RU2413504C3 - ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ПРОИЗВОДНЫЕ 2,3-ДИГИДРО-6-НИТРОИМИДАЗО[2,1-b]ОКСАЗОЛА - Google Patents

ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ПРОИЗВОДНЫЕ 2,3-ДИГИДРО-6-НИТРОИМИДАЗО[2,1-b]ОКСАЗОЛА

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Publication number
RU2413504C3
RU2413504C3 RU2008107595A RU2008107595A RU2413504C3 RU 2413504 C3 RU2413504 C3 RU 2413504C3 RU 2008107595 A RU2008107595 A RU 2008107595A RU 2008107595 A RU2008107595 A RU 2008107595A RU 2413504 C3 RU2413504 C3 RU 2413504C3
Authority
RU
Russia
Prior art keywords
oxazole
pharmaceutical composition
nitroimidazo
dihydro
composition containing
Prior art date
Application number
RU2008107595A
Other languages
English (en)
Other versions
RU2413504C2 (ru
RU2008107595A (ru
Original Assignee
Оцука Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Оцука Фармасьютикал Ко., Лтд. filed Critical Оцука Фармасьютикал Ко., Лтд.
Publication of RU2008107595A publication Critical patent/RU2008107595A/ru
Publication of RU2413504C2 publication Critical patent/RU2413504C2/ru
Application granted granted Critical
Publication of RU2413504C3 publication Critical patent/RU2413504C3/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Claims (1)

  1. Фармацевтическая композиция для лечения туберкулеза, содержащая: (I) оксазольное соединение (R)-2-метил-6-нитро-2-{4-[4-(4-трифторметоксифенокси)пиперидин-1-ил]феноксиметил}-2,3-дигидроимидазо[2,1-b]оксазол; (II) соединение целлюлозы фталат гидроксипропилметилцеллюлозы, причем соотношение ингредиента (II) к ингредиенту (I) таково, что ингредиент (II) используется в количестве, составляющем 3 массовые доли на массовую долю ингредиента (I); и витамин Е, который является dl-α-токоферолом.
RU2008107595A 2005-07-28 2006-07-19 ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ПРОИЗВОДНЫЕ 2,3-ДИГИДРО-6-НИТРОИМИДАЗО[2,1-b]ОКСАЗОЛА RU2413504C3 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005-218563 2005-07-28
JP2005218563 2005-07-28

Publications (3)

Publication Number Publication Date
RU2008107595A RU2008107595A (ru) 2009-09-10
RU2413504C2 RU2413504C2 (ru) 2011-03-10
RU2413504C3 true RU2413504C3 (ru) 2021-10-05

Family

ID=37038507

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2008107595A RU2413504C3 (ru) 2005-07-28 2006-07-19 ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ПРОИЗВОДНЫЕ 2,3-ДИГИДРО-6-НИТРОИМИДАЗО[2,1-b]ОКСАЗОЛА

Country Status (24)

Country Link
US (1) US7943623B2 (ru)
EP (1) EP1906926B1 (ru)
JP (1) JP4808246B2 (ru)
KR (1) KR101294921B1 (ru)
CN (1) CN101222913B (ru)
AR (1) AR055357A1 (ru)
AT (1) ATE489943T1 (ru)
AU (1) AU2006273355B2 (ru)
CA (1) CA2610749C (ru)
CY (1) CY1111653T1 (ru)
DE (1) DE602006018617D1 (ru)
DK (1) DK1906926T3 (ru)
ES (1) ES2355524T3 (ru)
HK (1) HK1114565A1 (ru)
MX (1) MX2008001210A (ru)
MY (1) MY144554A (ru)
PL (1) PL1906926T3 (ru)
PT (1) PT1906926E (ru)
RU (1) RU2413504C3 (ru)
SI (1) SI1906926T1 (ru)
TW (1) TWI382857B (ru)
UA (1) UA95251C2 (ru)
WO (1) WO2007013477A1 (ru)
ZA (1) ZA200710404B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2539335A1 (en) * 2003-10-31 2005-05-12 Otsuka Pharmaceutical Co., Ltd. 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis
TW201200523A (en) * 2010-01-29 2012-01-01 Otsuka Pharma Co Ltd Synthetic intermediate of oxazole compound and method for producing the same
WO2015049693A1 (en) 2013-10-04 2015-04-09 Council Of Scientific & Industrial Research 6-NITRO-2,3-DIHYDROIMIDAZO[2,1-b]OXAZOLES AND A PROCESS FOR THE PREPARATION THEREOF
AU2019287313A1 (en) * 2018-06-11 2021-01-07 Otsuka Pharmaceutical Co., Ltd. Delamanid-containing composition

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2287971T3 (es) * 1997-08-11 2007-12-16 Pfizer Products Inc. Dispersiones farmaceuticas solidas con biodisponibilidad incrementada.
CA2474838C (en) 2002-02-01 2009-01-06 Pfizer Products Inc. Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials
AR041198A1 (es) * 2002-10-11 2005-05-04 Otsuka Pharma Co Ltd Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b] oxaxol, y composiciones farmaceuticas que lo contienen
KR100655670B1 (ko) 2002-10-15 2007-02-28 오쓰까 세이야꾸 가부시키가이샤 1-치환된 4-니트로이미다졸 화합물 및 이의 제조 방법
JP4258630B2 (ja) * 2002-10-15 2009-04-30 大塚製薬株式会社 １位置換−４−ニトロイミダゾール化合物及びその製造法
CA2539335A1 (en) * 2003-10-31 2005-05-12 Otsuka Pharmaceutical Co., Ltd. 2,3-dihydro-6-nitroimidazo (2,1-b) oxazole compounds for the treatment of tuberculosis

Also Published As

Publication number Publication date
ES2355524T3 (es) 2011-03-28
RU2413504C2 (ru) 2011-03-10
MY144554A (en) 2011-09-30
AU2006273355B2 (en) 2012-01-19
KR101294921B1 (ko) 2013-08-08
EP1906926A1 (en) 2008-04-09
ATE489943T1 (de) 2010-12-15
BRPI0613883A2 (pt) 2011-02-15
CA2610749A1 (en) 2007-02-01
US20100130508A1 (en) 2010-05-27
PL1906926T3 (pl) 2011-04-29
CN101222913A (zh) 2008-07-16
RU2008107595A (ru) 2009-09-10
JP4808246B2 (ja) 2011-11-02
PT1906926E (pt) 2011-01-26
CA2610749C (en) 2013-06-04
AR055357A1 (es) 2007-08-22
HK1114565A1 (en) 2008-11-07
ZA200710404B (en) 2008-10-29
DE602006018617D1 (de) 2011-01-13
JP2009502736A (ja) 2009-01-29
DK1906926T3 (da) 2011-01-31
AU2006273355A1 (en) 2007-02-01
US7943623B2 (en) 2011-05-17
MX2008001210A (es) 2008-03-24
TWI382857B (zh) 2013-01-21
KR20080033458A (ko) 2008-04-16
SI1906926T1 (sl) 2011-02-28
CN101222913B (zh) 2011-09-21
WO2007013477A1 (en) 2007-02-01
CY1111653T1 (el) 2015-10-07
UA95251C2 (ru) 2011-07-25
EP1906926B1 (en) 2010-12-01
TW200727917A (en) 2007-08-01

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