RU2322434C2 - Способ получения no-донорных соединений, таких как no-донорный диклофенак - Google Patents

Способ получения no-донорных соединений, таких как no-донорный диклофенак Download PDF

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RU2322434C2
RU2322434C2 RU2005107785/04A RU2005107785A RU2322434C2 RU 2322434 C2 RU2322434 C2 RU 2322434C2 RU 2005107785/04 A RU2005107785/04 A RU 2005107785/04A RU 2005107785 A RU2005107785 A RU 2005107785A RU 2322434 C2 RU2322434 C2 RU 2322434C2
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RU
Russia
Prior art keywords
compound
formula
acetate
phenyl
solvent
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RU2005107785/04A
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English (en)
Russian (ru)
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RU2005107785A (ru
Inventor
Джохан АНДЕРССОН (SE)
Джохан АНДЕРССОН
Алдо БЕЛЛИ (IT)
Алдо БЕЛЛИ
Винченцо КАННАТА (IT)
Винченцо Канната
Мартин ХЕДБЕРГ (SE)
Мартин ХЕДБЕРГ
Андреас ПАЛМГРЕН (SE)
Андреас ПАЛМГРЕН
Зигрид ШУЛДЕЙ (SE)
Зигрид ШУЛДЕЙ
Марика ШТРЁМ (SE)
Марика ШТРЁМ
Марко ВИЛЛА (IT)
Марко Вилла
Original Assignee
Никокс С.А.
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Publication date
Priority claimed from SE0202801A external-priority patent/SE0202801D0/xx
Priority claimed from SE0301476A external-priority patent/SE0301476D0/xx
Application filed by Никокс С.А. filed Critical Никокс С.А.
Publication of RU2005107785A publication Critical patent/RU2005107785A/ru
Application granted granted Critical
Publication of RU2322434C2 publication Critical patent/RU2322434C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/54—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to two or three six-membered aromatic rings
    • C07C211/55—Diphenylamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2005107785/04A 2002-09-20 2003-09-18 Способ получения no-донорных соединений, таких как no-донорный диклофенак RU2322434C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE0202801A SE0202801D0 (sv) 2002-09-20 2002-09-20 New crystal form
SE0202801-7 2002-09-20
SE0301476A SE0301476D0 (sv) 2003-05-20 2003-05-20 Manufacturing process for no-donating compounds
SE0301476-8 2003-05-20

Publications (2)

Publication Number Publication Date
RU2005107785A RU2005107785A (ru) 2005-12-10
RU2322434C2 true RU2322434C2 (ru) 2008-04-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2005107785/04A RU2322434C2 (ru) 2002-09-20 2003-09-18 Способ получения no-донорных соединений, таких как no-донорный диклофенак

Country Status (13)

Country Link
US (2) US20060122402A1 (https=)
EP (1) EP1558559A1 (https=)
JP (1) JP2006500409A (https=)
KR (1) KR20050057496A (https=)
CN (1) CN1684940A (https=)
AU (1) AU2003265035A1 (https=)
BR (1) BR0314365A (https=)
CA (1) CA2498943A1 (https=)
MX (1) MXPA05003050A (https=)
NZ (1) NZ538727A (https=)
PL (1) PL375321A1 (https=)
RU (1) RU2322434C2 (https=)
WO (1) WO2004026808A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1319202B1 (it) 2000-10-12 2003-09-26 Nicox Sa Farmaci per le malattie a base infiammatoria.
CA2491127A1 (en) 2002-07-03 2004-01-15 Nitromed, Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
US7632866B2 (en) 2002-10-21 2009-12-15 Ramot At Tel Aviv University Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators
SE0301880D0 (sv) * 2003-06-25 2003-06-25 Astrazeneca Uk Ltd New drug delivery composition
WO2009037705A2 (en) * 2007-09-20 2009-03-26 Ramot At Tel Aviv University Ltd. Esters of n-phenylanthranilic acid for use in the treatment of cancer and inflammation
US8765815B2 (en) 2007-09-20 2014-07-01 Ramot At Tel-Aviv University Ltd. N-phenyl anthranilic acid derivatives and uses thereof
CN116789631B (zh) * 2023-07-06 2024-05-31 陕西理工大学 一种酶协同光控一氧化氮供体、其制备及应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995009831A1 (en) * 1993-10-06 1995-04-13 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
ES2073995A1 (es) * 1993-05-17 1995-08-16 Espanola Explosivos Procedimiento para la obtencion de nitratoalquil oxetanos.
WO1995030641A1 (en) * 1994-05-10 1995-11-16 Nicox S.A. Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities
RU2165921C2 (ru) * 1995-10-31 2001-04-27 Никокс С.А. Нитросоединения и фармацевтическая композиция, обладающие противовоспалительной и антитромботической активностями

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1546478A (fr) * 1967-01-27 1968-11-22 Rhone Poulenc Sa Nouveaux dérivés de l'acide benzoyl-3 phénylacétique et leur préparation
DE3811118C1 (https=) * 1988-03-31 1989-10-12 Merckle Gmbh, 7902 Blaubeuren, De
EP1126838A4 (en) * 1998-10-30 2005-02-16 Nitromed Inc NITROSIS AND NITROSYAL NON-STEROID ANTI-INFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE
US6355666B1 (en) * 2000-06-23 2002-03-12 Medinox, Inc. Protected forms of pharmacologically active agents and uses therefor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2073995A1 (es) * 1993-05-17 1995-08-16 Espanola Explosivos Procedimiento para la obtencion de nitratoalquil oxetanos.
WO1995009831A1 (en) * 1993-10-06 1995-04-13 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
WO1995030641A1 (en) * 1994-05-10 1995-11-16 Nicox S.A. Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities
RU2165921C2 (ru) * 1995-10-31 2001-04-27 Никокс С.А. Нитросоединения и фармацевтическая композиция, обладающие противовоспалительной и антитромботической активностями

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Gianfranco Cainelli et al. Tetrahedron, vol.41, no.7, 1985, p. 1385-1392. Gianfranco Cainelli et al. Tetrahedron Letters, vol.26, no.28, 1985, p. 3369-3372. Gianfranco Cainelli et al. J.CHEM.SOC.PERKIN TRANS, vol.1, 1987, p. 2637-2642. Kiyoshi Kawamura et al. CHEM.PHARM.BULL., vol.38, no.8, 1990, p. 2092-2096. Jih Ru Hwu et al. Synthesis, no.5, 1994, p. 471-474. *

Also Published As

Publication number Publication date
NZ538727A (en) 2008-01-31
RU2005107785A (ru) 2005-12-10
CA2498943A1 (en) 2004-04-01
MXPA05003050A (es) 2005-05-27
AU2003265035A1 (en) 2004-04-08
CN1684940A (zh) 2005-10-19
BR0314365A (pt) 2005-07-19
WO2004026808A1 (en) 2004-04-01
US20090170934A1 (en) 2009-07-02
PL375321A1 (en) 2005-11-28
EP1558559A1 (en) 2005-08-03
JP2006500409A (ja) 2006-01-05
US20060122402A1 (en) 2006-06-08
KR20050057496A (ko) 2005-06-16

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Effective date: 20100919