RU2366431C2 - Method for preparing disintoxicant for animals - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to method for preparing medical pharmacological agents for animals. Method for preparing disintoxicant for animals involves dissolution of 4.9-5.1% low-molecular polyvinylpyrrolidone and 0.44-0.46% sodium chloride in ecologically clean mineral water "Volzhanka". The prepared mixture is filtered through SF filters.

EFFECT: offered method allows preparing ecologically clean oral agent introduced to animals and possessing the best therapeutic and detoxification properties.

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Description

The invention relates to methods for the manufacture of therapeutic pharmacological preparations for animals.

A known method of manufacturing the drug "Enterodez" used in medicine and veterinary medicine as a detoxification agent by ingestion. The method consists in dissolving in distilled water 6% of low molecular weight polyvinylpyrrolidone, 0.55% sodium chloride, 0.042% potassium chloride, 0.055% calcium chloride, 0.0005% magnesium chloride, 0.023% sodium bicarbonate [1].

However, Enterodez does not contain trace elements that play a vital role in the body - copper, zinc, iron, lithium, manganese, fluorine, silver.

The purpose of the invention is to improve the therapeutic effect of the drug and its detoxification properties.

This goal is achieved by the fact that 4.9-5.1% of low molecular weight polyvinylpyrrolidone and 0.44-0.46% sodium chloride are added to Volzhanka mineral water. The resulting solution is filtered through a plate brand "SF".

Sterilizing plates "SF" are made from a mixture of pressed asbestos and fiber. The thickness of the plates is 4 ... 6 mm, the diameter is 30 ... 270 mm, and they can be of different porosity. For production purposes, multi-frame apparatuses with the number of plates from 5 to 40 are used. Mounted filters are closed in parchment paper and sterilized in an autoclave at a pressure of 0.15 MPa for 20 ... 30 minutes [2].

Mineral water Volzhanka belongs to the group of low-mineralized, and according to its ionic composition it belongs to hydrocarbonate-sulfate-calcium-magnesium (see table).

The chemical composition of the Volzhanka mineral water [3] Components Content in 1 liter of water, g Cations: sodium + potassium 0.0087 calcium 0.1884 magnesium 0,0384 iron 0.0049 Anions: fluorine 0.0016 chlorine 0.0119 sulfate 0,1391 bicarbonate 0.5978 Carbonic anhydride 0.1021 Silicic acid 0.0228 Bitumen 0,0218 Volatile phenols, v / l 1,5 Hard volatile phenols, v / l 0.74 Fatty acids, mEq. 0.08

In addition, Volzhanka mineral water contains trace elements: silver 0.04 ... 0.18 mg / l; copper 0.1 ... 0.2; lead 0.06 ... 0.08; tin 0.05; nickel 0.01; chromium 0.001; manganese 0.6; iron 8; 0.3 aluminum; zinc 0.5; titanium 0.01 ... 0.02; strontium 0.8 ... 1.5; barium 0.1 mg / l [3].

The detoxifying effect of the drug is due to the presence of low molecular weight polyvinylpyrrolidone in its composition, which has the ability to form stable complexes with many compounds, in particular with toxins.

The method is implemented as follows. Pour 1000 ml of Volzhanka mineral water into a container. From this volume, 100 ml of mineral water is poured into heat-resistant dishes, which is heated to 50 ... 60 ° C. 50 g of low molecular weight polyvinylpyrrolidone and 4.5 g of sodium chloride are added to heated water. Then the heated water is stirred until the added substances are completely dissolved in it. The resulting solution was poured into the original container and mixed again. After that, the contents of the container are passed through the filters "SF" and poured into sterile containers, which are stored in a dark place at a temperature of 5 ... 20 ° C for 12 months.

Each series of detoxification drugs is tested on rabbits and white mice by oral administration for harmlessness, toxicity, allergenicity.

The detoxification drug is a clear straw-yellow liquid without sediment and odor. Used by oral administration to the animal.

In order to study the therapeutic properties of a detoxification drug, an experiment was conducted on the farm of an educational and experimental farm of the Ulyanovsk State Agricultural Academy. Two groups of calves were formed with signs of acute digestive upset, ten animals each. In the first (experimental group), the obtained preparation was used, which was given orally at a dose of 200 ... 250 ml 2 times a day. In the second (control) group, treatment was carried out with glucose-saline solution (5% glucose solution in 0.9% sodium chloride solution) and a decoction of oak bark of 250 ml, also twice.

The following results were obtained: in the group where the detoxification drug was used, the calf recovery time was 3 ... 5 days, against 7 ... 8 days in the control. The normalization of the clinical status, as well as the morphological and biochemical parameters of the blood, took place more intensively.

A physiological experiment was also conducted on 100 pigs of large white breed, divided into 2 groups of 50 animals each. Piglets of all groups received the same feed. A detoxification drug in the amount of 5 ml / kg of live weight was introduced into the diet of the piglets of the experimental group.

As a result, the live weight of piglets at the time of their weaning from sows in the experimental group was 17.3% higher than in the control. The safety of piglets in the experimental group was also 10% higher than in the control.

The addition of a detoxification drug to piglets contributed to an increase in the level of red blood cells by 16.1% and white blood cells by 9.2% in newborn animals, as well as by 10.1% and 8, 9%, respectively, in the blood of 42 daily animals of the experimental group compared to the control group. The data obtained reflect the optimization of hematopoiesis function and the activation of redox processes in piglets of the experimental group.

The concentration of urea in the blood of piglets of the experimental group during the experimental period was lower than in control animals. An increase in the liver content of piglets of the experimental group of glucose by 10% and glycogen by 7.1% was found. All this indicates good detoxification properties of the drug.

42 daily animals of the experimental group showed a decrease of 11% in the level of cholesterol in the liver compared with the control group. In the liver of daily piglets from the experimental group, an increase in cholinesterase activity relative to the control was observed by 16.3%, which confirms an increase in the enzymatic activity of the liver and an improvement in its excretory ability.

Thus, the proposed method allows to obtain an environmentally friendly preparation intended for oral administration to animals and having the best therapeutic and detoxification properties.

Information sources

1. M.D. Mashkovsky. Medicines, part 2. - M.: Medicine, 1986, p. 104.

2. Veterinary Encyclopedia, t.1. - M.: Soviet Encyclopedia, 1968, p. 472.

3. E.M. Chuchkalov. Healing source. - Saratov: Volga Book Publishing House (Ulyanovsk Branch), 1989, pp. 40-43.

Claims (1)

A method of producing a detoxification drug for animals, comprising dissolving in water a low molecular weight polyvinyl pyrrolidone, characterized in that 4.9-5.1% low molecular weight polyvinyl pyrrolidone and 0.44-0.46% sodium chloride are added to the Volzhanka mineral water and filtered through filters of the brand "SF".