RU2423890C1 - Sobering action beverage - Google Patents

Abstract

FIELD: food industry. ^ SUBSTANCE: sobering action beverage contains the following ingredients (kg per 100 decalitres of the beverage): citric acid -1.0-1.5, a flavour additive - 90-200, sodium benzoate - 0.150-0.177, a mixture possessing an alcoprotective action including natural honey - 15-25, water-soluble extract of amberat - 0.15-0.25, rosehips syrup - 90, water - the rest. The ratio of amberat extract to water 1:8, water may be carbonated or non-carbonated. The flavour additive may be represented by syrup of berry and/or fruit and/or herb. The berry syrup may be represented by raspberry syrup and/or syrup of red bilberry and/or blueberry and/or cranberry and/or cherry; the herb syrup - by estragon syrup. The amberat extract may be represented by dry powder of amberat extract. ^ EFFECT: production of a beverage with high organoleptic and detoxicant properties; the beverage ensures prompter normalisation of body functions in case of alcohol withdrawal syndrome both with alcoholics and people without alcohol dependency; additionally the beverage has a low cost. ^ 5 cl, 3 tbl, 4 ex

Description

The invention relates to the field of narcology and relates to agents capable of attenuating the toxic effect of alcohol and its metabolic products. The invention can be used for prophylactic use in alcohol abusers.

In recent years, there has been a significant decrease in health indicators and an increase in the incidence of the population of Russia due to a number of objective reasons, among which the excessive consumption of alcohol, which according to the Federal State Statistics Service significantly exceeds the indicators of economically developed countries, is important. Alcohol violates tissue and cellular metabolism, causes electrolyte and microcirculatory disorders, suppresses the immune system, and has an embryotoxic and mutagenic effect. In alcohol abusers, fatty liver, liver cirrhosis, and other digestive diseases are the most common form of disorder. One of the options for mitigating the negative consequences of alcohol consumption is the development and release of products, as well as food products, including soft drinks, which impede its effect on the body. Such products can be recommended to people who consume moderate amounts of alcohol to prevent these disorders.

The prior art drinks with a sobering effect.

So, from the description of the patent of the Russian Federation No. 2255613 (IPC 7: A23L 2/38, publ. 07/10/2005), a carbonated drink that reduces “hangover syndrome” is known, which contains sugar, citric acid, extracts of thyme, oak bark, mountain ash, and dioxide carbon and water in the following ratio of ingredients per 1000 l of drink:

granulated sugar 70.54 kg citric acid (monohydrate) 1.6 kg oak bark extract 14.65 L mountain ash extract 1.47 L thyme extract 0.88 L carbon dioxide 4.15 kg water rest

Also from the RF patent No. 2150871 (IPC 7: A23L 2/39, publ. 06/20/2000), a non-alcoholic drink for relieving a hangover syndrome is known, including water, salt additives, medicinal herbs with a detoxifying, immunostimulating and sobering effect, as salt additives using a balanced salt mixture containing sodium salt, potassium salt, calcium salt and magnesium salt, having a ratio close to their ratio in human blood plasma, with the following components, g / l:

balanced salt mixture of salts sodium, potassium, calcium and magnesium 7.5-12.7 medicinal herbs possessing detoxifying, immunostimulating and sobering action 24.0-70.0 water the rest is up to 1 liter

In addition, from the RF patent No. 2272549 (IPC A23L 2/00 (2006.01), published March 27, 2006), the hangover soft drink “Hangover” is intended for the relief of a hangover syndrome. The drink contains vitamins, a caffeine-containing component, a flavoring additive and a water base, which is used as natural or artificially mineralized mineral water with a total salt content of at least 0.8 g / l with the following components, g / l:

vitamins 0.01-4.0 caffeinated component 0.01-5.0 flavoring additive 0.05-10.0 natural or artificial mineralized mineral water the rest is up to 1 liter

The disadvantages of the known drinks is that they contain a fairly large number of components, including expensive ones, and suggest the use of a long technological process in their production, which leads to increased cost. In addition, as practice shows, they have a weak detoxifying effect, improving subjective sensations; these agents cannot normalize impaired body functions in a fairly short time.

Based on the foregoing, a scientific and practical task was set to develop a recipe for a non-alcoholic beverage of mass consumption based on components widely used in traditional medicine of many peoples of the world, such as mummy extract, rosehip syrup and honey.

The technical result of the present invention is to obtain a tool with high organoleptic and detoxifying properties, which provides, in a shorter time, compared with known drinks, the normalization of impaired body functions in alcohol withdrawal syndrome both in patients with alcoholism and in people who do not have alcohol dependence. Also patented drink has a lower cost. In addition, the claimed technical solution makes it possible to obtain drinks with different taste qualities.

The claimed technical result is achieved through the use of a sobering drink containing citric acid, carbonated or non-carbonated water, a flavoring additive, sodium benzoate and a mixture having an alkoprotective effect, consisting of natural honey, a water-soluble extract of mummy and rosehip syrup, in the following ratio of components per 100 gave a drink:

natural honey 15-25 kg rosehip syrup 90 kg lemon acid 1.0-1.5 kg purified mumiye extract dissolved in water 0.15-0.25 kg

while the ratio of mummy extract to water is 1: 8

sodium benzoate 0.150-0.177 kg flavoring additive 90-200 kg water rest

As a flavoring additive, the drink may contain berry, and / or fruit, and / or herbal syrup, in particular syrup, rose hips, raspberries, cherries, milk thistle, tarragon, sea buckthorn, lemon, lime, as well as tea extract, matcha tea, green tea.

As an extract of the mummy, used as one of the components of the detoxifying mixture, a dry mummy extract of high purity can be used.

Mumiye dry extract contains micro and macro elements (cobalt, nickel, copper, zinc, manganese, chromium, iron, sodium, potassium, magnesium), humic acids, polyphenolic compounds, amino acids, steroids, phospholipids.

Immediately before the preparation of the drink, the dry mummy extract is dissolved in water in a ratio of 1: 8 (1 part mummy and 8 parts water).

Thanks to the use of the purified mummy extract, its 100% solubility in water is achieved in the selected ratio without the formation of a precipitate during its further storage.

Mummy is used as a restorative and tonic, replacing multivitamins and trace elements.

Mumiye has almost no side effects, except in cases of individual intolerance or its use in excessive doses.

In order to activate the antitoxic effect of non-oxidized compounds of phenolic nature and prevent their free spontaneous oxidation, ascorbic acid contained in rosehip syrup is included in the composition of the alkoprotective mixture. In addition, the use of rosehip syrup in the drink leads to the stabilization of the mummy dissolved in water due to the content of natural ascorbic acid in the syrup.

Also, due to the content of vitamins C and P, flavonoids, carotenoids, tannins, and pectins in rosehip syrup, it has a general strengthening effect on the body, stimulates its resistance, enhances tissue regeneration, reduces vascular permeability, takes part in carbohydrate and mineral metabolism, and has anti-inflammatory properties.

Honey is a source of vitamins, glucose and sucrose.

The use of honey in the composition of the drink has a positive effect on the therapeutic and prophylactic effect of this drink, and also improves its taste and aroma.

So, a mixture of natural honey and mummy contains (t / 100 g): water 23.8, protein 0.77, fat 0.23, carbohydrates 74.0, ash 0.26, the energy value of the product is 300 kcal .

The content of proteins in the detoxifying mixture and the high calorie content of honey in the presence of this combination of proteins contribute to the easy digestibility of the drink, creates the optimal concentration of the most important proteins and vitamins in the body, promotes digestion and assimilation of food, which is important for alcohol intoxication.

The process of preparing a detoxifying drink includes the following main technological stages:

- water treatment;

- preparation of an aqueous solution of mummy;

- preparation of blend syrup;

- bottling, clogging;

- storage and transportation.

Water treatment is carried out in accordance with the requirements of GOST R 51232-98.

Mumiye extract (Shilajit) in the amount of 0.15-0.25 kg is dissolved with stirring in water in a ratio of 1: 8. The obtained aqueous mummy solution is added to the blending tank and 100 l of water are added. After that, honey is added to the blending tank with constant stirring and the calculated amount of rosehip syrup is added. After that, pre-dissolved citric acid and sodium benzoate are introduced into the blending tank. By adding water, the volume of the drink is adjusted to 1000 l. All components are mixed for 15-20 minutes, after which they are left for 30 minutes for better assimilation of the aromatic substances of the blend, suppression of the growth of microorganisms by the preservative, and also for the possible isolation of insoluble components and colloidal particles in the sediment. After checking the physico-chemical and organoleptic characteristics, the drink is filtered and sent for bottling.

The invention is further illustrated by the following examples of specific beverage compositions, kg per 100 gave:

Example 1

Natural honey 15 kg lemon acid 1,0 kg Mumiye extract dissolved in water 0.15 kg (the ratio of mummy extract to water was 1: 8) sodium benzoate 0.150 kg rosehip syrup 90 kg flavoring additive (tarragon syrup) 90 kg sparkling water rest

Example 2

Natural honey 25 kg lemon acid 1,5 kg Mumiye extract dissolved in water 0.25 kg (ratio of mumiye extract to water 1: 8) sodium benzoate 0.177 rosehip syrup 115 kg cherry syrup 100 kg sparkling water rest

Example 3

Natural honey 20 kg lemon acid 1.3 kg Mumiye extract dissolved in water 0.25 kg (ratio of mumiye extract to water 1: 8) sodium benzoate 0.150 kg rosehip syrup 100 kg tarragon syrup 120 kg still water rest

Example 4

Natural honey 18 kg lemon acid 1.1 kg Mumiye extract dissolved in water 0.18 kg (ratio of mumiye extract to water 1: 8) sodium benzoate 0.160 kg rosehip syrup 50 kg cherry syrup 100 kg still water rest

Due to the selected composition of the components, the resulting drink is characterized by high alkoprotective properties, which was proved by preclinical trials of drinks prepared in accordance with examples carried out by the Institute of General and Experimental Biology SB RAS.

Studies were performed on white outbred male rats aged 5-6 months, with an initial weight of 200-230 g. Alcoholic hepatitis in animals was reproduced by the introduction of per os ethyl alcohol in the form of a 40% solution in a volume of 7 ml / kg of weight 1 time per day for 21 days. The studied drug “drink” was administered to rats intragastrically in a volume of 1 ml / 100 g during the experiment, the animals of the control group received distilled water according to a similar scheme in the indicated volume. To assess the functional state of the liver, the activity of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, the content of bilirubin, β-lipoproteins in blood serum was determined and a thymol test was performed (Menshikov, 1987). The data obtained are shown in tables 1-2.

Table 1 The influence of the “drink” on the biochemical parameters of the blood of white rats with ethanol damage to the liver Indicators Groups of animals Intact Control (ethanol) Experienced (ethanol + "drink") 7 days Total protein, g / l 7.45 ± 0.01 6.62 ± 0.54 7.12 ± 0.46 Alt, μm / ml · hour 2.62 ± 0.12 3.11 ± 0.13 2.51 ± 0.11 AST, μM / ml · hour 1.43 ± 0.11 2.22 ± 0.07 1.62 ± 0.08 ^* Alkaline phosphatase, units Baud. 7.43 ± 0.68 11.60 ± 0.31 9.81 ± 0.60 β-lipoproteins, conv. units 3.16 ± 0.01 4.75 ± 0.10 3.32 ± 0.10 ^* Total bilirubin, mmol / l 5.82 ± 0.51 16.50 ± 1.07 10.44 ± 0.70 ^* Thymol test, units OP 0.50 ± 0.03 0.66 ± 0.01 0.55 ± 0.03 ^* 14 days Total protein, g / l 7.45 ± 0.01 6.57 ± 0.52 6.98 ± 0.58 Alt, μm / ml · hour 2.62 ± 0.12 4.44 ± 0.06 3.91 ± 0.11 AST, μM / ml · hour 1.43 ± 0.11 2.33 ± 0.04 2.11 ± 0.07 Alkaline phosphatase, units Baud. 7.43 ± 0.68 16.77 ± 1.40 10.50 ± 1.00 ^* β-lipoproteins, conv. units 3.16 ± 0.01 5.21 ± 0.14 3.19 ± 0.16 ^* Total bilirubin, mmol / l 5.82 ± 0.51 24.23 ± 1.53 11.18 ± 1.13 ^* Thymol test, units OP 0.50 ± 0.03 0.96 ± 0.10 0.50 ± 0.03 ^* 21 days Total protein, g / l 7.45 ± 0.01 6.85 ± 0.48 7.20 ± 0.36 Alt, μm / ml · hour 2.60 ± 0.12 2.79 ± 0.25 2,30 ± 0,18 AST, μM / ml · hour 1.43 ± 0.11 1.79 ± 0.13 1.51 ± 0.12 Alkaline phosphatase, units Baud. 7.43 ± 0.68 12.17 ± 0.40 9.21 ± 0.56 ^* β-lipoproteins, conv. units 3.16 ± 0.01 5.42 ± 0.54 3.32 ± 0.40 ^* Total bilirubin, mmol / l 5.82 ± 0.51 8.24 ± 0.85 4.25 ± 0.30 ^* Thymol test, units OP 0.50 ± 0.03 0.73 ± 0.06 0.31 ± 0.02 ^*

With alcoholic damage to the liver of white rats, it was found that the administration of alcohol to animals was accompanied by an increase in the activity of membrane-bound enzymes - Alt and AcT, alkaline phosphatase; an increase in the content of β-lipoproteins, the development of dysproteinemia due to the mesenchymal-inflammatory reaction (Table 1).

Already in the early stages of the development of alcoholic hepatitis (7 days), AcT activity increased by 57%, alkaline phosphatase - by 56%, the concentration of β-lipoproteins increased by 52%, total bilirubin - by 2.8 times. As follows from the data given in table 1, the course introduction of the “drink” to the animals of the experimental group in the experimental therapeutic dose helped to reduce the severity of the syndromes of cytolysis, cholestasis and normalization of lipid metabolism.

The “drink” had the most pronounced positive effect on the manifestations of cholestatic syndrome, as evidenced by a decrease in alkaline phosphatase activity by 16.38 and 29%; bilirubin concentration - by 47% - on the 7th day and 2 times - after 14 and 21 days from the start of the experiment compared with the corresponding parameters in rats of the control group. The content of β-lipoproteins in the blood decreased at the corresponding time by 30.24 and 39% compared with the control, and the thymol test values significantly decreased by 2.3 times at a later date (21 days). The data presented in table 2 indicate that the introduction of ethanol was accompanied by a significant induction of the processes of free radical oxidation (CPO) of lipids and a decrease in the activity of the endogenous antioxidant system of the body. In order to assess the influence of a “drink” on the activity of free radical processes, the contents of malondialdehyde (MDA) (Steel, Garishvili, 1977), diene conjugates (DC) (Gavrilov, Mishkorudnaya, 1983), and reduced glutathione (VG) were determined (Anderson, 1989), as well as the activity of catalase (Korolyuk et al., 1988) and seperoxide dismutase (SOD) (Chevari et al., 1985) in the blood of animals. So, on the 7th day from the start of ethanol administration, an increase in the content of DC in the blood serum by 85% and MDA in the blood serum and liver of white rats was noted by 54 and 39%, respectively, compared with the data in the control. Against this background, there was a significant decrease in the activity of catalase and SOD (by 41 and 31%, respectively) and the content of reduced glutathione by 31% compared with the indices in the rats of the intact group.

table 2 The influence of the “drink” on the content of lipid peroxidation products and the state of antioxidant protection of rats with liver damage by ethanol Indicators Study Dates Groups of animals Intact Control (ethanol) Experienced (ethanol + "drink") MDA μm / ml min in serum 7 days 11.43 ± 0.57 17.61 ± 0.81 14.75 ± 0.14 ^* MDA nmol / g tissue in liver homogenate 2.30 ± 0.11 3.20 ± 0.12 2.70 ± 0.12 DK / srvc. 5.56 ± 0.39 10.32 ± 1.43 7.12 ± 0.54 ^* Catalase, mkat / l 8.67 ± 0.44 5.20 ± 0.11 6.62 ± 0.17 ^* SOD μM / L 12.01 ± 1.50 8.39 ± 0.73 9.70 ± 0.67 VG, μM / L 2.61 ± 0.12 1.81 ± 0.14 2.13 ± 0.14 MDA μm / ml min in serum 14 days 11.43 ± 0.57 20.60 ± 0.30 14.20 ± 0.16 ^* MDA nmol / g in liver homogenate 2.30 ± 0.11 4.50 ± 0.14 2.90 ± 0.25 ^* DK, conventional units 5.56 ± 0.39 18.95 ± 1.16 15,80 ± 1,51 Catalase, mkat / l 8.67 ± 0.44 3.25 ± 0.17 4.90 ± 0.32 ^* SOD μM / L 12.01 ± 1.50 6.73 ± 0.79 9.05 ± 0.76 ^* VG, μM / L 2.61 ± 0.12 1.24 ± 0.16 1.87 ± 0.19 ^*

The course introduction of the “drink” to animals receiving ethanol was accompanied by a significant decrease in the rate of accumulation of DC and MDA in the blood and liver. So, with the introduction of the “drink” after 7 days, a decrease in the concentration of DC in the blood serum was noted by 32%, the MDA content in the blood and liver homogenate of white rats after 14 days from the start of the experiment — by 32 and 36%, respectively, compared with the rats in the control groups. Along with this, the "drink" increased the viability of antioxidant protection: with its course administration after 7 days, the activity of catalase and SOD in blood serum increased compared with the control by 27 and 16%, respectively, after 14 days - by 50 and 34%; the content of reduced glutathione in blood serum increased by 18 and 50%, respectively, of the follow-up period compared with similar data in the control (table 2). Thus, it was found that the course administration of the “drink” in an experimental therapeutic dose in case of damage to rat liver with ethanol has a pronounced hepatoprotective effect, reduces the intensity of cytolysis and cholestasis syndromes, and normalizes lipid metabolism. The antioxidant effect of the “drink” is manifested in a significant decrease in the concentration of products of free radical oxidation of lipids in blood serum and liver homogenate and an increase in the activity of antioxidant enzymes.

The studies also determined the effect of the drink on the content of ethyl alcohol in the blood, which was also carried out on outbred male rats weighing 200-230 g with a single intragastric administration of 40% ethanol in a volume of 7 ml / kg. The animals of the experimental group received a “drink” in a volume of 1 ml / 100 g 2 hours after the introduction of ethyl alcohol, the animals of the control group received an intragastric equivolume amount of distilled water. The concentration of ethyl alcohol in the blood was determined 4 hours after its introduction using test strips "alkosensor" manufactured by LLC "Biosensor" Russia. The data obtained are presented in table 3.

Table 3 The influence of the "drink" on the content of ethyl alcohol in the blood of rats Groups of animals Dose Blood ethanol / ppm Control: alcohol + water - 2.2 ± 0.05 Experienced: alcohol + "drink" 10 ml / kg 1.5 ± 0.01 *

As follows from the data in table 1.1, the introduction of the "drink" to the rats of the experimental group on the background of alcohol helps to reduce the content of ethyl alcohol in the blood by 32% 4 hours after ingestion compared with the data in animals of the control group.

In the course of studies, it was found that the course introduction of a drink in a volume of 1 ml / 100 g in case of damage to rat liver with ethanol has a pronounced hepatoprotective effect, reduces the intensity of cytolysis and cholestasis syndromes, normalizes lipid metabolism, and has an antioxidant effect. It also helps to reduce the level of alcohol in the blood of rats after its administration by increasing the antitoxic function of the liver and accelerating the metabolism of ethanol. Given the above, a “drink” can be considered a food product, the use of which prevents damage to the hepatobiliary system when drinking alcohol and has a sobering effect after taking it.

Claims (5)

1. A sobering drink containing citric acid, carbonated or non-carbonated water, a flavoring additive, sodium benzoate and a mixture having an alkoprotective effect, consisting of natural honey, a water-soluble extract of mummy and rosehip syrup, with the following content of the starting components per 100 gave the drink:
natural honey 15-25 kg rosehip syrup 90 kg lemon acid 1.0-1.5 kg purified in water mummy extract 0.15-0.25 kg
while the ratio of mummy extract to water is 1: 8,
sodium benzoate 0.150-0.177 kg flavoring additive 90-200 kg water rest 2. The drink according to claim 1, characterized in that as a flavoring additive used berry, and / or fruit, and / or herbal syrup. 3. The drink according to claim 2, characterized in that the raspberry and / or lingonberry and / or blueberry and / or cranberry and / or cherry syrup is used as berry syrup. 4. The drink according to claim 2, characterized in that tarragon syrup is used as a herbal syrup. 5. The drink according to claim 1, characterized in that as the extract of the mummy use dry powder of the extract of the mummy.