RU2407743C2 - Фармацевтические соединения - Google Patents
Фармацевтические соединения Download PDFInfo
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- RU2407743C2 RU2407743C2 RU2008108623/04A RU2008108623A RU2407743C2 RU 2407743 C2 RU2407743 C2 RU 2407743C2 RU 2008108623/04 A RU2008108623/04 A RU 2008108623/04A RU 2008108623 A RU2008108623 A RU 2008108623A RU 2407743 C2 RU2407743 C2 RU 2407743C2
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- Prior art keywords
- dihydrotetrabenazine
- psychosis
- cis
- compound
- isomer
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
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- General Health & Medical Sciences (AREA)
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- Neurosurgery (AREA)
- Organic Chemistry (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| GB0516790.3 | 2005-08-16 | ||
| GB0516790A GB0516790D0 (en) | 2005-08-16 | 2005-08-16 | Pharmaceutical compounds |
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| SI (1) | SI1855677T1 (OSRAM) |
| WO (1) | WO2007017654A1 (OSRAM) |
Cited By (1)
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| RU2783865C2 (ru) * | 2017-04-01 | 2022-11-21 | Адептио Фармасьютикалз Лимитед | Фармацевтические композиции |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2007317242B2 (en) | 2006-11-08 | 2013-08-01 | Neurocrine Biosciences, Inc. | Substituted 3-isobutyl-9, 10-dimethoxy-1,3,4,6,7,11B-hexahydro-2H-pyrido[2,1-a] isoquinolin-2-ol compounds and methods relating thereto |
| US7897768B2 (en) | 2007-06-08 | 2011-03-01 | General Electric Company | Method for making tetrabenazine compounds |
| US8053578B2 (en) | 2007-11-29 | 2011-11-08 | General Electric Company | Alpha-fluoroalkyl dihydrotetrabenazine imaging agents and probes |
| GB0810857D0 (en) * | 2008-06-13 | 2008-07-23 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| GB2463451A (en) * | 2008-09-08 | 2010-03-17 | Cambridge Lab | 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia |
| GB2463283A (en) * | 2008-09-08 | 2010-03-10 | Cambridge Lab | 3,11b-cis-dihydrotetrabenazine for use in treating asthma |
| WO2011153157A2 (en) | 2010-06-01 | 2011-12-08 | Auspex Pharmaceutical, Inc. | Benzoquinolone inhibitors of vmat2 |
| KR101882044B1 (ko) | 2011-04-01 | 2018-07-25 | 쓰리엠 이노베이티브 프로퍼티즈 캄파니 | 트라이아진계 자외선 흡수제를 포함하는 필름 |
| MX2016009817A (es) | 2014-01-27 | 2017-02-28 | Auspex Pharmaceuticals Inc | Inhibidores de benzoquinolina del transportador vesicular de monoaminas 2. |
| CN113368110A (zh) | 2014-02-07 | 2021-09-10 | 纽罗克里生物科学有限公司 | 包含抗精神病药物和vmat2抑制剂的药物组合物及其用途 |
| ES2972600T3 (es) | 2015-10-30 | 2024-06-13 | Neurocrine Biosciences Inc | Sales de diclorhidrato de valbenazina y polimorfos de las mismas |
| DK3394057T3 (da) | 2015-12-23 | 2022-04-11 | Neurocrine Biosciences Inc | Syntetisk fremgangsmåde til fremstilling af (S)-(2R,3R,11BR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11B-hexahydro-1H-pyrido[2,1,-A]isoquinolin-2-yl 2-amino-3-methylbutanoat-di(4-methylbenzensulfonat) |
| TW202515564A (zh) * | 2016-12-02 | 2025-04-16 | 美商紐羅克里生物科學有限公司 | 戊苯那嗪（valbenazine）於治療精神分裂症或情感性精神分裂症之用途 |
| JP7199359B2 (ja) | 2017-01-27 | 2023-01-05 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | 特定のｖｍａｔ２インヒビターを投与するための方法 |
| GB201705306D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705304D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705302D0 (en) * | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705303D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| BR112020005373A2 (pt) | 2017-09-21 | 2020-09-24 | Neurocrine Biosciences Inc. | formulação de valbenazina em alta dosagem e composições, métodos e kits relacionados com valbenazina |
| KR20250070134A (ko) | 2017-10-10 | 2025-05-20 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 특정 vmat2 억제제의 투여 방법 |
| SG11202003194YA (en) | 2017-10-10 | 2020-05-28 | Neurocrine Biosciences Inc | Methods for the administration of certain vmat2 inhibitors |
| GB201808464D0 (en) | 2018-05-23 | 2018-07-11 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compounds for use in treating huntington's disease |
| MA53239A (fr) | 2018-08-15 | 2022-05-04 | Neurocrine Biosciences Inc | Procédés d'administration de certains inhibiteurs de vmat2 |
| US10940141B1 (en) | 2019-08-23 | 2021-03-09 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2073678C1 (ru) * | 1991-01-25 | 1997-02-20 | Ф.Хоффманн-Ля Рош Аг | (s)-1-[(10-хлор-6,7-дигидро-4-оксо-3-фенил-4h-бензо/а/хинолизин-1-ил)карбонил]-3-этоксипирролидин, (s)-1-[(10-хлор-6,7-дигидро-4-оксо-3-фенил-4h-бензо/а/хинолизин-1-ил)карбонил]-3-оксипирролидин в качестве промежуточного продукта, композиция, обладающая гипнотическим неседативным действием |
| WO1999021856A1 (fr) * | 1997-10-28 | 1999-05-06 | Pierre Fabre Medicament | Derives d'aminomethyl-benzo[a]quinolizidine, leur preparation et leur application en therapeutique pour les maladies neurodegeneratives |
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| US2830993A (en) * | 1958-04-15 | Quinolizine derivatives | ||
| US2843591A (en) | 1958-07-15 | Method for preparing same | ||
| US6087376A (en) * | 1997-02-05 | 2000-07-11 | University Of Kentucky Research Foundation | Use of lobeline compounds in the treatment of central nervous system diseases and pathologies |
| GB2410947B (en) * | 2004-02-11 | 2008-09-17 | Cambridge Lab Ltd | Pharmaceutical compounds |
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2009
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| RU2073678C1 (ru) * | 1991-01-25 | 1997-02-20 | Ф.Хоффманн-Ля Рош Аг | (s)-1-[(10-хлор-6,7-дигидро-4-оксо-3-фенил-4h-бензо/а/хинолизин-1-ил)карбонил]-3-этоксипирролидин, (s)-1-[(10-хлор-6,7-дигидро-4-оксо-3-фенил-4h-бензо/а/хинолизин-1-ил)карбонил]-3-оксипирролидин в качестве промежуточного продукта, композиция, обладающая гипнотическим неседативным действием |
| WO1999021856A1 (fr) * | 1997-10-28 | 1999-05-06 | Pierre Fabre Medicament | Derives d'aminomethyl-benzo[a]quinolizidine, leur preparation et leur application en therapeutique pour les maladies neurodegeneratives |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2783865C2 (ru) * | 2017-04-01 | 2022-11-21 | Адептио Фармасьютикалз Лимитед | Фармацевтические композиции |
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| JP2009504622A (ja) | 2009-02-05 |
| CY1108843T1 (el) | 2014-07-02 |
| WO2007017654A1 (en) | 2007-02-15 |
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| ATE415968T1 (de) | 2008-12-15 |
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| DK1855677T3 (da) | 2009-02-09 |
| SI1855677T1 (sl) | 2009-04-30 |
| AU2006277753B2 (en) | 2011-11-10 |
| NZ566011A (en) | 2011-01-28 |
| EP2050451B1 (en) | 2011-11-23 |
| ATE534391T1 (de) | 2011-12-15 |
| EP2050451A1 (en) | 2009-04-22 |
| KR20080033500A (ko) | 2008-04-16 |
| US20110257220A1 (en) | 2011-10-20 |
| DE602006004009D1 (de) | 2009-01-15 |
| HK1111083A1 (en) | 2008-08-01 |
| EP1855677A1 (en) | 2007-11-21 |
| HRP20090074T3 (en) | 2009-04-30 |
| RS50807B (sr) | 2010-08-31 |
| PL1855677T3 (pl) | 2009-07-31 |
| ES2318771T3 (es) | 2009-05-01 |
| AU2006277753A1 (en) | 2007-02-15 |
| CA2620960A1 (en) | 2007-02-15 |
| RU2008108623A (ru) | 2009-09-20 |
| MX2008001549A (es) | 2008-04-04 |
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