RU2442573C1 - Means of healing pigs dysentery - Google Patents

Abstract

FIELD: veterinary medicine. ^ SUBSTANCE: there was introduced a method for healing pigs dysentiry using a combination of antibacterial drugs in the form of an emulsion based on oil trivitamin solution in the following ratio, wt. %: Trihopol-2, Tilan-14, distilled water - 34, trivitamin oil injection -50. The drug is injected at a dose of 1 ml per 10 kg of animal weight, but not more than 5 ml per 1 injection, at intervals of 48 hours. ^ EFFECT: means has a high therapeutic effect without irritation and doesn't cause inflict and inflammation at the place of injection. ^ 2 tbl, 2 ex, 1 dwg

Description

FIELD OF THE INVENTION

The invention relates to agriculture, to veterinary medicine, and in particular to methods for treating pig dysentery.

State of the art

For the treatment of pig dysentery (the causative agent of Brachiospira hyodysenteriae), many methods have been proposed using antibiotics, nitrofurans, and sulfanilamides [1].

There is a method of treating pig dysentery with the combined use of tylosin (tilan): in the form of injections into muscles of 8-10 mg per 1 kg of body weight and at the same time feeding tylosin at 100 g per 1 ton of feed. The course of treatment is 5 days [2]. The disadvantages of this method are the complexity and cost.

A known method of treating pig dysentery using metronidazole (Trichopolum) in the form of injections in liquid paraffin at a dose of 10-15 mg per 1 kg of body weight [3].

There is a method of treating dysentery of pigs with Trichopolum when feeding it with food at a dose of 250 g per 1 ton of feed, 2 times a day, 3-5 days. However, with this method it is not possible to create bactericidal concentrations of the active substance against brachiospir in the body of sick animals, moreover, this action cannot be prolonged [4].

The use of one tilan or only Trichopolum does not allow to achieve a quick and 100% therapeutic effect in this disease of pigs.

Previously, we proposed a method for the treatment of pigs - leptospiracetes (AS No. 1513663 dated June 8, 1989) [5], including the parenteral administration of a therapeutic combination of tilan and trichopolum. The drug used in this method, we used with high efficiency also for the treatment of pigs with dysentery. However, the composition of the drug described in AS No. 1513663 often caused a pain reaction in pigs, and aseptic abscesses sometimes appeared at injection sites.

The purpose of the invention

The creation of a new method for the treatment of pig dysentery, the use of which provides high therapeutic efficacy and a reduction in inflammatory reactions with parenteral administration of the drug.

This goal is achieved by the fact that, as active substances, tilane and trichopolum are introduced into the composition of the preparation in amounts differing from the composition described in AS No. 1513663. For the treatment of pig dysentery, a drug (emulsion) is proposed, including (wt.%):

Tilan - fourteen Trichopolum (metronidazole) - 2 Distilled water (sterile) - 34 Trivitamin for injection - fifty

Distinctive features of the drug used in the proposed method of treatment and the known drug described in AS No. 1513663 are presented in table 1.

Table 1 Comparative indicators of the drug for the implementation of the proposed method and the drug according to AS No. 1513663 Indicators Known drug for AS No. 1513663 Suggested drug Composition, wt.%: trichopolum 6-8 2 tilan 10-12 fourteen trivitamin for injection 46 fifty distilled water 32-34 34 Dosage form Suspension, difficult to administer The emulsion is administered easily Complications Soreness due to the irritating effect of undissolved Trichopolum particles, aseptic abscesses may occur No

From table 1 it is seen that in the proposed preparation contains 2 wt.% Trichopolum. In our studies, we found that no more than 2 wt.% Trichopolum passes into the aqueous solution. Excess trichopolum in the form of insoluble particles in the preparation according to AS No. 1513663 is irritating, causes a significant pain reaction and leads to the appearance of aseptic abscesses at injection sites. The preparation of a new composition, while retaining the advantages (the ability to create and hold antibacterial concentration of active substances in the animal body for a long time), does not have these drawbacks.

An example of the manufacture of the proposed drug.

The drug is prepared before use as follows. Into a sterile container with a volume of 5-10 liters, 1400 g of tilane are added and dissolved in 3400 ml of sterile distilled water, 200 g of trichopolum are added to the solution of tilan and dissolved with stirring. Then the solution is centrifuged at 3000 rpm for 10 minutes. The supernatant is drained, the precipitate is removed from possible mechanical impurities. The resulting solution was poured into 50 ml into sterile vials and an equal (50 ml) volume of injection trivitamine was added. The vials are closed with sterile rubber stoppers and sealed with aluminum caps.

Before use, the drug is heated to animal body temperature and shaken. For the treatment of pigs with dysentery, the emulsion of the drug is administered intramuscularly (young animals in the thigh muscles, adults in the muscles of the scapula, neck) at a dose of 1 ml per 10 kg of body weight, but not more than 5 ml per 1 time. The drug is administered three times at intervals of 48 hours. The entire course of treatment is 6 days.

An example of a real use of the claimed method.

In the farm where the disease of pigs with dysentery was established (the causative agent of Brachiospira hyodysenteriae) (Act No. 1), a treatment method using the claimed preparation of the above composition (wt.%) Was tested:

Trichopol - 2 Tilan - fourteen Distilled water (sterile) - 34 Trivitamin Injection - fifty

The emulsion of the drug was administered intramuscularly at a dose of 1 ml per 10 kg of body weight, but not more than 5 ml at a time. The drug was administered three times with intervals between injections for 48 hours. Before administration, the drug was warmed to body temperature and shaken. The claimed method was processed 2330 pigs.

The control was sick pigs, for the treatment of which they used nifulin at a dose of 100 mg per 1 kg of animal body weight, inside with food. Nifulin was used to treat 100 pigs.

The therapeutic effectiveness of the proposed method of treatment was 99%, and the effectiveness of treatment with nifulin - 86.5%.

table 2 Comparative therapeutic efficacy of the claimed method of treatment and method using nifulin A drug The number of pigs in the group Therapeutic efficacy,% Case The proposed drug used in the claimed method 2330 99.5 Less than 1% Nifulin one hundred 86.5 13.5%

A simple calculation shows that, thanks to the use of the claimed method of treatment, the death of 303 pigs was prevented in this farm.

Technical result

The technical result, objectively manifested in the implementation of the proposed method, is as follows:

1. An increase in the safety of the livestock of pigs to 99.5% (against 86.5%).

2. Improving the effectiveness of veterinary measures for pig dysentery.

3. Trichopolum (metronidazole) in the new composition is used in an amount that completely dissolves - 2 wt.% Instead of 6-8 wt.% According to the prescription of AS No. 1513663, that is, during treatment with the claimed method, the drug does not irritate, no pain reaction, there are no conditions for the development of aseptic abscesses.

4. The drug, due to the changed quantitative composition, is easily administered, and a sufficient antibacterial concentration of the chemotherapeutic combination (trichopol + tilan) is created and held in the animal body for a long time (due to prolongation due to the presence of trivitamine).

5. Elimination of cost overrun of an expensive antibacterial drug Trichopolum.

6. Reducing the cost of manufacturing the drug, and, as a result, the treatment of animals with dysentery.

7. Due to the elimination of the irritating effect, the advantage of parenteral administration of the drug is more fully manifested - the rapid accumulation of active substances in a bactericidal concentration against Brachiospira hyodysenteriae.

Bibliography

1. Skvortsov V.N. and other pig dysentery. - Guidelines. - M., 2009.

2. Antipov V.A. The use of tylosin in veterinary medicine and livestock. - J. “Agriculture Abroad,” No. 6, 1984, p. 43-46.

3. Tikhonov V.L., Skvortsov V.N. The use of metronidazole in pig dysentery. - News is a breeze. farm. honey. - 1992. - T.8, No. 2. - S. 48-50.

4. Sidorkin V.A., Gavrish V.G., Egunova A.V., Ubiraev S.P. Diseases of pigs / Under the total. ed. V.A. Sidorkina. - M.: Aquarium-Print LLC, 2007, p. 322-327.

5. Soldatenko N.A., Azaryan R.P., Polubedov S.G., Radkov V.N. A method of treating pigs - leptospiracetes. - AS No. 1513663, 06/08/1989

Claims (1)

A method for the treatment of pig dysentery, including parenteral administration of antibacterial substances, distilled water and trivitamin, characterized in that for injection use the composition of the drug in the form of an emulsion in the following ratio, wt.%:
Trichopolum (metronidazole) 2 Tilan fourteen Distilled water 34 Trivitamin Oil Injection fifty,
moreover, the drug is administered at a rate of 1 ml per 10 kg of animal body weight, but not more than 5 ml per 1 injection, three times at intervals of 48 hours