JP2009504622A - 医薬化合物 - Google Patents
医薬化合物 Download PDFInfo
- Publication number
- JP2009504622A JP2009504622A JP2008525620A JP2008525620A JP2009504622A JP 2009504622 A JP2009504622 A JP 2009504622A JP 2008525620 A JP2008525620 A JP 2008525620A JP 2008525620 A JP2008525620 A JP 2008525620A JP 2009504622 A JP2009504622 A JP 2009504622A
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- Prior art keywords
- dihydrotetrabenazine
- cis
- psychosis
- compound
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0516167.4A GB0516167D0 (en) | 2005-08-06 | 2005-08-06 | Pharmaceutical compounds |
| GB0516790A GB0516790D0 (en) | 2005-08-16 | 2005-08-16 | Pharmaceutical compounds |
| PCT/GB2006/002936 WO2007017654A1 (en) | 2005-08-06 | 2006-08-04 | 3, hb cis dihydrotetrabanezine for the treatment of schizophrenia and other psychoses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009504622A true JP2009504622A (ja) | 2009-02-05 |
| JP2009504622A5 JP2009504622A5 (OSRAM) | 2009-09-24 |
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|---|---|---|---|
| JP2008525620A Ceased JP2009504622A (ja) | 2005-08-06 | 2006-08-04 | 医薬化合物 |
Country Status (20)
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|---|---|
| US (1) | US20110257220A1 (OSRAM) |
| EP (2) | EP1855677B1 (OSRAM) |
| JP (1) | JP2009504622A (OSRAM) |
| KR (1) | KR20080033500A (OSRAM) |
| AT (2) | ATE534391T1 (OSRAM) |
| AU (1) | AU2006277753B2 (OSRAM) |
| CA (1) | CA2620960A1 (OSRAM) |
| CY (1) | CY1108843T1 (OSRAM) |
| DE (1) | DE602006004009D1 (OSRAM) |
| DK (1) | DK1855677T3 (OSRAM) |
| ES (1) | ES2318771T3 (OSRAM) |
| HR (1) | HRP20090074T3 (OSRAM) |
| MX (1) | MX2008001549A (OSRAM) |
| NZ (1) | NZ566011A (OSRAM) |
| PL (1) | PL1855677T3 (OSRAM) |
| PT (1) | PT1855677E (OSRAM) |
| RS (1) | RS50807B (OSRAM) |
| RU (1) | RU2407743C2 (OSRAM) |
| SI (1) | SI1855677T1 (OSRAM) |
| WO (1) | WO2007017654A1 (OSRAM) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020500875A (ja) * | 2016-12-02 | 2020-01-16 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | 統合失調症または統合失調感情障害を処置するためのバルベナジンの使用 |
| US11311532B2 (en) | 2017-09-21 | 2022-04-26 | Neurocrine Biosciences, Inc. | High dosage valbenazine formulation and compositions, methods, and kits related thereto |
| US11439629B2 (en) | 2017-01-27 | 2022-09-13 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
| US11654142B2 (en) | 2017-10-10 | 2023-05-23 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007317242B2 (en) | 2006-11-08 | 2013-08-01 | Neurocrine Biosciences, Inc. | Substituted 3-isobutyl-9, 10-dimethoxy-1,3,4,6,7,11B-hexahydro-2H-pyrido[2,1-a] isoquinolin-2-ol compounds and methods relating thereto |
| US7897768B2 (en) | 2007-06-08 | 2011-03-01 | General Electric Company | Method for making tetrabenazine compounds |
| US8053578B2 (en) | 2007-11-29 | 2011-11-08 | General Electric Company | Alpha-fluoroalkyl dihydrotetrabenazine imaging agents and probes |
| GB0810857D0 (en) * | 2008-06-13 | 2008-07-23 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| GB2463451A (en) * | 2008-09-08 | 2010-03-17 | Cambridge Lab | 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia |
| GB2463283A (en) * | 2008-09-08 | 2010-03-10 | Cambridge Lab | 3,11b-cis-dihydrotetrabenazine for use in treating asthma |
| WO2011153157A2 (en) | 2010-06-01 | 2011-12-08 | Auspex Pharmaceutical, Inc. | Benzoquinolone inhibitors of vmat2 |
| KR101882044B1 (ko) | 2011-04-01 | 2018-07-25 | 쓰리엠 이노베이티브 프로퍼티즈 캄파니 | 트라이아진계 자외선 흡수제를 포함하는 필름 |
| MX2016009817A (es) | 2014-01-27 | 2017-02-28 | Auspex Pharmaceuticals Inc | Inhibidores de benzoquinolina del transportador vesicular de monoaminas 2. |
| CN113368110A (zh) | 2014-02-07 | 2021-09-10 | 纽罗克里生物科学有限公司 | 包含抗精神病药物和vmat2抑制剂的药物组合物及其用途 |
| ES2972600T3 (es) | 2015-10-30 | 2024-06-13 | Neurocrine Biosciences Inc | Sales de diclorhidrato de valbenazina y polimorfos de las mismas |
| DK3394057T3 (da) | 2015-12-23 | 2022-04-11 | Neurocrine Biosciences Inc | Syntetisk fremgangsmåde til fremstilling af (S)-(2R,3R,11BR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11B-hexahydro-1H-pyrido[2,1,-A]isoquinolin-2-yl 2-amino-3-methylbutanoat-di(4-methylbenzensulfonat) |
| GB201705306D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705304D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705302D0 (en) * | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705303D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| KR20250070134A (ko) | 2017-10-10 | 2025-05-20 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 특정 vmat2 억제제의 투여 방법 |
| GB201808464D0 (en) | 2018-05-23 | 2018-07-11 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compounds for use in treating huntington's disease |
| MA53239A (fr) | 2018-08-15 | 2022-05-04 | Neurocrine Biosciences Inc | Procédés d'administration de certains inhibiteurs de vmat2 |
| US10940141B1 (en) | 2019-08-23 | 2021-03-09 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US2830993A (en) * | 1958-04-15 | Quinolizine derivatives | ||
| US2843591A (en) * | 1958-07-15 | Method for preparing same | ||
| US6087376A (en) * | 1997-02-05 | 2000-07-11 | University Of Kentucky Research Foundation | Use of lobeline compounds in the treatment of central nervous system diseases and pathologies |
| JP2007522193A (ja) * | 2004-02-11 | 2007-08-09 | ケンブリッジ、ラボラトリーズ、（アイルランド）、リミテッド | ジヒドロテトラベナジン類およびそれらを含有する医薬組成物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2058640A1 (en) * | 1991-01-25 | 1992-07-26 | Richard R. Scherschlicht | Tricyclic pyridone derivative |
| FR2770215B1 (fr) * | 1997-10-28 | 2000-01-14 | Pf Medicament | Derives d'aminomethyl-benzo[a]quinolizidine, leur preparation et leur application en therapeutique pour les maladies neurodegeneratives |
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2006
- 2006-08-04 PT PT06765238T patent/PT1855677E/pt unknown
- 2006-08-04 JP JP2008525620A patent/JP2009504622A/ja not_active Ceased
- 2006-08-04 MX MX2008001549A patent/MX2008001549A/es active IP Right Grant
- 2006-08-04 CA CA002620960A patent/CA2620960A1/en not_active Abandoned
- 2006-08-04 DK DK06765238T patent/DK1855677T3/da active
- 2006-08-04 ES ES06765238T patent/ES2318771T3/es active Active
- 2006-08-04 AU AU2006277753A patent/AU2006277753B2/en not_active Expired - Fee Related
- 2006-08-04 AT AT08170385T patent/ATE534391T1/de active
- 2006-08-04 KR KR1020087005308A patent/KR20080033500A/ko not_active Withdrawn
- 2006-08-04 EP EP06765238A patent/EP1855677B1/en active Active
- 2006-08-04 SI SI200630210T patent/SI1855677T1/sl unknown
- 2006-08-04 EP EP08170385A patent/EP2050451B1/en active Active
- 2006-08-04 HR HR20090074T patent/HRP20090074T3/xx unknown
- 2006-08-04 NZ NZ566011A patent/NZ566011A/en not_active IP Right Cessation
- 2006-08-04 RU RU2008108623/04A patent/RU2407743C2/ru not_active IP Right Cessation
- 2006-08-04 DE DE602006004009T patent/DE602006004009D1/de active Active
- 2006-08-04 AT AT06765238T patent/ATE415968T1/de active
- 2006-08-04 RS RSP-2009/0055A patent/RS50807B/sr unknown
- 2006-08-04 US US11/997,591 patent/US20110257220A1/en not_active Abandoned
- 2006-08-04 PL PL06765238T patent/PL1855677T3/pl unknown
- 2006-08-04 WO PCT/GB2006/002936 patent/WO2007017654A1/en not_active Ceased
-
2009
- 2009-02-26 CY CY20091100221T patent/CY1108843T1/el unknown
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| US2830993A (en) * | 1958-04-15 | Quinolizine derivatives | ||
| US2843591A (en) * | 1958-07-15 | Method for preparing same | ||
| US6087376A (en) * | 1997-02-05 | 2000-07-11 | University Of Kentucky Research Foundation | Use of lobeline compounds in the treatment of central nervous system diseases and pathologies |
| JP2007522193A (ja) * | 2004-02-11 | 2007-08-09 | ケンブリッジ、ラボラトリーズ、（アイルランド）、リミテッド | ジヒドロテトラベナジン類およびそれらを含有する医薬組成物 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020500875A (ja) * | 2016-12-02 | 2020-01-16 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | 統合失調症または統合失調感情障害を処置するためのバルベナジンの使用 |
| US11439629B2 (en) | 2017-01-27 | 2022-09-13 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
| US11311532B2 (en) | 2017-09-21 | 2022-04-26 | Neurocrine Biosciences, Inc. | High dosage valbenazine formulation and compositions, methods, and kits related thereto |
| US11654142B2 (en) | 2017-10-10 | 2023-05-23 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| CY1108843T1 (el) | 2014-07-02 |
| RU2407743C2 (ru) | 2010-12-27 |
| WO2007017654A1 (en) | 2007-02-15 |
| EP1855677B1 (en) | 2008-12-03 |
| ATE415968T1 (de) | 2008-12-15 |
| PT1855677E (pt) | 2009-01-13 |
| DK1855677T3 (da) | 2009-02-09 |
| SI1855677T1 (sl) | 2009-04-30 |
| AU2006277753B2 (en) | 2011-11-10 |
| NZ566011A (en) | 2011-01-28 |
| EP2050451B1 (en) | 2011-11-23 |
| ATE534391T1 (de) | 2011-12-15 |
| EP2050451A1 (en) | 2009-04-22 |
| KR20080033500A (ko) | 2008-04-16 |
| US20110257220A1 (en) | 2011-10-20 |
| DE602006004009D1 (de) | 2009-01-15 |
| HK1111083A1 (en) | 2008-08-01 |
| EP1855677A1 (en) | 2007-11-21 |
| HRP20090074T3 (en) | 2009-04-30 |
| RS50807B (sr) | 2010-08-31 |
| PL1855677T3 (pl) | 2009-07-31 |
| ES2318771T3 (es) | 2009-05-01 |
| AU2006277753A1 (en) | 2007-02-15 |
| CA2620960A1 (en) | 2007-02-15 |
| RU2008108623A (ru) | 2009-09-20 |
| MX2008001549A (es) | 2008-04-04 |
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