JPH07118162A - Oral administration composition for livestock - Google Patents

Abstract

PURPOSE:To provide an oral administration composition effective for the prevention and treatment of diarrhea of young livestock such as calf and pigling. CONSTITUTION:This composition for the oral administration to young livestock contains dietary fiber containing pectin and protopectin, an electrolyte, citric acid, ascorbic acid and glucose.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an orally administered composition for dietary fiber-containing livestock for the purpose of preventing the occurrence of diarrhea which frequently occurs in calves and piglets.

[0002]

[Problems to be Solved by Conventional Techniques and Inventions] The environment surrounding livestock management today is becoming more and more severe with the liberalization of beef imports. In dairy farming and beef cattle management, the lactation capacity of dairy cows should be enhanced and the fattening efficiency of beef cattle should be enhanced. In pig farming management, breeding performance and fattening performance should be improved to stabilize management. Above all, the management of calves and piglets is important, and raising the accident rate and raising healthy dairy cattle, fattening cattle, and fattening piglets is an essential condition for stable management. .

It is known that diarrhea and pneumonia are the most common causes of high accident rates during the calf and piglet period. Among them, the occurrence of diarrhea is life-threatening due to the loss of large amounts of water and electrolytes. Furthermore, the nutritional intake decreases, resulting in chronic malnutrition, and the decrease in physical strength, resulting in pneumonia and other infectious diseases. This will make things worse and worse. Therefore, when diarrhea occurs in calves, piglets, and other small livestock, in order to treat the diarrhea as quickly as possible, a method of administering an oral rehydration solution containing electrolytes such as sodium, potassium, and chloride ions and glucose is generally performed. Cage,
The composition for that is also marketed. However, it is difficult to say that the therapeutic effect on diarrhea of these compositions is sufficiently satisfactory, and it is the actual situation that treatment with an antibiotic or the like is generally performed.

Therefore, the present inventors have conducted research to develop a better composition for preventing and treating diarrhea for livestock, and as a result, have obtained a dietary fiber containing both pectin and protopectin as an electrolyte, citric acid, It has been found that an orally administered composition containing ascorbic acid and glucose has a great effect on the preventive treatment of diarrhea of young livestock such as calves and piglets.

The preferred composition of the composition of the present invention is as follows. Pectin and Protope 35-70 wt% Dietary fiber containing cutin Glucose 30-60 wt% Sodium chloride 4-10 wt% Potassium chloride 0.5-2 wt% Sodium bicarbonate 2-4 wt% Potassium dihydrogen phosphate 0 1 to 2% by weight Magnesium oxide 0.05 to 1% by weight Citric acid 0.1 to 2% by weight Ascorbic acid 0.05 to 1% by weight

In calves, the composition of the present invention is generally orally administered by dissolving 40 to 80 g of the composition in 2 liters of water or milk substitute. In piglets, this composition is fed as a mixture with 3% of normal piglet feed, or it is dissolved in water to a concentration of 3% and orally administered.

In the present invention, glucose is for replenishing nutritional deficiency in the occurrence of diarrhea, and the purpose of incorporating an electrolyte such as sodium chloride is to reduce sodium, potassium, etc. lost from the body due to the occurrence of diarrhea. This is to replenish chlorine, bicarbonate, etc., and to accelerate the normal recovery of the acid-base equilibrium in the blood. The blending ratio of glucose and electrolyte is adjusted so that the osmotic pressure when the composition of the present invention is dissolved in 1 liter of water is about 300 mOsm / liter. Also, citric acid is to increase the palatability and to prevent the risk of a sudden change in pH after administration of the composition of the present invention such as the growth of E. coli, the addition of ascorbic acid, antibody production This is to promote the anti-disease and to reduce the occurrence of diarrhea.

In the present invention, the above-mentioned specific "dietary fiber" formulation is a special feature of the present invention, and will be described in detail below. The evaluation of fiber in animals has hitherto been considered as an unnecessary component that cannot be digested by animals other than ruminants such as cattle. In particular, it has been important to reduce the amount of fiber to be fed to calves and piglets that are just after birth. However, in recent years, what is called “dietary fiber” has been re-examined in the human world, and fiber, which has been conventionally considered as a non-nutritive ingredient, has been actively used for health. It is generally said that the health benefits of "dietary fiber" are to increase stool volume and frequency of defecation, shorten colonic transit time, dilute colonic contents, promote the growth of normal intestinal bacteria, and suppress bile acid secretion. , Adsorption and excretion of harmful substances, etc. The present inventors focused their attention on the health effects of this "dietary fiber", and by administering this dietary fiber to calves and piglets, which were not previously considered, the occurrence of diarrhea was significantly reduced. I found that.

The mechanism of the effect of the composition of the present invention on diarrhea is derived from various physicochemical properties of "dietary fiber" as a polymer compound. In other words, "dietary fiber" is roughly divided into two types, water-soluble and insoluble, according to their affinity for water, but insoluble ones become colloidal in the digestive tract of animals, increasing the volume of feces and intestinal wall. Has the property of stimulating intestinal motility and promoting intestinal motility, and shortening the time for feces to pass through the large intestine. It is known to delay the time to reach and slow the absorption rate of nutrients.

Among the various physicochemical properties of "dietary fiber", the present invention is particularly characterized by utilizing both the water-soluble property and the insoluble property. Protopectin is a parent substance of water-soluble fiber pectin existing in plants, but it is usually present in the intercellular membrane in combination with insoluble fibers such as cellulose, hemicellulose and lignin.
However, protopectin is a unique "dietary fiber" that can utilize both water-soluble and insoluble physicochemical properties because it is decomposed into pectin and cellulose in the digestive tract environment of animals. Therefore, due to its characteristics, the expected efficacy for calves and piglets is that the increase in viscosity slows the outflow rate of the intestinal contents, which enhances the digestion and absorption rate of nutrients even in an unstable gastrointestinal tract environment. It has the effect of absorbing and excreting harmful bacteria in the intestines, bacterial toxins and other harmful substances, which alleviate dehydration symptoms.
Improving the intestinal environment, etc., can restore the health of frail calves and piglets and provide effective nutrition. Such an effect can be achieved only by the synergistic action of both insoluble and soluble properties, and the water-soluble fiber pectin alone cannot provide a sufficient effect. Therefore, in the present invention, dietary fiber containing both pectin and protopectin is used together from this point of view.

Japanese Examined Patent Publication (Kokoku) No. 3-21006 describes a composition for treating oral diarrhea of livestock, which contains one type of dietary fiber, guar gum. However, the guar gum described therein is sufficiently soluble in water. Diarrhea treatment effect is not obtained.

As the feed raw material containing pectin and protopectin used in the present invention, fruits, fruit skins, fruit squeezed lees, potatoes and the like are used. For example, citrus peels, squeezed lees such as apples, and potatoes are used as feed ingredients. As the dietary fiber derived from these feed raw materials, these raw materials are dried and used as they are or after being crushed (hereinafter, such a pulp is referred to as pulp). At this time, the mixing ratio of the dietary fiber raw material is adjusted so that the total content of pectin and protopectin is 2.5% by weight to 10% by weight. If the total content of pectin and protopectin is less than 2.5% by weight, the expected therapeutic and preventive effect for diarrhea cannot be obtained. On the other hand, if it is more than 10% by weight, the viscosity of the solution at the time of dissolution becomes too high to obtain a homogeneous solution, and it becomes difficult to maintain the osmotic pressure at the time of dissolution at about 300 mOsm / liter.

The present invention and its effects will be specifically described below with reference to examples. Unless otherwise specified,% in each example is% by weight.
Indicates.

Example 1 The composition of the present invention was prepared by blending the following raw materials. The total content of pectin and protopectin in the composition was 6.80%. 50 g of this composition
Dissolved in 2 liters of commercially available cow milk replacer and showing 10 diarrhea-induced Holstein male calves (average weight 50k)
g). Dried citrus pulp 10% Dried apple pulp 20 Dried potato pulp 17.1 Glucose 39 Sodium chloride 7.7 Potassium chloride 1.5 Sodium hydrogencarbonate 3 Potassium dihydrogen phosphate 1 Magnesium oxide 0.1 Citrate 0.5 Ascorbic acid 0.1 As a result, in all calves, diarrhea was healed and normal stools returned by the third day after the start of administration.

[0014]

[Example 2] One 20 Holstein calves immediately after introduction
Each group was divided into 2 groups, and 2 liters of commercially available milk replacer were fed twice in the morning and evening by the conventional method to 1 group (control group), and to the other group, the same milk replacer as the control group was used. Composition (total content of pectin and protopectin 5.40%) 50
g was dissolved and administered twice daily in the morning and evening twice for a total of 3 days (invention group). Then, the occurrence status of diarrhea in the two wards for two weeks was compared. The milk substitute used had the following composition. In the control group, diarrhea occurred in 6 out of 10 cows in 2 weeks, but in the group of the present invention, diarrhea occurred in only 1 cow. This indicates that the composition of the present invention has a preventive effect on diarrhea.

[0015]

Example 3 Twelve 22-day-old piglets were divided into two groups,
Group 1 is allowed to freely ingest the commercially available formula feed for artificial milk,
In the other group, 3% of the composition of the present invention having the same composition as in Example 1 was mixed with the feed of the control group and freely ingested. The test was conducted for 15 days, and the incidence of diarrhea and the growth performance were observed. The results are shown in Table 1.

[0016]

[Table 1] In the present invention group, diarrhea was less likely to occur as in the case of calves, and as a result, the growth performance was improved.

As shown in the above examples, the orally administered composition of the present invention was found to have a clear preventive and therapeutic effect on diarrhea in both calves and piglets.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Office reference number FI technical display location A61K 33/00 9454-4C 33/08 9454-4C 33/14 9454-4C // (A61K 35 / (78) 33:14 33:08 33:00 31:19 31: 375 31:70) (72) Inventor Kiyonori Yoshimoto 4-43 Minami Nakatsu-dori, Naka-ku, Yokohama-shi, Kanagawa Kenkyukai Co., Ltd. (72) Inventor Takaaki Tozaki 663-5 Oto, Yono City, Saitama Prefecture

Claims (3)

[Claims] 1. An orally administered composition for larvae useful for preventing diarrhea of larvae, which comprises dietary fiber containing pectin and protopectin, an electrolyte, citric acid, ascorbic acid and glucose. 2. The dietary fiber containing pectin and protopectin is a dietary fiber derived from one or more of raw materials selected from the group consisting of fruits, peels, squeezed lees, and potatoes. The oral administration composition for larvae according to claim 1, wherein the total content of pectin and protopectin is 2.5 to 10% by weight. 3. The electrolyte is one or more electrolytes selected from the group consisting of sodium chloride, potassium chloride, sodium hydrogen carbonate, potassium dihydrogen phosphate, and magnesium oxide. The orally administered composition for larvae as described above.