RU2228185C1 - Method for treating cows in case of afterbirth retention - Google Patents

Abstract

FIELD: medicine, veterinary science. SUBSTANCE: one should at first carry out intrauterine injection of anode fraction of electrochemically activated water (anolyte) with redox potential (RP) being + 850Е+ 950 mV and pH 3.5 - 4.0, then - cathode fraction (catholyte) with RP being - 450 - 550 mV and pH 9.5 - 10.5 introduced at the quantity of 250-300 ml each. Moreover, catholyte should be injected 30 min after anolyte's injection , not earlier and repeatedly according to the same scheme in 10-12 h. As for anolyte's RP, in case of repeated injection it corresponds to 1000 - 1100 mV and pH 2.4 - 3.0. The present innovation enables to shorten the period of uterine involution, prevent the development of endometritis and increase cattle population. EFFECT: higher efficiency of therapy.

Description

The invention relates to veterinary medicine, and in particular to methods of treating retention of the placenta, and can be used in industrial animal husbandry to increase the number of livestock of farm animals.

An acute problem in animal husbandry is the prolonged sterility of cows as a result of animal diseases after calving. Cow infertility is associated with various diseases. One of them is endometritis.

After calving, when there are residual placental tissues in the uterine cavity, which is an excellent nutrient medium for microorganisms, the pathogenic microflora rapidly multiplies with the development of endometritis. Under such conditions, sperm cannot survive, and in the case of fertilization, the egg cannot remain in the uterine cavity and a miscarriage occurs during pregnancy.

A complex effect on the microflora of the uterine cavity is known, which includes etiotropic therapy. At the same time, solutions of antiseptic and cauterizing substances (potassium permanganate, carbolic and boric acid, mercuric chloride, formalin, etc.) are used to prevent postpartum endometritis. Solutions are used by douching, injection into the uterine cavity and constant irrigation for several days. The use of such funds is very irrational. These substances have a strong irritating and cauterizing effect and they are used, as a rule, not for the prevention of endometritis, but for treatment. These funds, in addition, have a toxic effect on the animal's body, violate the protective mechanism of the mucous membranes of the genital organs. Their use, in addition, lowers the muscle tone of the uterus [1].

A known method of antibacterial prevention of postpartum endometritis, which consists in the fact that on the first day after calving, that is, before the formation of the mucous plug in the cervical canal, a broad-spectrum antimicrobial drug is introduced into the uterine cavity. However, prolonged use of medications, especially antibiotics, leads to the emergence of highly resistant strains of microorganisms that are insensitive to antibiotics and other therapeutic drugs. Practical experience shows that microorganisms are sensitive to chlortetracycline only in 12%, penicillin in 20%, tetracycline in 27%, erythromycin in 43% of cases. This entails an increase in terms of infertility, increases culling of the uterine population [1].

In addition, the antibiotics used to treat animal diseases after 1 to 2 hours go into milk, which becomes unsuitable in human writing.

A known method of treating cows with retention of the placenta, including local effects on endometritis by introducing into the uterine cavity a mixture of a 0.08-0.12% electrolysis solution of sodium hypochlorite and 4-6% hydrogen peroxide solution 6-12 hours after calving during 1-2 days [2].

The disadvantage of this method is that both components of the mixture are antiseptic, which ensures the neutralization of both pathogenic and normal microflora, which can lead to dysbiosis - a complication of treatment.

The technical result of the claimed invention is to increase the effectiveness of the treatment method, reduce the period of uterine involution, prevent the development of endometritis and increase herd reproduction.

This is achieved by the fact that after the establishment of the detention of the calving cow, the drug is administered intrauterine after 6-8 hours after calving, the first is the anode fraction (anolyte) of electrochemically activated water with redox potential (ORP) +850. . + 950 mV and pH 3.5-4.0, then the cathode fraction (catholyte) with an ORP of -450 ...- 550 mV and a pH of 9.5-10.5, which are introduced in an amount of 250-300 ml at a temperature 37 ° C. The introduction of catholyte is carried out no earlier than 30 minutes after the introduction of the anolyte (time the bactericidal action of the anolyte). To increase the effectiveness of treatment, the procedure is repeated after 10-12 hours, while the anolyte AFP is 1000 ... 1100 mV and a pH of 2.4-3.0, and the catholyte AFP has the same characteristics.

Anolyte and catholyte are obtained by electrolysis of an aqueous salt solution in a diaphragm electrolyzer. In this case, the electroactivation of molecules, atoms, ions and the redistribution of ions in an electric field occur. As a result, an aqueous solution located in the anode zone (anolyte) acquires oxidizing properties and antifungal, antibacterial and antiviral activity due to the content of chemical compounds that produce chlorine, oxygen and ozone. Simultaneously with the anolyte, a biostimulant (catholyte) is obtained in the cathode chamber, the properties of which are determined by the reducing ability. Catholyte accelerates all natural biological processes.

The treatment method is as follows. After establishing a retention of the placenta in the calving cow in order to remove it from the uterine cavity and prevent the development of postpartum endometritis, the tail root and external genital organs were sanitized with anolyte with an ORP of 900 mV and pH 3.8, which was obtained in a diaphragm electrolyzer from tap water with the addition of 8-9 g / l NaCl (sodium chloride) in the anode zone.

After sanitization, the anolyte, heated to 37 ° C, was administered intrauterine in an amount of 300 ml using a Janet syringe. Then, after 1 hour, the catholyte heated to 37 ° С was introduced intrauterine with an ORP of -500 mV and a pH of 10.0 in the same amount.

The introduction of the drug was accompanied by a reduction in the smooth muscles of the uterus, which was determined by rectal examination of the uterus. Systematically controlled the body temperature of the animal, pulse, respiration, the nature of uterine secretions, the general behavior of the animal.

After 10 hours, the procedure was repeated. Moreover, the anolyte ORP was 1000-1100 mV and a pH of 2.4-3.0.

Various indicators of the redox potential of the anolyte are due to its milder effect on the uterine tissue upon first administration, eliminating burning, constriction and other painful sensations.

A bacteriological study of exudate after the proposed treatment showed the absence of pathogenic microflora. Changes in the condition of the animal were not observed.

A positive effect on the contractility of the uterus, its postpartum involution as a whole, which was noted on the 15th day of calving, was noted.

The effectiveness of the treatment of the proposed method was studied in comparison with animals that were injected with the hormonal drug estradiol dipropionate. The separation of the placenta in the control group was 50%, in the experimental group - 100% 2 hours after the first injection of catholyte.

Repeated administration of anolyte and catholyte after 10 hours prevented the animals from endometritis and carried out fruitful insemination on the 28th day after calving.

The high efficiency of treating cows with delayed afterbirth is due to the strong antibacterial, fungicidal, antiviral, anti-inflammatory effects of anolyte and high regenerating, immunostimulating and enhancing capillary circulation and trophic tissue catholyte.

Moreover, the anolyte has a selective antibacterial effect against pathogenic and conditionally pathogenic bacterial flora, without destroying gram-positive bacilli, which are normal microflora of a healthy body (lactobacillus, bifidobacteria). Due to this property of the anolyte, the formation of lactic acid and the breakdown of glycogen are ensured, which ultimately leads to the normalization of metabolic processes in tissues and the rapid relief of inflammatory processes.

Sources of information

1. Kononov G.A. Veterinary Reference. - L .: Kolos, 1978, p. 140-177.

2. RF patent No. 2010573, MKI A 61 K 33/14, publ. 04/15/94.

Claims (1)

A method of treating cows while retaining a placenta by intrauterine administration of a drug 6-8 hours after calving, characterized in that the anode fraction of electrochemically activated water (anolyte) with oxidation-reduction potential (OPV) of +850 is used first as a drug. +950 mV and pH 3.5 - 4.0, then the cathode fraction (catholyte) with OPV - 450 ...- 550 mV and pH 9.5 - 10.5, which are administered in an amount of 250-300 ml each, the introduction of catholyte is carried out not earlier than 30 minutes after the introduction of the anolyte and again according to the same scheme of 10-12 hours and OPV anolyte upon repeated administration is 1000 - 1100 mV and a pH of 2.4 - 3.0.