RU2200000C2 - Preparation for treating diseases of parodontium - Google Patents

Abstract

FIELD: medicine, stomatology. SUBSTANCE: the present preparation for treating diseases of parodontium contains extract of St. John's wort, oily extract of plant raw material, hydroxyethylcellulose, distilled monoglycerides, triethanolamine, the highest fatty alcohols, cosmetic stearin, 1,2-propylene glycol, nipagin, alpha-tocopherol acetate, food aromatizer, soybean oil and purified water. The preparation in question enables to shorten therapy terms and is poorly washed out with saliva. EFFECT: higher efficiency of therapy. 1 cl, 1 tbl

Description

 The invention relates to medicine, in particular medicines in the field of dentistry, and can be used to treat periodontal disease.

 Known substance for the treatment of periodontal disease, containing extracts of herbal medicines (A.I. Marchenko, A.I. Baranyuk. Medicinal plants in dentistry. Chisinau, 1881, p.25-36).

 The disadvantage of these funds is the low treatment effectiveness associated with the one-sided impact on the disease process, and the high duration of treatment.

 There is a method of treating periodontal diseases by prescribing oral baths using extracts of herbal medicines (PI Roshchina, LN Maksimovskaya. Medicines. Dentistry. M., 1989, p. 75-76).

 A disadvantage of the known methods is the low effectiveness of treatment associated with the rapid loss of activity of drugs due to the constant exposure to saliva and a significant duration of treatment.

 The purpose of the invention: to increase efficiency and reduce the duration of treatment.

The goal is achieved by the fact that produce a substance containing an aqueous extract of herbal preparations, and its composition includes (in percent):
Herbal oil extract (1:10) - 0.50-1.00
Hypericum hypericum extract (1:10) - 8.00-10.00
Hydroxyethyl cellulose - 1.00-2.00
Triethanolamine - 0.04-0.05
1,2-propylene glycol - 1.00-2.00
Nipagin - 0.20-0.30
Distilled monoglycerides - 0.40-0.50
Higher fatty alcohols - 0.40-0.50
Cosmetic stearin - 0.50-1.00
Alpha-Tocopherol Acetate - 0.10-0.20
Food flavoring - 0.40-0.50
Soybean Oil - 3.00-4.00
Purified water - Up to 100
and for the treatment of periodontal disease, it is placed in the affected area, and is separated from the effects of saliva, for example, by placing in an individually made mouthguard.

The substance is made as follows. In a 90 ml volume of St. John's wort aqueous extract (1: 10), 1 ml of an oil extract of a medicinal plant material (1:10), 2 ml of hydroxyethyl cellulose, 0.5 ml of triethanolamine, 2 ml of 1,2-propylene glycol, 0.3 ml of nipagin are added, 0.5 ml of monoglycerides, 0.5 ml of higher fatty alcohols, up to 1 ml of cosmetic stearin, 0.2 ml of alpha-tocopherol acetate, 0.5 ml of food flavoring, 3 ml of soybean oil and mix thoroughly until smooth and placed inside container temperature 8 ^o C. Prior to use in a container of the substance obtained was added 867 ml of eyes ennoy water. The resulting mixture is thoroughly mixed until a homogeneous mass and packaged.

 In the treatment of periodontal disease, the substance is placed in an individual mouthguard, which is located in the affected area.

 The prevalence of periodontal disease (see table 1.2). Epidemiological studies of schoolchildren in Italy aged 8 to 12 years showed the presence of periodontal lesions in 97% (I. Angelo, G. Cjssard, 1971). According to K. Jacson (1975), Murrau J. (1974) in England and the United States under the age of 17 years, gingivitis occurs in 36-90% of cases. B. Kowalski (1974) and A. Semeruk-Mazurkewier (1974) found gingivitis in 30.42 and 65% of students in Poland, respectively. In the USA, 60% of adolescents suffer from periodontal disease (Green G., 1972). N. Miihlemann and A. Masor, having examined more than 1000 Zurich schoolchildren aged 7 to 17 years, found inflammatory changes in the gums in 80%.

 Patient I., 42 years old (control group) - (see table 3).

 Diagnosis: chronic generalized periodontitis of moderate severity.

 In the process of treatment, a circular flap operation on the upper and lower jaw was performed with gingivoplasty, as well as the introduction of hydroxylapatite and honsuride into the bone pockets.

 In the postoperative period, the oral cavity was irrigated with chamomile solutions 3 times a day for 10 days, and oral baths with chamomile solutions 3 times a day for 10 days.

Recommended by:
- 2 times a day (in the morning - after breakfast, in the evening - at bedtime), brush your teeth with a toothbrush and toothpaste for 5 minutes;
- repeat oral irrigation with the same solution, as well as conduct oral baths;
- after each meal, rinse your mouth actively for 3 minutes.

1 month after treatment:
- Schiller-Pisarev test - weakly positive;
- hygiene index - 2 points;
- Kulazhenko test - 30 seconds;
- RMA index - 2 points;
- bleeding index - 0.1.

6 months after treatment:
- Schiller-Pisarev test - weakly positive;
- hygiene index - 3 points;
- Kulazhenko test - 25 seconds;
- RMA index - 3 points;
- bleeding index - 0.1.

12 months after surgery:
- Schiller-Pisarev test - weakly positive;
- hygiene index - 3 points;
- Kulazhenko test - 22 seconds;
- RMA index - 3 points;
- bleeding index - 0.1.

 Patient U., 44 years old (experimental group) - (Table 4).

 Diagnosis: chronic generalized periodontitis of moderate severity.

 In the process of treatment, a circular flap operation on the upper and lower jaw was performed with gingivoplasty, as well as the introduction of hydroxylapatite and honsuride into the bone pockets.

In the postoperative period, an application was carried out containing an aqueous extract of herbal preparations, and its composition included (in percent):
Herbal oil extract (1:10) - 0.50-1.00
Hypericum hypericum extract (1:10) - 8.00-10.00
Hydroxyethyl cellulose - 1.00-2.00
Triethanolamine - 0.04-0.05
1,2-propylene glycol - 1.00-2.00
Nipagin - 0.20-0.30
Distilled monoglycerides - 0.40-0.50
Higher fatty alcohols - 0.40-0.50
Cosmetic stearin - 0.50-1.00
Alpha-Tocopherol Acetate - 0.10-0.20
Food flavoring - 0.40-0.50
Soybean Oil - 3.00-4.00
Purified water - Up to 100
and for the treatment of periodontal disease, it was placed in the affected area, and was separated from the effects of saliva by placement in an individually made mouthguard. This manipulation was performed twice within 7 days.

Recommended by:
- 2 times a day (in the morning - after breakfast; in the evening - before bedtime), brush your teeth with a toothbrush and toothpaste for 5 minutes;
- Once a month for 7 days, using an individual mouthguard, repeat applications at home;
- after each meal, rinse your mouth actively for 3 minutes.

1 month after treatment:
- Schiller-Pisarev test is negative;
- hygiene index - 1 point;
- Kulazhenko test - 35 seconds;
- RMA index - 0 points;
- bleeding index - 0.

6 months after treatment:
- Schiller-Pisarev test is negative;
- hygiene index - 1 point;
- Kulazhenko test - 40 seconds;
- RMA index - 0 points;
- bleeding index - 0.

12 months after surgery:
- Schiller-Pisarev test is negative;
- hygiene index - 2 points;
- Kulazhenko test - 42 seconds;
- RMA index - 1 point;
- bleeding index - 0.

 Based on the results of these clinical examples, it follows that it is possible to improve efficiency and reduce treatment time by using the above composition of herbal preparations for application by placing it in an individually made mouthguard.

Claims (1)

An agent for the treatment of periodontal diseases, containing St. John's wort extract, characterized in that it includes oil extract of plant materials, hydroxyethyl cellulose, distilled monoglycerides, triethanolamine, higher fatty alcohols, cosmetic stearin, 1,2-propylene glycol, nipagin, alpha-tocopherol acetate food flavoring, soybean oil, purified water at the following content of components, wt. %:
Vegetable oil extract (1: 10) - 0.50 - 1.00
Hypericum hypericum extract (1: 10) - 8.00 - 10.00
Hydroxyethyl cellulose - 1.00 - 2.00
Distilled monoglycerides - 0.40 - 0.50
Triethanolamine - 0.04 - 0.05
Higher fatty alcohols - 0.40 - 0.50
Cosmetic stearin - 0.50 - 1.00
1,2-Propylene glycol - 1.00 - 2.00
Nipagin - 0.20 - 0.30
Alpha-Tocopherol Acetate - 0.10 - 0.20
Food flavoring - 0.40 - 0.50
Soybean Oil - 3.00 - 4.00
Purified water - Up to 100

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