RU2280074C2 - Способы стабильной трансдукции клеток вирусными векторами - Google Patents

Способы стабильной трансдукции клеток вирусными векторами Download PDF

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RU2280074C2
RU2280074C2 RU2003108736/13A RU2003108736A RU2280074C2 RU 2280074 C2 RU2280074 C2 RU 2280074C2 RU 2003108736/13 A RU2003108736/13 A RU 2003108736/13A RU 2003108736 A RU2003108736 A RU 2003108736A RU 2280074 C2 RU2280074 C2 RU 2280074C2
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cell
cells
molecule
cell surface
transduction
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RU2003108736A (ru
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Лоран ЮМО (US)
Лоран ЮМО
Вей ХАН (US)
Вей Хан
Ксиаобин ЛУ (US)
Ксиаобин ЛУ
Владимир СЛЕПУШКИН (US)
Владимир СЛЕПУШКИН
Мишелль ЛЕШЕР (US)
Мишелль ЛЕШЕР
Брайан ДЭВИС (US)
Брайан ДЭВИС
Юнг-Ниен ЧАНГ (US)
Юнг-Ниен ЧАНГ
Боро ДРОПУЛИК (US)
Боро ДРОПУЛИК
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Вирэкссис Корпорейшн
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2003108736/13A 2000-08-31 2001-08-29 Способы стабильной трансдукции клеток вирусными векторами RU2280074C2 (ru)

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US09/653,088 2000-08-31
US09/653,088 US6627442B1 (en) 2000-08-31 2000-08-31 Methods for stable transduction of cells with hiv-derived viral vectors

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RU2003108736A RU2003108736A (ru) 2005-02-10
RU2280074C2 true RU2280074C2 (ru) 2006-07-20

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US (2) US6627442B1 (https=)
EP (2) EP1315823A2 (https=)
JP (1) JP2004528806A (https=)
KR (1) KR20030074592A (https=)
CN (1) CN100443593C (https=)
AU (2) AU2001286947B2 (https=)
BR (1) BR0113619A (https=)
CA (1) CA2421063C (https=)
CZ (1) CZ2003569A3 (https=)
IL (1) IL154599A0 (https=)
MX (1) MXPA03001758A (https=)
NO (1) NO20030901L (https=)
NZ (1) NZ524642A (https=)
RU (1) RU2280074C2 (https=)
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RU2478711C1 (ru) * 2011-12-19 2013-04-10 Открытое акционерное общество "Институт стволовых клеток человека" Способ повышения эффективности вирусной трансдукции
RU2625033C2 (ru) * 2011-12-22 2017-07-11 Ф. Хоффманн-Ля Рош Аг Система индикации на основе полноразмерного антитела для эукариотических клеток и ее применение
RU2744603C2 (ru) * 2016-02-12 2021-03-11 Блубёрд Био, Инк. Композиции, повышающие число копий вектора (чкв), и способы их применения
US11286501B2 (en) 2016-04-20 2022-03-29 Centro De Investigaciones Energeticas, Medioambientales Y Tecnologicas O.A, M.P. Methods of treating or preventing pyruvate kinase deficiency
US11326183B2 (en) 2016-02-12 2022-05-10 Bluebird Bio, Inc. VCN enhancer compositions and methods of using the same
RU2777934C2 (ru) * 2017-10-16 2022-08-12 Сентро Де Инвестигасьонес Энерхетикас, Медиоамбьенталес И Текнолохикас, О.А., М.П. Лентивирусные векторы для доставки pklr для лечения дефицита пируваткиназы
US11642422B2 (en) 2017-10-16 2023-05-09 Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, O.A, M.P. Lentiviral vectors for delivery of PKLR to treat pyruvate kinase deficiency
US11883506B2 (en) 2020-08-07 2024-01-30 Spacecraft Seven, Llc Plakophilin-2 (PKP2) gene therapy using AAV vector
US12378576B2 (en) 2018-04-27 2025-08-05 Spacecraft Seven, Llc Gene therapy for CNS degeneration
US12539316B2 (en) 2018-04-11 2026-02-03 Spacecraft Seven, Llc Compositions and methods for stem cell transplant

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