RU2204990C1 - Dental disease and parodontium prophylaxis composition - Google Patents

Abstract

FIELD: medicine, in particular, dentistry. SUBSTANCE: composition comprises sodium fluoride or sodium monofluorophosphate, sodium laurylsulfate, sodium carboxy-methyl cellulose, titanium dioxide, food grade dye, vaseline oil, fragrant, water, and additionally comprises laminaria extract, pantenole, calcium glycerophosphate, polyvinyl pyrrolidone. EFFECT: increased efficiency by improved antioxidizing, remineralizing, antiphlogistic, curing and antiallergic action. 3 tbl

Description

 The invention relates to medicine, namely to dentistry. Known compositions for the prevention of dental caries and periodontal diseases in the form of toothpastes, elixirs, rinses containing fluorides, herbal extracts, minerals, perfumes and water, such as toothpastes "Fluorodent", "Comme il faut", "Parodontol", "Phosphodent" , dental elixirs and rinses "Elam", "Spring", "Polion Mirta" and others (Fedorov Yu.A., 1984; Fedorov Yu.A. et al., 1997, 2000).

 Comilfo toothpaste is produced (RF patent 2141815, BI, 1999, 33), which contains silicon dioxide, glycerin, carboxymethyl cellulose, sodium bicarbonate, sodium lauryl sulfate, sodium fluoride, titanium dioxide, sodium benzoate, carbamide, calcium glycerophosphate, saccharin, composition and water.

 The aim of this development is to create a composition for the prevention of diseases of teeth and periodontal tissues in the form of toothpaste, which significantly and more effectively improves tooth cleaning, mineralization, increases the resistance of enamel and periodontal tissues by stimulating the healing processes, trophism and microcirculation of periodontal tissues, prevents allergic reaction, which generally provides a good therapeutic effect.

 The creation of the proposed composition in the form of toothpaste is based on many years of research on the effect of natural biologically active substances on the tissues of the oral cavity (Drozhzhina V.A., 1995; Fedorov Yu.A. et al., 1997, 2000).

 The proposed composition contains an extract of kelp, sodium fluoride or sodium monofluorophosphate, calcium glycerophosphate, panthenol, polyvinylpyrrolidone, sorbitol or glycerin, silicon dioxide, sodium lauryl sulfate, sodium carboxymethyl cellulose, titanium dioxide, vaseline oil, sodium saccharinate, sodium saccharinate, sodium saccharinate, sodium saccharinate drinking water.

 The difference from the known prototype is the introduction to the proposed composition of the extract of kelp in combination with panthenol, calcium glycerophosphate, sodium fluoride or sodium monofluorophosphate and polyvinylpyrrolidone, which in combination provides a higher and more reliable therapeutic and prophylactic and good cleansing effect.

 Laminaria extract contains a complex of essential microelements (titanium, nickel, copper, silver, zinc, iron, etc.), macroelements (phosphorus, calcium, magnesium, etc.), all amino acids, including essential ones, chlorophyll, carotenoids, vitamins and other useful biologically active substances .

 In general, the composition of the kelp extract provides anti-inflammatory, mineralizing, antiseptic, anti-allergic, astringent, healing effect, improves trophic tissue of the oral cavity.

Panthenol (provitamin B ₅ ) is a component of coenzyme A, participates in the processes of acetylation and oxidation of carbohydrates and fats, the synthesis of fatty acids and steroids from carbohydrates, in the implementation of glycolysis bonds, Krebs cycle and fat oxidation. It belongs to amido alcohols, has pantothenic acid activity. It has a healing, anti-inflammatory effect, stimulates metabolic processes in the tissues of the oral cavity. The combination of kelp extract and panthenol creates a special preventive effect.

 Sodium fluoride (sodium monofluorophosphate) is known as an anticariogenic drug, which has the greatest effect in children under 14-15 years of age, that is, during enamel maturation and bite changes. It was introduced into the formulation in order to improve the mineralization of tooth tissues by macro- and microelements that are part of and coming from saliva, which increases the therapeutic effect of the composition as a whole.

 Calcium glycerophosphate is the drug that most easily penetrates the mineralized tissues and especially the teeth. Therefore, it is the main source of calcium and phosphorus for teeth and periodontal tissues, enhancing the mineralization processes and increasing the anticariogenic effect of the composition as a whole.

 Sorbitol has a bacteriostatic effect, inhibits the growth of periodontal plaque, inhibits the metabolism of streptococci, contributes to a certain increase in the pH of saliva, thereby creating favorable conditions for remineralization of tooth enamel.

 High molecular weight polyvinylpyrrolidone actively dissolves the protein-lipid base of dental plaque, that is, it provides a significant improvement in dental cleaning and, therefore, eliminates toxins, microflora and other negative components of plaque. In addition, good toothbrushing helps to increase the level of mineralization of enamel. Along with this, polyvinylpyrrolidone helps the penetration of natural biologically active substances and other active components of the composition into the teeth, as well as through the mucous membrane of the oral cavity into periodontal tissues, which improves trophism, has an antioxidant effect, increasing the preventive effect of this composition.

 This made it possible, on the whole, to create a highly effective composition for the prevention of diseases of the teeth and soft tissues of the oral cavity, in which synergistic drugs enhanced each other's action.

Thus, the goal was achieved in that the proposed composition in the form of a toothpaste for the prevention of teeth and oral tissues, containing silicon dioxide, sorbitol or glycerin, sodium carboxymethyl cellulose, sodium lauryl sulfate, titanium dioxide, liquid paraffin, preservative preservatives: sodium benzoate and thymol, sodium saccharinate, perfume, drinking water, food colors, additionally included kelp extract in combination with panthenol, sodium fluoride or sodium monofluorophosphate, calcium glycerophosphate, polyvinylp rrolidonom implemented in the following components (wt.%):
Silicon dioxide (TU 6-00-0204868-6-91) - 14.0-30.0
Sorbitol (FS 42-2660-99) or glycerin (GOST 6824-96) - 14.0-35.0
Sodium carboxymethyl cellulose (TU 6-55-38-90) - 1.0-1.5
Sodium lauryl sulfate (TU 6-01-7-89) - 1.2-2.0
Calcium glycerophosphate (FS 42-1809-96) - 0.5-1.0
Laminaria extract (TU 9154-002-45581000-97) - 0.3-2.0
Panthenol ("Zohar", Israel) - 0.02-0.1
Sodium fluoride (GOST 4463-76) - 0.22-0.25
or sodium monofluorophosphate ("VK Guilini Chemie", Germany), - 0.70-0.80
Titanium dioxide (GOST 9808-84) - 0.1-1.0
Polyvinylpyrrolidone (TU 9365-007-23107887-96) - 0.1-0.5
Vaseline oil (GOST 3164-78) - 0.1-0.5
Sodium benzoate (FS 42-2458-94) - 0.2-0.4
Thymol (FS 42-1010-75) - 0.001-0.1
Sodium saccharinate ("Productos aditivos", Spain) - 0.1-0.3
Dye - 0.0005-0.01
Fragrance - 1.0-1.5
Drinking water (SanPiN 2.1.4.559-96) - Up to 100.0%
Prepared composition in the form of toothpaste as follows.

 The manufacturing technology of the composition in the form of toothpaste consists of two stages: preparation of a Na-CMC solution and preparation of a paste.

 Preparation of Na-CMC solution.

 With half the amount of water required by the recipe, Na-CMC is added in portions with constant stirring, stirred for 3 hours at room temperature, then the remaining water is added in two doses at intervals of 1 hour. The resulting mass is stirred for another 3 hours until a homogeneous viscous solution is formed, which is maintained at room temperature for a day.

Cooking composition
Sorbitol (glycerin), liquid paraffin, silicon dioxide, surfactants (sodium lauryl sulfate), preservative antiseptics, sodium saccharin, polyvinylpyrrolidone and biologically active substances: kelp extract are added to the prepared Na-CMC solution with constant stirring in portions in a certain sequence; panthenol, calcium glycerophosphate, sodium fluoride (sodium monofluorophosphate). For greater ductility, the composition is passed through a dispersant mill. The entire process of preparing the composition is recommended to be carried out within an hour. The finished composition is packaged in metal or plastic tubes.

 We give examples of the implementation of the formulation.

 In accordance with the method of preparing the composition in the form of toothpaste in example 1 presents the maximum dosage of the components.

 In example 2, the composition in the form of a toothpaste is prepared in the same way as in example 1, but the components are taken in the optimal (median) ratio.

 Example 3 shows data on the preparation of the composition in the form of a toothpaste with a minimum content of components (table. 1).

Use the composition in two ways:
1. For daily double brushing of teeth with a new composition for 3-3.5 minutes for 2-3 months.

 2. For applications of the new composition on the teeth and gums for 7-8 minutes with auto-massage of the gums, courses of 10-12 days in a row, on average one course every 3 months.

 The proposed composition in the form of toothpaste was used for the prevention and treatment of hyperesthesia and dental caries, as well as periodontal diseases in 20 patients, in whom the process of mineralization of the teeth and the periodontal condition were monitored and evaluated over a period of 2-6 months.

 The observations were carried out, determining the prevalence indices (IRHI) and dental hyperesthesia intensity (IIHI), the indices of hygiene indices, PMA and Schiller-Pisarev tests.

 Indicators of diseases of the teeth and periodontium in the studied population are given in the dynamics in table. 2, 3.

 From the data given in table. 2, it follows that indicators are clearly changing, indicating an improvement in the mineralization of tooth enamel: hygiene indices, prevalence and intensity of dentin hyperesthesia. The difference is significant (P <0.05).

 Along with this, the observed group of people showed an improvement in the condition of periodontal tissues in all objective indicators (hygiene indices, PMA and Schiller-Pisarev samples), which are given in table. 3. The difference is significant (P <0.01).

 We give examples of the use of the new composition in medical practice.

 Example 1. Gr. X., 34 years old, turned 22.02.2001, suffers from diffuse chronic catarrhal gingivitis, complaints of bleeding during brushing, hyperemia, sharp hyperesthesia of the teeth, spontaneous soreness of the gums, bad breath, I used Extra toothpaste unsuccessfully. Objective research results: hygiene index - 2.8 points, Schiller-Pisarev test is sharply positive, PMA index - 39.6%, IRGZ - 48.6%, IIHZ - 2.5 points.

 After removing the dental plaque, the traditionally accepted treatment of periodontal tissues was performed (rinsing with a solution of hydrogen peroxide, potassium permanganate) and a new composition for brushing your teeth and self-massage of the gums with the optimal concentration of components was prescribed for double daily use.

 After 30 days of using the new composition, the patient did not complain, noted the almost complete disappearance of bleeding and inflammation in the gums, swelling, bad breath and hyperemia disappeared, hyperesthesia decreased. The hygiene index was 1.7 points, the Schiller-Pisarev test was weakly positive, the IRGZ - 32.5%, the IIGZ - 1.7 points.

 After 64 days of observation, the signs of the therapeutic and prophylactic effect of the new composition became more pronounced: there were no complaints, the hygiene index was 1.4 points, the PMA index decreased to 8.7%, the Schiller-Pisarev test was negative, tooth hyperesthesia disappeared, IRGZ -17, 6%, IIHZ - 1.2 points.

 Example 2. Gr. N., 26 years old, first complained on March 25, 2001 with complaints of frequent bleeding of the gums, her pain, swelling, hyperemia, itching, severe hyperesthesia of the teeth. Diagnosis: diffuse catarrhal gingivitis. Objectively: the hygiene index is 3.1 points, the PMA index is 38.7%, the Schiller-Pisarev test is positive, the IRGZ is 62.4%, the IIHZ is 2.3 points.

 After removing dental plaque and antiseptic, generally accepted treatment of periodontal tissues, the patient was prescribed brushing and self-massage of the gums with a new composition with a minimum content of biologically active components. After 30 days of its use, the patient felt a significant improvement: she noted a decrease in bleeding and inflammation of the gums, the hygiene index decreased to 1.6 points, the Schiller-Pisarev test was weakly positive, decreased hyperesthesia of the teeth, IRGZ - 52.6%, IIHZ - 1.6 point.

 After 65 days of applying the new composition, signs of improvement in periodontal conditions became more pronounced: the hygiene index improved (1.5 points), qualitative signs of inflammation were not detected (negative Schiller-Pisarev test), the PMA index decreased to 17.8%, dentine hyperesthesia disappeared, IRGZ - 14.2%, IIGZ - 1.4 points.

 Example 3. Gr. K., 40 years old, examined for the first time on February 26, 2001. Complaints about the pronounced sensitivity of the necks of most teeth, frequent bleeding, swelling and frequent inflammation of the gums. Objectively: the hygiene index is 3.5 points, the Schiller-Pisarev test is positive, the PMA index is 39.6%, IHRH - 62.4%, IIHZ - 2.8 points.

 After removing dental deposits and standard treatment of periodontal tissues with antiseptics, it is recommended to use a new composition with a median content of components for daily brushing for 3-3.5 minutes and its applications on the teeth and gums (10-12 procedures) for 7-10 minutes.

 After 35 days, improvement was noted. Significantly decreased bleeding and swelling of the gums, as well as tooth sensitivity: hygiene index - 2.3 points, Schiller-Pisarev test - slightly positive, PMA index - 21.8%, IRGZ - 32.6%, IIHP - 1.7 points.

 When examined after 66 days, bleeding and swelling of the gums completely disappeared, dental hyperesthesia was practically absent: hygiene index -1.5 points, Schiller-Pisarev test - negative, PMA index - 11.4%, IRGZ - 15.2%, IIHZ - 1 , 3 points.

 Thus, the above examples testify to the positive effect of the new therapeutic and prophylactic composition, and with an optimal and median ratio of the components, the results of using a new toothpaste were better. Using it for the prevention of dental and periodontal diseases has improved the cleaning and mineralization, eliminated or reduced dentin hyperesthesia, as evidenced by the indicators of IHRH and IIHI.

 Along with this, inflammation in the gum, bleeding, as evidenced by the dynamics of the PMA index and Schiller-Pisarev test, were eliminated or reduced.

 The above allows us to recommend a new composition for the prevention of diseases of the oral cavity.

Sources of information
1. Drozhzhina V.A. Natural biologically active substances in the prevention and treatment of diseases of the teeth and periodontal disease: Abstract. dis. Doct. honey. sciences. - St. Petersburg, 1995 .-- 33 p.

 2. Fedorov Yu.A. Hygiene products for oral care. - L .: Medicine, 1984. - 96 p.

 3. Fedorov Yu.A., Drozhzhina V.A., Rybakova M.G. New data on the mechanism of influence of natural biologically active substances on periodontal tissues. // New in dentistry. - 1997. - 4. - S.8-18.

 4. Fedorov Yu.A., Drozhzhina V.A., Blokhin V.P. et al. Dental elixirs and rinses in the prevention and treatment of periodontal diseases. // New in dentistry. - 2000. - 7. - p. 55-64.

Claims (1)

Composition for the prevention of dental and periodontal diseases, containing sodium fluoride or sodium monofluorophosphate, sodium lauryl sulfate, sodium carboxymethyl cellulose, titanium dioxide, sodium saccharinate, sorbitol or glycerin, silicon dioxide, food coloring, liquid paraffin, perfume and water, and as preservatives sodium benzoate and thymol, characterized in that it additionally contains kelp extract, panthenol, calcium glycerophosphate, polyvinylpyrrolidone in the following proportions, wt. %:
Laminaria extract - 0.3 - 2.0
Calcium Glycerophosphate - 0.5 - 1.0
Panthenol - 0.02 - 0.1
Sodium fluoride or - 0.22 - 0.25
Sodium Monofluorophosphate - 0.70 - 0.80
Polyvinylpyrrolidone - 0.1 - 0.5
Sorbitol or glycerin - 14.0 - 35.0
Silicon Dioxide - 14.0 - 30.0
Sodium carboxymethyl cellulose - 1.0 - 1.5
Sodium lauryl sulfate - 1.2 - 2.0
Titanium Dioxide - 0.1 - 1.0
Vaseline oil - 0.1 - 0.5
Sodium benzoate - 0.2 - 0.4
Thymol - 0.001 - 0.1
Sodium saccharinate - 0.1 - 0.3
Food coloring - 0.0005 - 0.01
Fragrance - 1.0 - 1.5
Water - Up to 100%

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