RU2341972C2 - Применение гуанидинуксусной кислоты в качестве кормовой добавки - Google Patents
Применение гуанидинуксусной кислоты в качестве кормовой добавки Download PDFInfo
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- RU2341972C2 RU2341972C2 RU2006146983/13A RU2006146983A RU2341972C2 RU 2341972 C2 RU2341972 C2 RU 2341972C2 RU 2006146983/13 A RU2006146983/13 A RU 2006146983/13A RU 2006146983 A RU2006146983 A RU 2006146983A RU 2341972 C2 RU2341972 C2 RU 2341972C2
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- RU
- Russia
- Prior art keywords
- feed
- creatine
- salts
- guanidinoacetic acid
- acid
- Prior art date
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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| DE102004059761.8 | 2004-12-11 | ||
| DE102004059761 | 2004-12-11 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12252460B2 (en) | 2019-07-12 | 2025-03-18 | Alzchem Trostberg Gmbh | Process for the preparation of a metastable crystal modification of n-(aminoiminomethyl)-2-aminoacetic acid (III) |
| RU2849774C2 (ru) * | 2020-06-25 | 2025-10-29 | Альцхем Тростберг Гмбх | Метастабильная кристаллическая модификация и способ ее получения |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8536222B2 (en) | 2005-03-04 | 2013-09-17 | Alzchem Ag | Addition compounds of guanidinoacetic acid |
| DE102005009990A1 (de) * | 2005-03-04 | 2006-09-07 | Degussa Ag | Salze, Anlagerungs- und Komplexverbindungen der Guanidinoessigsäure |
| BRPI0615160A2 (pt) * | 2005-08-02 | 2011-05-03 | Alzchem Trostberg Gmbh | uso de uma formulação lìquida à base de um componente de ácido guanidinoacético e seu produto pronto para beber |
| DE102006009373A1 (de) * | 2006-03-01 | 2007-09-06 | Degussa Gmbh | Fertigfutter für Haustiere |
| DE102006050931A1 (de) * | 2006-10-28 | 2008-04-30 | Alzchem Trostberg Gmbh | Feste oder wässrige alkalische Zubereitung auf Basis einer Kreatin-Komponente, Verfahren zu deren Herstellung und ihre Verwendung |
| WO2008065827A1 (fr) | 2006-11-28 | 2008-06-05 | Tokyo Ohka Kogyo Co., Ltd. | Composition de résine photosensible de type positif chimiquement amplifié pour film épais, film sec chimiquement amplifié pour film épais, et procédé de fabrication d'un motif de résine photosensible sur film épais |
| DE102007004781A1 (de) * | 2007-01-31 | 2008-08-07 | Alzchem Trostberg Gmbh | Verwendung von Guanidinoessigsäure(-Salzen) zur Herstellung eines gesundheitsfördernden Mittels |
| DE102007034102A1 (de) * | 2007-07-21 | 2009-01-22 | Alzchem Trostberg Gmbh | Abriebfeste und rieselfähige Glycocyamin-haltige Formlinge und Verfahren zu deren Herstellung |
| DE102007053369A1 (de) | 2007-11-09 | 2009-07-02 | Alzchem Trostberg Gmbh | Verwendung einer eine Kreatin-Komponente enthaltende Zusammensetzung zur Verbesserung der männlichen Fruchtbarkeit |
| CN101912044A (zh) * | 2010-08-13 | 2010-12-15 | 青岛天通生物科技有限公司 | 促肌肉生成的组合物及其制备方法 |
| CN103549198B (zh) * | 2013-11-05 | 2015-09-09 | 安徽科技学院 | 一种无抗生素肉鸡复合饲料添加剂 |
| CN103549134B (zh) * | 2013-11-05 | 2014-11-05 | 安徽科技学院 | 一种不含抗生素的肉鸡复合饲料添加剂 |
| EP2904911A1 (de) * | 2014-02-11 | 2015-08-12 | Evonik Degussa GmbH | Verwendung von Guanidinoessigsäure und/oder Kreatin zur Erhöhung der Schlupfrate |
| CN104082202A (zh) * | 2014-06-17 | 2014-10-08 | 怀远县孔津湖农业开发有限公司 | 一种泥鳅产卵孵化用环道 |
| CN104082205A (zh) * | 2014-06-17 | 2014-10-08 | 怀远县孔津湖农业开发有限公司 | 一种泥鳅人工养殖池塘的防逃、防敌害设施 |
| CN104605161B (zh) * | 2015-01-23 | 2018-02-27 | 长沙兴嘉生物工程股份有限公司 | 胍基乙酸配合物的制备方法及其应用 |
| CN105076719A (zh) * | 2015-08-04 | 2015-11-25 | 北京君德同创农牧科技股份有限公司 | 一种肉鸡用预混料及其制备和使用方法 |
| CN105076769A (zh) * | 2015-08-04 | 2015-11-25 | 固安君德同创生物工程有限公司 | 一种猪饲料添加剂及其制备和使用方法 |
| CN106036197A (zh) * | 2016-05-25 | 2016-10-26 | 中国水产科学研究院黑龙江水产研究所 | 一种无鱼粉鲟鱼饲料的添加剂及其制备方法和使用方法 |
| CN107183341A (zh) * | 2017-06-13 | 2017-09-22 | 肖鹏宏 | 无草育肥驴饲料及其制备方法 |
| EP3772985A1 (en) * | 2018-03-27 | 2021-02-17 | Evonik Operations GmbH | Use of guanidinoacetic acid and/or creatine in aquaculture |
| CN108308402A (zh) * | 2018-04-02 | 2018-07-24 | 四川铁骑力士实业有限公司 | 一种用于60kg以上乌金猪的配合饲料 |
| CN109258935A (zh) * | 2018-10-10 | 2019-01-25 | 江苏奥迈生物科技有限公司 | 饲料用促生长抗氧化复合添加剂及其制备方法和应用 |
| EP3677329B1 (en) | 2019-01-02 | 2021-07-21 | Evonik Operations GmbH | Process for preparing guanidino acetic acid |
| BR112021014403A2 (pt) | 2019-01-24 | 2021-09-28 | Sil'innov Srcl | Composição de ração e água potável para aves que compreende um complexo de silício estável e biodisponível |
| MX2021016024A (es) | 2019-06-28 | 2022-04-06 | Rxw Group Nv | Composicion de agua potable y pienso para aves de corral que comprende monometilsilanotriol. |
| DE102019118898A1 (de) | 2019-07-12 | 2021-01-14 | Alzchem Trostberg Gmbh | Konzentrat zur Herstellung einer Tränklösung |
| DE102019120246A1 (de) | 2019-07-26 | 2021-01-28 | Alzchem Trostberg Gmbh | Verfahren zur Fütterung von Geflügel |
| DE102019120249A1 (de) * | 2019-07-26 | 2021-01-28 | Alzchem Trostberg Gmbh | Verwendung einer Zusammensetzung zur Reduzierung der Feuchtigkeit und des Stickstoffgehalts in Faeces von Geflügel |
| DE102019120244A1 (de) * | 2019-07-26 | 2021-01-28 | Alzchem Trostberg Gmbh | Verwendung einer Zusammensetzung zur Verminderung des Federverlustes von Vögeln |
| DE102019121526A1 (de) | 2019-08-09 | 2021-02-11 | Alzchem Trostberg Gmbh | Konzentrat zur Herstellung von Tränklösungen (II) |
| EP3839051A1 (en) | 2019-12-19 | 2021-06-23 | Evonik Operations GmbH | Method for the fermentative production of guanidinoacetic acid |
| US11633373B2 (en) | 2020-03-04 | 2023-04-25 | Alzchem Trostberg Gmbh | Method for reduction of behavioral disorders in pigs |
| CN116133528A (zh) * | 2020-06-15 | 2023-05-16 | 澳泽化学特罗斯特贝格有限公司 | 增加动物饲料中的代谢能 |
| AU2021303704A1 (en) | 2020-07-09 | 2023-03-09 | Evonik Operations Gmbh | Method for the fermentative production of guanidinoacetic acid |
| PH12023550036A1 (en) | 2020-07-09 | 2024-03-11 | Evonik Operations Gmbh | Method for the fermentative production of guanidinoacetic acid |
| JP2023539760A (ja) | 2020-09-01 | 2023-09-19 | エボニック オペレーションズ ゲーエムベーハー | グアニジノ酢酸の製造方法 |
| DK4208436T3 (da) | 2020-09-01 | 2024-07-22 | Evonik Operations Gmbh | Fremgangsmåde til fremstilling af guanidinoeddikesyre |
| IL308626A (en) | 2021-05-21 | 2024-01-01 | Evonik Operations Gmbh | An improved biotechnological method for the production of guanidino acetic acid (GAA) by inhibiting an amino acid exporter |
| DE102021126581A1 (de) * | 2021-10-13 | 2023-04-13 | Alzchem Trostberg Gmbh | Verwendung eines Futtermitteladditives in energiearmen Futter für Schweine |
| EP4503948A1 (en) * | 2022-04-08 | 2025-02-12 | Can Technologies, Inc. | Fish feed or fish feed additive |
| CN114938830A (zh) * | 2022-05-05 | 2022-08-26 | 北京中科万联科技有限公司 | 一种基于氨基酸提升畜禽瘦肉率的饲料添加剂及其制备方法和应用 |
| US20250163481A1 (en) | 2022-06-03 | 2025-05-22 | Evonik Operations Gmbh | Improved biotechnological method for producing guanidino acetic acid (gaa) by using nadh-dependent dehydrogenases |
| US12312622B2 (en) | 2022-06-03 | 2025-05-27 | Evonik Operations Gmbh | Method for producing guanidino acetic acid (GAA) |
| CN114751845B (zh) * | 2022-06-13 | 2022-09-20 | 北京君德同创生物技术股份有限公司 | 一种易溶的胍基乙酸络合物的合成方法 |
| EP4612280A1 (en) | 2022-11-03 | 2025-09-10 | Evonik Operations GmbH | Improved biotechnological process to produce guanidinoacetic acid (gaa) by targeted introduction or by increasing the activity of a transmembrane exporter protein |
| CN120129742A (zh) | 2022-11-03 | 2025-06-10 | 赢创运营有限公司 | 通过靶向引入或增加属于氨基酸-多胺-有机阳离子超家族的跨膜转运蛋白的活性来产生胍基乙酸(gaa)的改进的生物技术工艺 |
| CN115553403A (zh) * | 2022-11-03 | 2023-01-03 | 上海海洋大学 | 凡纳滨对虾肉质改善剂及其制备方法和应用 |
| CN120641563A (zh) | 2023-02-01 | 2025-09-12 | 赢创运营有限公司 | 使用包含异源l-苏氨酸醛缩酶基因的微生物发酵生产胍基乙酸的方法 |
| AU2024214542A1 (en) | 2023-02-01 | 2025-09-11 | Evonik Operations Gmbh | Method for the fermentative production of guanidinoacetic acid using a microorganism comprising a heterologous l-threonine 3-dehydrogenase gene (tdh) and a glycine c-acetyltransferase gene (kbl) |
| WO2024165348A1 (en) | 2023-02-06 | 2024-08-15 | Evonik Operations Gmbh | Process for preparing an n-guanylamino acid |
| CN116268200A (zh) * | 2023-03-15 | 2023-06-23 | 广东瑞科营养科技有限公司 | 提高动物肌细胞atp利用率的饲料添加剂、制法及应用 |
| BE1031726B1 (fr) | 2023-06-20 | 2025-02-03 | Apr Pharma Srl | Dispersion de silicium biodisponible pour volaille |
| WO2025009281A1 (ja) * | 2023-07-03 | 2025-01-09 | 住友化学株式会社 | 飼料添加物及び家畜用飼料 |
| CN117044840A (zh) * | 2023-08-15 | 2023-11-14 | 青岛诺安百特生物技术有限公司 | 一种增强猫肠道功能的宠物食品制备方法 |
| DE102023123941A1 (de) | 2023-09-06 | 2025-03-06 | Alzchem Trostberg Gmbh | Verwendung eines Futtermitteladditivs zur Fütterung trächtiger Sauen |
| BE1032231B1 (nl) * | 2023-12-15 | 2025-07-14 | Curafyt Bv | Samenstelling voor gebruik ter behandeling van ovulatoire sub- of infertiliteit bij paardachtigen |
| DE102023135640A1 (de) | 2023-12-18 | 2025-06-18 | Alzchem Trostberg Gmbh | Verwendung eines Futtermitteladditivs zur Verkürzung der Abferkeldauer |
| US20250221430A1 (en) * | 2024-01-05 | 2025-07-10 | Numega Nutrition Pte. Ltd | A newest preparation method (NT-PB) and applications for improving ATP utilization in animal muscle cells |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3089771A (en) * | 1960-02-16 | 1963-05-14 | Armoar And Company | Method of feeding chicks |
| DD206735A1 (de) * | 1981-07-15 | 1984-02-08 | Helmut Just | Verfahren zur anwendung ergotroper wirkstoff-kombinationen in der gefluegelmast |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE738131C (de) | 1936-07-26 | 1943-08-04 | Ig Farbenindustrie Ag | Eiweissersetzendes Futtermittel |
| US2654779A (en) | 1950-12-23 | 1953-10-06 | Int Minerals & Chem Corp | Method of preparation of guanidino fatty acids |
| US2620354A (en) | 1951-01-12 | 1952-12-02 | Int Minerals & Chem Corp | Production of guanidino fatty acids |
| US3843798A (en) * | 1973-03-12 | 1974-10-22 | Stanley Drug Products Inc | Methods and compositions for inducing resistance to bacterial infections |
| DE2441777A1 (de) | 1974-08-31 | 1976-03-11 | Stanley Drug Products Inc | Antibakterielles mittel |
| DE2937358A1 (de) | 1979-09-13 | 1981-04-02 | Erhard Heisler | Praeparat aus pflanzlichen und/oder tierischen extrakten zur enteralen und parenteralen ernaehrung |
| US6413962B1 (en) * | 1988-05-02 | 2002-07-02 | N. Eric Naftchi | Guanidino compounds effective as anesthetics |
| JP2749871B2 (ja) * | 1989-05-26 | 1998-05-13 | 協和醗酵工業株式会社 | 魚類の養殖法および養魚用飼料 |
| IT1237519B (it) | 1989-11-27 | 1993-06-08 | Impiego dell'acido guanidinacetico per indurre un incremento del contenuto muscolare di creatina | |
| GB9508443D0 (en) | 1995-04-26 | 1995-06-14 | Gilbertson & Page | Biscuit for working racing or sporting dogs |
| US5962043A (en) * | 1996-02-29 | 1999-10-05 | Seal Rock Technologies Incorporated | Weight reduction method for dogs and other pets |
| IL127148A (en) | 1996-12-20 | 2002-11-10 | Sueddeutsche Kalkstickstoff | Keratin pyruvates, a method of their production and the physiologically appropriate compositions that contain them |
| DE19707694A1 (de) | 1997-02-26 | 1998-08-27 | Sueddeutsche Kalkstickstoff | Kreatin-ascorbate und Verfahren zu deren Herstellung |
| DE19836450A1 (de) | 1998-08-12 | 2000-02-17 | Sueddeutsche Kalkstickstoff | Stabile, Brenztraubensäure (Salze) enthaltende Formulierung für die Tierernährung |
| EP1051914A1 (de) * | 1999-05-08 | 2000-11-15 | DSM Fine Chemicals Austria GmbH | Verwendung von Kreatin als Futterzusatz |
| WO2001000212A1 (en) | 1999-06-25 | 2001-01-04 | Avicena Group, Inc. | Use of creatine or creatine analogs for the prevention and treatment of transmissible spongiform encephalopathies |
| GB2358135A (en) * | 1999-12-09 | 2001-07-18 | Finnfeeds Int Ltd | Animal feed additives comprising betaine and a protease |
| DE10003835A1 (de) | 2000-01-28 | 2001-08-16 | Sueddeutsche Kalkstickstoff | Formulierungen bei Dehydratationszuständen |
| JP3827139B2 (ja) | 2000-07-17 | 2006-09-27 | 伊藤忠飼料株式会社 | グリシンによって強化された採卵鶏用植物性飼料組成物及び採卵鶏の飼育方法 |
| ATE457726T1 (de) | 2002-06-19 | 2010-03-15 | Nutricia Nv | Nahrungs- oder pharmazeutische zusammensetzungen zur erhöhung der creatin-antwort von organismen |
-
2005
- 2005-06-07 HR HR20080035T patent/HRP20080035T3/xx unknown
- 2005-06-07 ES ES05747802T patent/ES2296186T3/es not_active Expired - Lifetime
- 2005-06-07 CN CN2005800181881A patent/CN1964633B/zh not_active Expired - Lifetime
- 2005-06-07 DK DK05747802T patent/DK1758463T3/da active
- 2005-06-07 PT PT05747802T patent/PT1758463E/pt unknown
- 2005-06-07 RU RU2006146983/13A patent/RU2341972C2/ru active
- 2005-06-07 WO PCT/EP2005/006110 patent/WO2005120246A1/de not_active Ceased
- 2005-06-07 JP JP2007526278A patent/JP5227021B2/ja not_active Expired - Fee Related
- 2005-06-07 NZ NZ551661A patent/NZ551661A/xx not_active IP Right Cessation
- 2005-06-07 AU AU2005251451A patent/AU2005251451B2/en not_active Expired
- 2005-06-07 RS RSP-2008/0122A patent/RS50556B/sr unknown
- 2005-06-07 US US11/596,771 patent/US20070231370A1/en not_active Abandoned
- 2005-06-07 KR KR1020077000485A patent/KR101230977B1/ko not_active Expired - Fee Related
- 2005-06-07 DE DE502005002355T patent/DE502005002355D1/de not_active Expired - Lifetime
- 2005-06-07 SI SI200530170T patent/SI1758463T1/sl unknown
- 2005-06-07 MX MXPA06014279A patent/MXPA06014279A/es active IP Right Grant
- 2005-06-07 BR BRPI0511842-5A patent/BRPI0511842B1/pt active IP Right Grant
- 2005-06-07 AT AT05747802T patent/ATE381892T1/de active
- 2005-06-07 CA CA2569269A patent/CA2569269C/en not_active Expired - Lifetime
- 2005-06-07 EP EP05747802A patent/EP1758463B1/de not_active Expired - Lifetime
- 2005-06-07 PL PL05747802T patent/PL1758463T3/pl unknown
-
2006
- 2006-11-27 ZA ZA200609861A patent/ZA200609861B/en unknown
- 2006-12-29 NO NO20066085A patent/NO335082B1/no unknown
-
2008
- 2008-03-17 CY CY20081100294T patent/CY1107249T1/el unknown
-
2011
- 2011-06-21 US US13/164,973 patent/US8501810B2/en not_active Expired - Fee Related
-
2013
- 2013-01-10 US US13/738,452 patent/US20130296431A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3089771A (en) * | 1960-02-16 | 1963-05-14 | Armoar And Company | Method of feeding chicks |
| DD206735A1 (de) * | 1981-07-15 | 1984-02-08 | Helmut Just | Verfahren zur anwendung ergotroper wirkstoff-kombinationen in der gefluegelmast |
Non-Patent Citations (1)
| Title |
|---|
| К.KESHAVARZ et al. Relationship of Arginine and Metionine to Creatine Formation in Chicks, The Journal of Nutrition, 1971 101, p.855-862. * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12252460B2 (en) | 2019-07-12 | 2025-03-18 | Alzchem Trostberg Gmbh | Process for the preparation of a metastable crystal modification of n-(aminoiminomethyl)-2-aminoacetic acid (III) |
| US12351543B2 (en) | 2019-07-12 | 2025-07-08 | Alzchem Trostberg Gmbh | Process for the preparation of a metastable crystal modification of N-(aminoiminomethyl)-2-aminoethanoic acid (IV) |
| RU2849774C2 (ru) * | 2020-06-25 | 2025-10-29 | Альцхем Тростберг Гмбх | Метастабильная кристаллическая модификация и способ ее получения |
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