RU2307652C1 - Method for treating respiratory diseases in farm animals youngsters - Google Patents

Abstract

FIELD: veterinary science.

SUBSTANCE: the present innovation deals with applying a preparation consisting of the following components, weight%: norfloxacin 9.0; dioxidine 1.0; 1,2-propylene glycol 19.8; low-molecular polyvinyl pyrrolidone 0.2; distilled water - the rest. For calves this preparation should be introduced subcutaneously at the dosage of 0.5 ml/10 kg body weight once daily in the course of 3 d. For piglets this preparation should be injected intramuscularly at the dosage of 0.5 ml/10 kg body weight once daily for 3 d. Application of the present method is efficient, moreover, it is technologically and economically profitable.

EFFECT: higher efficiency of therapy.

2 cl, 2 ex, 4 tbl

Description

The invention relates to the field of veterinary medicine, for the treatment of respiratory diseases of animals.

At the present stage of development of livestock breeding, respiratory diseases of calves and piglets have become widespread, due to manning of farms with a “collective” livestock from supplying farms with different epizootic situations and non-compliance with standard indicators of their maintenance and feeding.

The union of calves, piglets with different immune status in the period of completing the livestock leads to their rebooting and an outbreak of infection.

The concentration in a limited area of a large number of monotonous, same-aged, sensitive young animals causes the disease to quickly reach large groups of animals with a complex etiology and unclear symptom complexes.

The high incidence of young animals leads to a significant forced slaughter and mortality of animals, lack of live weight, which impedes the further development of animal husbandry.

The huge economic damage caused to livestock farms by respiratory diseases necessitates the search for ways and methods to improve and find new effective means in their prevention and treatment.

In the complex of measures to combat respiratory diseases of bacterial etiology in young farm animals, such chemotherapeutic agents as sulfanilamides, antibiotics, nitrofurans, etc. are widely used. However, their prolonged and unsystematic use in animal husbandry has led to the appearance of resistant strains of microorganisms to them.

A known method of treating calves bronchopneumonia using the drug "Eridinum", containing, wt.%: Erythromycin 5.0-10.0; starch 7.5-12.5; calcium stearate 1.0-2.0; dioxidine 4.0-8.0 and lactose up to 100%. Assign it to 1 briquette 1-2 times a day for 3-5 days / 1 /.

The closest technical solution is a method of treating young farm animals with Enroxil 5%, which is a clear yellow solution, 1 ml of which contains 50 mg of enrofloxacin / 2 /.

The technical result of the invention is improving efficiency.

The method is as follows. After diagnosis, the animals are administered a drug consisting of the following ratio of components, wt.%:

Norfloxacin 9.0; Dioxidine 1.0; 1,2 Propylene glycol 19.8; Low molecular weight polyvinylpyrrolidone 0.2; Distilled water rest.

Norfloxacin is a bactericidal drug, the degree of bactericidal activity depends on the concentration of the drug. In this case, the death of bacterial cells sensitive to the drug is observed within 20-30 minutes after exposure to the drug. Norfloxacin has a significant post-antibiotic effect against gram-negative and gram-positive bacteria, is effective both in latent and in the phase of bacterial reproduction. The drug inhibits bacterial DNA hydrase (type II topoisomerase), thereby preventing the process of supercoiling and DNA synthesis.

The antibacterial action of dioxidine is based on the selective suppression of DNA synthesis. In addition, the drug reduces the activity of extracellular nuclease and plasmocoagulase in microorganisms, which leads to dysfunction of the genetic apparatus of the microbial cell and, as a result, the biosynthesis of biologically active macromolecules, which are pathogenicity factors, is suppressed.

The validity of this combination is due to the fact that two bactericidal agents are simultaneously combined in the dosage form. This provides a synergistic effect due to the fact that these drugs act on one phase of cell growth, but on different metabolic pathways. The main purpose of the combined use of norfloxacin and diokidin is to expand the spectrum of antibacterial action, fill in the gaps in the spectrum of each of the components of the combination and prevent the formation of resistance of microorganisms.

The drug is made as follows. Water is heated in the reactor to a temperature of (50 ± 5) ° C. Dioxidine and norfloxacin are introduced into the reactor sequentially at intervals of 10 minutes. In a stainless steel container, low molecular weight polyvinylpyrrolidone is dissolved in 1.2 propylene glycol at a temperature of (70 ± 5) ° C. Cool to (40 ± 5) ° C. A solution of low molecular weight polyvinylpyrrolidone in 1.2 propylene glycol is introduced into the reactor.

The drug is heated to 37-38 ° C before use. The drug is administered to the calves subcutaneously at a dose of 0.5 ml / 10 kg of body weight 1 time per day for three days. To piglets, the drug is administered intramuscularly at a dose of 0.5 ml / 10 kg of body weight 1 time per day for 3 days. Calves are not recommended to inject more than 5 ml in one place, pigs - more than 2.5 ml of the drug. With the introduction of large volumes, the dose is divided and administered in different places. With repeated injections, it is recommended to change the injection site. In the recommended doses, no side effects and complications are observed. After injection, animals may experience a short-term pain reaction and anxiety. The drug is incompatible with antibiotics from the groups of chloramphenicol, macrolides and tetracyclines, is contraindicated in animals with increased sensitivity to norfloxacin and dioxidine. Slaughter for meat is permitted no earlier than 7 days after the last injection. The meat of animals forcibly killed before the expiration of the specified period can be used for feeding carnivores or for the production of meat and bone meal.

The essence of the method is illustrated by examples.

Example 1. Performance indicators in the treatment of bronchopneumonia in calves.

The study of the effectiveness of treatment of bronchopneumonia in calves was carried out in two experiments on calves of 2-2.5 months of age weighing 55-95 kg.

According to the principle of paired analogues, animals were divided into two groups.

The diagnosis of bronchopneumonia was established comprehensively on the basis of data from a clinical examination of animals, laboratory tests, postmortem autopsy.

The animals were monitored daily for 10-15 days, taking into account the general condition, mortality, growth rate, and timing of recovery.

The first experience in studying the effectiveness of the use of dioxinor for the treatment of calf bronchopneumonia was carried out in Krinichenskoye LLC, Ostrogozhsky District, Voronezh Region.

For the treatment of calves of the first group (74 goals), 5% enroxil / 4 / was used, which was administered subcutaneously at a dose of 1 ml per 20 kg of body weight (2.5 mg of enrofloxacin per 1 kg of body weight) once a day for 3 days.

The calves of the experimental group were administered a drug consisting of the following ratio of components, wt.%:

Norfloxacin 9.0; Dioxidine 1.0; 1,2 Propylene glycol 19.8; Low molecular weight polyvinylpyrrolidone 0.2; Distilled water rest.

The drug was heated to 37-38 ° C before use. The drug was administered subcutaneously at a dose of 0.5 ml / 10 kg of body weight 1 time per day for three days. The results of the experience in the study of effectiveness are presented in table 1.

Table 1 The effectiveness of the treatment of bronchopneumonia in calves Indicators Group of animals The control Experience Number of animals, goals 74 82 Recover, Goals 66 74 % 89.2 90.2 Fallen, goals 5 four % 6.8 4.9 Remained sick, goals 3 four % 4.1 4.9 Duration of recovery, days 5.9 ± 0.8 4.7 ± 0.6 Therapeutic efficacy,% 89.2 90.2

The second experience in studying the effectiveness of treatment of calf bronchopneumonia was carried out in the Agricultural Association “Freedom” of the Rossoshansky district of the Voronezh region.

For the treatment of calves of the first group (45 goals), 5% enroxil was used, which was administered subcutaneously at a dose of 1 ml per 20 kg of weight once a day for 3 days.

The calves of the second group were injected with a drug consisting of the following ratio of components, wt.%:

Norfloxacin 9.0; Dioxidine 1.0; 1,2 Propylene glycol 19.8; Low molecular weight polyvinylpyrrolidone 0.2; Distilled water rest.

The drug was heated to 37-38 ° C before use. The drug was administered subcutaneously at a dose of 0.5 ml / 10 kg of body weight 1 time per day for three days. The results of the experiment to study the effectiveness of treatment of bronchopneumonia in calves are presented in table 2.

table 2 The effectiveness of the treatment of bronchopneumonia in calves Indicators Group of animals The control Experience Number of animals, goals 45 fifty Recover, Goals 39 45 % 86.7 90.0 Fallen, goals four 3 % 8.9 6.0 Remained sick, goals 2 2 % 4.4 4.0 Duration of recovery, days 5.1 ± 0.6 4.4 ± 0.3 Therapeutic efficacy,% 86.7 90.0

As shown by studies, the inventive method has high therapeutic efficacy in the treatment of bronchopneumonia in calves. In all experiments, when applying the method compared with the control groups, the recovery time and death of the animals decreased.

Example 2. The effectiveness of the treatment of bronchopneumonia in piglets.

The study of the effectiveness of treatment of bronchopneumonia in piglets was carried out in two experiments on pigs 30-45 days of age weighing 8.0-12.0 kg.

According to the principle of paired analogues, animals were divided into two groups.

The diagnosis of bronchopneumonia was established comprehensively on the basis of data from a clinical examination of animals, laboratory tests, postmortem autopsy.

The animals were monitored daily for 10-15 days, taking into account the general condition, mortality, growth rate, and timing of recovery.

The first experiment was carried out in the State Unitary Enterprise OPK “Dokuchaevskoye” in the Talovsk district of the Voronezh region.

Animals of the control group (126 animals) were treated with 5% enroxil, which was administered intramuscularly at a dose of 1 ml per 20 kg of body weight (2.5 mg of enrofloxacin per 1 kg of body weight) once a day for 3 days.

Animals of the experimental group. treated using the proposed method. The drug was administered, consisting of the following ratio of components, wt.%:

Norfloxacin 9.0; Dioxidine 1.0; 1,2 Propylene glycol 19.8; Low molecular weight polyvinylpyrrolidone 0.2; Distilled water rest.

The drug was heated to 37-38 ° C before use. The drug was administered intramuscularly at a dose of 0.5 ml / 10 kg of body weight 1 time per day for 3 days.

The results of the experiment are presented in table 3.

Table 3
The effectiveness of the treatment of bronchopneumonia in piglets Indicators Group of animals Control Experienced Number of animals, goals 126 138 Recover, Goals 104 119 % 82.5 86.2 Fallen, goals 9 3 % 7.1 2.2 Stayed sick goals 13 16 % 10.3 11.6 Duration of recovery, days 5.2 ± 0.3 4.9 ± 0.6 Therapeutic efficacy,% 82.5 86.2

The second experience in the study of therapeutic efficacy was carried out in the SCA "Homeland" Rossoshansky district of the Voronezh region.

Animals of the control group (165 animals) were treated with 5% enroxil, which was administered intramuscularly at a dose of 1 ml per 20 kg of body weight (2.5 mg of enrofloxacin per 1 kg of body weight) once a day for 3 days.

The animals of the experimental group (180 animals) were treated using the proposed method. The drug was administered, consisting of the following ratio of components, wt.%:

Norfloxacin 9.0; Dioxidine 1.0; 1,2 Propylene glycol 19.8; Low molecular weight polyvinylpyrrolidone 0.2; Distilled water rest.

The drug was heated to 37-38 ° C before use. The drug was administered intramuscularly at a dose of 0.5 ml / 10 kg of body weight 1 time per day for 3 days.

The results of the experiment to study the effectiveness of the treatment of bronchopneumonia in piglets are presented in table 4.

Table 4
The effectiveness of the treatment of bronchopneumonia in piglets Indicators Group of animals Control Experienced Number of animals, goals 165 180 Recover, Goals 143 161 % 86.7 89.4 Fallen, goals 9 6 % 5.5 3.3 Stayed sick goals 13 13 % 7.9 7.2 Duration of recovery, days 6.5 ± 0.4 5.8 ± 0.5 Therapeutic efficacy,% 86.7 89.4

Studies have shown that the proposed method has high therapeutic efficacy in the treatment of bronchopneumonia in piglets. Compared to the control groups, the recovery time and mortality of animals decreased.

The tests of the method in the treatment of respiratory diseases of bacterial etiology in piglets and calves showed its high efficiency.

Based on the results of the studies, it was found: the use of the method has a pronounced therapeutic effect in respiratory diseases of bacterial etiology in piglets and calves.

The application of the method is technologically and cost-effective.

Information sources.

1. RU, 1424170 C, December 20, 1995

2. Klenova IF, Yaremenko NA, Veterinary preparations in Russia. Directory. - M .: Selkhozizdat, 2001 .-- p. 144.

3. Veterinary drugs in Russia: a guide in 2 volumes. T.1 / I.F.Klenova, K.L. Maltsev, N.A. Eremenko, A.I. Arkhipov. - M .: Selkhozizdat, 2004.

Claims (3)

1. A method of treating respiratory diseases of young farm animals, comprising administering a preparation containing norfloxacin, dioxidine, 1,2-propylene glycol, low molecular weight polyvinylpyrrolidone and distilled water in the following ratio, wt.%: Norfloxacin  9.0 Dioxidine  1,0 1,2-propylene glycol  19.8 Low molecular weight polyvinylpyrrolidone  0.2 Distilled water  Rest moreover, the introduction is carried out in a dose of 0.5 ml / 10 kg of body weight 1 time per day for three days. 2. The method according to claim 1, characterized in that the drug is administered subcutaneously to the calves. 3. The method according to claim 1, characterized in that the drug is administered to the piglets intramuscularly.