RU2180228C1 - Agent for treatment of chronic viral hepatitis b - Google Patents

Abstract

FIELD: medicine, virology, phytotherapy. SUBSTANCE: invention proposes the herb species that can be used for treatment of patients with chronic viral hepatitis B. Invention proposes an agent that is the herb species containing common tansy flowers, medicinal matricary flowers, tall elecampane roots and it has additionally the following components: Eleutherococcus senticosus roots, medicinal melissa leaves, major celandine herb, medicinal marjoram herb, upright tormentil roots, umbellate centaury herb, common thyme herb, common barberry roots, pot-marigold flowers, sandy immortelle flowers, maize stigmas, sweet clover, sweet flag rhizomes with roots, dandelion roots, cowberry leaves, bear berry leaves, eucalyptus leaves, juniper fruits, common wormwood herb, pink periwinkle herb, common pine buds and linden flowers taken in the definite ratio. The use of the proposed agent results to decrease of inflammatory process and prevention of further fibromatosis process in liver, improvement of bile efflux from hepatic ducts and gall bladder, choleresis normalization and increase of remission period. EFFECT: enhanced therapeutic effectiveness of agent. 1 cl, 2 tbl, 4 ex

Description

 The present invention relates to medicine and is an herbal collection that can be used to treat chronic viral hepatitis B.

 Most often, in the treatment of chronic viral hepatitis B, the following scheme is used: for the purpose of detoxification and correction of water-electrolyte balance, a 5% glucose solution and hemodesis are used; hepatoprotectors - legal, selibor and others; antioxidants - vitamin E or essentiale, and with a decrease in the prothrombin index, vitamin K, Vikasol or freshly frozen plasma are prescribed (Meyer A.A.; Therapy, M., 1998, p. 301).

 Known drugs used to treat chronic viral hepatitis B, such as, for example, suramin. This drug is an effective antiviral agent. However, it turned out that suramin is not effective enough and too toxic, which makes it inappropriate to use it for the treatment of chronic viral hepatitis B infection (Mayer K.P. Hepatitis and the effects of hepatitis, M., 1999, p. 164).

 Ribavirin was prescribed orally for patients with chronic hepatitis B. A decrease in the concentration of DNA of viral hepatitis B (HBV-DNA) and a decrease in the activity of transaminases were detected, but there was no complete disappearance of HBV-DNA and a long-term positive effect of treatment was not observed (Mayer K.P. Hepatitis and consequences of hepatitis , M., 1999, p. 164).

 In the treatment of patients with viral hepatitis B, alpha-interferon produced by lymphoblasts was found to be the most effective. Currently, interferon preparations obtained using recombinant technology are used: alpha-2-interferon and alpha-2b-interferon (intron A). But in the treatment of patients with chronic hepatitis B, requiring a longer use of interferon, in addition to fever, mild malaise, chilling, a slight decrease in the content of leukocytes and platelets, weight loss and hair loss can occur (Zmyzgova A.V. Interferon therapy of viral hepatitis, M., 1999 p. 59-60).

 It is also proposed the treatment of chronic viral hepatitis B with various interferons (IFN), which are a group of autogenous glycoproteins that protect cells from viral infection, which give a certain clinical effect, but some patients with chronic hepatitis develop a specific IFN inhibitor, and therefore IFN therapy for these patients is small effective, and combination therapy using various interferons does not give good clinical results, and sometimes hepatic symptoms do not develop sufficiency.

 Thus, the ideal regimen for treating HBV-DNA positive patients has not yet been worked out (Mayer K.P. Hepatitis and the effects of hepatitis, M., 1999, p. 164, 170-1).

 Along with the introduction of exogenous interferon, leukocyte or recombinant in the treatment of chronic viral hepatitis B, interferonogens can be used - interferon inducers that stimulate its production in the cells of the body, which are herbal tonic agents: tincture of ginseng, lemongrass, aralia and eleutherococcus. But even when used for a long time, the clinical effect is not always achieved (Sorinson S. N. Viral hepatitis in clinical practice. St. Petersburg 1996, p. 98-99).

 Sometimes, hapobene and hepatofalk plant are used to treat patients with viral hepatitis B. Gapobene consists of a mixture of extracts of spotted raspberry and smoky officinalis. Milk thistle is close in action to flavonoids, and a haze helps restore bile secretion, normalizes the tone of the sphincter of Oddi. Therefore, this drug is indicated for biliary dyskinesia in patients with viral hepatitis. Hepatofalk plant is a combination of three medicinal herbs: thistle, celandine, and Javanese turmeric, each of which is used in folk medicine for diseases of the liver and biliary tract. Thistle has an effect similar to flavonoids, Javanese turmeric stimulates the formation of bile, lowers cholesterol, and has an anti-inflammatory effect. But hapobene does not have a pronounced antiviral effect, and hepatofalk plant does not always have a positive effect and is effective only for easily occurring forms of viral hepatitis B and should not be used for gallstone disease and for pronounced violations of the outflow of bile (in the book. "The concept of treatment of chronic diseases hepatobiliary sphere ", Sorinson SN Viral hepatitis in clinical practice. St. Petersburg, 1996, pp. 103-104).

 A prototype of the present invention is a collection comprising St. John's wort grass 1, tansy flowers 1, yarrow grass 1, chamomile flowers 1, burdock root 1, rose hips 1, sage leaves 1, elecampane root 1, bird highlander grass 1. The collection was used according to the following scheme: one tablespoon of the mixture was poured with a glass of boiling water, insisted for 30 minutes, appointed 0.5 cups 3 times a day 20 minutes before meals (Tarasenko V.P., Ipatiev V.A., Shubin V.A., Ivanina E.V., Ta Rasenko, I.A. and Kholodilova, L.V., Modern Herbal Medicine, Novosibirsk, Nauka, 1998., p. 304, collection 11).

 The disadvantage of this tool is not enough pronounced therapeutic effect and not always there is an improvement in liver function, expressed in the normalization of its biochemical parameters. In addition, the content of tansy of common flowers reaches 10% of the collection, but tansy is contraindicated in the treatment of pregnant women and nursing mothers, as this can lead to toxic reactions, and in some cases the collection does not always ensure the normalization of the outflow of bile from the hepatic ducts and gall bladder (Mashkovsky M.D. Medicines, M., New Wave., 1996, p. 445).

 The objective of the invention is the elimination of hepatitis B virus, reducing the inflammatory process and preventing further fibrosis in the liver, improving the outflow of bile from the hepatic ducts and gall bladder, normalizing choleresis and increasing the duration of remission.

The problem is solved in that the remedy, which is a herbal collection, including common tansy flowers, chamomile flowers, elecampane root, additionally contains prickly eleutherococcus roots, medicinal lemon balm leaves, celandine grass large, marjoram herb, erect cinquefoil, centaury grass umbrella, thyme grass, roots of barberry ordinary, calendula flowers, flowers of Helichrysum, corn stigmas, Melilotus officinalis, rhizomes with calamus root, dandelion root, leaves cranberries, bearberry leaf, eucalyptus leaves, fruits, juniper, Artemisia herb and grass vinca, Scots pine buds, linden flowers in the following component ratio, wt.%:
Eleutherococcus prickly, roots - 5-7
Melissa officinalis, leaves - 10-12
Large celandine, grass - 2-4
Oregano officinalis, herb - 9-11
The cinquefoil is erect, roots - 6-8
Chamomile, flowers - 9-11
Umbrella centaury, grass - 5-7
Common thyme, grass - 7-9
Barberry ordinary, roots - 4-6
Calendula, flowers - 10-12
Immortelle sandy, flowers - 5-7
Corn stigmas - 7-9
Melilotus officinalis - 11-13
Air, rhizome with roots - 3-5
Dandelion, root - 7-9
Elecampane, root - 6-8
Lingonberry, leaves - 9-12
Bearberry, leaves - 3-5
Eucalyptus, leaves - 3-5
Tansy, flowers - 2-4
Juniper, fruits - 5-7
Wormwood, grass - 4-6
Periwinkle pink, grass - 6-8
Common pine, kidneys - 4-6
Linden, flowers - 17-19
Eleutherococcus of prickly roots have a virologostatic effect, increase the nonspecific resistance of the body to various pathogens, including viruses. In addition, it reduces the manifestations of intoxication, improves choleresis, helps to reduce the size of the liver, reduces the content of cholesterol and beta-lipoproteins in the blood serum and reduces the toxic effect of various drugs (Phytotherapy - compiler Demyanova M.V. - M., 1992. Issue. 5-6 p. 31-32.).

 * Melissa officinalis leaves have antispasmodic, analgesic and soothing effects on the nervous system, improve the outflow of bile from the hepatic ducts, gall bladder. The anti-inflammatory and antiviral effects of lemon balm are also known.

 * Celandine large grass has a wide spectrum of antimicrobial activity, including antiviral effect. In addition, it has an antispasmodic effect, relieves spasms of the gallbladder and promotes the release of bile from it, improves choleresis, reduces congestion in the liver, and causes an analgesic effect.

 * Oregano officinalis herb may have anti-inflammatory, antimicrobial and antiviral effects. The grass has the ability to stimulate the secretion of digestive glands and the release of bile from the hepatic ducts, gall bladder, causes diuretic and sedative effects, thereby reducing tissue swelling.

 * The cinquefoil erect rhizome exhibits multiple therapeutic effects, including antimicrobial, antiviral and astringent. It reduces the viscosity of bile, promotes its outflow and reduces inflammatory manifestations in the gallbladder, and also helps to normalize the biochemical function of the liver.

 * Chamomile officinalis flowers can exhibit anti-inflammatory, antimicrobial and antiviral effects, have a choleretic effect, promote the exit of bile from the liver passages, improve choleresis, normalize bile viscosity, reduce inflammation in the liver, and improve biochemical parameters in it (Pastushenkov L.V., Lesiovskaya EE Plants antihypoxants (phytotherapy). St. Petersburg, 1991, 96 pp. The link refers to the names of medicinal plants, which are denoted by *).

 The centaury of the umbrella grass has an anti-inflammatory and stimulating effect, promotes the outflow of bile from the hepatic ducts and gall bladder. Due to the fact that it enhances secretion and causes a diuretic effect, swelling of the liver decreases, and the function of hepatocytes improves.

 Common thyme grass acts bacteriostatically on gram-negative microorganisms and exhibits antimycotic activity against pathogenic fungi. Grass reduces the tone of the gallbladder and normalizes its contractility, restores the functional state of the liver.

 Barberry ordinary roots have anti-inflammatory, astringent, antimicrobial, hemostatic and choleretic effects. The roots reduce inflammation in the gallbladder and hepatic ducts, thereby improving the outflow of bile from the liver and gallbladder, provide regenerative processes in it, and normalize metabolism in patients with viral hepatitis. They also improve kidney and pancreas function. Calendula flowers have an anti-inflammatory effect, enhance secretory activity, increase bile formation and bile secretion, and activate regeneration processes in the liver. Due to the high content of carotenoids, flavanoids, ascorbic acid and organic acids in the marigold flowers, it causes an increase in the metabolic function of the liver, improves the composition of bile, and increases the secretory and excretory function of the liver. The therapeutic effect is especially pronounced when combined with the appointment of calendula with other herbs.

 Immortelle sand flowers enhance the secretion of bile and have a pronounced antispasmodic effect, thereby improving the metabolic function of the liver, reduce the viscosity and relative density of bile. In addition, immortelle sand flowers have anti-inflammatory, antibacterial, choleretic and antispasmodic effects.

 Corn stigmas have pronounced choleretic properties, reduce the viscosity of bile, its relative density, accelerate the blood coagulation process, increase diuresis, and promote the release of sand and stones from the bile ducts and gall bladder.

 Melilotus officinalis has pronounced detoxifying properties, increases the phagocytic activity of leukocytes, improves peripheral blood supply and blood supply to liver tissues, exhibits antibacterial properties, improves liver function, and enhances choleresis.

 Rhizome with calamus roots has anti-inflammatory, bacteriostatic, antifungicidal properties and have some antispasmodic effect. Improves digestion in the stomach, increases the tone of the gallbladder, enhances the biliary function of the liver.

 Dandelion root can have a choleretic effect, enhancing the secretion of gastric juice and pancreas, has antispasmodic and laxative properties, normalizes the composition and flow of bile, enhances diuresis, promotes and improves fluid flow through the intestines, stimulates appetite, acting on the food center, and causes a laxative effect .

 Elecampane root has a variety of properties, including increasing bile formation and biliary excretion into the duodenum, regulates intestinal motility, enhances diuresis, and has antimicrobial properties. It restores the normal digestion process, reduces inflammatory manifestations in the organs of the gastrointestinal tract, in the bile ducts and gall bladder. Accelerates regenerative processes in the liver.

 Lingonberry leaves have a disinfectant, diuretic, choleretic, antiseptic, bactericidal and anti-inflammatory effect. The positive effect is due to the ability of lingonberry leaves to reduce the permeability and fragility of the capillaries of the liver.

 Bearberry leaves cause diuretic, anti-inflammatory and antibacterial effects. In addition, they have an antispasmodic and choleretic effect, positively affect the vessels of the microvasculature and enhance the regeneration of liver cells. Due to their disinfecting properties, bearberry leaves are able to relieve inflammation in the biliary tract and partially the gall bladder and help cleanse its bacterial flora and inflammatory products.

 Eucalyptus leaves have pronounced antibacterial properties and are able to inhibit the development of coccal flora, as well as have a positive effect in viral infections, have a detrimental effect on fungi and giardia. The leaves increase choleresis and relieve spasms of the sphincter of the gallbladder and increase the excretion of fluid through the intestines, including normalizing the absorption function of the intestines, reduce inflammation of the liver and thereby slow down the fibrosis in it and act antiseptically in the hepatic ducts.

 Tansy flowers cause an antibacterial, anti-inflammatory, antihelminthic effect, enhance the secretion of bile in the liver and its exit from the hepatic ducts, and also reduce the amount of mucus in it. They tone the muscles of the intestinal tract and enhance the secretion processes, as well as suppress the pathogenic flora.

 Juniper fruits have a diuretic effect, enhance bile formation and biliary excretion, improve the secretion of gastric juice, and increase intestinal motility. In addition, they have a pronounced antibacterial and anti-inflammatory effect, help to reduce stagnation of bile in the hepatic ducts and in the gall bladder.

 Wormwood grass has an anti-inflammatory effect, helps to stabilize immune responses, stimulates the function of the reticuloendothelial system, has a choleretic effect - accelerates the excretion of bile through the choleretic pathways, stimulates the function of the pancreas, reduces dyspeptic symptoms, and normalizes stool. Vinca pink grass has a wide range of antitumor effects and inhibits the vital activity of certain microorganisms. The grass improves blood supply to the liver tissue, increases the resistance of capillaries and reduces bleeding that occurs with functional failure, has an astringent effect, increases daily diuresis.

 The buds of Scots pine show anti-inflammatory and antimicrobial properties in the liver tissue, bile ducts and gall bladder. They also contribute to a decrease in the viscosity of bile and its outflow along the bile ducts and normalize the exit of bile from the gallbladder.

 Linden flowers have an antimicrobial, anti-inflammatory and anti-edematous effect, have a calming effect. They contribute to an increase in bile formation and facilitate the flow of bile into the duodenum, stimulate the secretion of gastric juice, increase diuresis, and enhance exocrine pancreatic function.

 These herbs, when used together in the proposed doses, give a pronounced clinical effect in the treatment of patients with chronic hepatitis B.

 The proposed tool is prepared for use in the following ratio of components, wt. %: eleutherococcus spiny roots 5-7, Melissa officinalis leaves 10-12, celandine big grass 2-4, marjoram medicinal herb 9-11, cinquefoil erect roots 6-8, centaury umbellate grass 5-7, thyme ordinary grass 7-9 , barberry ordinary roots 4-6, chamomile officinalis flowers 9-11, marigold flowers 10-12, immortelle sand flowers 5-7, stigmas corn 7-9, sweet clover 11-13, rhizome with calamus roots 3-5, dandelion root 7-9, elecampane root 8-10, lingonberry leaves 10-12, bearberry leaves 3-5, eucalyptus leaves 2-4, juniper leaves dy 5-7, wormwood grass 4-6, vinca pink grass 6-8, buds of ordinary pine 4-6, linden flowers 17-19.

 The mixture is ground to a powdery consistency, then 2/3 of a teaspoon is brewed in 300.0 ml of boiling water, infused for 15 minutes. Take 100.0 ml 3 times a day after meals with normal and high acidity, and with low acidity in the same way before meals. The course of treatment lasts 2 months, then a break of 1 month. Depending on the condition of the patient, it is recommended to carry out from 2 to 5 courses of treatment.

EXAMPLES
Example 1 (prototype)
The history of the disease 4781. Patient I.

 Diagnosis: chronic viral hepatitis B with moderate activity.

 Complains of weakness, pain in the right hypochondrium, bloating, unstable stool. He was ill for about 4 years when he suffered acute viral hepatitis B. He was treated in an infectious diseases hospital. After discharge, after 6 months, pain appeared in the right hypochondrium, an unstable chair. In the analyzes, an increase in AlAT activity was determined. Treated on an outpatient basis. He took the essentials. Recently, increased weakness, bloating.

 Objectively: the condition is satisfactory, the skin and mucous jaundice, the stomach is swollen, the enlarged liver is palpated, the lower edge of which extends 4 cm from the costal arch, the spleen is not palpated.

In the analyzes: Hb 125.0 g / l. Er. 3.8 • 10 ¹² / l, leukocytes 3.9 • 10 ⁹ / l, platelets 175.0 • 10 ⁹ / l, ESR 32 mm / h, total protein 63.0 g / l, albumin 41.0%, gamma globulin 23.0%, AlAT 1.90 mmol / L, AcAT 1.80 mmol / L, thymol sample 40.0 ALL, sublimate sample 1.5 units, bilirubin 50.0 μmol / L, prothrombin index 67 , 0%, HbsAg (+++), HBV DNA (+).

 The patient underwent treatment: essentiale, aminophylline, vitamins B1, B6, C, mesim forte - without a significant effect. In the future, as a medicine, a collection was used, including St. John's wort, perforated grass 1 (5 g.), Tansy ordinary flowers 1 (5 g.), Yarrow ordinary grass 1 (5 g.), Chamomile pharmacy flowers 1 (5 g.), burdock large root 1 (5 gr.), wild rose hips 1 (5 gr.), medicinal sage leaves 1 (5 gr.), Elecampane high root 1 (5 gr.), Highlander bird grass 1 (5 gr.). The collection was used as an infusion of 0.5 cup 3 times a day 20 minutes before meals, was taken for 2 months, then a break was taken. Conducted 2 courses of treatment. After the therapy, the condition improved - weakness, pain in the right hypochondrium, bloating decreased.

In the analyzes: Нb 130.5 g / l. Er. 4.0 • 10 ¹² / l, white blood cells 4.21 • 10 ⁹ / l, platelets 185.0 • 10 ⁹ / l, ESR 25 mm / h, total protein 68.4 g / l, albumin 49.0%, gamma globulin 21%, AlAT 1.38 mmol / L, AcAT 1.42 mmol / L, thymol sample 38.1 ALL, sublimate sample 1.60 units, bilirubin 25.4 μmol / L, prothrombin index 70.0 %, HbsAg (+++), HBV DNA (+). After treatment, clinical remission for 4 months.

Example 2
The history of the disease 11486. Patient A.

 Diagnosis: chronic viral hepatitis B with moderate activity.

 Complains of yellowness of the skin, weakness, pain in the right hypochondrium, bloating.

 Sick for about 5 years. Treated on an outpatient basis. Recently, jaundice, pain in the right hypochondrium, bloating appeared.

 Objectively: satisfactory condition, ictericity of the skin of the upper half of the body, "spider veins", pulse 68 beats per minute, rhythmic. Heart sounds are muffled, vesicular breathing. The abdomen is of the correct shape, slightly swollen, an enlarged liver is palpated, the lower edge of which extends 3 cm from the costal arch, the spleen is not enlarged, and fluid in the abdominal cavity is not detected.

In the analyzes: Нb 120.0 g / l. Er. 3.65 • 10 ¹² / l, white blood cells 3.89 • 10%, platelets 165.0 • 10 ⁹ / l, ESR 35 mm / h, total protein 62.0 g / l, albumin 39.0%, gamma globulins 25.0%, AlAT 1.91 mmol / L, AcAT 1.80 mmol / L, thymol sample 52.7 ALL, sublimate sample 1.46 units, bilirubin 55.0 μmol / L, prothrombin index 67.0 %, HBsAg (+++), HBV DNA (+).

 Treatment: corsil, festal, galstena, vitamins B1, B6, C - without a significant effect. Subsequently, a collection consisting of eleutherococcus of prickly root 5.0 (25 g.) Was used as a medicine; Melissa officinalis 10.0 (50 gr.); celandine of large grass 2.0 (10 gr.); marjoram 9.0 (45 gr.); cinquefoil erect roots 6.0 (30 gr.); chamomile medicinal flowers 9.0 (45 gr.); centaury of umbrella grass 5.0 (45 g.); thyme ordinary grass 7.0 (35 gr.); barberry ordinary roots 4.0 (20 gr.); flower calendula 10.0 (50 gr.); Helichrysum sand flowers 5.0 (25 gr.); stigmas of corn 7.0 (35 gr.); Melilotus officinalis 11.0 (55 gr.); rhizomes with calamus roots 3.0 (15 g.); dandelion root 7.0 (35 gr.); elecampane root 6.0 (30 gr.); lingonberry leaves 9.0 (45 gr.); bearberry leaves 3.0 (15 g.); eucalyptus leaves 3.0 (15 g.); tansy of flowers 2.0 (10 g.); juniper fruit 5.0 (25 gr.); wormwood grass 4.0 (20 gr.); periwinkle of pink grass 6.0 (30 gr.); kidneys of ordinary pine 4.0 (20 gr.); linden flowers 17.0 (85 gr.).

The mixture was ground to a powdery consistency, 2/3 teaspoon of the mixture was brewed in 300 ml of boiling water, insisted for 15 minutes, then the patient took 100 ml 3 times a day after meals for 2 months. After which a month-long break was held, in the future the treatment was repeated,
After the therapy, the condition improved - the yellowness of the skin, pain, bloating disappeared, and the size of the liver decreased.

In the analyzes: Нb 131.1 g / l, red blood cells 4.15 • 10 ¹² / l, white blood cells 4.20 • 10 ⁹ / l, platelets 210.0 • 10 ⁹ / l, ESR 17.0 mm / h, total protein 68.3 g / l, albumin 46.0%, gamma globulins 22.5%, AlAT 1.31 mmol / L, AcAT 1.20 mmol / L, thymol sample 37.1 ALL, sublimate sample 11.65 units, bilirubin 21.0 μmol / L, prothrombin index 75.3%, HBsAg (-), HBV DNA (-). Clinical remission for 10 months.

Example 3
The history of the disease 3226. Patient B.

 Diagnosis: chronic viral hepatitis B with pronounced activity.

 Complains of pain in the right hypochondrium, itching of the skin, yellowness of the skin, bloating.

 Sick for about 3 years. He was twice treated in hospitals.

 Objectively: moderate condition, icteric skin, pulse 72 beats per minute, rhythmic, blood pressure 120 * 70 mm Hg. Art. Heart sounds are muffled, vesicular breathing, the abdomen is soft, swollen, painful in the right hypochondrium, the liver is enlarged, extends 4 cm from the edge of the costal arch, the spleen is not palpated.

In the analyzes: Нb 115.0 g / l, red blood cells 3.6 • 10 ¹² / l, white blood cells 3.9 • 10 ⁹ / l, platelets 171.0 • 10 ⁹ / l, ESR 32.0 mm / h, total protein 61.0 g / l, albumin 38.0%, gamma globulins 25.0%, AlAT 2.0 mmol / l, AcAT 1.94 mmol / l, thymol sample 56.0 ALL, sublimate sample 1.38 units, bilirubin 52 μmol / L, prothrombin index 65.0%, HBsAg (+++), HBV DNA (+).

 Treatment: essentials, riboxin, festal, thymogen, vitamins B1, B6, C - without a significant effect. Subsequently, a collection was added to the therapy, including eleutherococcus of prickly roots 6.0 (30 gr.); lemon balm leaves 11.0 (55 gr.); celandine large grass 3.0 (15 gr.); oregano herb 10.0 (50 gr.); cinquefoil erect roots 7.0 (35 gr.); chamomile officinalis flowers 10.0 (50 gr.); centaury umbrella grass 6.0 (30 g.); thyme ordinary grass 8.0 (40 gr.); barberry ordinary roots 5.0 (25 gr.); calendula flowers 11.0 (55 gr.); immortelle sand flowers 6.0 (30 g.); stigmas of corn 8.0 (40 gr.); Melilotus officinalis 12.0 (60 gr.); rhizome with calamus roots 4.0 (20 gr.); dandelion root 8.0 (40 gr.); elecampane root 7.0 (35 gr.); lingonberry leaves 10.0 (50 gr.); bearberry leaves 4.0 (20 gr.); eucalyptus leaves 4.0 (20 gr.); tansy flowers 3.0 (15 g.); juniper fruit 6.0 (30 g.); wormwood grass 5.0 (25 gr.); periwinkle of pink grass 7.0 (35 gr.); kidneys of ordinary pine 5.0 (25 gr.); linden flowers 18.0 (90 gr.). The mixture was ground to a powdery consistency, 2/3 teaspoon of the mixture was brewed in 300 ml of boiling water, insisted for 15 minutes, then the patient took 100 ml 3 times a day after meals for 2 months. After the methods of collection, a monthly break was held, in the future the course was repeated.

 After the therapy, the condition improved - the pain in the right hypochondrium, itching of the skin, yellowness of the skin, bloating disappeared.

In the analyzes: Нb 134.0 g / l, red blood cells 4.3 • 10 ¹² / l, white blood cells 4.19 • 10 ⁹ / l, platelets 205.0 • 10 ⁹ / l, ESR 17.0 mm / h, total protein 70.0 g / l, albumin 47.5%, gamma globulins 20.0%, AlAT 1.20 mmol / l, AcAT 1.20 mmol / l, thymol sample 36.0 ALL, sublimate sample 1.64 units, bilirubin 22.0 μmol / L, prothrombin index 72.0%, HbsAg (-), HBV DNA (-).

 Clinical remission of 12 months.

Example 4
The history of the disease 23664. Patient D.

 Diagnosis: chronic viral hepatitis B with moderate activity.

 Complains of itchy skin, pain in the right hypochondrium, bloating, increased bleeding.

 Sick 5 years. Repeatedly treated on an outpatient basis and in hospitals. Recently, itching of the skin has intensified, bleeding of the gums has appeared.

 Objectively: satisfactory condition, yellowness of the skin, traces of scratching, pulse of 70 beats per minute, rhythmic, Hell 110/70 mm RT. Art. Heart sounds are muffled, vesicular breathing, the abdomen is swollen, painful in the right hypochondrium, the liver is enlarged, comes out from under the edge of the costal arch by 2 cm, the spleen is not palpated.

In the analyzes: Нb 124.0 g / l, red blood cells 3.6 • 10 ¹² / l, white blood cells 4.05 • 10 ⁹ / l, platelets 172.0 • 10 ⁹ / l, ESR 31.0 mm / h, total protein 62.0 g / l, albumin 41.0%, gamma globulins 24.5%, AlAT 1.75 mmol / l, AcAT 1.75 mmol / l, thymol sample 48.0 ALL, sublimate sample 1.50 units, bilirubin 47.0 μmol / L, prothrombin index 65.0%, HBsAg (+++), HBV DNA (+).

 Treatment: corsil, mesim forte, thiomogen, vitamins B1, B6, C. A significant effect of the therapy has not been established. Subsequently, a collection was added to the treatment, which included eleutherococcus roots 7.0 (35 g.); lemon balm leaves 12.0 (60 gr.); celandine large grass 4.0 (20 gr.); marjoram herb 11.0 (55 gr.); cinquefoil erect roots 8.0 (40 gr.); Chamomile officinalis flowers 11.0 (55 gr.); centaury umbrella grass 7.0 (35 gr.); thyme ordinary grass 9.0 (45 gr.); barberry ordinary roots 6.0 (30 gr.); calendula flowers 12.0 (60 gr.); Helichrysum sand flowers 7.0 (35 gr.); stigmas of corn 9.0 (45 g.); Melilotus officinalis 13.0 (65 gr.); rhizomes with calamus roots 5.0 (25 gr.); elecampane root 9.0 (45 gr.); lingonberry leaves 12.0 (60 gr.); bearberry leaves 5.0 (25 gr.); eucalyptus leaves 5.0 (25 gr.); tansy flowers 4.0 (20 gr.); juniper fruit 7.0 (35 gr.); wormwood grass 6.0 (30 gr.); periwinkle of pink grass 8.0 (40 gr.); kidneys of ordinary pine 6.0 (30 gr.); linden flowers 19.0 (95 gr.). The mixture was ground to a powdery consistency, 2/3 teaspoon of the mixture was brewed in 300 ml of boiling water, insisted for 15 minutes, then the patient took 100 ml 3 times a day after meals for 2 months. After the first course of treatment, a month-long break was carried out, then the course of treatment was repeated.

 After the therapy, the condition improved - itching of the skin, pain in the right hypochondrium, bloating, increased bleeding disappeared.

In the analyzes: Нb 132.0 g / l, red blood cells 4.115 • 10 ¹² / l, white blood cells 4.22 • 10 ⁹ / l, platelets 204.0 • 10 ⁹ / l, ESR 17.5 mm / h, total protein 70 , 0 g / l, albumin 47.0%, gamma globulins 22.04%, AlAT 1.35 mmol / L, AcAT 1.12 mmol / L, thymol sample 37.0 ALL, sublimate sample 1.60 units. , bilirubin 22.5 μmol / L, prothrombin index 75%, HBsAg (-), HBV DNA (-).

 Clinical remission of 12 months.

 Thus, the extracts presented indicate that when taking the proposed collection, a positive effect was obtained in all patients.

 The results of treatment of patients using the proposed collection are presented in table. 1. After the end of treatment, the absence of clinical manifestations, as well as hepatitis B virus, normalization of biochemical parameters, and an increase in the duration of remission were established. Data on the prototype method are presented in table. 2. The advantage of the proposed collection is to reduce the indicators of biochemical activity, clinical manifestations of the disease, elimination of the virus from the patient's body. Remission in the observed patients increased by 2-3 times (prototype method - remission 4 months), according to the claimed method up to 12 months.

Claims (1)

An agent for the treatment of chronic viral hepatitis B, including tansy flowers, chamomile flowers, elecampane root, characterized in that it additionally contains prickly eleutherococcus roots, medicinal lemon balm leaves, celandine grass large, oregano herb, erect cinquefoil, centaury grass umbellate, thyme grass, barberry roots, marigold flowers, immortelle sand flowers, corn stigmas, sweet clover, rhizome with calamus roots, dandelion root, lingonberry leaves, bearberry leaves, eucalyptus leaves, juniper fruits, wormwood grass, pink vinca grass, ordinary pine buds, linden flowers in the following ratio of components, wt. %:
Eleutherococcus prickly, roots - 5-7
Melissa officinalis, leaves - 10-12
Large celandine, grass - 2-4
Oregano officinalis, herb - 9-11
The cinquefoil is erect, roots - 6-8
Chamomile, flowers - 9-11
Umbrella centaury, grass - 5-7
Common thyme, grass - 7-9
Barberry ordinary, roots - 4-6
Calendula, flowers - 10-12
Immortelle sandy, flowers - 5-7
Corn stigmas - 7-9
Melilotus officinalis - 11-13
Air, rhizome with roots - 3-5
Dandelion, root - 7-9
Elecampane, root - 6-8
Lingonberry, leaves - 9-12
Bearberry, leaves - 3-5
Eucalyptus, leaves - 3-5
Tansy, flowers - 2-4
Juniper, fruits - 5-7
Wormwood, grass - 4-6
Periwinkle pink, grass - 6-8
Common pine, kidneys - 4-6
Linden, flowers - 17-19

Images