RU2262922C2 - Способ прессования для получения лекарственной формы фенитоина натрия - Google Patents

Способ прессования для получения лекарственной формы фенитоина натрия Download PDF

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Publication number
RU2262922C2
RU2262922C2 RU2003133299/15A RU2003133299A RU2262922C2 RU 2262922 C2 RU2262922 C2 RU 2262922C2 RU 2003133299/15 A RU2003133299/15 A RU 2003133299/15A RU 2003133299 A RU2003133299 A RU 2003133299A RU 2262922 C2 RU2262922 C2 RU 2262922C2
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RU
Russia
Prior art keywords
mixture
phenytoin
excipient
rolls
specified
Prior art date
Application number
RU2003133299/15A
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English (en)
Russian (ru)
Other versions
RU2003133299A (ru
Inventor
Джордж Харланд КРОТТС III (US)
Джордж Харланд КРОТТС III
Мебрахту Гебретенсае ФЕССЕХАЙЕ (US)
Мебрахту Гебретенсае ФЕССЕХАЙЕ
Сринивас Раджу ГАДИРАДЖУ (US)
Сринивас Раджу ГАДИРАДЖУ
Джон Джозеф ГОЭЛ (US)
Джон Джозеф ГОЭЛ
Исаак ГЕБРЕ-СЕЛЛАССИЕ (US)
Исаак ГЕБРЕ-СЕЛЛАССИЕ
Ашлеш Калианбхай ШЕТ (US)
Ашлеш Калианбхай ШЕТ
Original Assignee
Уорнер-Ламберт Компани Ллс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Уорнер-Ламберт Компани Ллс filed Critical Уорнер-Ламберт Компани Ллс
Publication of RU2003133299A publication Critical patent/RU2003133299A/ru
Application granted granted Critical
Publication of RU2262922C2 publication Critical patent/RU2262922C2/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
RU2003133299/15A 2001-05-15 2002-04-25 Способ прессования для получения лекарственной формы фенитоина натрия RU2262922C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29097001P 2001-05-15 2001-05-15
US60/290,970 2001-05-15

Publications (2)

Publication Number Publication Date
RU2003133299A RU2003133299A (ru) 2005-04-10
RU2262922C2 true RU2262922C2 (ru) 2005-10-27

Family

ID=23118256

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2003133299/15A RU2262922C2 (ru) 2001-05-15 2002-04-25 Способ прессования для получения лекарственной формы фенитоина натрия

Country Status (16)

Country Link
US (1) US20030083360A1 (zh)
EP (1) EP1392246A1 (zh)
JP (1) JP2004531548A (zh)
KR (1) KR20030096392A (zh)
CN (1) CN1527700A (zh)
AR (1) AR034332A1 (zh)
BR (1) BR0209644A (zh)
CA (1) CA2446957A1 (zh)
CZ (1) CZ20033116A3 (zh)
HU (1) HUP0304078A2 (zh)
IL (1) IL158518A0 (zh)
MX (1) MXPA03009805A (zh)
PL (1) PL366728A1 (zh)
RU (1) RU2262922C2 (zh)
WO (1) WO2002092056A1 (zh)
ZA (1) ZA200308353B (zh)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060222713A1 (en) * 2002-12-16 2006-10-05 Deepak Murpani Extended release pharmaceutical composition of phenytoin sodium
WO2004075826A2 (en) * 2003-02-28 2004-09-10 Ranbaxy Laboratories Limited Extended release, multiple unit dosage forms of phenytoin sodium and processes for their preparation
US20060034910A1 (en) * 2004-08-09 2006-02-16 Sanjay Patel Pharmaceutical composition for extended release of phenytoin sodium
EP3095447B1 (en) 2006-02-03 2021-11-24 OPKO Renal, LLC Treating vitamin d insufficiency and deficiency with 25-hydroxyvitamin d2 and 25-hydroxyvitamin d3
PT2037936E (pt) 2006-06-21 2014-09-04 Opko Renal Llc Método de tratamento e prevenção do hiperparatiroidismo secundário
FI20080348A0 (fi) * 2008-02-15 2008-05-09 Atacama Labs Oy Uudenlainen farmaseuttinen formulaatio
US11752158B2 (en) 2007-04-25 2023-09-12 Eirgen Pharma Ltd. Method of treating vitamin D insufficiency and deficiency
CN104523707B (zh) 2007-04-25 2022-08-26 欧普科Ip 控股Ii 有限公司 包含维生素d化合物和蜡质载体的口服控释组合物
ES2686081T3 (es) * 2007-07-31 2018-10-16 Cargill, Incorporated Dextrosa comprimible directamente
CN102125522B (zh) * 2010-01-15 2013-01-16 复旦大学附属华山医院 P-糖蛋白单克隆抗体修饰的苯妥英靶向纳米制剂及其制备方法
WO2011123476A1 (en) 2010-03-29 2011-10-06 Cytochroma Inc. Methods and compositions for reducing parathyroid levels
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형
CR20170085A (es) 2014-08-07 2017-04-25 Opko Ireland Global Holdings Ltd Terapia adjuntiva con 25-hidroxi vitamina d
KR20180123100A (ko) 2016-03-28 2018-11-14 옵코 아일랜드 글로벌 홀딩스 리미티드 비타민 d 치료 방법
IL267114B1 (en) * 2016-12-06 2024-04-01 Topical Innovations B V Topical phenytoin for the treatment of peripheral neuropathic pain
EP3551182A1 (en) 2016-12-06 2019-10-16 Topical Innovations B.V. Topical pharmaceutical composition containing phenytoin and a (co -)an algesic for the treatment of chronic pain

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274168B1 (en) * 1999-02-23 2001-08-14 Mylan Pharmaceuticals Inc. Phenytoin sodium pharmaceutical compositions

Also Published As

Publication number Publication date
BR0209644A (pt) 2004-07-06
HUP0304078A2 (hu) 2004-04-28
CN1527700A (zh) 2004-09-08
US20030083360A1 (en) 2003-05-01
CZ20033116A3 (cs) 2004-09-15
WO2002092056A1 (en) 2002-11-21
PL366728A1 (en) 2005-02-07
AR034332A1 (es) 2004-02-18
IL158518A0 (en) 2004-05-12
EP1392246A1 (en) 2004-03-03
KR20030096392A (ko) 2003-12-24
CA2446957A1 (en) 2002-11-21
ZA200308353B (en) 2004-07-08
WO2002092056A8 (en) 2003-10-23
JP2004531548A (ja) 2004-10-14
MXPA03009805A (es) 2005-03-07
RU2003133299A (ru) 2005-04-10

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20070426