RU2791454C1 - Method for treatment of viral diarrhea of young cattle - Google Patents

Abstract

FIELD: veterinary medicine.

SUBSTANCE: invention relates to the field of veterinary medicine and is intended for therapeutic measures in outbreaks of viral diarrhea of young cattle. A method for the treatment of viral diarrhea of young cattle is proposed, including the vitaminization of animals, and on the first day the diseased animals are injected with fat-soluble vitamins “Tetravit” in an amount of 5 ml per head, after 2 days the drug “Mixoferon” is injected at a dosage of 1000 MG per 1 kg of weight twice with an interval of 48 hours, a day later during the following three days, group inhalation is carried out, all gates, doors and windows in the room are closed, four plastic buckets are placed equidistant from opposite gates and each other, an equal amount of iodine chloride in an amount of 3 liters is poured into each bucket, 70 g of aluminum wire is placed and the start of the reaction is anticipated, after 3 hours, the room is ventilated.

EFFECT: invention makes it possible to effectively treat viral diarrhea.

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Description

The invention relates to the field of veterinary medicine and is intended for carrying out therapeutic measures in case of outbreaks of viral diarrhea in young cattle at breeding and commercial enterprises for the production of beef.

Viral diarrhea (mucosal disease) is a contagious disease of cattle, mainly young animals. It is caused by an RNA-containing virus of the Togaviridae family, accompanied by fever, erosive and ulcerative inflammation of the mucous membranes of the gastrointestinal tract, rhinitis and diarrhea. Mostly unvaccinated young animals from 2 months to 2 years are affected. Infection occurs mainly by airborne droplets and alimentary. Viral diarrhea can occur as part of mixed respiratory diseases of both viral (infectious rhinotracheitis, parainfluenza 3) and bacterial (pasteurellosis) etiology.

In this regard, traditional treatment is reduced to the use of antiviral agents, fortification of animals (to increase nonspecific immunity) and antibiotic therapy with tetracycline drugs (to prevent secondary microbial infections). In some cases, an intramuscular injection of hyperimmune serum against classical swine fever is used, since the causative agent of this disease is antigenically close to the causative agent of viral diarrhea in cattle. In parallel, symptomatic therapy of sick animals is carried out. However, as practice shows, such measures are often insufficient for the complete elimination of the disease, as a result of which cases of the death of about half of the diseased animals were recorded (even among adult livestock). Therefore, there is an urgent need in cattle breeding to develop an effective way to combat bovine viral diarrhea.

EFFECT: elimination of symptoms of viral diarrhea and the full significance of sick livestock from this disease.

The technical result is achieved by a method for treating viral diarrhea of young cattle, including fortification of animals, characterized in that on the first day sick animals are injected with fat-soluble vitamins Tetravit in the amount of 5 ml per head, after 2 days the drug "Mixoferon" is injected at a dosage of 1000 IU. per 1 kg. body weight twice with an interval of 48 hours, a day later, for the next three days, group inhalation is carried out, consisting of iodine chloride vapor in the amount of 3 l and 70 g of aluminum wire, while inhalation is carried out for 3 hours.

Saturation of the body with vitamins A, E and D helps to strengthen nonspecific immunity, in particular, Retinol has a beneficial effect on the mucous membranes and epithelium of the respiratory and digestive organs. The mechanism of action of vitamin E (tocopherol) is associated with an antioxidant effect that prevents lipid peroxidation (including retinol). (Komov V.P., Shvedova V.N. Biochemistry. M., "Bud" - 2004. - 640 p.).

The interferon drug "Mixoferon" has antiviral and immunomodulatory effects. They suppress the reproduction of DNA and RNA containing viruses by inhibiting the expression of viral genes. The immunomodulatory effect of interferon includes an effect on the cellular parts of the immune system: it stimulates the lytic activity of lymphocytes, specific cytotoxic T-lymphocytes and macrophages, affects the formation of specific antibodies by B-lymphocytes, regulates the expression of KLA antigens on cell membranes and stimulates the production of its own interferon alpha.

Iodine chloride belongs to the group of oxidizing agents. When interacting with aluminum, a chemical reaction occurs with the release of molecular iodine and partial chlorine into the environment. Iodine vapor has a strong disinfectant effect on bacteria (including mycobacteria), viruses, fungi, mycoplasmas, spores, coccidia oocysts, helminth eggs and others. Moreover, microorganisms do not develop resistance to molecular iodine as well as to antibiotics. At the same time, the air of the livestock building is sanitized, which also prevents the spread of the causative agent of viral diarrhea in cattle.

Thus, the multi-stage cleaning of the respiratory and digestive systems of the body contributes to the activation of the pathogenic Agent and provides a stable therapeutic effect.

An example of a specific application. The claimed method was tested during an outbreak of cattle diarrhea in New Agrarian Technologies LLC (Krutoy Verkh branch) in the Zaraisky district of the Moscow region on a commercial beef farm. Scientific production tests of the proposed method of treatment were carried out at the end of the pasture season in November on crossbred animals n=165.

Crossbred young cattle (Hereford, Yaroslavl and Galloway breeds), 4-12 months of age, were kept loose in a standard calf barn with a walking area. Feeding: crushed barley 0.5 kg / head from the feeder, wheat straw ad libitum. Livestock had free access to drinking water and table salt. The preliminary diagnosis of "bovine viral diarrhea" was made on the basis of the epizootic situation in the area and clinical signs, as well as according to laboratory tests.

Tetravit and mixoferon injections were carried out under standard split conditions for veterinary treatments. With the appearance of the first signs of the disease (depressed state, elevated body temperature (up to 39.5C), rapid intermittent breathing, profuse lacrimation and salivation), the animals had a sharp decrease in appetite, severe cough and shortness of breath appeared, and some individuals had diarrhea or rumenostasis. In severe cases, erosions appeared on the lips, nasal mucosa and in the nasolabial mirror; in 17 heads, beginning signs of bronchitis and bronchopneumonia were noted. After laboratory confirmation of the diagnosis, a complex of therapeutic and preventive measures aimed at eliminating the disease was carried out.

On the first day, the entire livestock was fortified. Each animal was intramuscularly injected with 5 ml of tetravit, then, after 2 days, the animals were intramuscularly injected with 1000 IU of the drug "Mixoferon" per 1 kg. body weight twice with an interval of 48 hours (we select the area for injection, wash with warm water and a solution with an antiseptic, wipe the needle insertion site with an alcohol solution, bring the syringe to the animal’s body at a right angle, insert the needle, push the solution out of the syringe with a piston, remove the needle from body, treat the injection site with iodine). A day later, for 3 days, all the livestock were subjected to a group 3-hour inhalation with iodine vapor, driving all the cattle into the calf.

For group inhalation:

1. Closed all gates, doors and windows in the room;

2. Four plastic buckets were placed equidistant from the opposite gates and each other;

3. Poured into each bucket an equal amount of iodine chloride in the amount of 3 liters, put 70 g of aluminum wire and waited for the reaction to begin;

4. After 3 hours, the room was ventilated.

The procedure was repeated for three consecutive days.

As a result, after inhalation, the main symptoms of the disease disappeared in all animals, and the stopped cases of the disease made it possible to ascertain the complete recovery of the animals.

Thus, the proposed method of treatment ensures the elimination of the symptoms of viral diarrhea in cattle and the complete cure of animals from this disease.

Claims (1)

A method for the treatment of viral diarrhea in young cattle, including fortification of animals, characterized in that on the first day, sick animals are injected with fat-soluble vitamins "Tetravit" in the amount of 5 ml per head, after 2 days the drug "Mixoferon" is injected at a dosage of 1000 IU per 1 kg body weight twice with an interval of 48 hours, a day later for the next three days for group inhalation, all gates, doors and windows in the room are closed, four plastic buckets are placed equidistant from the opposite gates and each other, an equal amount of iodine chloride is poured into each bucket in amount of 3 l, put 70 g of aluminum wire and wait for the reaction to begin, after 3 hours ventilate the room.