RU2224531C2 - Agent for treatment of chronic pyelonephritis - Google Patents

Abstract

FIELD: medicine, nephrology, phytotherapy. SUBSTANCE: invention relates to the development of medicinal agents as herb species that can be used for treatment of chronic pyelonephritis. Invention proposes the agent representing species of medicinal plants comprising Orthosiphon stamineus herb, common bear berry herb, glabrous licorice roots, pot-marigold flowers, matricary flowers and comprising additionally violet pensy (tricolor) herb, cowberry leaves, maize stigmas, common sandy immortelle flowers, sweet flag rhizome with roots, juniper fruits, flax seeds, common fennel fruits, common wormwood herb, common mother-of-thyme herb, gum-tree leaves, black elder flowers, knot-grass herb, linden flowers taken in the definite ratio. Intake of this agent provides the stable remission of patient state and the absence of adverse effects or toxic effect. EFFECT: valuable medicinal properties of agent. 2 tbl, 4 ex

Description

 The invention relates to medicine, in particular to herbal medicine, and can be used to treat chronic pyelonephritis.

 For the treatment of chronic pyelonephritis, antibacterial agents are used, including antibiotics, sulfonamides, derivatives of nitrofuran, oxalic acid, etc.

 It is known that antibiotics - chloramphenicol, terrimycin, rondomycin, erythromycin and lincomycin - have a bacteriostatic effect, but can interact with penicillins, cephalosporins, aminoglycosides. With a decrease in the functional ability of the kidneys, aminoglycosides have a nephrotoxic effect. Antibiotics of the tetracycline series with a long shelf life also have a nephrotoxic effect (Nephrology. Edited by M. Tareeva - M., 1995 - vol. II, - pp. 137-138). It is known that when using antibacterial drugs it is far from always possible to achieve a cure for a patient with pyelonephritis (Diagnosis and treatment of kidney diseases. Mukhin N.A., Tareeva I.E. - M .: Medicine, 1985, - p.200-204) .

 Treatment with sulfonamide drugs may be accompanied by impaired renal function (Mashkovsky M. D. Medicines. - M.: Medicine. - 1993. - Part II. - p. 321).

 Nitrofurans - furadonin, furagin, furazolidone - exhibit antagonism of action in relation to preparations of B vitamins, and naphthyridine derivatives - nalidoxic acid, negrams, nevigramone, as well as drugs - gramurin, 5-NOC, nitroxoline - always give non-chronic pyelonephritis persistent clinical effect, but can cause allergic reactions (Mashkovsky M.D. Medicines. - M.: Medicine. - 1983, part II, - p. 351).

 For the treatment of chronic pyelonephritis, phyto-collection is used, including birch leaves 10.0, bearberry leaves 10.0, horsetail field grass 10.0, dandelion root 10.0, lingonberry leaf 20.0, flax seed 20.0. The collection is prescribed in 3/4 cup 30 minutes before meals 4 times a day.

 However, this collection does not have a sufficiently strong antimicrobial effect and it is recommended to combine it with the use of antibacterial drugs (Goncharova T.A. Encyclopedia of medicinal plants. - M. - 1997, - T. II, -s.272).

 The prototype of the present invention is the collection of medicinal plants used to treat chronic pyelonephritis, which includes the following herbs: kidney tea herb 20.0, bearberry ordinary leaves 10.0, horsetail field grass 10.0, licorice bare root 15.0, calendula medicinal flowers 15.0, chamomile pharmacy flowers 15.0, plantain big leaves 15.0 (Sokolov S.Ya., Zamotaev I.P. Handbook of medicinal plants. - M., 1990, - p. 450). An infusion of individual medicinal plants or fees is prepared as follows. 10 g (1-2 tablespoons) of the raw material are placed in an enameled dish, 200.0 ml (1 cup) of hot boiled water is poured, kept (in a water bath), cooled for 15 minutes at room temperature for 45 minutes, and the remaining raw material is squeezed out. The volume of the resulting infusion is adjusted with boiled water to 200 ml.

 It is recommended to take 1 / 4-1 / 3 cups of infusion 3-4 times a day. However, this collection contains a relatively large amount of bearberry. This can contribute to exacerbation of inflammation in the urinary system and the development of renal symptoms as a result of irritation of the renal tubules. In addition, some patients experience nausea, vomiting, and diarrhea.

 With prolonged use, field horsetail can cause kidney irritation, manifested in increased urination and discomfort in the lower back.

 The task of the invention is to enhance the clinical action of the collection and obtain stable remission in the patient's condition in the absence of adverse reactions and toxic effects.

The problem is solved in that the product, which is a herbal collection, including kidney tea grass, bearberry grass, licorice root, calendula officinalis flowers, pharmacy chamomile flowers, additionally contains tricolor violet grass, lingonberry leaves, corn stigmas, immortelle flowers, rhizome with calamus roots, juniper fruits, flax seed, fennel fruits, wormwood grass, thyme grass, eucalyptus leaves, black elderberry flowers, linden flowers in the following mass ratio of components:
Kidney Herb Tea - 9-11
Bearberry ordinary grass - 2-4
Licorice bare root - 6-8
Calendula officinalis flowers - 7-9
Chamomile officinalis herb - 8-10
Violets tricolor grass - 9-11
Lingonberry leaves - 8-10
Corn stigmas - 5-7
Immortelle sandy flowers - 2-4
Rhizome with calamus roots - 3-5
Juniper fruit - 3-5
Flax Seed - 9-11
Fennel common fruit - 7-9
Wormwood grass - 2-4
Common thyme grass - 4-6
Eucalyptus leaves - 2-4
Elderberry black flowers - 7-9
Highlander bird grass - 6-8
Linden flowers - 14-16
Lingonberry leaves have a disinfectant, diuretic, choleretic, antiseptic, bactericidal and anti-inflammatory effect.

 The positive effect is due to the ability of lingonberry leaves to reduce the permeability and fragility of the vessels of the kidneys.

 Corn stigmas have a pronounced diuretic property, normalize the blood coagulation process, and contribute to the release of sand and stones from the kidneys and bladder.

 Immortelle sand flowers enhance the secretory function of the kidneys, have a pronounced antispasmodic effect, improving metabolic function of the kidneys. In addition, immortelle sandy flowers have anti-inflammatory, antibacterial effects.

 Rhizome with calamus roots has bacteriostatic, antifungicidal and anti-inflammatory properties, has some antispasmodic effect, improves digestion in the stomach, tone the bladder, and enhances urinary function of the kidneys.

 Juniper fruits have a diuretic effect, enhance bile formation and biliary excretion, improve the secretion of gastric juice, and increase intestinal motility. In addition, they have a pronounced antibacterial and anti-inflammatory effect, help to reduce urinary stagnation in the urinary tract and bladder.

 The seed of flax ordinary is rich in mucus, has an enveloping effect. Mucus has a protective and calming effect, a positive effect is exhibited by the liquid oil contained in the seeds, in which fat-soluble vitamins are found in small quantities. Flax seeds help improve kidney function.

 Fennel vulgaris fruits exhibit antimicrobial and antispasmodic effects, therefore, it is used for chronic kidney diseases. Fennel enhances diuresis, restoration of kidney function.

 Wormwood herb has an anti-inflammatory effect, helps to stabilize immune responses, stimulates the function of the reticuloendothelial system. It stimulates the urinary function of the kidneys, the function of the gall bladder, pancreas, reduces dyspeptic symptoms, and normalizes stool.

 Thyme ordinary grass has a bactericidal effect on the pathogenic renal flora and bacteriostatic effect on gram-negative microorganisms, inhibits the growth of pathogenic fungi, and is effective in inflammatory processes caused by pathogenic flora resistant to antibiotics.

 Eucalyptus leaves have pronounced antibacterial properties, leaves are able to suppress the development of coccal flora, have a positive effect on viral infections, a destructive effect on fungi, reduce spasm of the sphincter of the bladder, and increase fluid excretion through the intestines.

 Elderberry black flowers have an anti-inflammatory effect, enhance diuresis, reduce the specific gravity of urine, while increasing perspiration. They can cause a mild laxative effect, stimulate pancreatic function, improve liver function, reduce sensitization effects and reduce vascular wall permeability.

 The grass of the mountaineer increases the daily diuresis, as it has a diuretic effect. It contains vitamins C, B and K and a sufficient amount of mineral elements, including manganese, copper, molybdenum and bromine. It has a hemostatic effect. Effective in many chronic diseases of the kidneys and urinary tract, urolithiasis.

 Bearberry ordinary grass causes a diuretic, anti-inflammatory and antibacterial effect. In addition, the grass has an antispasmodic effect, positively affects the vessels of the microvasculature, enhances the regeneration of renal tissue. Most effective for diseases of the bladder, urinary tract, urethra and urolithiasis.

 Licorice naked root has a pronounced anti-inflammatory effect, stimulates the adrenal cortex, has a corticosteroid-like effect, improves urine flow, restores impaired renal function.

 Calendula flowers have an anti-inflammatory effect, enhance secretory activity, increase the diuretic effect, activate regeneration processes due to the high content of calendula, flavanides, ascorbic acid and organic acids in calendula flowers. Flowers cause an increase in the metabolic function of the kidneys, normalize the composition of urine.

 Chamomile herb has a pronounced anti-inflammatory effect, enhances intestinal motility, in addition, it has antibacterial and anti-allergic effects, enhances the regeneration processes in the kidneys.

 Violets tricolor grass has an anti-inflammatory effect, helps to densify cell membranes, reduce vascular permeability. Effective for long-term inflammatory processes in the kidneys and urinary tract, as well as in urolithiasis and uric acid diathesis.

 Kidney tea can cause a diuretic effect, accompanied by increased excretion of uric acid and chlorides from the body, which further leads to an improvement in the general condition and the disappearance of a number of painful symptoms.

 Linden flowers have an antimicrobial, anti-inflammatory and anti-edematous effect, and with increased excitability, they have a calming effect. Flowers increase diuresis, increase bile formation and facilitate the flow of bile into the duodenum, stimulate the secretion of gastric juice, and increase exocrine pancreatic function.

 These herbs when used together in the proposed doses give a well-defined clinical effect in the treatment of patients with chronic pyelonephritis.

 The proposed tool is prepared for use in the following mass ratio of components: kidney tea herb 9-11, bearberry ordinary grass 2-4, licorice root 6-8, calendula officinalis flowers 7-9, chamomile medicinal flowers 8-10, violets tricolor grass 9 -11, lingonberry leaves 8-10, corn stigmas 5-7, sandwort immortelle flowers 2-4, rhizome with calamus roots 3-5, juniper fruits 3-5, flax seed 9-11, common fennel 7-9, wormwood grass 2-4, thyme ordinary grass 4-6, eucalyptus leaves 2-4, black elderberry flowers 7-9. Highlander bird grass 6-8, linden flowers 14-16.

 The mixture is ground to a powdery consistency, then 2/3 of a teaspoon is brewed in 300 ml of boiling water, infused for 15 minutes. Take 100 ml 3 times a day after meals with normal and high acidity, and with reduced according to the same scheme before meals. The course of treatment lasts 2 months, then a break of 1 month. Depending on the patient’s condition, two to four courses of treatment are recommended.

Examples
Example 1 (prototype).

 The history of the disease 2484. Patient N., 42 years old.

Diagnosis: chronic pyelonephritis in the acute phase, impaired mineral metabolism. CRF ₀ .

 Complains of dull pain in the lumbar region, dysuria, chills, low-grade fever. Sick for about 5 years. It was treated on an outpatient basis without a significant effect. Recently, after hypothermia, dysuric phenomena, pain in the lumbar region, and subfebrile temperature have intensified.

Objectively: the condition is satisfactory, the skin is pale, the pulse is 86 beats / min, rhythmic, blood pressure 140/90, heart sounds are muffled, vesicular breathing, the stomach is soft, the liver, spleen, kidneys are not palpated, a positive symptom of lumbar effusion on both sides. In blood tests: HB 120 g / l. Er 3.8 • 10 ¹² / l, white blood cells 9.0 • 10 ⁹ / l, platelets 200.0 • 10 ⁹ / l, ESR 35 mm / h. Urinalysis: urine is cloudy, acidic, specific gravity 1005, protein 0.099 g / l, oxalates, white blood cells 25-30 in n / a, red blood cells 14-8 in n / a, cylinders 1-2 in n / a, in 1 ml of urine 100,000 bacteria. Total protein 70 g / l, albumin 49%, globulins 51%, cholesterol 5.0 mmol / l, creatinine 78.4 mmol / l, urea 3.4 mmol / l, K 4.0 g / l, Na 125 mmol / l, Ca 2.20 mmol / l, glomerular filtration 70.0 ml / min, reabsorption 50.0%. With intravenous urography, deformation and expansion of the abdominal system of both kidneys. Ultrasound of the kidneys - expansion and deformation, compaction and ectasia of the pyelocaliceal structures.

лейкоциты 8 в п/зр, эритроциты 7-9 в п/зр, количество бактерий в 1 мл мочи 100000, общий белок 70,0 г/л, альбумины 49%, глобулины 51%, холестерин 5,3 ммоль/л, креатинин 77,0 ммоль/л, мочевина 3,4 ммоль/л, К 3,9 г/л, Na 124,0 ммоль/л, Са 2,15 ммоль/л, клубочковая фильтрация 71,0 мл/мин, реабсорбция 56,0%.The patient was treated: ampicillin 0.25 4 times a day for 10 days, then gentamicin 0.08 3 times a day for 10 days, methyluracil 0.5 3 3 times a day. In the analyzes: HB 118.0 g / l, erythrocytes 3.8 • 10 ¹² / l, white blood cells 7.9 • 10 ⁹ / l, platelets 203.0 • 10 ⁹ / l, ESR 15 mm / hour. Urinalysis: urine is clear, acidic, specific gravity 1005, protein 0.033

leukocytes 8 in n / a, red blood cells 7-9 in n / a, number of bacteria in 1 ml of urine 100,000, total protein 70.0 g / l, albumin 49%, globulins 51%, cholesterol 5.3 mmol / l, creatinine 77.0 mmol / L, urea 3.4 mmol / L, K 3.9 g / L, Na 124.0 mmol / L, Ca 2.15 mmol / L, glomerular filtration 71.0 ml / min, reabsorption 56 , 0%.

 Subsequently, a medicinal collection was prescribed, which included the following components: kidney tea herb 20.0 (20 g), bearberry ordinary leaves 10.0 (10 g), horsetail field grass 10.0 (10 g), licorice root 15.0 ( 15 g), calendula officinalis flowers 15.0 (15.0 g), chamomile pharmacy flowers 15.0 (15 g), plantain large leaves 15.0 (15 g). This collection was used in the form of an infusion or a decoction of 1/2 cup (100 ml) 30 minutes before meals 3 times a day. The collection was taken within 6 months.

 After the therapy, the condition improved, dysuric phenomena, chills disappeared, the temperature returned to normal, and aching pains in the lumbar region remained. Objectively: satisfactory condition, pulse 78 beats / min, rhythmic, blood pressure 130/75, heart sounds muffled, vesicular breathing. The abdomen is soft, the liver, spleen, kidneys are not palpable, the symptom of thrumming along the lumbar region is weakly positive on both sides.

цилиндры 1-2 в п/зр, лейкоциты 7-10 в п/зр, количество бактерий в 1 мл мочи менее 100000, общий белок 72,0 г/л, альбумины 50%, глобулины 50%, холестерин 5,1 ммоль/л, креатинин 76,0 ммоль/л, мочевина 3,4 ммоль/л, К 3,1 г/л, Nа 120,0 ммоль/л, Са 2,8 ммоль/л, клубочковая фильтрация 72,0 мл/мин, реабсорбция 58,0%. Ремиссия в течение 6 месяцев.In blood tests: HB 125 g / l, red blood cells 3.9 • 10 ¹² / l, white blood cells 8.0 • 10 ⁹ / l, platelets 210.0 • 10 ⁹ / l, ESR 27 mm / hour. Urinalysis: urine is clear, acidic, specific gravity 1010, protein 0.066

cylinders 1-2 in s / sp, white blood cells 7-10 in s / sp, the number of bacteria in 1 ml of urine is less than 100,000, total protein 72.0 g / l, albumin 50%, globulins 50%, cholesterol 5.1 mmol / l, creatinine 76.0 mmol / l, urea 3.4 mmol / l, K 3.1 g / l, Na 120.0 mmol / l, Ca 2.8 mmol / l, glomerular filtration 72.0 ml / min reabsorption of 58.0%. Remission for 6 months.

 Example 2

 The history of the disease 19179. Patient B., 23 years old.

Diagnosis: chronic pyelonephritis in the acute phase. Bilateral nephroptosis. CRF ₀ .

 Complains of weakness, headache, aching pain in the lumbar region, dysuric phenomena, subfebrile temperature.

 Sick for about a year, when there were pain in the lumbar region, weakness, dysuric phenomena after hypothermia. I did not seek medical help. This exacerbation occurred about 10 days, when after physical exertion, pain in the lumbar region, dysuric phenomena, and low-grade fever intensified.

 Objectively: the condition is satisfactory, the skin is pale, pulse 88 beats / min, rhythmic, blood pressure 145/90. Heart sounds are muffled. Vesicular breathing. The abdomen is soft, liver, spleen, pancreas are not palpable. Palpated left and right kidneys. The symptom of lumbar effusion is positive on both sides.

лейкоциты 30-40 в п/зр, эритроциты 15-20 в п/зр. При посеве мочи выявлен рост кишечной палочки 1000000 в 1 мл мочи.In blood tests: HB 115 g / l, red blood cells 3.7 • 10 ¹² / l, white blood cells 10.5 • 10 ⁹ / l, platelets 190.0 • 10 ⁹ / l, ESR 35 mm / hour. Urinalysis: urine is cloudy, acidic, specific gravity 1006, protein 0.066

white blood cells 30-40 in s / sp, red blood cells 15-20 in s / sp. When urine was sown, an increase in E. coli of 1,000,000 in 1 ml of urine was detected.

 Total protein 72 g / l, albumin 45%, globulins 55%, cholesterol 5.4 mmol / l, creatinine 85.0 mmol / l, urea 3.9 mmol / l, K 1.7 g / l, Na 150, 0 nmol / L, Ca 3.1 mmol / L, sugar 5.4 mmol / L, glomerular filtration 65.0 ml / min, reabsorption 54.0%.

 With intravenous urography, bilateral nephroptosis, expansion and deformation of the abdominal system of both kidneys are determined. Ultrasound of the kidneys - compaction and ectasia of the pyelocaliceal structures.

Treatment: ampicillin 0.25 4 times a day for 10 days, then gentamicin 0.08 3 times a day for 10 days, methyluracil 0.5 3 3 times a day. In blood tests: HB 120.0 g / l, erythrocytes 3.9 • 10 ¹² / l, white blood cells 7.8 • 10 ⁹ / l, platelets 204.0 • 10 ⁹ / l, ESR 17.0 mm / hour. Urinalysis: urine is clear, acidic, specific gravity 1006, protein 0.033%, white blood cells 4-6 in n / a, red blood cells 3-5 in n / a, 100,000 bacteria in 1 ml of urine.

 Total protein 73 g / l, albumin 49%, globulins 51.0%, cholesterol 5.4 mmol / l, creatinine 80.0 mmol / l, urea 3.4 mmol / l, glomerular filtration 68.0 ml / min, reabsorption of 58.0%.

 Later, after the end of antibiotic therapy, a drug collection was prescribed, including kidney tea herb 9.0 (45 g), bearberry ordinary herb 2.0 (10 g), licorice root 6.0 (30 g), calendula officinalis flowers 7.0 (35 g), chamomile officinalis flowers 2.0 (10 g), violets of three-colored grass 9.0 (45 g), lingonberries leaves 8.0 (40 g), stigmas of corn 5.0 (25 g), immortelle sandy flowers 2.0 (10 g), rhizome with calamus roots 3.0 (15 g), juniper fruit 3.0 (15 g), flax seed 9.0 (45 g), common fennel fruit 7.0 (35 g) , wormwood herb 2.0 (10 g), thyme ordinary herbs 4,0 (20 g), 2,0 eucalyptus leaves (10 g), linden flowers 14.0 (60 g), 2,0 Knotweed grass (10 g), flowers, elderberry 7.0 (35 g). The collection was used as an infusion of 100 ml 3 times a day after meals. The collection was taken for 6 months (3 courses of 2 months with monthly intervals). After this therapy, the patient's condition improved, weakness, headache, pain in the lumbar region, dysuric phenomena, low-grade fever disappeared.

 Objectively: satisfactory condition, pulse 76 beats / min, rhythmic, blood pressure 130/80. The tones are muffled, vesicular breathing. The abdomen is soft, painless on palpation. Palpated left and right kidneys. The symptom of lumbar effusion is negative on both sides.

лейкоциты 4-5 в п/зр, эритроциты 2-5 в п/зр, бактерий менее 100000 в 1 мл мочи, рост кишечной палочки в моче не определяется.Blood test: HB 130 g / l, red blood cells 4.0 • 10 ¹² / l, white blood cells 7.3 • 10 ⁹ / l, platelets 200.0 • 10 ⁹ / l, ESR 17 mm / hour. Urinalysis: clear urine, specific gravity 1012, protein 0.033

leukocytes 4-5 in n / a, red blood cells 2-5 in n / a, bacteria less than 100,000 in 1 ml of urine, the growth of E. coli in urine is not determined.

 Total protein 74.0 g / l, albumin 52%, globulins 48%, cholesterol 5.4 mmol / l, creatinine 65.0 mmol / l, urea 3.0 mmol / l, K 1.6 g / l, Na 120.0 mmol / L, Ca 3.0 mmol / L, sugar 5.4 mmol / L, glomerular filtration 78.0 ml / min, reabsorption 90.0%.

 Remission for 12 months.

 Example 3

 Case history 305. Patient F., 54 years old.

Diagnosis: chronic pyelonephritis in the acute phase, right-sided nephroptosis. CRF ₀ .

 Complains of aching pain in the lumbar region, pain during urination, weakness, low-grade fever.

 Sick for about 7 years. Repeatedly treated in therapeutic hospitals. This exacerbation occurred about a week when, after hypothermia, pain in the lumbar region intensified, the temperature rose, dysuric phenomena appeared.

 Objectively: a state of moderate severity, the skin is pale. Pulse 92 beats / min, rhythmic. HELL 140/95, muffled heart sounds, systolic murmur at the apex, vesicular breathing. The abdomen is soft, the liver, spleen are not palpable. The lowered painful right kidney is palpated. The symptom of striking on the right lumbar region is positive, swelling on the face.

In blood tests: HB 110 g / l, erythrocytes 3.65 • 10 ¹² / l, white blood cells 10.5 • 10 ⁹ / l, platelets 200.0 • 10 ⁹ / l, ESR 45 mm / hour. Urinalysis: urine is cloudy, acidic, specific gravity 1005, protein 0.099%, white blood cells 50-60 in n / a, red blood cells 10-15 in n / a, 1,000,000 bacteria in 1 ml of urine.

 Total protein 68.0 g / l, albumin 48%, globulins 52%, cholesterol 5.1 mmol / l, creatinine 89.0 mmol / l, urea 4.0 mmol / l, K 1.6 g / l, Na 160.0 mmol / L, Ca 3.2 mol / L, glomerular filtration 60.0 ml / min, 50.0% reabsorption.

 With intravenous urography - omission, deformation and expansion of the abdominal system of the right kidney.

 Ultrasound of the kidneys - compaction and ectasia of the pyelocaliceal structures of the right kidney.

Treatment: ampicillin 0.25 4 times a day for 10 days, then gentamicin 0.08 3 times a day for 10 days, methyluracil 0.5 3 3 times a day. In blood tests: HB 122 g / l, red blood cells 3 • 10 ¹² / l, white blood cells 7.8 • 10 ⁹ / l, platelets 206.0 • 10 ⁹ / l, ESR 16 mm / hour. Urinalysis: urine is clear, acidic, specific gravity 1007, protein not detected, white blood cells 4-5 in n / a, red blood cells 3-6 in n / a, 100,000 bacteria in 1 ml of urine.

 Total protein 72.0 g / l, albumin 49.0%, globulins 51.0%, cholesterol 5.2 mmol / l, urea 3.5 mmol / l, creatinine 83.0 mmol / l, glomerular filtration 64 ml / min, reabsorption of 58.0%.

 In the future, after antibiotic therapy, the patient was prescribed a drug collection, including kidney tea herb 10.0 (50 g), bearberry ordinary herb 3.0 (15 g), licorice root 7.0 (35 g), calendula officinalis flowers 10.0 (50 g), chamomile medicinal flowers 9.0 (45 g), violet tricolor grass 10.0 (50 g), lingonberry leaves 9.0 (45 g), stigmas of corn 6.0 (30 g), immortelle sand flowers 3, 0 (15 g), rhizome with calamus roots 4.0 (20 g), juniper fruit 4.0 (20 g), flax seed 10.0 (50 g), common fennel fruit 8.0 (40 g), wormwood grass 3.0 (15 g), thyme ordinary grass 5.0 (25 g), eucalyptus leaves 3.0 (15 g), elderberry flowers 8.0 (40 g), mountaineer 7.0 (35 g), linden flowers 15.0 (75 g). The collection was used as an infusion of 1225 ml 3 times a day after meals. The collection was taken for 6 months (3 courses of 2 months with monthly intervals).

 After the treatment, the patient's condition improved, aching pain in the lumbar region, dysuric phenomena, weakness disappeared, the temperature returned to normal.

 Objectively: the patient's condition is satisfactory, the pulse is 76 beats / min, rhythmic, blood pressure 120/80, heart sounds are clean, there is no systolic murmur, vesicular breathing. The abdomen is soft, painless on palpation. Liver, spleen not palpable. The painless lowered right kidney is palpated, the symptom of thrumming along the lumbar region is negative, there is no swelling on the face.

Blood test: HB 135 g / l, red blood cells 4.1 • 10 ¹² / l, white blood cells 6.0 • 10 ⁹ / l, platelets 210.0 • 10 ⁹ / l, ESR 12 mm / hour. Urinalysis: urine is clear, acidic, specific gravity 1010, protein not detected, leukocytes 1-3 in s / sp, red blood cells 1-3 in s / sp, less than 100,000 bacteria in 1 ml of urine.

 Total protein 78.0 g / l, albumin 51.0%, globulins 49%, cholesterol 5.3 mmol / l, urea 3.2 mmol / l, creatinine 80.0 mmol / l, K 1.2 g / l Na 110.0 mmol / L, CA 3.1 mmol / L, sugar 5.3 mmol / L, glomerular filtration 90.0 ml / min, reabsorption 105.0%.

 Remission lasts for 12 months.

 Example 4

 Case history 742. Patient K., 44 years old.

Diagnosis: chronic pyelonephritis in the acute phase. Multiple cysts of both kidneys. CRF ₀ .

 Complains of fever, aching pain in the lumbar region, pain during urination, weakness.

 Sick for about 4 years, when when conducting ultrasound examination of the kidneys, the presence of multiple cysts of both kidneys was established. Further notes the periodic appearance of edema on the face, legs, pulling pains in the lumbar region. The real deterioration occurred about 5 days, when after hypothermia there was a high temperature, aching pain in the lumbar region, dysuric phenomena, weakness.

 Objectively: the condition is satisfactory, the skin is pale, puffiness under the eyes. Pulse 90 beats / min, rhythmic. HELL 150/90, muffled heart sounds, vesicular breathing. The abdomen is soft, painful on palpation in the left and right iliac regions. The liver, spleen, kidneys are not palpable. The symptom of lumbar effusion is positive on both sides.

лейкоциты 50-60 в п/зр, эритроциты 15-20 в п/зр, 500000 бактерий в 1 мл мочи, при посеве определяется рост E. coli.Blood test: HB 115.0 g / l, red blood cells 3.5 • 10 ¹² / l, white blood cells 10.5 • 10 ⁹ / l, platelets 220.0 • 10 ⁹ / l, ESR 40 mm / hour. Urinalysis: urine is cloudy, acidic, specific gravity 1006, protein 0.066

leukocytes 50-60 in n / a, red blood cells 15-20 in n / a, 500,000 bacteria in 1 ml of urine, when sown, the growth of E. coli is determined.

 Protein 72 g / l, albumin 46%, globulins 54%, cholesterol 5.0 mmol / l, sugar 5.6 mmol / l, urea 4.1 mmol / l, creatinine 91.0 mmol / l, K 1.4 g / l, Na 140.0 mmol / l, Ca 3.4 mmol / l, glomerular filtration 62.0 ml / min, reabsorption 59.0%. With intravenous urography, multiple cysts of both kidneys, deformation and expansion of their abdominal systems are determined. Ultrasound of the kidneys - multiple cystic formations, expansion of the abdominal systems of both kidneys.

 Treatment: ampicillin 0.25 4 times a day for 10 days, then gentamicin 0.08 3 times a day for 10 days, methyluracil 0.5 3 3 times a day.

In blood tests: HB 118.0 g / l, red blood cells 3 • 10 ¹² / l, white blood cells 7.9 • 10 ⁹ / l, platelets 206.0 • 10 ⁹ / l, ESR 15.0 mm / hour. Urinalysis: urine is clear, acidic, specific gravity 1008, protein - traces, white blood cells 5-6 in n / a, red blood cells 3-4 in n / a, 10,000 bacteria in 1 ml of urine.

 Total protein 72.0 g / l, albumin 48.0%, globulins 52.0%, cholesterol 5.0 mmol / l, urea 3.6 mmol / l, creatinine 78.0 mmol / l, glomerular filtration 61.0 ml / min, reabsorption of 60.0%.

 After antibiotic treatment was completed, the patient was prescribed a drug collection, including kidney tea herb 11.0 (55 g), bearberry ordinary herb 4.0 (20 g), licorice root 8.0 (40 g), calendula officinalis flowers 9.0 ( 45 g), chamomile officinalis flowers 10.0 (50 g), violet tricolor grass 11.0 (55 g), lingonberry leaves 10.0 (50 g), stigmas 7.0 (35 g), immortelle sand flowers 4 , 0 (20 g), rhizomes with calamus roots 5.0 (25 g), juniper fruits 5.0 (25 g), flax seed 11.0 (55 g), ordinary fennel fruits 9.0 (45 g), wormwood grass 4.0 (20 g), thyme ordinary grass 6.0 (30 g ), eucalyptus leaves 4.0 (20 g), black elderberry flowers 9.0 (45 g), highlander bird grass 8.0 (40 g), linden flowers 16.0 (80 g). The collection was used as an infusion of 125 ml (1/2 cup) after meals 3 times a day. The collection was taken for 6 months (3 courses of 2 months with monthly intervals).

 After the therapy, the condition improved, the temperature returned to normal, pain in the lumbar region, dysuric phenomena, weakness disappeared.

 Objectively: the patient's condition is satisfactory. There is no swelling on the face. Pulse 78 beats / min, rhythmic, blood pressure 125/80, heart sounds are clean, vesicular breathing. The abdomen is soft, painless on palpation. The liver, spleen, kidneys are not palpable. The symptom of lumbar effusion is negative on both sides.

Blood test: HB 128.0 g / l, red blood cells 4.1 • 10 ¹² / l, white blood cells 7.0 • 10 ⁹ / l, platelets 200.0 • 10 ⁹ / l, ESR 11 mm / hour. Urinalysis: urine is clear, acidic, specific gravity 1011, no protein, no sugar, leukocytes 1-2 in s / sp, red blood cells 2-4 in s / sp, less than 100,000 bacteria in 1 ml of urine.

 Total protein 82.0 g / l, albumin 52%, globulins 48%, cholesterol 5.1 mmol / l, sugar 5.2 mmol / l, urea 3.8 mmol / l, creatinine 80.0 mmol / l, Na 115.0 mmol / L, K 1.3 g / L, Ca 3.3 mmol / L, glomerular filtration 80.0 ml / min, 96% reabsorption.

 After completion of treatment, remission is observed for 10 months.

 Thus, the cited extracts from the medical records show that when taking the proposed collection, a positive effect was obtained in all patients.

 With the claimed method, the treatment of patients using the proposed collection is presented in table 1, after the end of treatment, the absence of clinical signs, the absence of signs of inflammation according to clinical tests of urine and blood, normalization of the functional state of the kidneys were established. The treatment data using the prototype are presented in table 2. The advantage of the proposed collection is the absence of side effects (allergic reactions, toxic effects on the kidney, urinary tract) in comparison with other drugs. The inflammatory process disappears in the parenchyma of the kidneys and urinary tract, normalization of the functional state of the kidneys, remission in the observed patients increased by 2-3 times (prototype method - remission of 6 months), and according to the claimed method - up to 12 months.

 The process of normalizing clinical blood and urine tests is shown in tables 1 and 2.

Claims (1)

An agent for treating chronic pyelonephritis, which is an herbal collection, including kidney tea grass, bearberry grass, licorice root, calendula officinalis flowers, pharmacy chamomile flowers, characterized in that it additionally contains tricolor violet grass, lingonberry leaves, corn stigmas, immortelle flowers , rhizome with calamus roots, juniper fruits, flax seed, common fennel fruits, wormwood grass, common thyme grass, eucalyptus leaves, black elderberry flowers, bird of highlander, flower and linden in the following mass ratio of components: Kidney Tea, Herb 9-11 Bearberry ordinary, grass 2-4 Licorice naked, root 6-8 Calendula officinalis, flowers 7-9 Chamomile, flowers 8-10 Violet tricolor, grass 9-11 Lingonberry, leaves 8-10 Corn stalks 5-7 Immortelle sandy, flowers 2-4 Air, rhizome with roots 3-5 Juniper, fruits 3-5 Flax Seed 9-11 Fennel, fruits 7-9 Wormwood, grass 2-4 Common thyme, grass 4-6 Eucalyptus leaves 2-4 Elderberry black, flowers 7-9 Highlander bird, grass 6-8 Linden flowers 14-16

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