RU2208433C1 - Composite for mouth cavity disease prophylaxis - Google Patents

Abstract

FIELD: medicine, stomatology. SUBSTANCE: invention relates to prophylaxis of mouth cavity diseases. The composition for prophylaxis of mouth cavity diseases comprising sodium carboxymethylcellulose, sorbitol or glycerol, silicon dioxide, sodium lauryl sulfate, titanium dioxide, vaseline oil, sodium saccharinate, food dye, perfume and water involves additionally nettle extract, homeopathic additives (Arurum-C and Apior), calcium glycerophosphate and polyvinylpyrrlidone. The composite shows an antioxidant, remineralizing, antihemorrhagic, anti- -inflammatory effect, improves metabolic processes and microcirculation in parodontium tissues. EFFECT: enhanced and valuable medicinal properties of composite. 4 tbl, 3 ex

Description

 The invention relates to medicine, namely to dentistry.

 Known compositions for the prevention of diseases of the oral cavity in the form of toothpastes, elixirs, rinses containing fluorides, plant extracts, minerals, flavors, perfumes and water, such as toothpastes "Parodontol", "Phosphodent", "Komilfo" and others, and also dental elixirs and rinses "Elam", "Spring", "Polion Mirta" and others (Fedorov Yu. A., 1984, Fedorov Yu.A. et al., 1997, 2000).

 Parodontol toothpaste is produced (RF patent 2131723, BI 17, 1999), which contains silicon dioxide, hydroxyapatite, yarrow and nettle extracts, glycerin, sorbitol, titanium dioxide, sodium benzoate, carboxymethyl cellulose, sodium lauryl sulfate, aromatic composition and water.

 The aim of this development is to create a composition for the prevention of oral diseases in the form of toothpaste, which significantly improves tooth cleaning, mineralization, increases enamel and gum resistance, stimulates the healing and trophic processes of periodontal tissues and oral mucosa, prevents an allergic reaction, and for enhancing the therapeutic and adaptive action, its prolongation and potentiation, homeopathic supplements are introduced into the composition.

 This development is based on many years of research on the effect of natural biologically active substances on the tissues of the oral cavity (Drozhzhina V.A., 1995; Fedorov Yu.A. et al., 1997, 2000) and homeopathic medicines (Kovalenko T.V. et al., 1997).

 The developed composition contains homeopathic additives: Aurum-S and Apior (Aquior), concentrated nettle extract, calcium glycerophosphate, sorbitol (glycerin), silicon dioxide, sodium carboxymethyl cellulose, sodium lauryl sulfate, titanium dioxide, polyvinylpyrrolidone, sodium benzoate, sodium benzoate, food coloring, perfume and drinking water.

 The difference from the known prototype is the introduction into the proposed composition of a concentrated extract of nettle and calcium glycerophosphate in combination with homeopathic preparations Aurum-S and Apior (Aquior), which in combination provides a higher and prolonged therapeutic and prophylactic effect, potentiates the effect of other components on the oral tissue composition, and also improves adaptogenic perception of the proposed composition.

 Nettle extract contains active natural antioxidants (ascorbic acid, carotenoids, chlorophyll, some trace elements), vitamin K, pantothenic acid, sitosterol, histamine, violaxanthin. This whole complex provides antioxidant, anti-inflammatory, hemostatic effect.

 Calcium glycerophosphate is a source of active intake of phosphorus and calcium in the teeth and periodontal tissues, which accelerates the mineralization processes and increases the anti-carious effect of the composition. In addition, it enhances the anabolic processes in the tissues, which is important for the prevention of dental diseases.

 Homeopathic preparations Aurum-S and Apior (Aquior) contain vital macro- and microelements from natural raw materials in biological micro quantities (calcium, fluorine, magnesium, chromium, etc.) that are easily used by body tissues (T. Kovalenko et al., 1997 )

Homeopathic components Aurum-S and Apior (Aquior) due to potentiation by repeated dilution and structuring of the composition have the following effect:
a) antioxidant due to the activation of the protective systems of the body, including the restoration of glutathione and the increased effect of ascorbic acid;
b) anti-stress due to the beneficial effect on the antioxidant defense system and trophic tissue of the oral cavity;
c) adaptogenic and tonic by protecting against adverse environmental factors or reducing their influence, improving the body's adaptation to adverse effects.

 Along with this, the indicated action of homeopathic components is due to the special technology for preparing the composition.

 High molecular weight polyvinylpyrrolidone actively promotes the dissolution of the protein-lipid base of dental plaque, providing a significant improvement in dental cleaning, and therefore the elimination of plaque toxins and microflora. Along with this, polyvinylpyrrolidone promotes the penetration of biologically active substances and calcium preparations through the oral mucosa and tooth tissue, which improves trophism of periodontal tissues and mineralization of teeth, and generally increases the preventive effect.

 Sorbitol has a bacteriostatic effect, inhibits the growth of periodontal plaque, inhibits the metabolism of streptococci, helping to increase the pH of saliva, thereby creating favorable conditions for the mineralization of tooth enamel.

 Therefore, a highly effective composition has been created for the prevention of diseases of the teeth and soft tissues of the oral cavity, in which synergistic drugs enhance and prolong the action of each other.

Thus, the goal was achieved by the fact that the proposed composition for the prevention of diseases of the oral cavity, containing silicon dioxide, sodium carboxymethyl cellulose, sorbitol or glycerin, sodium lauryl sulfate, titanium dioxide, liquid paraffin, sodium benzoate, sodium saccharin, dye, perfume and water, additionally included nettle extract, calcium glycerophosphate, homeopathic supplements: Aurum-S and Apior, as well as high molecular weight polyvinylpyrrolidone, was realized in the following components, wt.%:
Silicon dioxide (TU 6-00-0204868-6-91) - 14.0-30.0
Sorbitol (FS 42-2660-99) or glycerin (GOST 6824-96) - 14.0-35.0
Sodium carboxymethyl cellulose (TU 6-55-3 8-90) - 1.0-1.5
Sodium lauryl sulfate (TU 6-01-7-89) - 1.2-2.0
Calcium glycerophosphate (FS 42-1809-96) - 0.5-1.0
Nettle extract (TU 9154-002-45581000-97) - 0.3-2.0
Aurum-S (TU 20815276-08-00) - 0.01-0.02
Apior (Aquior) (TU 20815276-06-00) - 0.01-0.02
Titanium dioxide (GOST 9808-84) - 0.1-1.0
Polyvinylpyrrolidone (TU 9365-007-23107887-96) - 0.1-0.5
Vaseline oil (GOST 3164-78) - 0.1-0.5
Sodium benzoate (FS 42-2458-94) - 0.3-0.5
Sodium saccharinate ("Productos aditivos", Spain) - 0.1-0.3
Dye - 0.0005-0.01
Fragrance - 0.5-1.5
Drinking water (SanPiN 2.1.4.1074-2001) - Up to 100.0%
Prepared composition in the form of toothpaste as follows. The manufacturing technology of the composition in the form of toothpaste consists of several stages: preparing a potentiated, structured composition, preparing a solution of Na-CMC and preparing a paste.

 A potentiated, structured solution is prepared by dissolving in four liters of water a quarter of the total dosage (in wt.% Based on 100 ml) of calcium glycerophosphate and nettle extract. Then, Aurum-S and Apior (Aquior) are added to the resulting solution with constant vigorous shaking until complete dissolution at the rate of 0.01-0.02 wt.%.

 After the homeopathic preparations are completely dissolved, add water to half the total composition and proceed to the next step.

 Preparation of Na-CMC solution. With constant stirring, Na-CMC is added in portions of the obtained potentiated and structured solution, stirred for 3 hours at room temperature, then the remaining water is added in two doses with an interval of 1 hour. The resulting mass is stirred for another 3 hours until a homogeneous viscous solution is formed, which is maintained at room temperature for a day.

 Cooking pasta. The remaining solution, with constant stirring, in portions, add the remaining three quarters of the extract of nettle and calcium glycerophosphate, glycerin, sorbitol, paraffin oil, silicon dioxide, surfactants (sodium lauryl sulfate), antiseptic preservative, polyvinylpyrrolidone. For greater ductility, the composition is passed through a dispersant mill. The entire process of preparing the composition is recommended to be carried out within an hour. The finished composition is packaged in metal or plastic tubes.

 We give examples of the implementation of the formulation.

 In accordance with the method of preparing the composition in the form of toothpaste in example 1 presents the maximum dosage of the components.

 In example 2, the composition in the form of a toothpaste is prepared in the same way as in example 1, but the components are taken in the optimal (median) ratio.

 Example 3 shows data on the preparation of a toothpaste composition with a minimum content of components (Table 1).

Use the composition as follows:
1) For daily double brushing for 3-3.5 minutes.

 2) For applications on the teeth of the composition within 10-12 minutes 2-3 times a week and auto-massage of the gums for 3-4 minutes in courses of 10-12 days in a row every 2-3 months.

 The proposed composition was used to prevent and treat hyperesthesia of teeth and periodontal diseases in 21 patients, in which it was possible to trace and evaluate the mineralization processes of enamel and the state of periodontal tissues in dynamics for 3-6 months. Observations were carried out, determining the prevalence indices (IRHI) and intensity (IIHI) of hyperesthesia of the teeth, indicators of hygiene indices, PMA, and Schiller-Pisarev tests, and also studied personal data on the sensations of patients in the oral cavity as a whole after applying toothpastes directly and in the long term using the methods of Ch.D. Spielberger, J. Theulore, G. Eysenck (Marischuk V.L. et al., 1984).

 Indicators of diseases of the teeth and periodontium in the studied population are given in the dynamics in table. 2, 3.

 From the data given in table. 2, it follows that the indices of hygiene, prevalence and intensity of hyperesthesia of the teeth are clearly changing, indicating an improvement in the mineralization of the teeth. The difference is significant (P <0.05).

 Along with this, the observed people showed a significant improvement in periodontal status for all objective indicators (PMA index and Schiller-Pisarev test, which are presented in Table 3 (P <0.01).

 At the same time, the majority of the examined according to the questionnaire revealed a feeling of comfort and peace, and in the oral cavity a sensation of polishing of the teeth and elasticity of the gums, which is explained by the prolonged action of structured homeopathic preparations (Table 4).

 We give examples of the use of the new composition in medical practice.

 Example 1. Patient P., 28 years old, first came on 24.01.2002 with complaints of bleeding gums when brushing, hyperemia, swelling, sore gums, bad breath, hyperesthesia of the teeth, she used Blendamed toothpaste rather unsuccessfully. Diagnosis: chronic catarrhal gingivitis, dentin hyperesthesia. Objective research results: hygiene index 2.8 points, Schiller-Pisarev test sharply positive, PMA index 30.0%. The prevalence of hyperesthesia (IRHI) is 59.8%, its intensity (IIHI) is 2.2 points.

 After removing the dental plaque, the traditionally accepted treatment of periodontal tissues was carried out (rinsing with a solution of hydrogen peroxide, potassium permanganate) and a new composition for brushing and self-massage of the gums, as well as for applications on the teeth, was prescribed for double daily use.

 When viewed after 30 days of using the new composition, the patient showed almost no complaints, noted an almost complete disappearance of bleeding and inflammation in the gums, swelling, bad breath and hyperemia disappeared, tooth hyperesthesia significantly decreased. The hygiene index was 1.75 points, the Schiller-Pisarev test was slightly negative. After 60 days of observation, the signs of the therapeutic and prophylactic effect of the new composition became more pronounced: there were no complaints, the hygiene index was 1.7 points, the PMA index dropped to 14.8%, the Schiller-Pisarev test was negative. Dentin hyperesthesia has almost disappeared. Its prevalence was only 9.9%, the intensity of 1.15 points. The patient noted a feeling of comfort in the oral cavity.

 Example 2. Patient M., 25 years old, first came on 04.02.2002 with complaints of frequent bleeding of the gums, its soreness, swelling, hyperemia, itching, and tooth sensitivity. Diagnosis: diffuse chronic catarrhal gingivitis complicated by dentin hyperesthesia. Objectively: hygiene index 2.9 points, PMA index 36.2%, Schiller-Pisarev test positive. The prevalence of dental hyperesthesia (IHRH) was 58.6%, its intensity (IIHI) 2.2 points.

 After removing dental plaque and the generally accepted antiseptic treatment of periodontal tissues, the patient was prescribed a new composition for daily brushing and gum self-massage, as well as 30 tooth sessions on his teeth.

 After 35 days of its use, the patient felt a significant improvement: she noted a decrease in bleeding, hyperemia and gum inflammation, and dentin hyperesthesia decreased. The hygiene index fell to 1.65 points, the Schiller-Pisarev test was weakly positive.

 After 65 days of applying the new composition, signs of improvement in periodontal conditions became more pronounced: the hygiene index improved - 1.52 points, no qualitative signs of inflammation were detected - the Schiller-Pisarev test was negative, the PMA index decreased to 9.2%. Hyperesthesia of dentin disappeared completely. The patient noted a feeling of comfort, polished teeth and elasticity of the gums after brushing and even outside.

 Example 3. Patient Z., 35 years old, first came on February 28, 2002 with complaints about the sensitivity of the necks of most teeth, bleeding of the gums when brushing, and their swelling, their periodic inflammation.

 Survey results: hygiene index 3.1 points, Schiller-Pisarev test sharply positive, PMA index 38.6%, IRGZ 52.8%, IIHZ 2.3 points.

 The oral hygiene, the generally accepted antiseptic treatment of the oral cavity, and the removal of dental plaque were given. Appointed for daily brushing and applications for teeth a new composition.

 After 35 days of its use, a significant improvement was noted: the hygiene index was 1.82 points, the PMA index was 22.3%, tooth hyperesthesia decreased.

 At the follow-up after 2 months the patient did not complain, hygiene index 1.5 points, RMA index 12.3%, IHRH 12.5%, IHRH 1.2 points. A sense of comfort and elasticity of the gums was noted.

 Thus, the use of the proposed composition for the prevention of diseases of the oral cavity has improved the cleaning and mineralization of the teeth, eliminate or reduce dentin hyperesthesia, as evidenced by the indices of the IHRH, IIHC, RMA, hygiene, as well as eliminate or significantly reduce inflammation in the gum, including bleeding, as evidenced by the dynamics of hygiene indices, PMA and Schiller-Pisarev tests.

 Along with this, in 70-85% of patients according to the questionnaire, the appearance of a feeling of comfort, vigor, elasticity of the gums was revealed, which indicates the effect of homeopathic preparations on the tissues of the oral cavity.

 The above allows us to recommend a new composition for the prevention of diseases of the oral cavity.

Sources of information
1. Drozhzhina V.A. Natural biologically active substances in the prevention and treatment of diseases of the teeth and periodontium: Abstract dis. doctors honey. sciences. - St. Petersburg, 1995 .-- 33 p.

 2. Kovalenko T.V., Pokhis K.A., Sergeeva K.M. and other Methodological approaches to the creation of an environmental health program for children (Textbook). - SPb .: AOZT "Victorita", 1997. - 133 p.

 3. Marishchuk V. L. et al. Psychodiagnostics techniques in sports. Tutorial. - M .: Education, 1984. - 191 p.

 4. Nash E.B. Leading symptoms in homeopathy. - Kharkov: Education of the LDC, 1993. - 223 p.

 5. Fedorov Yu.A. Hygiene products for oral care. - L .: Medicine, 1984. - 96 p.

 6. Fedorov Yu.A., Drozhzhina V.A., Rybakova M.G. New data on the mechanism of influence of natural biologically active substances on periodontal tissues // New in dentistry, - 1997. - 4. - P. 8-18.

 7. Fedorov Yu.A., Drozhzhina V.A., Blokhin V.P. et al. Dental elixirs and rinses in the prevention and treatment of periodontal diseases // New in dentistry.-2000. - 7. - S. 55-64.

Claims (1)

Composition for the prevention of oral diseases in the form of a toothpaste containing polyvinylpyrrolidone, sodium carboxymethyl cellulose, sorbitol or glycerin, silicon dioxide, sodium lauryl sulfate, titanium dioxide, liquid paraffin, sodium saccharinate, food coloring, perfume and water, and as an antiseptic preservative sodium, characterized in that it additionally contains nettle extract, calcium glycerophosphate and homeopathic components Aurum-S and Apior (Aquior) in the following proportions, wt.%:
Nettle extract - 0.3-2.0
Calcium Glycerophosphate - 0.5-1.0
Aurum-S - 0.01-0.02
Apior (Aquior) - 0.01-0.02
Polyvinylpyrrolidone - 0.1-0.5
Sorbitol or glycerin - 14.0-35.0
Sodium carboxymethyl cellulose - 1.0-1.5
Silicon Dioxide - 14.0-30.0
Sodium lauryl sulfate - 1.2-2.0
Titanium Dioxide - 0.1-1.0
Vaseline oil - 0.1-0.5
Sodium benzoate - 0.3-0.5
Sodium saccharinate - 0.1-0.3
Food coloring - 0.0005-0.01
Fragrance - 0.5-1.5
Drinking water - Up to 100.0a

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