RU2382653C2 - Пленка для ухода за полостью рта - Google Patents

Info

Publication number

RU2382653C2

RU2382653C2 RU2007101534/15A RU2007101534A RU2382653C2 RU 2382653 C2 RU2382653 C2 RU 2382653C2 RU 2007101534/15 A RU2007101534/15 A RU 2007101534/15A RU 2007101534 A RU2007101534 A RU 2007101534A RU 2382653 C2 RU2382653 C2 RU 2382653C2

Authority

RU

Russia

Prior art keywords

composition

composition according

film

substance

oral cavity

Prior art date

2004-06-17

Links

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• 210000000214 mouth Anatomy 0.000 title claims description 32
• 239000000203 mixture Substances 0.000 claims abstract description 116
• -1 poly(vinylpyrrolidone/ vinylacetate) Polymers 0.000 claims abstract description 64
• 239000000126 substance Substances 0.000 claims abstract description 51
• 229920000642 polymer Polymers 0.000 claims abstract description 45
• 229920001577 copolymer Polymers 0.000 claims abstract description 34
• 239000003795 chemical substances by application Substances 0.000 claims abstract description 32
• 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract description 32
• 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 32
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 32
• 239000011159 matrix material Substances 0.000 claims abstract description 20
• 230000002087 whitening effect Effects 0.000 claims abstract description 16
• 230000015572 biosynthetic process Effects 0.000 claims abstract description 8
• 229920003171 Poly (ethylene oxide) Polymers 0.000 claims abstract description 6
• 239000003814 drug Substances 0.000 claims abstract 2
• XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 25
• WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 19
• 238000000034 method Methods 0.000 claims description 17
• 150000003839 salts Chemical class 0.000 claims description 17
• 229920000058 polyacrylate Polymers 0.000 claims description 13
• 210000003296 saliva Anatomy 0.000 claims description 12
• MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 11
• 239000004599 antimicrobial Substances 0.000 claims description 10
• 208000006558 Dental Calculus Diseases 0.000 claims description 9
• 239000003975 dentin desensitizing agent Substances 0.000 claims description 9
• 235000003599 food sweetener Nutrition 0.000 claims description 9
• 239000010410 layer Substances 0.000 claims description 9
• 230000002209 hydrophobic effect Effects 0.000 claims description 8
• 239000003765 sweetening agent Substances 0.000 claims description 8
• PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims description 7
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
• 229910052784 alkaline earth metal Inorganic materials 0.000 claims description 6
• 239000003963 antioxidant agent Substances 0.000 claims description 6
• VTIIJXUACCWYHX-UHFFFAOYSA-L disodium;carboxylatooxy carbonate Chemical compound [Na+].[Na+].[O-]C(=O)OOC([O-])=O VTIIJXUACCWYHX-UHFFFAOYSA-L 0.000 claims description 6
• 239000011347 resin Substances 0.000 claims description 6
• 229920005989 resin Polymers 0.000 claims description 6
• 229940045872 sodium percarbonate Drugs 0.000 claims description 6
• MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims description 6
• 239000001856 Ethyl cellulose Substances 0.000 claims description 5
• ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 5
• 229920002125 Sokalan® Polymers 0.000 claims description 5
• 239000003513 alkali Substances 0.000 claims description 5
• FYUWIEKAVLOHSE-UHFFFAOYSA-N ethenyl acetate;1-ethenylpyrrolidin-2-one Chemical compound CC(=O)OC=C.C=CN1CCCC1=O FYUWIEKAVLOHSE-UHFFFAOYSA-N 0.000 claims description 5
• 229920001249 ethyl cellulose Polymers 0.000 claims description 5
• 235000019325 ethyl cellulose Nutrition 0.000 claims description 5
• 239000000284 extract Substances 0.000 claims description 5
• 239000011241 protective layer Substances 0.000 claims description 5
• FHEHIXJLCWUPCZ-UHFFFAOYSA-N 4-prop-2-enylbenzene-1,2-diol Chemical compound OC1=CC=C(CC=C)C=C1O FHEHIXJLCWUPCZ-UHFFFAOYSA-N 0.000 claims description 4
• NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 4
• GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 claims description 4
• WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 4
• INVGWHRKADIJHF-UHFFFAOYSA-N Sanguinarin Chemical compound C1=C2OCOC2=CC2=C3[N+](C)=CC4=C(OCO5)C5=CC=C4C3=CC=C21 INVGWHRKADIJHF-UHFFFAOYSA-N 0.000 claims description 4
• 239000000853 adhesive Substances 0.000 claims description 4
• 230000001070 adhesive effect Effects 0.000 claims description 4
• 239000008376 breath freshener Substances 0.000 claims description 4
• OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 claims description 4
• 150000002222 fluorine compounds Chemical class 0.000 claims description 4
• 229940041616 menthol Drugs 0.000 claims description 4
• 229920000609 methyl cellulose Polymers 0.000 claims description 4
• OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims description 4
• 239000001923 methylcellulose Substances 0.000 claims description 4
• 235000010981 methylcellulose Nutrition 0.000 claims description 4
• XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 claims description 4
• FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 claims description 4
• VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 claims description 4
• NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 3
• WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 claims description 3
• WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 claims description 3
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 3
• 239000005844 Thymol Substances 0.000 claims description 3
• ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims description 3
• XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 3
• 150000001342 alkaline earth metals Chemical class 0.000 claims description 3
• 229940035676 analgesics Drugs 0.000 claims description 3
• 239000000730 antalgic agent Substances 0.000 claims description 3
• 239000003242 anti bacterial agent Substances 0.000 claims description 3
• 229940124599 anti-inflammatory drug Drugs 0.000 claims description 3
• QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical class OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 claims description 3
• 229960005233 cineole Drugs 0.000 claims description 3
• WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical class Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 claims description 3
• 150000004965 peroxy acids Chemical class 0.000 claims description 3
• 239000000021 stimulant Substances 0.000 claims description 3
• 229960000790 thymol Drugs 0.000 claims description 3
• 229910052718 tin Inorganic materials 0.000 claims description 3
• DTOUUUZOYKYHEP-UHFFFAOYSA-N 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine Chemical compound CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 DTOUUUZOYKYHEP-UHFFFAOYSA-N 0.000 claims description 2
• WFJIVOKAWHGMBH-UHFFFAOYSA-N 4-hexylbenzene-1,3-diol Chemical compound CCCCCCC1=CC=C(O)C=C1O WFJIVOKAWHGMBH-UHFFFAOYSA-N 0.000 claims description 2
• 239000005725 8-Hydroxyquinoline Substances 0.000 claims description 2
• 239000004155 Chlorine dioxide Substances 0.000 claims description 2
• WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 claims description 2
• FCEXWTOTHXCQCQ-UHFFFAOYSA-N Ethoxydihydrosanguinarine Natural products C12=CC=C3OCOC3=C2C(OCC)N(C)C(C2=C3)=C1C=CC2=CC1=C3OCO1 FCEXWTOTHXCQCQ-UHFFFAOYSA-N 0.000 claims description 2
• KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 2
• 239000005792 Geraniol Substances 0.000 claims description 2
• GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 claims description 2
• 229940088710 antibiotic agent Drugs 0.000 claims description 2
• 229960000686 benzalkonium chloride Drugs 0.000 claims description 2
• CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 2
• 150000004287 bisbiguanides Chemical class 0.000 claims description 2
• RECUKUPTGUEGMW-UHFFFAOYSA-N carvacrol Chemical compound CC(C)C1=CC=C(C)C(O)=C1 RECUKUPTGUEGMW-UHFFFAOYSA-N 0.000 claims description 2
• HHTWOMMSBMNRKP-UHFFFAOYSA-N carvacrol Natural products CC(=C)C1=CC=C(C)C(O)=C1 HHTWOMMSBMNRKP-UHFFFAOYSA-N 0.000 claims description 2
• 235000007746 carvacrol Nutrition 0.000 claims description 2
• 150000001805 chlorine compounds Chemical class 0.000 claims description 2
• 235000019398 chlorine dioxide Nutrition 0.000 claims description 2
• 229940043350 citral Drugs 0.000 claims description 2
• WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 claims description 2
• 229940113087 geraniol Drugs 0.000 claims description 2
• 229960004867 hexetidine Drugs 0.000 claims description 2
• 229960003258 hexylresorcinol Drugs 0.000 claims description 2
• 150000002500 ions Chemical class 0.000 claims description 2
• WYXXLXHHWYNKJF-UHFFFAOYSA-N isocarvacrol Natural products CC(C)C1=CC=C(O)C(C)=C1 WYXXLXHHWYNKJF-UHFFFAOYSA-N 0.000 claims description 2
• 229960001047 methyl salicylate Drugs 0.000 claims description 2
• 239000000025 natural resin Substances 0.000 claims description 2
• 235000016709 nutrition Nutrition 0.000 claims description 2
• 229960001774 octenidine Drugs 0.000 claims description 2
• SMGTYJPMKXNQFY-UHFFFAOYSA-N octenidine dihydrochloride Chemical compound Cl.Cl.C1=CC(=NCCCCCCCC)C=CN1CCCCCCCCCCN1C=CC(=NCCCCCCCC)C=C1 SMGTYJPMKXNQFY-UHFFFAOYSA-N 0.000 claims description 2
• 229960003540 oxyquinoline Drugs 0.000 claims description 2
• 150000002978 peroxides Chemical class 0.000 claims description 2
• 229960003742 phenol Drugs 0.000 claims description 2
• AVTYONGGKAJVTE-OLXYHTOASA-L potassium L-tartrate Chemical compound [K+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O AVTYONGGKAJVTE-OLXYHTOASA-L 0.000 claims description 2
• 239000001103 potassium chloride Substances 0.000 claims description 2
• 235000011164 potassium chloride Nutrition 0.000 claims description 2
• 239000001508 potassium citrate Substances 0.000 claims description 2
• 229960002635 potassium citrate Drugs 0.000 claims description 2
• QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims description 2
• 235000011082 potassium citrates Nutrition 0.000 claims description 2
• 235000010333 potassium nitrate Nutrition 0.000 claims description 2
• 239000004323 potassium nitrate Substances 0.000 claims description 2
• OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 claims description 2
• 229910052939 potassium sulfate Inorganic materials 0.000 claims description 2
• 235000011151 potassium sulphates Nutrition 0.000 claims description 2
• 239000001472 potassium tartrate Substances 0.000 claims description 2
• 229940111695 potassium tartrate Drugs 0.000 claims description 2
• 235000011005 potassium tartrates Nutrition 0.000 claims description 2
• MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 claims description 2
• WKEDVNSFRWHDNR-UHFFFAOYSA-N salicylanilide Chemical compound OC1=CC=CC=C1C(=O)NC1=CC=CC=C1 WKEDVNSFRWHDNR-UHFFFAOYSA-N 0.000 claims description 2
• 229950000975 salicylanilide Drugs 0.000 claims description 2
• 229940084560 sanguinarine Drugs 0.000 claims description 2
• YZRQUTZNTDAYPJ-UHFFFAOYSA-N sanguinarine pseudobase Natural products C1=C2OCOC2=CC2=C3N(C)C(O)C4=C(OCO5)C5=CC=C4C3=CC=C21 YZRQUTZNTDAYPJ-UHFFFAOYSA-N 0.000 claims description 2
• 235000010344 sodium nitrate Nutrition 0.000 claims description 2
• 239000004317 sodium nitrate Substances 0.000 claims description 2
• 229940124530 sulfonamide Drugs 0.000 claims description 2
• 229960003500 triclosan Drugs 0.000 claims description 2
• NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
• 241000219095 Vitis Species 0.000 claims 2
• 235000009754 Vitis X bourquina Nutrition 0.000 claims 2
• 235000012333 Vitis X labruscana Nutrition 0.000 claims 2
• 235000014787 Vitis vinifera Nutrition 0.000 claims 2
• YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 claims 2
• ZVNPWFOVUDMGRP-UHFFFAOYSA-N 4-methylaminophenol sulfate Chemical compound OS(O)(=O)=O.CNC1=CC=C(O)C=C1.CNC1=CC=C(O)C=C1 ZVNPWFOVUDMGRP-UHFFFAOYSA-N 0.000 claims 1
• JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical class [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 230000003239 periodontal effect Effects 0.000 claims 1
• 239000005011 phenolic resin Substances 0.000 claims 1
• 229920001568 phenolic resin Polymers 0.000 claims 1
• 150000003053 piperidines Chemical class 0.000 claims 1
• 238000004090 dissolution Methods 0.000 abstract description 14
• 230000000694 effects Effects 0.000 abstract description 5
• 239000000178 monomer Substances 0.000 description 27
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 19
• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 15
• 239000002904 solvent Substances 0.000 description 9
• NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 7
• JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 7
• CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 7
• PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 7
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 6
• VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 6
• 229910052708 sodium Inorganic materials 0.000 description 6
• 239000011734 sodium Substances 0.000 description 6
• SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 5
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 5
• 235000006708 antioxidants Nutrition 0.000 description 5
• 239000003086 colorant Substances 0.000 description 5
• 239000000975 dye Substances 0.000 description 5
• 235000013355 food flavoring agent Nutrition 0.000 description 5
• 239000011118 polyvinyl acetate Substances 0.000 description 5
• 229910052700 potassium Inorganic materials 0.000 description 5
• 239000011591 potassium Substances 0.000 description 5
• 229960003975 potassium Drugs 0.000 description 5
• 239000002202 Polyethylene glycol Substances 0.000 description 4
• GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
• 239000011575 calcium Substances 0.000 description 4
• 150000001875 compounds Chemical class 0.000 description 4
• 150000002148 esters Chemical class 0.000 description 4
• RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 4
• 239000000796 flavoring agent Substances 0.000 description 4
• 230000006870 function Effects 0.000 description 4
• 229910052588 hydroxylapatite Inorganic materials 0.000 description 4
• CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 4
• XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 4
• 229920001223 polyethylene glycol Polymers 0.000 description 4
• CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 4
• PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 4
• 229920006027 ternary co-polymer Polymers 0.000 description 4
• 229910001432 tin ion Inorganic materials 0.000 description 4
• 238000011282 treatment Methods 0.000 description 4
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 3
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
• 229920001800 Shellac Polymers 0.000 description 3
• 239000002253 acid Substances 0.000 description 3
• 239000004480 active ingredient Substances 0.000 description 3
• 229910052783 alkali metal Inorganic materials 0.000 description 3
• 150000004974 alkaline earth metal peroxides Chemical class 0.000 description 3
• 230000008901 benefit Effects 0.000 description 3
• 229910052791 calcium Inorganic materials 0.000 description 3
• 229960005069 calcium Drugs 0.000 description 3
• 238000005538 encapsulation Methods 0.000 description 3
• 229910052749 magnesium Inorganic materials 0.000 description 3
• 239000011777 magnesium Substances 0.000 description 3
• 239000013521 mastic Substances 0.000 description 3
• FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 3
• 239000003921 oil Substances 0.000 description 3
• 235000019198 oils Nutrition 0.000 description 3
• 239000006069 physical mixture Substances 0.000 description 3
• 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 3
• 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 3
• 229920002689 polyvinyl acetate Polymers 0.000 description 3
• 239000004208 shellac Substances 0.000 description 3
• ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 3
• 229940113147 shellac Drugs 0.000 description 3
• 235000013874 shellac Nutrition 0.000 description 3
• WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 3
• 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 3
• 239000002023 wood Substances 0.000 description 3
• 239000011746 zinc citrate Substances 0.000 description 3
• 235000006076 zinc citrate Nutrition 0.000 description 3
• 229940068475 zinc citrate Drugs 0.000 description 3
• XHXUANMFYXWVNG-ADEWGFFLSA-N (-)-Menthyl acetate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(C)=O XHXUANMFYXWVNG-ADEWGFFLSA-N 0.000 description 2
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