RU2420271C1 - Method of treating respiratory diseases of young farm animals - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to field of veterinary. Method includes application of medication Cidisept-o according to the following scheme: in dose 0.5-1 ml/kg of body weight, for 7-10 days.

EFFECT: application of method increases efficiency of treatment of respiratory diseases in young farm animals.

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Description

The invention relates to the field of veterinary medicine and for the treatment of respiratory diseases of young farm animals.

Respiratory diseases of young farm animals are widespread in large farms, have a complicated etiology, especially when using intensive animal husbandry methods, characterized by long stay of animals indoors, their high concentration in production areas, exposure to various technological stressors on the body (A.G. Shakhov // Etiology of factorial infections of animals and measures for their prevention / Veterinary pathology. No. 3 - 2005 S. 22-24).

Respiratory diseases mainly occur in the form of mixed viral and bacterial infections, for the prevention and treatment of which strategic medication is important. It implies giving a feed or water of effective antimicrobial agents at therapeutic doses during critical growing periods, which are determined on the basis of epizootological monitoring carried out on farms (A.N. Grechukhin // Effective Treatment and Prevention for Pig Respiratory Symptom Complex / Veterinary Medicine. No. 11 - 2006, S.13-15).

This allows you to significantly reduce the loss of farms from death and shortage of products, reduce stress on animals and reduce labor costs for the therapeutic treatment of large groups of animals in intensive production.

Most often, in preventive therapy, antibiotics are used mixed with food.

However, the activity of antibiotics decreases over time, which is due to the formation of drug resistance, which is almost impossible to prevent (A.G. Khmylov // Doksimag-o - a new drug / Industrial and pedigree pig breeding, No. 3. 2009, p. 71-72 )

In this regard, there is a need for the development and use of antimicrobial agents of non-antibiotic origin, such as, for example, salts of quaternary ammonium compounds, guanidinic acid, etc.

Despite the significant success of veterinary pharmacy, the choice of substances with the indicated properties is limited, and their use does not provide the proper therapeutic effect.

A known method of treating pneumonia using the drug pharmazin. This is an antimicrobial drug in powder form, 1 g of which contains 500 mg of tylosin as the active substance (Veterinary preparations in Russia: A Handbook in 2 volumes. T.1 / I.F.Klenova, K.L. Maltsev, N.A. .Yaremenko, I.A. Arkhipov. - M.: Selkhozizdat, 2004. - p. 187).

Other methods are also known for treating swine pneumonia using, in particular, a 4% gentamicin solution, an antimicrobial drug in the form of a solution for injection and oral administration, 1 ml of which contains 40 mg of gentamicin in the form of gentamicin sulfate as the active substance (Veterinary Preparations in Russia: A Handbook in 2 volumes, Vol. 1 / I.F.Klenova, K.L. 169).

Often used is a method of treating pneumonia with the use of the drug tilovet - a drug in the form of a powder for oral administration, 100 g of which contains 50 g of tylosin tartrate and auxiliary components as the active substance (Veterinary preparations in Russia: A Handbook in 2 volumes. I.F.Klenova, K.L. Maltsev, N.A. Yaremenko, I.A. Arkhipov. - M .: Selkhozizdat, 2004. - p. 182).

The closest technical solution is a method of treating pneumonia using the drug enroflon 10%. This is an oral solution containing 100 mg of enrofloxacin as an active ingredient in 1 ml. The drug is used for young farm animals orally 1 time per day for 5 days in doses of 2.5-5 mg / kg (Veterinary preparations in Russia: a Handbook in 2 volumes. T.1 / I.F.Klenova, K.L. Maltsev , N.A. Yaremenko, I.A. Arkhipov. - M .: Selkhozizdat, 2004. - pp. 235-236).

However, the drug can not be used in conjunction with chloramphenicol tetracyclines, theophylline. And in addition, slaughter for meat of animals that used enroflon is allowed only after 14 days. Meat of animals slaughtered before the expiration of the specified periods shall not be used for food purposes. In addition, the use of this drug does not always lead to positive results, which, apparently, is associated with the development of resistance of the pathogen to the drug.

The technical result of the invention is to increase the effectiveness of the treatment of respiratory diseases of young farm animals.

The method is as follows.

After diagnosis, the animals are administered cidisept-o at a dose of 0.5-1 ml / kg body weight for 7-10 days.

Tsidisept-o - a new antibacterial drug based on cinal (V.I. Belyaev, G. A. Vostroilova, A. L. Indyukov, Yu. M. Kosenko. Pharmacological and toxicological properties and effectiveness of the new antibacterial drug cidisept-o // Agrarian Bulletin of the Urals. - 2008. - No. 8. - P.71-73), consisting of the following ratio of components, wt.%:

Tsiminal - 0.2-0.4;

Methyl cellulose - 0.8%;

Polyethylene oxide-400 - 4.6%;

Water distill. - up to 100.0 g.

Ciminal is a para-nitro-α-chloro-cinnamic aldehyde used in medicine as a part of cimesol and cidipole preparations for the treatment and prevention of purulent complications in soft tissue damage, for the prevention and treatment of urinary tract diseases caused by treponemas, gonococci, and trichomonads (M.D. Mashkovsky. Medicines. - M.: RIA "New Wave": Publisher Umerenkov, 2008. - S.943-944). Ciminal is active against gram-positive and gram-negative microorganisms, promotes epithelization and wound healing.

The essence of the method is illustrated by examples.

Example 1. Performance indicators in the treatment of respiratory diseases in piglets.

The study of the therapeutic efficacy of the drug for respiratory diseases of piglets was carried out in three experiments. The etiology of pneumonia was established comprehensively on the basis of clinical, pathoanatomical data and laboratory results.

The first experiment was conducted at Liven Meat OJSC Agrofirm of the Liven district of the Oryol region on pigs of 40-45 days old, which were divided into 2 groups, taking into account the general condition and severity of the disease, under the same feeding and maintenance conditions.

During bacteriological examination of pathological material from piglets killed for diagnostic purposes, pneumonia, Pasteurella multocida, Salmonella cholerae suis, Salmonella typhimurium, Streptococcus pneumoniae were isolated. Molecular genetic studies have revealed the genomes of Mycoplasma hyopneumoniae, PRRS and CVS-II viruses.

The animals of the experimental group (n = 34) once a day for 10 consecutive days were administered cidisept-o orally at a dose of 0.5 ml / kg body weight. Piglets of the second (control) group (n = 32) were administered the drug enroflox orally 1 time per day for 10 days at a dose of 2 ml per animal.

For experimental animals, daily clinical observations were carried out for 10 days, taking into account the number of recovered animals, mortality, and weight gain. The test results are presented in table 1.

From table 1 it is seen that the therapeutic efficacy of cidisept-o was 79.4%. When using enroflox, it amounted to 75.0%. In the experimental group of piglets treated with cidisept-o, there was no death; when enroflox was prescribed, 2 (6.2%) piglets fell. When using cidisept-o, the average daily weight gain was 145 g, in the base case - 150 g. In both groups, the animals recovered on the 8th day of treatment.

Table 1 Comparative therapeutic efficacy of cidisept-o for respiratory infections in piglets Indicators Tsidisept-o Enroflox Number of animals, goal. 34 32 Fallen, goal.% 0 (0) 2 (6.2) Recover, goal.% 27 (79.4) 24 (75.0) Remained sick, goal.% 7 (20.6) 6 (18.8) Recovery time, days 8.2 ± 0.2 8.3 ± 0.4 The average daily weight gain, g 145 150 Therapeutic efficacy,% 79.4 75.0

The second experiment was carried out in the Livestock Meat Agrofirm OJSC of the Liven district of the Oryol Region on piglets of 2.5 months of age.

Pasteurella multocida, Haemophilus parasuis, Streptococcus pneumoniae were isolated during bacteriological examination of pathological material from piglets killed for diagnostic purposes with pneumonia. In a molecular genetic study, the genomes of the CVC-II virus, chlamydia, Mycoplasma hyiopneumoniae, Mycoplasma hyorhinis were isolated.

The animals of the experimental group (n = 12) once a day for 10 consecutive days were administered cidisept-o orally at a dose of 0.5 ml / kg body weight. Piglets of the second (control) group (n = 11) were administered the drug enroflox orally 1 time per day for 10 days at a dose of 2 ml per animal.

For experimental animals, daily clinical observations were carried out for 10 days, taking into account the number of recovered animals, mortality, and weight gain. The test results are presented in table 2.

From table 2 it is seen that the therapeutic efficacy of cidisept-o was 83.3%, enroflox - 81.8%. When using cidisept-o, the average daily weight gain of animals was 285 g, in the control - 289 g. Recovery of piglets in the experimental group occurred on the 8th day of treatment, in the control group on the 7th day.

table 2 Comparative therapeutic efficacy of cidisept-o for respiratory infections in piglets Indicators Tsidisept-o Enroflox Number of animals, goal. 12 eleven Fallen, goal.% 0 0 Recover, goal.% 10 (83.3) 9 (81.8) Remained sick, goal.% 2 (16.7) 2 (18.2) Recovery time, days 8.0 ± 0.31 7.6 ± 0.26 The average daily weight gain, g 285 ± 5.6 289 ± 4.0 Therapeutic efficacy,% 83.3 81.8

The third experiment was carried out on the collective farm-breeding plant them. Lenin of the Tambov district of the Tambov region on piglets of 50-55 days of age, divided into two groups and under the same conditions.

During bacteriological examination of pathological material, cultures of Pasteurella multocida and Salmonella cholerae suis were isolated. Molecular genetic studies revealed the genomes of Mycoplasma hyopneumoniae, Mycoplasma hyorhinis and CVS-II.

The animals of the experimental group (n = 22) once a day for 9 consecutive days were administered cidisept-o orally at a dose of 0.75 ml / kg body weight. Piglets of the second (control) group (n = 20) served as the basic version and they used the drug tylosin (manufactured by ZAO Nita-Farm, Saratov; series 487210408) intramuscularly at a dose of 1 ml per 10 kg of body weight 1 time per day within 9 days.

For experimental animals, daily clinical observations were made for 10 days, taking into account the number of recovered animals, mortality, and weight gain. The test results are presented in table 3.

Table 3 Comparative therapeutic efficacy of cidisept-o for respiratory infections in piglets Indicators Tsidisept-o Tylosin Number of animals, goal. 22 twenty Fallen, goal.% 0 (0) 0 (0) Recover, goal.% 18 (81.8) 16 (80.0) Remained sick, goal.% 4 (18.2) 4 (20.0) Recovery time, days 6.78 ± 0.13 7.00 ± 0.16 The average daily weight gain, g 175 ± 5.2 181 ± 5.9 Therapeutic efficacy,% 81.8 80.0

From table 3 it is seen that the therapeutic efficacy of cidisept-o was 81.8%, enroflox - 80.0%. When using cidisept-o, the average daily weight gain of piglets was 175 g, enroflox - 181 g. In the experimental group, the animals recovered on the 6th day of treatment, in the control group on the 7th day.

Example 2. Performance indicators in the treatment of respiratory diseases in calves.

The study of the therapeutic effectiveness of cidisept-o in respiratory diseases of calves was carried out in two experiments. The etiology of pneumonia was established comprehensively on the basis of clinical, pathological data and laboratory results.

The first experiment was conducted in the SEC "Staronikolskoye" of the Khokholsky district of the Voronezh region on calves of 2-2.5 months of age weighing 60-85 kg.

During bacteriological examination of pathological material from sick calves, cultures of Streptococcus pneumoniae, Streptococcus bovis, Staph. aureus. In the study of nasal swabs by PCR, the herpes virus of the cattle type I virus (virus ИРТ) was isolated.

The calves of the experimental group (n = 16) were used cidisept-o orally at a dose of 0.5 ml / kg body weight, control (n = 15) - enroflox 10%, dose, method, frequency of administration of the drug was determined according to the instructions for use.

The animals were clinically monitored, taking into account the general condition, mortality, and terms of clinical recovery.

The results of the experiment are presented in table 4.

Table 4 Therapeutic efficacy of cidisept-o in respiratory diseases in calves Indicators Group of animals Enroflox 10% Tsidisept-o Number of animals, goal. 17 16 Recover, goal. (%) 14 (82.4) 14 (87.5) It’s fallen, a goal. (%) - - Remained sick, goal. (%) 3 (17.6) 2 (12.5) Recovery time, days 7.5 ± 0.5 6.2 ± 0.4 Therapeutic efficacy,% 82,4 87.5

The use of cidisept-o contributed to the recovery of 87.5% of the animals with 82.4% in the control group. In the experimental group, recovery averaged 1.3 days faster than in the control group (Table 4).

The second experience in studying the therapeutic effectiveness of cidisept-o in respiratory diseases in calves of 2 months of age was carried out in the SEC (Artel) "Dawn" of Kolpnyansky district, Oryol region.

During bacteriological examination of pathological material (lungs with mediastinal nodes) streptococcus gr. Was isolated from a fallen calf with respiratory pathology. D. A molecular genome study of a lung suspension from this calf revealed the genomes of Mycoplasma spp. and the IRT virus.

For the treatment of calves in the control group, Enroflox 10% was used in accordance with the instructions for use.

The animals of the experimental group were treated with cidisept-o orally at a dose of 0.5 ml / kg body weight once a day for 7 days.

The results of the experiment are presented in table 5.

Table 5 Therapeutic efficacy of cidisept-o in respiratory diseases in calves Indicators Tsidisept-o Enroflox 10% Number of animals, goals 41 43 Healed, goals (%) 35 (85.4) 35 (81.4) Fallen, goals (%) - - Remained sick, goals (%) 6 (14.6) 8 (18.6) Duration of recovery, days 6.4 ± 0.3 7.6 ± 0.6 Therapeutic efficacy,% 85,4 82.5

It was found that cidisept-o has a fairly high therapeutic efficacy in respiratory diseases of calves (85.4%), which exceeds by 4.0% that of the base case. The drug provides an earlier recovery (1.2 days), high safety of animals.

Thus, studies have established that the drug has a pronounced therapeutic effect in respiratory diseases of piglets and calves. The use of the drug is technologically and cost-effective.

Claims (1)

A method of treating respiratory diseases of young farm animals, comprising the use of a complex preparation, characterized in that Tsidisept-o is used as such a preparation according to the following scheme: at a dose of 0.5-1 ml / kg body weight for 7-10 days.