Limited Liquid dosage forms of imatinib
CN113292537B (zh) 2018-06-15 2024-04-05 汉达癌症医药责任有限公司 激酶抑制剂的盐类及其组合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004005281A1 (en) * 2002-07-05 2004-01-15 Novartis Ag Inhibitors of tyrosine kinases
RU2005118417A (ru) * 2002-11-15 2006-01-20 Суджен, Инк. (Us) Комбинированное введение индолинона с химиотерапевтическим средством при нарушениях, вызванных клеточной пролиферацией

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO4940418A1 (es) 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
AU2006255559B2 (en) * 2005-06-03 2009-12-17 Novartis Ag Combination of pyrimidylaminobenzamide compounds and imatinib for treating or preventing proliferative diseases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004005281A1 (en) * 2002-07-05 2004-01-15 Novartis Ag Inhibitors of tyrosine kinases
RU2005118417A (ru) * 2002-11-15 2006-01-20 Суджен, Инк. (Us) Комбинированное введение индолинона с химиотерапевтическим средством при нарушениях, вызванных клеточной пролиферацией

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DEMETRI G.D. et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. // The New England Journal of Medicine, vol.347, no.7. 15 Aug 2002. P.472-480. GLEIXNER K.V. PKS412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mytated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects. // BLOOD, vol.107, no.2, January 2006, p.752-759. МЕЩЕРЯКОВ A.A. Гастроинтестинальные стромальные опухоли - современные возможности лекарственного контроля. // Трудный пациент. Онкология. 2006.№11. *

Also Published As

Publication number Publication date
PL1893213T3 (pl) 2010-08-31
EP1893213A1 (en) 2008-03-05
RU2007147957A (ru) 2009-07-20
TNSN07453A1 (en) 2009-03-17
MA29565B1 (fr) 2008-06-02
CY1110027T1 (el) 2015-01-14
JP2013035853A (ja) 2013-02-21
MX2007015159A (es) 2008-02-15
ATE457727T1 (de) 2010-03-15
NZ563446A (en) 2011-02-25
US7767688B2 (en) 2010-08-03
AU2006255559B2 (en) 2009-12-17
IL187408A0 (en) 2011-07-31
DE602006012313D1 (de) 2010-04-01
EP1893213B1 (en) 2010-02-17
US8653093B2 (en) 2014-02-18
CN101180060A (zh) 2008-05-14
JP5281887B2 (ja) 2013-09-04
HRP20100265T1 (hr) 2010-06-30
KR20080021633A (ko) 2008-03-07
CA2608814C (en) 2013-09-03
SI1893213T1 (sl) 2010-05-31
KR101276425B1 (ko) 2013-06-19
ZA200709473B (en) 2008-12-31
US20100190800A1 (en) 2010-07-29
ES2339593T3 (es) 2010-05-21
DK1893213T3 (da) 2010-06-07
BRPI0611506A2 (pt) 2010-09-14
AU2006255559A1 (en) 2006-12-14
CA2608814A1 (en) 2006-12-14
US20080312252A1 (en) 2008-12-18
WO2006132930A1 (en) 2006-12-14
PT1893213E (pt) 2010-04-19
JP2008542390A (ja) 2008-11-27
NO20080037L (no) 2008-01-03
CN101180060B (zh) 2011-12-28
HK1115528A1 (en) 2008-12-05

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Effective date: 20140603