RU2270691C2 - Композиции и способы достижения иммунной супрессии - Google Patents
Композиции и способы достижения иммунной супрессии Download PDFInfo
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| RU2701301C2 (ru) * | 2014-03-03 | 2019-09-25 | Ситюн Фарма | Способ очистки конъюгатов на основе il-15/il-15r-альфа |
| RU2847345C1 (ru) * | 2020-01-24 | 2025-10-03 | Эйприлбио Ко., Лтд. | Мультиспецифичные антитела, содержащие их композиции, векторы и способы их применения |
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| US7235358B2 (en) | 2001-06-08 | 2007-06-26 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
| US6905827B2 (en) | 2001-06-08 | 2005-06-14 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases |
| US7026121B1 (en) | 2001-06-08 | 2006-04-11 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
| WO2004035787A2 (de) * | 2002-10-14 | 2004-04-29 | F. Hoffmann-La Roche Ag | Transplantierbare zelle mit immunmodulator |
| US7892745B2 (en) | 2003-04-24 | 2011-02-22 | Xdx, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
| KR20050082389A (ko) * | 2004-02-18 | 2005-08-23 | 메덱스젠 주식회사 | 직렬 연쇄체를 갖는 면역접합체를 포함하는 장기이식합병증 치료용 약제학적 조성물 |
| EP1756155A2 (en) * | 2004-04-14 | 2007-02-28 | F.Hoffmann-La Roche Ag | PURIFIED INTERLEUKIN-15/Fc FUSION PROTEIN AND PREPARATION THEREOF |
| US7645575B2 (en) * | 2004-09-08 | 2010-01-12 | Xdx, Inc. | Genes useful for diagnosing and monitoring inflammation related disorders |
| JP2008539765A (ja) * | 2005-05-13 | 2008-11-20 | ユニバーシティー オブ マイアミ | 移植片拒絶反応および自己免疫疾患における、同種異系抗原または自己抗原に対する細胞応答の分子精査 |
| PL1901773T3 (pl) * | 2005-06-09 | 2012-09-28 | Hansa Medical Ab | Zastosowanie proteinazy IDES (Z S. Pyogenes) do leczenia chorób autoimmunologicznych oraz odrzutów przeszczepu |
| JP5709356B2 (ja) | 2006-01-13 | 2015-04-30 | アメリカ合衆国 | 哺乳動物細胞における発現のためのコドン最適化ＩＬ−１５およびＩＬ−１５Ｒ−α遺伝子 |
| WO2008021431A2 (en) | 2006-08-14 | 2008-02-21 | Xdx, Inc. | Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders |
| EP2102367A2 (en) | 2006-11-09 | 2009-09-23 | XDX, Inc. | Methods for diagnosing and monitoring the status of systemic lupus erythematosus |
| CA2690825C (en) * | 2007-05-11 | 2019-02-12 | Altor Bioscience Corporation | Fusion molecules and il-15 variants |
| NZ714757A (en) | 2009-08-14 | 2018-07-27 | Us Gov Health & Human Services | Use of il-15 to increase thymic output and to treat lymphopenia |
| CN105017429B (zh) | 2010-09-21 | 2021-04-06 | 阿尔托生物科学有限公司 | 多聚体il-15可溶性融合分子与其制造与使用方法 |
| US11053299B2 (en) | 2010-09-21 | 2021-07-06 | Immunity Bio, Inc. | Superkine |
| SI2665486T1 (sl) | 2011-01-18 | 2020-07-31 | Bioniz, Llc | Sestavki za moduliranje aktivnosti gama-C-citokina |
| WO2015089217A2 (en) | 2013-12-10 | 2015-06-18 | Bionz, Llc | Methods of developing selective peptide antagonists |
| EP3160498B1 (en) | 2014-06-30 | 2021-10-06 | Altor BioScience Corporation | Il-15-based molecules and methods of use thereof |
| MA41459A (fr) | 2015-02-03 | 2017-12-12 | Als Therapy Development Inst | Anticorps anti-cd40l et méthodes pour traiter des maladies ou des troubles liés aux cd40l |
| WO2017062685A1 (en) | 2015-10-09 | 2017-04-13 | Bioniz, Llc | Modulating gamma - c -cytokine activity |
| WO2018075989A1 (en) | 2016-10-21 | 2018-04-26 | Altor Bioscience Corporation | Multimeric il-15-based molecules |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| CN110753555A (zh) | 2017-04-19 | 2020-02-04 | 得克萨斯州大学系统董事会 | 表达工程化抗原受体的免疫细胞 |
| EP3630843A2 (en) | 2017-05-24 | 2020-04-08 | ALS Therapy Development Institute | Therapeutic anti-cd40 ligand antibodies |
| CN107474143B (zh) * | 2017-09-13 | 2020-08-11 | 深圳市因诺赛生物科技有限公司 | (Anti-CD40 mAb)-CTLA4融合蛋白及其用途 |
| EP3755349A4 (en) | 2018-02-21 | 2021-11-17 | Board of Regents, The University of Texas System | PROCESS FOR ACTIVATION AND EXPANSION OF NATURAL KILLER CELLS AND THEIR USES |
| WO2020227019A1 (en) | 2019-05-03 | 2020-11-12 | Bioniz, Llc | Modulating the effects of gamma-c-cytokine signaling for the treatment of alopecia and alopecia associated disorders |
| WO2021050789A1 (en) | 2019-09-10 | 2021-03-18 | Obsidian Therapeutics, Inc. | Ca2-il15 fusion proteins for tunable regulation |
| EP4619421A2 (en) * | 2023-05-01 | 2025-09-24 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | Mutant interleukin 15 expressing immune cells |
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| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
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| GB9207732D0 (en) | 1992-04-06 | 1992-05-27 | Isis Innovation | Wound repair |
| KR0170037B1 (ko) | 1992-08-20 | 1999-02-01 | 에릭 에스. 딕커 | 인터루킨-4 및/또는 인터루킨-10을 함유하는 약제학적 조성물 |
| WO1994004570A1 (en) | 1992-08-21 | 1994-03-03 | Schering Corporation | Cd40 ligand, anti cd40 antibodies, and soluble cd40 |
| JPH08510719A (ja) | 1993-02-01 | 1996-11-12 | ユニヴェルシテ リブル ドゥ ブリュッセル アンスティテュション ダンセニュマン ユニヴェルシテル | 有効量のインターロイキン−１０、その類似体および／または作動薬を含有する医薬組成物の使用 |
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| US5574138A (en) | 1993-03-08 | 1996-11-12 | Immunex Corporation | Epithelium-derived T-cell factor |
| EP0721346B1 (en) | 1993-09-02 | 1998-06-10 | Trustees of Dartmouth College | Methods for inducing antigen-specific t cell tolerance |
| CN1137726C (zh) | 1993-09-02 | 2004-02-11 | 达特茅斯学院理事 | 延长体液免疫抑制的方法 |
| CA2186747C (en) | 1994-04-06 | 2009-01-27 | Kenneth H. Grabstein | Interleukin-15 |
| US5683693A (en) | 1994-04-25 | 1997-11-04 | Trustees Of Dartmouth College | Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40 |
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| US6340459B1 (en) | 1995-12-01 | 2002-01-22 | The Trustees Of Columbia University In The City Of New York | Therapeutic applications for the anti-T-BAM (CD40-L) monoclonal antibody 5C8 in the treatment of reperfusion injury in non-transplant recipients |
| US6132978A (en) | 1995-12-19 | 2000-10-17 | National Jewish Medical And Research Center | Method to regulate CD40 signaling |
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2001
- 2001-05-14 JP JP2001583797A patent/JP2003533488A/ja active Pending
- 2001-05-14 WO PCT/US2001/015578 patent/WO2001087330A2/en not_active Ceased
- 2001-05-14 CA CA002408691A patent/CA2408691A1/en not_active Abandoned
- 2001-05-14 EP EP01935495A patent/EP1284747A2/en not_active Withdrawn
- 2001-05-14 AU AU6158501A patent/AU6158501A/xx active Pending
- 2001-05-14 AU AU2001261585A patent/AU2001261585B2/en not_active Ceased
- 2001-05-14 RU RU2002133447/15A patent/RU2270691C2/ru not_active IP Right Cessation
- 2001-05-14 BR BR0110779-8A patent/BR0110779A/pt not_active IP Right Cessation
- 2001-05-14 CN CN01812646A patent/CN1441675A/zh active Pending
- 2001-05-14 US US09/855,313 patent/US6797263B2/en not_active Expired - Fee Related
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2004
- 2004-05-25 US US10/853,466 patent/US7347995B2/en not_active Expired - Fee Related
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| DE19823351A1 (de) * | 1997-05-16 | 1998-12-10 | Krause Hans | Mittel zur Verhinderung der Zellapoptose bei Krankheiten |
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| C. Agostmi et al. CD8 T-Cell infiltration in extravascular tissues.... Blood. V.93, n.4, p.1277-1286. * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2701301C2 (ru) * | 2014-03-03 | 2019-09-25 | Ситюн Фарма | Способ очистки конъюгатов на основе il-15/il-15r-альфа |
| RU2847345C1 (ru) * | 2020-01-24 | 2025-10-03 | Эйприлбио Ко., Лтд. | Мультиспецифичные антитела, содержащие их композиции, векторы и способы их применения |
Also Published As
| Publication number | Publication date |
|---|---|
| US6797263B2 (en) | 2004-09-28 |
| CA2408691A1 (en) | 2001-11-22 |
| US20020128436A1 (en) | 2002-09-12 |
| JP2003533488A (ja) | 2003-11-11 |
| EP1284747A2 (en) | 2003-02-26 |
| WO2001087330A2 (en) | 2001-11-22 |
| AU6158501A (en) | 2001-11-26 |
| AU2001261585C1 (en) | 2001-11-26 |
| WO2001087330A3 (en) | 2002-05-30 |
| AU2001261585B2 (en) | 2006-08-31 |
| BR0110779A (pt) | 2005-01-11 |
| CN1441675A (zh) | 2003-09-10 |
| US20040219148A1 (en) | 2004-11-04 |
| US7347995B2 (en) | 2008-03-25 |
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