RU2281781C1 - Agent for treatment of urolithiasis - Google Patents

Abstract

FIELD: medicine, pharmacy, phytotherapy.

SUBSTANCE: invention relates to an agent that can be used in treatment of urolithiasis. Agent represents the herbal species comprising the following components: common juniper fruits, common hop cones, cowberry leaves, horse-tail herb, medicinal sweet clove herb, shepherd's purse herb, cornflower flowers, flax seeds, parsley herb, madder roots, linden flowers, knot-grass herb, fenestrate Saint-Johns-wort herb, field rest-harrow roots, Java tea herb, medicinal garden angelica rhizomes and roots, medicinal anise fruits, birch buds, tricolor violet herb, fennel fruits, maize stigmas, sandy common immortelle flowers, sweet flag roots and rhizomes, licorice roots, medicinal dandelion roots, common berry herb and common wormwood herb taken in the definite ratio. Intake of the proposed agent results to elimination of concretions from kidneys, disappearance of inflammatory symptoms, normalization of functional state of kidneys and the stable remission in the patient state and the absence of adverse reactions and toxic effect. Invention can be used in treatment of urolithiasis.

EFFECT: improved and enhanced properties and effectiveness of agent.

2 tbl, 4 ex

Description

The invention relates to the field of pharmacy, in particular to herbal medicine, and can be used to treat urolithiasis.

Urolithiasis continues to occupy one of the first places among all urological diseases, accounting for an average of 34.25% in Russia (Dzernov N.K., Yanenko E.K. Surgical treatment of coral nephrothiasis. Urology, 2004, No. 1, p. 34- 38).

There is a method of treating urolithic nephrolithiasis according to a scheme that includes the use of drugs: blemoren under the control of urine pH, aloirinol, chimes, festal in usual doses and diuretic herbs that are used 10 days for a month (Dziurak BC, Savchuk V.I. Zastonuvannya citrate sum "Blomoren "in the complex lycovanny decahydrate nephrolithiasis. In the book: Urolithiasis. Under the editorship of prof. Pereverzev. Kharkov, 1999, p. 395-399).

But when using this method of treatment, the desired clinical effect is not always achieved and some patients sometimes experience allergic skin rashes, dyspepsia and nausea (Dziurak BC, Savchuk V.I. Sinking of citrate citric acid "Blemoren" in the complex liquefaction of decahydrate nephrolithiasis. In the book. : Urolithiasis. Edited by Prof. Pereverzev. Kharkov, 1999, pp. 395-399).

Over the years, prescriptions for medicinal preparations for the treatment of urolithiasis were created, for example, a collection consisting of ordinary bean pods 20.0, motherwort leaves 25.0, femur roots (saxifrage) 10.0, smooth hernia grass 10.0, shepherd’s grass bags 5.0. The mixture (2 tablespoons) is steamed in a glass of boiling water, insisted for 3-4 hours, drink 2 tables. tablespoons 3-4 times a day (Kruglyak L. Kidney stones. St. Petersburg, Peter, 2002, p. 94).

However, the collection is not always effective due to insufficient diuretic effect and, since the leaves of the motherwort have commutative properties, toxic effects are possible with prolonged use of this collection.

It is also known to use the collection, which includes the fruits of anise 50.0, the fruits of parsley 50.0, shepherd’s grass 15.0, the fruits of common juniper 15.0, the root of the prickly steel 15.0, the root of the lovage 15.0, dandelion root officinalis 15.0. It is recommended to take a decoction obtained from two tablespoons of the mixture and drink it in two glasses of water in two doses (Kruglyak L. Kidney stones. St. Petersburg, Peter, 2002, p. 95).

However, this collection can cause side effects in the form of increased choleresis, which subsequently leads to seizures of cholecystitis due to the relatively high content of anise fruits. In some patients, this collection can cause the movement of calculi, which leads to pain and sometimes emergency surgery.

Known collection, including dioica nettle 5.0, rhizomes of calamus marsh 5.0, peppermint leaf 5.0, field horsetail 15.0, elderberry flowers 15.0, linden blossoms 15.0, juniperus fruits 15, 0, rosehips 15.0. A decoction prepared at a rate of 1:20 is taken in 1 glass in the morning and in the evening (Tiktinsky O.A., Alexandrov V.P. Urolithiasis. St. Petersburg, Peter, 2000, p.221).

The use of this collection does not always lead to a clinical effect, since it does not have a significant effect on diuresis and does not always normalize the function of the urinary system.

The prototype of the present invention is a collection consisting of 14 types of medicinal plant material: spikelet lavender grass 10.0, black currant leaves 10.0, birch leaves 10.0, coniferous buds 10.0, juniper 10.0, hop cones 10 , 0, lingonberry leaves 20.0, plantain leaves 28.0, wild strawberry 60.0, horsetail 60.0, sweet clover 50.0, shepherd’s grass 15.0, blue cornflower 30.0 flax seed 40.0.

The available components are brewed in 10 g per 750 ml of boiling water, boiled for 5-6 minutes, insisted for 2 hours. For stone discharge, the dose of the mixture is recommended (Kruglyak L. Kidney stones. St. Petersburg, Peter, 2002, p. 94) to reduce to 5 g per 500 ml of boiling water (Tiktinsky O.A., Alexandrov V.P. Urolithiasis. C Petersburg. Peter, 2000, p. 223).

The collection of the prototype does not always give the desired clinical effect. When applying this collection, allergic reactions to spike-like lavender herbs are possible in the form of cough and runny nose. Due to the high content of large plantain leaves, patients with high acidity may experience dyspeptic symptoms in the form of heaviness in the epigastric region, nausea, and constipation. With prolonged use of the fruits of wild strawberries, some patients may develop increased sensitivity to them, accompanied by allergic rashes. The ivy budra can sometimes cause kidney irritation, expressed in increased urination and discomfort in the lower back and back. Since the medicinal raw materials, which are part of the collection, are not crushed, there is no complete extraction of the active substances, and thereby the clinical effect is weakened.

The objective of the invention is to enhance the clinical action of the collection and obtaining a therapeutic effect, which is expressed in the dissolution and removal of calculi and sand from the kidneys of the patient in the absence of adverse reactions and toxic effects.

The problem is solved in that the remedy, which is a herbal collection, includes the fruits of juniper ordinary, hop cones, lingonberry leaves, field horsetail grass, sweet clover grass, shepherd’s bag grass, blue cornflower flowers, flax seeds, additionally includes 19 medicinal plants: parsley grass, roots of madder dye, linden flowers, bird of the mountaineer, perforated St. John's wort grass, roots of the field gland, kidney tea grass, rhizomes and roots of angelica officinalis, anise l fruits drug, birch buds, tricolor violet grass, fennel fruits, corn stigmas, sand immortelle flowers, calamus roots and rhizomes, licorice root, medicinal dandelion roots, bearberry grass, wormwood grass in the following weight ratio of components:

Juniper fruit 3-5 Hop cones 9-11 Lingonberries, leaves 7-9 Horsetail field, grass 6-8 Melilotus officinalis, grass 8-10 Shepherd's bags, grass 7-9 Cornflower blue, flowers 4-6 Flax seed 10-12 Parsley, grass 9-11 Madder dyeing, roots 5-7 Limes, flowers 14-16 Highlander, grass 7-9 Hypericum perforatum, grass 8-10 Stalnik field, roots 7-9 Kidney tea, grass 10-12 Angelica officinalis, rhizomes and roots 7-9 Anise officinalis, fruits 11-13 Birch buds 5-7 Three-colored violets, grass 12-14 Fennel fruit 7-9 Corn silk 6-8 Immortelle sandy, flowers 4-6 Roots and rhizomes of calamus 3-6 Licorice root 6-8 Dandelion officinalis, roots 5-7 Bearberry ordinary, grass 3-5 Wormwood, grass 2-4

The fruits of juniper ordinary have anti-inflammatory and bactericidal effects. They provide filtration in the renal glomeruli and inhibit the reverse resorption of sodium and chlorine ions in the convoluted tubules of the kidneys, thereby improving their function, increasing diuresis and facilitating the discharge of small stones and sand along the ureters.

Cones of ordinary hop provide anti-inflammatory, anti-ulcer, hypersensitizing and analgesic effects. They regulate renal function, enhance urination, promote the passage of sand through the ureters and excretion of it from the bladder. Hop cones reduce spasms in the intestines, promote the release of bile from the gallbladder, and generally regulate mineral metabolism.

Lingonberry leaves have a bactericidal, antiseptic, anti-inflammatory, astringent, diuretic and choleretic action. They reduce the permeability and fragility of capillaries, improve blood supply to the gastric mucosa, thereby contributing to the epithelization of gastric and duodenal ulcers.

Horsetail grass causes a hemostatic and anti-inflammatory effect. It also has a pronounced diuretic effect, plays an important role in the processes of metabolism and functional activity of connective tissue, mucous membranes and walls of blood vessels. In the urine, silicon substances contained in the grass of horsetail form protective colloids that prevent the crystallization of some mineral components and thereby impede the formation of urinary stones and contribute to their dissolution.

The grass of Melilotus officinalis has a pronounced detoxifying property, increases the phagocytic activity of leukocytes, improves peripheral blood supply to liver tissues, exhibits antibacterial properties, improves liver function, and enhances choleresis.

The grass of the shepherd’s bag has a phytoncid and pronounced hemostatic effect. The shepherd's purse is highly effective in case of renal bleeding, therefore it plays an important role in stopping bleeding that occurs after stones and fine sand pass through the ureters, which in some cases leads to trauma.

Blue cornflower flowers have anti-inflammatory and disinfectant properties. They are effective for urolithiasis, as they enhance filtration and improve microcirculation in the renal glomeruli and tubules. They also contribute to the discharge of urine and have an antimicrobial effect in the kidneys, ureter and bladder.

Flax seeds have anti-inflammatory, enveloping and minor analgesic properties. When ingested per os, flax seeds cover a thin layer of the mucous membrane of the stomach and duodenum, protecting it from irritation. This action is especially effective for gastric ulcers, accompanied by hypersecretion. Under the influence of enveloping agents, the absorption of infectious toxins from the intestine, which can cause the phenomena of general intoxication of the body, also decreases.

Parsley grass has an antimicrobial property, improves choleresis and enhances filtration in the renal tubules, thereby contributing to the dissolution of stones. It also stimulates diuresis and normalizes the function of the bladder, helps to remove small stones and sand from the ureter.

The roots of madder madder contribute to the loosening of kidney stones, cause the process of grinding and removing stones and sand from the kidneys and urinary tract. In addition, moraine dye increases tone and enhances peristaltic contractions of the muscles of the renal pelvis and ureter, while at the same time reduces spasms, facilitating this passage of stones from the kidneys and urinary tract.

Linden flowers have an antimicrobial, anti-inflammatory and anti-edematous effect, have a calming effect. In addition, linden flowers contribute to an increase in bile formation and facilitate the flow of bile into the duodenum, stimulate the secretion of gastric juice, increase diuresis, and increase exocrine pancreatic function.

Highlander's grass is distinguished by its diverse clinical properties, including antimicrobial, anti-inflammatory and astringent. It also increases diuresis, removes excess sodium and chlorine ions in the urine, resulting in increased filtration of the renal glomeruli and decreased reverse resorption in the renal tubules. The grass of the mountaineer bird contains soluble compounds of silicic acid, which are removed in significant concentrations in the urine, thereby contributing to the dissolution of kidney stones and preventing the formation of new ones.

Hypericum perforatum has an antimicrobial, bactericidal, anti-inflammatory and astringent effect, improves bile secretion in the duodenum, restores normal peristalsis, enhances the digestive capacity of the gastrointestinal tract, relieves spasm of blood vessels, especially capillary, improves blood flow, improves blood flow whole blood supply to the stomach. The herb of St. John's wort perforated increases the regenerative properties of tissues, thereby contributing to scarring of ulcers of the stomach and duodenum.

The roots of the field stalnik cause diuretic and laxative effects and exhibit anti-inflammatory and laxative effects. In addition, the roots of the field stalnik reduce the permeability and fragility of capillaries, causing a diuretic effect, contribute to the dissolution of stones and the subsequent removal of small stones and sand from the kidneys. They reduce soreness when passing sand through the ureters and the bladder.

The grass of kidney tea has pronounced diuretic properties, helps to eliminate chlorides, urea and uric acid from the body, which causes the dissolution of stones, especially urates. The combination of a mild diuretic effect and some antispasmodic action helps to reduce pain during attacks of urolithiasis. Renal tea has a beneficial effect on patients with cholelithiasis and urolithiasis, as it improves appetite, reduces the amount of mucus and white blood cells in bile, and also normalizes the function of the kidneys and bladder.

Rhizomes and roots of angelica officinalis have anti-inflammatory, antispasmodic and diaphoretic effects. They also have a bactericidal and diuretic effect, enhance filtration in the kidneys and facilitate the passage of sand through the ureters.

The fruits of anise officinalis have anti-inflammatory, antispasmodic and some bactericidal effects. They reduce spasms of the smooth muscles of the intestines and ureters, have a diuretic and anti-inflammatory effect, help normalize the function of the kidneys and bladder and improve the excretion of small stones and sand from the kidneys and their passage through the ureter.

Birch buds have antiseptic, anti-inflammatory, disinfectant and diuretic effects. They also contribute to the dissolution of stones, mainly phosphate and carbonate origin. In addition, birch buds enhance diuresis and have a positive effect in removing small stones and sand through the ureters and removing them from the bladder.

The tricolor violet grass causes anti-inflammatory, antispasmodic, choleretic and diuretic effects, and also reduces vascular permeability and inhibits the development of traumatic edema, thereby enhancing urine output helps to remove sand from the kidneys and urinary tract.

Fennel fruits increase the secretion of digestive glands, have a choleretic, antispasmodic and diuretic effect, have some antibacterial effect, increase the secretion of pancreatic juice and bile secretion.

Corn stigmas can cause a pronounced choleretic effect by regulating the secretion of bile from the gallbladder and the outflow of pancreatic juice, thereby normalizing the evacuation of food from the stomach. They help to stop nausea and vomiting, and also accelerate blood coagulation and cause a hemostatic effect in peptic ulcer of the stomach and duodenum.

Sandy immortelle flowers have an anti-inflammatory, antibacterial, antispasmodic and choleretic effect. They stimulate the secretion of gastric juice and activate the secretory ability of the pancreas, have an antispasmodic effect on the blood vessels, helping to improve blood circulation of the stomach and duodenum.

Calamus roots and rhizomes are capable of exerting anti-inflammatory, bacteriostatic, fungistatic and some antispasmodic effects. They also have a weak analgesic effect and contribute to the cure of chronic gastritis, especially in cases with low acidity of gastric juice, and also accelerate the scarring of gastric and duodenal ulcers.

Licorice root has a pronounced anti-inflammatory property, and also stimulates the adrenal cortex, providing a corticosteroid-like effect, improves choleresis, reduces bile viscosity, thereby restoring impaired liver function.

The roots of dandelion drug normalize the secretory and motor function of the stomach and intestines, increasing bile secretion and secretion of the digestive glands. They have antispasmodic, diuretic and laxative effects, stimulate appetite, improve digestion and normalize the evacuation of food from the stomach.

European bearberry causes a diuretic and antibacterial effect, in addition, it has an antispasmodic and choleretic effect, positively affects the vessels of the microvasculature and enhances the regeneration of liver cells. Due to its disinfecting properties, it relieves inflammation in the biliary tract and partially the gallbladder.

Bitter wormwood grass has anti-inflammatory, bactericidal and fungicidal properties, and also helps to stabilize immune responses, enhances the proliferative phase in places of stomach ulcers or duodenal ulcers, thereby exerting an antiulcer effect. It relieves dyspeptic symptoms, improves digestion, and also has antiparasitic and anthelmintic effects.

The mixture is ground to a powdery consistency, then 2/3 of a teaspoon is brewed in 300 ml of boiling water, insisted for 15 minutes. Take 100 ml three times a day after meals with normal and high acidity, and with low - before meals for one to one and a half months.

Extracts from case histories are given as examples.

Example 1

And / b No. 1021. Patient I., 44 years old.

Diagnosis: urolithiasis

Complains of pain in the lumbar region radiating to the right thigh, dysuric phenomena in the form of painful urination, urine the color of "meat slops", a decrease in the amount of urine. Considers himself ill for about 5 years, when aching pain in the lumbar region, dysuric phenomena first appeared. I did not seek medical help. About a week ago, after physical exertion, pain in the lumbar region intensified, the amount of urine decreased, dysuric phenomena appeared. Hospitalized in a therapeutic hospital.

Objective: The state of moderate severity. The skin is clean. Pastosity of the face. Pulse 88 beats. in minutes, rhythmic. HELL 130/90. Heart sounds are muffled. Vesicular breathing. The tongue is coated with white plaque. The stomach is soft. Liver, spleen not palpable. A painful right kidney is palpated. A positive symptom of thrumming on the lumbar region on the right. No peripheral edema.

Wedge. blood test: Hb 120 g / l; Er. 3.8 × 10 ¹² / l, white blood cells 8.6 × 10 ⁹ / l; b.1, e.2, p.3, s. 66, l 22, m. 6; ESR 25 mm / hour.

Urinalysis - urine with a reddish tinge, turbid, acidic 200.0, beats. c. 1014, protein 0.66%, no sugar; er. 20-25 p.z .; white blood cells 10-15 in p.z .; bacteria 150,000 in 1 ml; cylinders are absent.

Urinalysis according to Nechiporenko: white blood cells 6000 in 1 nl; erythrocytes 9000 in 1 ml; cylinders 2.

Biochemical blood test: total protein 80 g / l; albumin 60%: globulins α ₁ 3%; α ₂ 8%; β12%; γ17%; creatinine 115 μmol / l; urea 8.3 μmol / L; uric acid 430 μmol / l; glomerular filtration 80 ml / min; tubular reabsorption 96%.

Ultrasound of the kidneys and urinary tract of the kidney: the abdominal system of normal size and shape, is not deformed. In the pelvis of the right kidney, 3 calculi are visualized in the form of a hyperechoic round formation with a diameter of 5 mm, the ureters and the bladder are not changed.

On the survey roentgenogram of 3 projections of the right kidney, shadows suspicious of calculi are determined.

In / in urography - the kidneys are usually located, not changed in size and shape. The abdominal renal system is not changed, 3 calculi are visualized in the pelvis of the right kidney in the form of an echogenic round formation with an acoustic shadow in diameter of 5 mm.

In the clinic, the patient underwent treatment: Avison 2 tons 3 times a day, nitroxoline 0.05 g 4 times a day, 2% solution of noshpa - 2.0.

Against the background of the therapy, pain in the lumbar region decreased, at the same time, dysuric phenomena increased, urine remained with a red tint. Urinalysis - urine with a reddish tinge, turbid, acidic, 200.0 beats. c. 1012, protein 0.066% no sugar; er. 30-35 p.p .; L10-12 in p.p .; bacteria 45000 in 1 ml. Urinalysis according to Nechiporenko: leukocytes 5000 in 1 ml; erythrocytes 7000 in 1 ml; no cylinders ..

Wedge. blood test: Hb 115 g / l; Er. 3.7 1012 / l, white blood cells 8.4 10 ⁹ / l; b.1, e.1, p.4, c.66, l.21, m.7; ESR 30 mm / hour.

Biochemical blood test: total protein 78 g / l; albumin 52%; globulins α ₁ 4%; α ₂ 9%; β12%; γ17%; creatinine 110 μmol / l; urea 8.2 mmol / l; uric acid 430 μmol / l; glomerular filtration 84 ml / min; tubular reabsorption 98%.

Ultrasound of the kidneys and urinary tract of the kidney: 3 calculi are visualized in the pelvis of the right kidney in the form of a hyperechoic round formation with a diameter of 5 mm.

Due to the lack of a positive result of treatment, the patient was prescribed a herbal collection, including: fruits of common juniper 3.0 (15 g), hop cones 9 (45 g), lingonberry leaves 7 (3 5 g), field horsetail grass 6 (30 g), sweet clover herb 8 (40 g), shepherd’s bag grass 7 (35 g), blue cornflower flowers 4 (20 g), flax seeds 10 (50 g), parsley grass 9 (45 g), madder roots dyeing 5 (25 g), linden flowers 14 (70 g), grass of the mountaineer bird 7 (35 g), grass of St. John's wort perforated 8 (40 g), roots of the field gland 7 (35 g), grass of kidney tea 10 (50 g), rhizomes and roots of angelica officinalis 7 (3-5 g), aniseed fruits 11 (55 g), birch buds 5 (25 g), tricolor violet grass 12 (60 g), fennel fruits 7 (35 g) , corn stigmas 6 (30 g), sandwort immortelle flowers 4 (20 g), calamus 3 roots and rhizomes (15 g), licorice root 6 (30 g), dandelion roots 5 (25 g), bearberry grass 3 ( 15 g), wormwood herb 2 (10 g).

The mixture was ground to a powdery consistency, then 2/3 of a teaspoon was brewed in 300 ml of boiling water, insisted for 15 minutes. The prepared mixture was defended, and the patient took 100 ml three times a day for two months.

After this therapy, the patient's condition improved. The pain in the lumbar region, dysuric phenomena disappeared, the color of urine returned to normal.

Objectively: The condition is satisfactory. The skin is clean. Pulse 78 beats. in minutes, rhythmic. HELL 130/80. Heart sounds are muffled. Vesicular breathing. The language is clear. The stomach is soft. Liver, spleen not palpable. The kidneys are not palpable. The symptom of lumbar effusion is negative on both sides. No swelling.

Wedge. blood test: Hb 125 g / l; Er. 4 × 10 ¹² / l, white blood cells 6.5 × 10 ⁹ / l; b. 1, p. 4, p. 65, l. 25, m. 5; ESR 10 mm / hour.

Urinalysis: color - yellow straw, transparent, beats. at. 1015, no protein, no sugar; Er. 0-1 p.p .; white blood cells 1-2 in p.z .; bacteria are not detected.

Urinalysis according to Nechiporenko: leukocytes 3000 in 1 nc; red blood cells 500 in 1 ml; no cylinders.

Biochemical blood test: total protein 78 g / l; albumin 60%: globulins α ₁ 2%; α ₂ 8%; β13%; γ17% ;; creatinine 70 μmol / l; urea 4.5 μmol / l; uric acid 320 μmol / l; glomerular filtration 90 ml / min; tubular reabsorption 98%.

Ultrasound of the kidneys and urinary tract: kidneys of normal size and shape, the abdominal system is not deformed. Stones are not visualized. The ureters and bladder are not changed.

In / in urography - kidneys of normal shape and size, the abdominal cavity system is not changed. Stone counts are not determined. Excretory function is not impaired.

Remission after treatment is 12 months.

Example 2

And / b No. 325. Patient P., 37 years old.

Diagnosis: urolithiasis, stones in the left kidney.

Complains of stitching pains in the lower back with irradiation to the inguinal region, painful urination, "dark urine", fever up to 38 ° C. Sick for about 3 years, when dysuric phenomena first appeared, facial swelling in the morning. Ultrasound of the kidneys revealed the calculus of the left kidney for the first time. Not treated. Yesterday, after classes in the gym, there were sharp pains in the lumbar region on the left, pain during urination, dark urine, the temperature rose to 37.8 ° C. I went to the polyclinic for medical help, from where I was sent by the doctor to a therapeutic hospital.

Objective: The state of moderate severity. The skin is clean. Pastosity of the face. Pulse 86 beats in minutes, rhythmic. HELL 135/90. Heart sounds are muffled. Vesicular breathing. The language is clear. The stomach is soft. Liver, spleen not palpable. A painful left kidney is palpated. A positive symptom of thrumming on the lumbar region on the left. No peripheral edema.

Wedge. blood test: Hb 118 g / l; Er. 3.7 × 10 ¹² / l, white blood cells 8.4 × 10 ⁹ / l; e. 3, p. 5, p. 64, l 21, m. 7; ESR 20 mm / hour.

Clinic. urinalysis - count - 200.0, turbid, acidic 200.0 beats. at. 1011, protein 0.33%, no sugar; er. 30-35 p.p .; white blood cells 15-20 in p.z .; bacteria 100,000 in 1 ml.

Urinalysis according to Nechiporenko: leukocytes 5700 in 1 ml; erythrocytes 8000 in 1 ml.

Biochemical blood test: total protein 75 g / l; albumin 50%: globulins α ₁ 4%; α ₂ 8%; β15%; γ23%; creatinine 118 μmol / l; urea 8.2 μmol / l; uric acid 430 μmol / l; glomerular filtration 78 ml / min; tubular reabsorption 96%, uric acid 430 μmol / L.

Ultrasound of the kidneys and urinary tract: a kidney of normal size and shape, the abdominal system is not deformed. 2 calculi are determined in the pelvis of the left kidney in the form of a hyperechoic round formation with a diameter of 6 mm, the ureters and the bladder are not changed.

On the survey radiograph in the projection of the right kidney, shadows suspicious of calculi are determined.

In / in urography - the kidneys are usually located, not changed in size and shape. The renal abdominal system is not changed, 2 calculi are visualized in the pelvis of the right kidney in the form of an echogenic round formation with an acoustic shadow in diameter of 6 mm. Excretory function is not impaired.

In the hospital, the patient was treated: Avisan 2 t. 3 times a day, nitroxaline 0.05 g 4 times a day, no-shpa solution 2-2.0,

Against the background of the therapy, the pain in the renal region did not decrease, painful urination remains, body temperature of 37.5 ° C.

Wedge. blood test: Hb 120 g / l; Er. 3.8 10 × 12 / L, white blood cells 8.2 × 10 ⁹ / L; e. 2, p 5, p. 63 l. 22, m. 8; ESR 22 mm / hour.

Clinic. urinalysis - count - 250.0, turbid, acidic 200.0, beats. at. 1012, protein 0.33%, no sugar; er. 25-20 p.z .; white blood cells 35-50 in par.; bacteria over 100,000 in 1 ml.

Urinalysis according to Nechiporenko: leukocytes 4700 in 1 ml; red blood cells 6000 in 1 ml.

Biochemical blood test: total protein 72 g / l; albumin 48%: globulins α ₁ 4%; α ₂ 9%; β16%; γ23%; creatinine 116 μmol / l; urea 8.0 μmol / L; uric acid 410 μmol / l; glomerular filtration 76 ml / min; tubular reabsorption 97%, uric acid 430 μmol / L.

Ultrasound of the kidneys and urinary tract in the pelvis of the left kidney visualizes 2 calculi in the form of a hyperechoic round formation with a diameter of 6 mm.

Due to the lack of a positive result of treatment, the patient was prescribed herbal collection, including: common juniper fruits 4.0 (20 g), ordinary hop cones 10 (50 g), lingonberry leaves 8 (40 g), field horsetail grass 7 ( 35 g), sweet clover grass 9 (45 g), shepherd’s grass grass 8 (40 g), blue cornflower flowers 5 (25 g), flax seeds 11 (55 g), parsley grass 10 (50 g), madder roots 6 (30 g), linden flowers 15 (75 g), grass of the mountaineer poultry 8 (40 g), grass of St. John's wort perforated 9 (45 g), roots of the field gland 8 (40 g), grass of kidney tea 11 (55 g), rhizomes and roots of angelica officinalis 8 (40 g), aniseed fruits 12 (60 g), birch buds 6 (30 g), tricolor violet grass 13 (65 g), fennel fruits 8 (40 g), corn stigmas 7 (35 g), sandwort immortelle flowers 5 (25 g), calamus 4 roots and rhizomes (20 g), licorice root 7 (35 g), dandelion roots 6 (30 g), bearberry grass 4 (20 g), wormwood grass bitter 3 (15 g).

The mixture was ground to a powdery consistency, then 2/3 of a teaspoon was brewed in 300 ml of boiling water, insisted for 15 minutes. The prepared mixture was defended and the patient took 100 ml three times a day for two months.

After this therapy, the patient's condition improved. The pain in the lumbar region, dysuric phenomena disappeared, the color of urine returned to normal.

Objectively: The patient is in satisfactory condition. The skin is clean. Pulse 74 beats. in minutes, rhythmic. HELL 115/80. Heart sounds are muffled. The vesicular breathing, no wheezing. The language is clear. The stomach is soft. Liver, spleen not palpable. The kidneys are not palpable. The symptom of lumbar effusion is negative on both sides. No swelling.

Wedge. blood test: Hb 122 g / l; Er. 4.1 × 10 ¹² / L, white blood cells 6.0 × 10 ⁹ / L; e. 1, p. 2, p. 67 l. 24, m. 6; ESR 7 mm / hour.

Wedge. urinalysis - count of 210.0; straw yellow, slightly acidic, transparent, beats. at. 1015, no protein, no sugar; erythrocytes 0-1 in p.z .; white blood cells - 0-1v p.oz .; bacteria are absent, cylinders are absent.

Urinalysis according to Nechiporenko: 2500 white blood cells in 1 nc; red blood cells 750 in 1 ml.

Biochemical blood test: total protein 80 g / l; albumin 56%: globulins α ₁ 4%; α ₂ 7%; β13%; γ19%; creatinine 80 μmol / l; urea 6.0 μmol / L; uric acid 250 μmol / l; glomerular filtration 120 ml / min; tubular reabsorption 98%.

Ultrasound of the kidneys and urinary tract: kidneys of normal size and shape, the abdominal system is not deformed. Stones are not visualized. The ureters and bladder are not changed.

In / in urography - kidneys of normal shape and size, the abdominal cavity system is not changed. Stone counts are not determined. Excretory function is not impaired.

Remission after therapy is 18 months.

Example 3

And / b No. 1120. Patient V., 43 years old

Diagnosis: Urolithiasis stone of the right kidney.

Complains of stitching pains in the lumbar region on the right with irradiation to the inguinal region, thigh, pain during urination, “red urine”, fever - 38 ° С. Sick for about 5 years, when pain in the lumbar region first appeared. I did not seek medical help. About a week ago, after physical exertion, stitching pains appeared in the lumbar region on the right, dysuric phenomena, and a change in the color of urine. I went to the doctor of the clinic. Directed to hospital treatment in a therapeutic hospital.

Objective: The state of moderate severity. The skin and mucous membranes are clean. Pastosity of the face. Pulse 88 beats. in minutes, rhythmic. HELL 140/90. Heart sounds are muffled. Vesicular breathing. The tongue is coated with white plaque. The stomach is soft. Liver, spleen not palpable. A painful right kidney is palpated. A positive symptom of thrumming on the lumbar region on the right. Pastosity of the legs.

Wedge. blood test: Hb 115 g / l; Er. 3.6 × 10 ¹² / L, white blood cells 8.3 × 10 ⁹ / L; e. 2, p. 6, p. 62, l 23, m. 7; ESR 28 mm / hour.

Clinic. urinalysis - count - 250.0, cloudy, sour with a "reddish" tint, beats. at. 1012, protein 0.33%, no sugar; er. 35-40 p.z .; white blood cells 20-25 in p.z .; bacteria 200,000 in 1 ml.

Urinalysis according to Nechiporenko: white blood cells 6000 in 1 ml; erythrocytes 8500 in 1 ml.

Biochemical blood test: total protein 74 g / l; albumin 49%: globulins α ₁ 3%; α ₂ 8%; β165%; γ25%; creatinine 110 μmol / l; urea 8.3 μmol / L; uric acid 400 μmol / l; glomerular filtration 70 ml / min; tubular reabsorption 96%, uric acid 400 μmol / L.

Ultrasound of the kidneys and urinary tract: kidneys of normal size and shape, the abdominal system is not deformed. In the pelvis of the left kidney, 2 calculi are determined in the form of a hyperechoic round formation with a diameter of 6 mm and 5 mm. The ureters and bladder are not changed.

On the survey radiograph in the projection of the right kidney, shadows suspicious of calculi are determined.

In / in urography - the kidneys are usually located, not changed in size and shape. The renal abdominal system is not changed, 2 calculi are visualized in the pelvis of the right kidney in the form of an echogenic round formation with an acoustic shadow in diameter of 6 mm and 5 mm.

In the hospital, the patient was treated: Avisan 2 t. 3 times a day, nitroxaline 0.05 g 4 times a day, 2% solution of no-shpa 2-2.0.

Against the background of the therapy, no significant dynamics in the state of health was noted. Lumbar pain, dysuric phenomena, and fever continue to bother.

Wedge. blood test: Hb 118 g / l; Er. 3.7 × 10 ¹² / l, white blood cells 8.0 × 10 ⁹ / l; e. 3, p. 6, p. 61, l.22, m. 8; ESR 25 mm / hour.

Clinic. urinalysis - count - 230.0, turbid, acidic 200.0, shock 1014, protein 0.33%, no sugar; er.25-28 in p.z .; white blood cells 18-20 in p.z .; bacteria 100,000 in 1 ml.

Urinalysis according to Nechiporenko: leukocytes 5000 in 1 ml; erythrocytes 7200 in 1 ml.

Biochemical blood test: total protein 72 g / l; albumin 50%: globulins α ₁ 3%; α ₂ 9%; β14%; γ24%; creatinine 114 μmol / l; urea 8.2 micromol / l; uric acid 410 μmol / l; glomerular filtration 80 ml / min; tubular reabsorption 96%, uric acid 400 μmol / L.

Ultrasound of the kidneys and urinary tract: 2 calculi are visualized in the pelvis of the left kidney in the form of a hyperechoic round formation with a diameter of 6 mm and 5 mm.

The absence of a positive effect from the therapy provided the basis for prescribing the patient herbal collection, including: fruits of ordinary juniper 5.0 (25 g), hop cones ordinary 11 (55 g), lingonberry leaves 9 (45 g), field horsetail grass 8 (40 g), sweet clover herb 10 (50 g), shepherd’s bag grass 7 (45 g), blue cornflower flowers 6 (30 g), flax seeds 12 (60 g), parsley grass 11 (5 5 g), madder roots 7 (3 5 g), linden flowers 16 (80 g), grass of the mountaineer poultry 9 (45 g), grass of St. John's wort perforated 10 (50 g), roots of the field steel 9 (45 g), tra kidney tea 12 (60 g), rhizomes and roots of angelica officinalis 9 (45 g), fruits of anise officinalis 13 (65 g), birch buds 7 (35 g), tricolor violet grass 14 (70 g), fennel fruits 9 ( 45 g), corn stigmas 8 (40 g), sandwort flowers 6 (30 g), calamus 5 roots and rhizomes (25 g), licorice root 8 (40 g), dandelion roots 7 (35 g), bearberry grass ordinary 5 (25 g), wormwood herb 34 (20 g).

The mixture was ground to a powdery consistency, then 2/3 of a teaspoon was brewed in 300 ml of boiling water, insisted for 15 minutes. The prepared mixture was defended, and the patient took 100 ml three times a day for two months.

After this therapy, the patient's condition improved. The pain in the lumbar region, dysuric phenomena disappeared, the color of urine returned to normal.

Objectively: The patient is in satisfactory condition. The skin is clean. Pulse 72 beats. in minutes, rhythmic. HELL 120/80. Heart sounds are muffled. The vesicular breathing, no wheezing. The language is clear. The stomach is soft. The liver, spleen, kidneys are not palpable. The symptom of lumbar effusion is negative. No swelling.

Wedge. blood test: Hb 122 g / l; Er. 4.1 × 10 ¹² / l, white blood cells 6.2 / 10 ⁹ / l; e. 2, item 4, p. 62, l.23, m. 8; ESR 10 mm / hour.

Wedge. urinalysis - count 200.0; straw yellow, slightly acidic, transparent, ud. 1015, no protein, no sugar; erythrocytes 1-3 in p.z .; white blood cells - 1-2-3 in p.z .; bacteria are absent, cylinders are absent.

Urinalysis according to Nechiporenko: white blood cells 3200 in 1 nc; red blood cells 1000 in 1 ml.

Biochemical blood test: total protein 78 g / l; albumin 54%: globulins α ₁ 4%; α ₂ 8%; β15%; γ19%; creatinine 80 μmol / l; urea 7.0 μmol / L; uric acid 280 μmol / l; glomerular filtration 114 ml / min; tubular reabsorption of 97%.

Ultrasound of the kidneys and urinary tract: kidneys of normal size and shape, the abdominal system is not deformed. Stones are not visualized. The ureters and bladder are not changed.

Intravenous urography - kidneys of usual shape and size, the abdominal cavity system is not deformed. Stones are not visualized. The ureters and bladder are not changed.

Remission after therapy is 18 months.

Example 4 (prototype)

And / b No. 1382. Patient O., 41 years old

Diagnosis: Urolithiasis stones of the right kidney.

Complains of stitching pains in the lumbar region on the right with irradiation to the inguinal region, thigh, pain when urinating, discoloration of urine, fever up to 37.8 ° С. Sick for 5 years, when the first pain appeared in the lumbar region, "red urine." I went to the clinic for medical help, where kidney ultrasound revealed a calculus in the ureter. She took a ciston, against which the stone moved away. Further notes aching pain in the lumbar region. Not treated. 10 days ago after classes in the gym, pain in the lumbar region on the right sharply intensified, dysuric phenomena, red urine, and an increase in body temperature appeared. I turned for medical care to the clinic, from where I was sent to a therapeutic hospital.

Objectively: Upon admission, the patient's condition is moderate. Temperature 38.0 ° C. The skin is clean, pasty face. Pulse 86 beats in minutes, rhythmic. HELL 135/90. Heart sounds are muffled. Vesicular breathing. The tongue is coated with white plaque. The abdomen is regular in shape, soft, and takes an active part in breathing. Liver, spleen not palpable. A painful right kidney is palpated. A positive symptom of thrumming on the lumbar region on the right. Pastosity of the legs.

Wedge. blood test: Hb 116 g / l; Er. 3.7 × 10 ¹² / l, white blood cells 8.5 × 10 ⁹ / l; e. 1, p 1, s 61, l. 23, m. 8; ESR 25 mm / hour.

Clinic. urine analysis - count - 250.0, cloudy, sour, color of "meat slops", ud.v.1013, protein 0.33%, no sugar; er. 25-30 p.z .; white blood cells 20-30 in p.z .; bacteria 200,000 in 1 ml.

Urinalysis according to Nechiporenko: leukocytes 5000 in 1 ml; erythrocytes 7500 in 1 ml.

Biochemical blood test: total protein 78 g / l; albumin 51%: globulins α ₁ 4%; α ₂ 7%; β14%; γ24%; creatinine 120 μmol / l; urea 8.0 μmol / L; uric acid 420 μmol / L; glomerular filtration 708 ml / min; tubular reabsorption 96%, uric acid 420 μmol / L.

Ultrasound of the kidneys and urinary tract: kidneys of normal size and shape, the abdominal system is not deformed. In the pelvis of the right kidney, 2 calculi are determined in the form of a hyperechoic round formation with a diameter of 6 and 5 mm. The ureters and bladder are not changed.

On the survey radiograph in the projection of the left kidney, shadows suspicious of calculi are determined.

In / in urography - the kidneys are usually located, not changed in size and shape. The renal cavity system has not been changed, 2 calculi are visualized in the pelvis of the right kidney in the form of a hyperechoic round formation with an acoustic shadow of 5 mm diameter.

In the hospital, the patient was treated: Avisan 2 t. 3 times a day, nitroxaline 0.05 g 4 times a day, 2% solution of no-shpa 2-2.0.

Against the background of the therapy, no positive dynamics in the state of health were noted, pain in the lumbar region, dysuric phenomena, and fever were disturbing.

Wedge. blood test: Hb 115 g / l; Er. 3.8 × 10 ¹² / l, white blood cells 8.3 × 10 ⁹ / l; e.2, b.1, p 5, s. 62, l 22, m. 8; ESR 23 mm / hour.

Clinic. urinalysis - count - 220.0, cloudy, sour with a reddish "tint", beats. at. 1014, protein 0.33%, no sugar; er. 20-25 p.z .; white blood cells 20-25 in p.z .; bacteria 100,000 in 1 ml.

Urinalysis according to Nechiporenko: leukocytes 4500 in 1 ml; red blood cells 6000 in 1 ml.

Biochemical blood test: total protein 80 g / l; albumin 52%: globulins α ₁ 3%; α ₂ 8%; β14%; γ23%; creatinine 115 μmol / l; urea 8.3 μmol / L; uric acid 410 μmol / l; glomerular filtration 82 ml / min; tubular reabsorption 97%, uric acid 410 μmol / L.

Ultrasound of the kidneys and urinary tract: 2 calculi are visualized in the pelvis of the right kidney in the form of a hyperechoic round formation with a diameter of 5 mm.

In the absence of a positive effect of the therapy, the patient was prescribed a herbal collection, including spike-like lavender grass - 10.0 (50 g); black currant leaves - 10.0 (50 g); birch leaves - 10.0 (50 g); ivy budra - 10.0 (50 g); fruits of common juniper - 10.0 (50 g); hop cones - 10.0 (50 g); lingonberry leaves - 20.0 (100 g); leaves of large plantain - 28.0 (140 g); fruits of wild strawberry - 60.0 (300 g); shoots of field horsetail - 60.0 (300 g); sweet clover grass - 50.0 (250 g); grass shepherd's purse - 15.0 (75 g); blue cornflower flowers - 30.0 (150 g); flax seed - 40.0 (200 g).

These components were brewed at 10.0 per 740 ml of boiling water, boiled for 5-6 minutes, insisted for 2 hours. The patient took the prepared mixture 100 ml three times a day. After the stones left, the dose of the mixture was reduced to 5.0, which was similarly brewed in 500 ml of boiling water. The patient took herbal collection for two months.

After this therapy, the patient's condition improved, however, there were small aching pains in the lumbar region, pain during urination, frequent urination, and severity appeared in epigastrium.

Objectively: The patient is in satisfactory condition. The skin is clean, pastes of the face remains. Pulse 78 beats. in minutes, rhythmic. HELL 125/80. Heart sounds are muffled. The vesicular breathing, no wheezing. The tongue is coated with white plaque. The stomach is soft. The liver, spleen, kidneys are not palpable. The symptom of striking the lumbar region on the right is slightly positive.

No swelling.

Wedge. blood test: Hb 120 g / l, Er. 3.9 × 10 ¹² / l, white blood cells 7.8 × 10 ⁹ / l; E.G. b.1, p.5, p.57, l.28, m.7; ESR 15 mm / hour.

Wedge. urinalysis - count 200.0; weakly acid, cloudy, ud 1015, no protein, no sugar; erythrocytes 5-7 in p.z .; white blood cells - 3-5 in p.z .; bacteria 50,000 in 1 mg.

Urinalysis according to Nechiporenko: leukocytes 4500 in 1 nc; red blood cells 1500 in 1 ml.

Biochemical blood test: total protein 78 g / l; albumin 52%: globulins α ₁ 5%; α ₂ 8%; β14%; γ21%; creatinine 116 μmol / l; urea 7.8 μmol / L; uric acid 410 μmol / l; glomerular filtration 83 ml / min; tubular reabsorption 98%.

Ultrasound of the kidneys and urinary tract: kidneys of normal size and shape, the abdominal system is not deformed. In the pelvis of the right kidney, the calculus is visualized in the form of an echogenic round formation with a diameter of 3 mm.

Intravenous urography - kidneys of usual shape and size, the abdominal cavity system is not deformed. In the pelvis of the right kidney, the calculus is visualized in the form of an echogenic round formation with a diameter of 3 mm. Clinical remission after treatment is 6 months. Thus, the cited extracts from medical histories indicate that when taking the proposed collection, a positive effect was obtained in all patients.

When treating with the help of the proposed collection (Table 1) after the end of treatment, the absence of kidney stones and the normalization of laboratory parameters were established. The treatment data using the prototype are presented in Table 2. The advantage of the proposed collection is the absence of side effects compared with other drugs. Removal of calculi from the kidney, disappearance of inflammatory phenomena, normalization of the functional state of the kidneys are observed. Remission in the observed patients increased by 2-3 times. In the prototype method, remission is 6 months, and in the treatment with the proposed collection - 18 months.

Claims (1)

An agent for treating urolithiasis, which is a herbal collection, including the fruits of juniper ordinary, hop cones, lingonberry leaves, field horsetail grass, sweet clover grass, shepherd’s bag grass, blue cornflower flowers, flax seeds, characterized in that it additionally contains grass parsley, madder roots, linden flowers, bird of the mountaineer, perforated St. John's wort grass, roots of the field gland, kidney tea grass, rhizomes and roots of angelica officinalis, anise fruit rstvennogo, birch buds, herb Viola tricolor, fennel fruit, corn silk, Helichrysum arenarium flowers, roots and rhizome, licorice root, dandelion root, grass, bearberry, wormwood herb next weight ratio of the components: Juniper fruit 3-5 Hops 9-11 Lingonberry leaves 7-9 Horsetail, grass 6-8 Melilotus officinalis, grass 8-10 Shepherd's bag, grass 7-9 Cornflower blue, flowers 4-6 Flax seed 10-12 Parsley, grass 9-11 Madder dyeing, roots 5-7 Linden flowers 14-16 Highlander bird, grass 7-9 Hypericum perforatum, grass 8-10 Stalnik field, roots 7-9 Kidney tea, grass 10-12 Angelica officinalis, rhizomes and roots 7-9 Anise officinalis, fruits 11-13 Birch buds 5-7 Violet tricolor, grass 12 Fennel fruit 7-9 Corn silk 6-8 Immortelle sandy, flowers 4-6 Air, roots and rhizomes 3-6 Licorice root 6-8 Medicinal dandelion, roots 5-7 Bearberry ordinary, grass 3-5 Wormwood, grass 2-4