RU2342122C1 - Medical product for calf diarrhea treatment - Google Patents

Abstract

FIELD: medicine; veterinary medicine.

SUBSTANCE: medical product contains polyvinylpyrolidone, Furacilinum, glucose, Acidum ascorbinicum and sodium hypochlorite at the certain component proportion.

EFFECT: reduction of diarrhea duration on 36% (to 2.8 days); calf safety at level of 95% and additional weight increase on 15-44% after treatment, reduction of medical products consumption.

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Description

The invention relates to veterinary medicine, in particular to drugs for the treatment of diarrhea in animals.

A known drug is a gentamicin solution (1 ml of the solution contains 40 mg of gentamicin in the form of a sulfate with a wide spectrum of action), used to treat and prevent infections of the gastrointestinal tract, respiratory and urinary tracts at a dose of 3 mg / kg calf body weight 2 times per day for 3-5 days. (See the Manual on the use of gentamicin solution in veterinary medicine. Approved by the deputy head of the Department of Veterinary Medicine).

However, the use of antibiotics for mass diseases is often carried out without taking into account laboratory diagnostics of the sensitivity of the drug to pathogenic microflora, which requires additional research time and, as a result, is accompanied by a violation of the microbial balance in the digestive tract with secondary dysbacterioses. In addition, conditions are created for the selective development of more pathogenic and drug-resistant strains of microorganisms against the background of a simultaneous decrease in the body's resistance.

A known drug for the treatment of diarrhea in calves is a solution of sodium hypochlorite in a concentration of 300-500 mg / l in a volume of 500 ml, which is evaporated 30 minutes before feeding 2 times a day until recovery for 3-5 days. An active solution of sodium hypochlorite is obtained by electrolysis of a solution of sodium chloride on an EDO-4 apparatus. (See "The effectiveness of the dosage form of sodium hypochlorite," Journal of Veterinary Medicine, No. 4, 1992, p.14).

However, an active solution of sodium hypochlorite, given in large doses (500 ml), does not provide high therapeutic efficacy with associative principles, and, being a powerful oxidizing agent in large doses, reduces the effect of the use of symptomatic agents. In addition, as practice has shown, drinking large doses (500 ml) of sodium hypochlorite is difficult due to its sharp unpleasant odor; at a concentration of 500 mg / l, calves refuse to drink the solution even in a mixture with milk.

Known drug Lers for the treatment of diarrhea of calves. Lers helps to remove toxins from the gastrointestinal tract, prevents the formation of casein bezoars in the abomasum, normalizes the water-salt balance, and has a bacteriostatic effect. The drug is a kit - a package of powdered substances, packaged in three bags. Package No. 1 - polyvinylpyrrolidone (PVP) - 200 g, Package No. 2 - glucose 200 g, Package No. 3: potassium chloride 2 g, sodium chloride 50 g, aminoacetic acid (glycol) 30 g, calcium lactic acid 10 g, ascorbic acid 5 g, ethacridine lactate 2 g, furatsilin 1 g. The drug is prepared in the form of a solution from the contents of three packets in 10 l of water (70-80 ° C). For prophylactic purposes, the calves in the first 6 drinks after birth are drunk 250 ml with each serving of colostrum, for the treatment of calves, the next 2 milk drinks are replaced with a solution of Lers in the volume of one liter at a time, and 250 ml of Lers solution is added to the subsequent portion of milk until recovery. (See the Instructions for the manufacture and production control of the drug Lers. Approved by the Ministry of Agriculture of the USSR. The Main Directorate of Veterinary Medicine November, 1985. Temporary instruction on the use of the drug LERS - prototype).

However, this drug is inconvenient to use due to the need to prepare the solution directly on the farm, where the conditions usually do not meet the requirements of the veterinary and sanitary standards necessary for the preparation of the drug (microbial contamination during preparation and periodic mixing throughout the day). In addition, it is difficult to solicit the prescription drug in large volumes with insufficient efficiency, at high costs of constituent components.

It is necessary to develop a comprehensive drug for the treatment of calf diarrhea, which provides an increase in the effectiveness of treatment, contributes to the preservation of calves, reduces treatment time at the lowest doses of the drug, reduces the loss of average daily weight gain, eliminates side and negative effects when using the drug.

The technical result is achieved in that the drug, including polyvinylpyrrolidone, furatsilin, glucose, ascorbic acid, additionally contains sodium hypochlorite with a concentration of 300-350 mg / l, with the following ratios of components, g / l: polyvinylpyrrolidone 9-10, furatsilin 5- 6, glucose 18-20, ascorbic acid 4, sodium hypochlorite per liter, while the daily dose of a drug administered in 2-3 doses with colostrum or milk is not more than 150 ml.

The essence of the claimed drug lies in the fact that the applicant’s studies revealed the optimal combination of drugs (part of the complex drug Lers and sodium hypochlorite), which significantly reduced the daily dose of the drug administered to newborn calves (6-8 times), reduced the consumption of polyvinylpyrrolidone and glucose . So with one liter of lers 20 g of polyvinylpyrrolidone and 20 g of glucose are consumed, while in 150 ml (daily dose) of the claimed drug 1.5 g of polyvinylpyrrolidone and 3.0 g of glucose (on average) when a high therapeutic effect is achieved that exceeds this an indicator, both when using Lers, and sodium hypochlorite. As comparative tests showed, the result of using sodium hypochlorite, which has antimicrobial, detoxifying, antifungal, anti-inflammatory effects, was lower in the treatment of calf diarrhea than in the treatment with the claimed agent. A similar result was obtained in comparative tests from the use of Lers.

Studies to identify the optimal ratio of components in the drug were carried out in three experiments on 570 calves up to 1.5 months of age, 9-10 calves per group. Each experiment differed from the previous one with a daily dose of a medicinal product (75, 150, 225 ml), which was drunk with colostrum or milk in three doses, i.e. 25, 50, 75 ml per dose, respectively. In the experiments, the effectiveness of the drug was studied with a sodium hypochlorite content of 250 to 450 mg / l in combination with four sets (sets) consisting of polyvinylpyrrolidone, furatsilin, glucose. Each set differs from the previous one in a higher content of substances, while the content of ascorbic acid in all sets remained at the level of 4 g / l. Set No. 1: polyvinylpyrrolidone - 8, furatsilin 4, glucose 15 g / l, set No. 2 - 9; 5; 18, set No. 3 - 10.0; 6.0, set No. 4 - 11; 6.5; 23 g / l, respectively.

The results of the study are shown in table 1. Experiments on the use of sodium hypochlorite with a concentration of 450 mg / l are not reflected in this table due to an unreliable difference in the results at its concentration of 400 mg / l.

As can be seen from table 1, the duration of treatment of calf diarrhea was significantly reduced as the content of sodium hypochlorite activity in the medicinal product increased. So, for example, in the first experiment, when using the first set of other components, the treatment duration decreased from 126 hours with a sodium hypochlorite content of 250 mg / l to 89 hours, with its content of 400 mg / l (reduction in treatment duration by 29%). At a higher concentration of polyvinylpyrrolidone, furatsilin, glucose (sets 2 and 4), this indicator increased from 29 to 39%, which is typical for all three experiments. An increase in the concentration of these substances in the claimed drug (from 1 to 4 sets) also influenced the decrease in the duration of treatment, so at a concentration of sodium hypochlorite of 250 mg / l when using the first set, the treatment duration was 126 hours.

When using the fourth set - 109 hours (decrease in treatment duration from the previous one by 2%). As can be seen from the studies, the dynamics of reducing the duration of treatment increased in all cases of using the second and third sets and was unreliable when using the fourth. At the same time, given the increase in the concentration of sodium hypochlorite from 250 to 400 mg / l, the duration of treatment was reduced by 13% at its concentration of 250 mg / l (from 126 to 109 hours), by 25% at a concentration of sodium hypochlorite of 400 mg / l ( from 89 to 67 hours). A similar trend in reducing the duration of treatment persisted in all three experiments. Based on this experience, sodium hypochlorite with an active substance concentration of 300 to 350 mg / l with a content of polyvinylpyrrolidone of 9-10 g / l, furatsilin 5-6 mg / l, glucose 18-20 mg / l at a daily dose of 150 ml. The duration of treatment ranged from 87 hours at a concentration of sodium hypochlorite of 300 mg / l to 63 hours at a concentration of 350 mg / l, i.e. from 3.6 to 2.6 days. The use of the claimed funds for the treatment of diarrhea in a dose of 225 ml provided an unreliable decrease in the duration of treatment (from 84 to 63 hours) relative to a dose of 150 ml.

The comparative effectiveness of the treatment of severe diarrhea with analogues and the claimed therapeutic agent is shown in table 2.

Analyzing the data of Table 2, it should be noted that, unlike analogues, the use of the claimed medicinal product in the treatment of severe forms (toxic course) of diarrhea made it possible to reduce the duration of the disease by an average of 36%, reduce calf mortality by 53-71%, while weight gain 30 days after treatment were 15-44% higher. The conservation of calves increased from 80 to 95%.

table 2 No. p / p Indicators Experienced groups one 2 3 four 5 gentamicin sodium hypochlorite lers claimed remedy one The number of sick animals, goal. 130 135 135 140 145 2 Live weight of experimental calves, kg 32 ± 2 38 ± 5 34 ± 3 32 ± 3 34 ± 2 3 Dose of drug 3 mg / kg calf weight 2 times a day 500 ml 2 times a day according to instructions 50 ml 3 times a day 75 ml 2 times a day four The average duration of the disease, days 4,5 4.2 4.7 2,8 2.9 5 Fallen, goals 26 16 twenty 7 8 6 Preservation,% 80 88 85 95 94 7 The average daily weight gain (g) on the 30th day after the course of treatment 300.7 306.7 375.3 435.2 430.4

The manufacture (production) of the drug consists in weighing powdered substances according to the claims at the rate of g / l, for example (polyvinylpyrrolidone 9 g, furatsilin 5 g, glucose 18 g, ascorbic acid 4 g, sodium hypochlorite with a concentration of 300-350 mg / l to liter ) A portion of powdered substances was made based on a certain amount of the finished medicinal product, for example 10-20-50-100 liters or more.

A mixture of the four powdered substances indicated in the formula is pre-sieved, lumps are crushed, everything is poured into a container corresponding to the volume and quantity of the sample, it is poured with sodium hypochlorite at a concentration of 300-350 mg / l, it is thoroughly mixed until all components are completely dissolved (homogeneous suspension).

The resulting product is Packed in prepared containers (0.5, 1.5, 2.0, 2.5 L in glass, plastic bottles, cans), tightly cork, mark. Store in a dark place at a temperature of +1 to + 20 ° С.

Example 1. On the farm, at the first sign of calf disease (10 goals, selected in separate groups), a container with a drug is opened at the rate of 150 ml of the drug per 1 calf per day, i.e. one and a half liter bottle (150 ml × 10 heads) and is drunk with milk or colostrum three times, 50 ml per one drink for each calf.

Example 2. At the first signs of calf disease (20 goals, allocated in a separate group), two containers of 1.5 liters of the drug (150 ml × 20 goals) are opened and two times 75 ml are drunk (morning and evening) for one drink.

Thus, the claimed drug for the treatment of diarrhea in calves provides high efficiency, expressed in increasing the safety of calves, reducing treatment time, with a small dose of the drug, increasing the average daily gain after treatment. In addition, the consumption of polyvinylpyrrolidone and glucose is significantly reduced.

The use of the drug in the treatment of diarrhea in calves in 20 farms of the Altai Territory confirmed its high efficiency.

Claims (1)

A medicine for treating diarrhea in calves, including polyvinylpyrrolidone, furatsilin, glucose, ascorbic acid, characterized in that it additionally contains sodium hypochlorite with a concentration of 300-350 mg / l in the following ratios of components, g / l: polyvinylpyrrolidone 9-10 furatsilin 5-6 glucose 18-20 vitamin C four sodium hypochlorite rest in this case, the daily dose of the drug, which is drunk in 2-3 doses, is not more than 150 ml.