RU2165931C2 - Ди- и тривалентные небольшие молекулы ингибиторов селектина, фармацевтическая композиция, способ ингибирования селектина - Google Patents

Ди- и тривалентные небольшие молекулы ингибиторов селектина, фармацевтическая композиция, способ ингибирования селектина Download PDF

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RU2165931C2
RU2165931C2 RU98101240/04A RU98101240A RU2165931C2 RU 2165931 C2 RU2165931 C2 RU 2165931C2 RU 98101240/04 A RU98101240/04 A RU 98101240/04A RU 98101240 A RU98101240 A RU 98101240A RU 2165931 C2 RU2165931 C2 RU 2165931C2
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mmol
bis
mannopyranosyloxy
selectin
phenyl
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RU98101240/04A
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Russian (ru)
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RU98101240A (ru
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П. КОГАН Тимоти
Дюпрэ Брайан
Л. СКОТТ Ян
Буи Хуонг
Л. ВИЛЕР Кэти
М. КЕЛЛЕР Карин
М. КАССИР Джамал
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Тексэс Биотекнолоджи Корпорейшн
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • External Artificial Organs (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
RU98101240/04A 1995-06-29 1996-06-26 Ди- и тривалентные небольшие молекулы ингибиторов селектина, фармацевтическая композиция, способ ингибирования селектина RU2165931C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US278495P 1995-06-29 1995-06-29
US53395P 1995-06-29 1995-06-29
US60/002,784 1995-06-29
US60/000,533 1995-06-29

Publications (2)

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RU98101240A RU98101240A (ru) 1999-09-20
RU2165931C2 true RU2165931C2 (ru) 2001-04-27

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RU98101240/04A RU2165931C2 (ru) 1995-06-29 1996-06-26 Ди- и тривалентные небольшие молекулы ингибиторов селектина, фармацевтическая композиция, способ ингибирования селектина

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Country Link
EP (1) EP0840606B1 (cg-RX-API-DMAC10.html)
JP (1) JP4046351B2 (cg-RX-API-DMAC10.html)
KR (1) KR100438136B1 (cg-RX-API-DMAC10.html)
CN (1) CN1149082C (cg-RX-API-DMAC10.html)
AT (1) ATE193647T1 (cg-RX-API-DMAC10.html)
AU (1) AU704596B2 (cg-RX-API-DMAC10.html)
BR (1) BR9608873A (cg-RX-API-DMAC10.html)
CA (1) CA2221991C (cg-RX-API-DMAC10.html)
CZ (1) CZ290072B6 (cg-RX-API-DMAC10.html)
DE (1) DE69608804T2 (cg-RX-API-DMAC10.html)
DK (1) DK0840606T3 (cg-RX-API-DMAC10.html)
ES (1) ES2146886T3 (cg-RX-API-DMAC10.html)
FI (1) FI974618L (cg-RX-API-DMAC10.html)
GR (1) GR3034289T3 (cg-RX-API-DMAC10.html)
HU (1) HU224590B1 (cg-RX-API-DMAC10.html)
NO (1) NO310623B1 (cg-RX-API-DMAC10.html)
PL (1) PL185372B1 (cg-RX-API-DMAC10.html)
PT (1) PT840606E (cg-RX-API-DMAC10.html)
RU (1) RU2165931C2 (cg-RX-API-DMAC10.html)
UA (1) UA52607C2 (cg-RX-API-DMAC10.html)
WO (1) WO1997001335A1 (cg-RX-API-DMAC10.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2386631C2 (ru) * 2004-07-27 2010-04-20 Чугаи Сейяку Кабусики Кайся Новое производное глюцитола, его пролекарство и его соль и содержащий их терапевтический агент для лечения диабета
RU2428979C2 (ru) * 2005-09-20 2011-09-20 Ревотар Биофармасьютикалз Аг Новые производные нитрокатехола, обладающие активностью в качестве лигандов селектина

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AU6024998A (en) * 1997-01-15 1998-08-07 Glycomed Incorporated Aryl c-glycoside compounds and sulfated esters thereof
AU1903699A (en) * 1997-12-08 1999-06-28 Glycomed Incorporated Disalicylate analog based sialyl lewisx mimetics
CA2342855A1 (en) * 1998-09-04 2000-03-16 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel pyranoses
PH12000002657B1 (en) 1999-10-12 2006-02-21 Bristol Myers Squibb Co C-aryl glucoside SGLT2 inhibitors
GB9924990D0 (en) * 1999-10-21 1999-12-22 Glaxo Group Ltd Medicaments
US6555519B2 (en) 2000-03-30 2003-04-29 Bristol-Myers Squibb Company O-glucosylated benzamide SGLT2 inhibitors and method
US6683056B2 (en) 2000-03-30 2004-01-27 Bristol-Myers Squibb Company O-aryl glucoside SGLT2 inhibitors and method
US6936590B2 (en) 2001-03-13 2005-08-30 Bristol Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
CA2486106C (en) 2002-05-16 2013-07-16 Glycomimetics, Inc. Compounds and methods for inhibiting selectin-mediated function
DE602004011272T2 (de) 2003-11-19 2008-12-24 Glycomimetics, Inc. Spezifischer antagonist sowohl für e- als auch p-selektine
EP1577289A1 (en) 2004-03-18 2005-09-21 Revotar Biopharmaceuticals AG Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders
EP1928892B1 (en) 2005-08-09 2011-10-12 GlycoMimetics, Inc. Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas
ES2651929T3 (es) 2005-09-02 2018-01-30 Glycomimetics, Inc. Inhibidores de pan-selectina heterobifuncionales
EP1764096A1 (en) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel phloroglucinol derivatives having selectin ligand activity
EP1764093A1 (en) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel aromatic compounds and their use in medical applications
KR100827674B1 (ko) * 2006-05-23 2008-05-07 (주)한빛테크 자동트립 장치와 그 제어방법
EP1897533A1 (en) * 2006-09-08 2008-03-12 Revotar Biopharmaceuticals AG Use of 1,6-Bis [3-(3-carboxymethylphenyl)-4-(2-alpha -D-mannopyranosyl-oxy)-phenyl] hexane for the preparation of cosmetic compositions
EP1903049A1 (en) 2006-09-08 2008-03-26 Revotar Biopharmaceuticals AG Crystalline forms of 1,6-Bis [3-(3-carboxymethylphenyl)-4-(2-alpha -D-mannopyranosyloxy)-phenyl] hexane
EP1958637A1 (en) * 2007-02-14 2008-08-20 Revotar Biopharmaceuticals AG Pharmaceutical composition for the treatment of IL-8 mediated diseases
RU2527177C2 (ru) 2007-12-20 2014-08-27 Энвиво Фармасьютикалз, Инк. Четырехзамещенные бензолы
US8895510B2 (en) 2008-04-08 2014-11-25 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
RU2012152633A (ru) * 2010-05-07 2014-06-20 Ревотар Биофармасьютикалз Аг Способ получения бимосиамозы
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
PL2794626T6 (pl) 2011-12-22 2020-11-02 Glycomimetics, Inc. Związki antagonistyczne E-selektyny
US9867841B2 (en) 2012-12-07 2018-01-16 Glycomimetics, Inc. Compounds, compositions and methods using E-selectin antagonists for mobilization of hematopoietic cells
EP3569609A1 (en) 2014-12-03 2019-11-20 GlycoMimetics, Inc. Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
EP3497131B1 (en) 2016-08-08 2022-03-09 GlycoMimetics, Inc. Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4.
WO2018169853A1 (en) 2017-03-15 2018-09-20 Glycomimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists

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SU1272996A3 (ru) * 1982-11-15 1986-11-23 Пфайзер Инк.(Фирма) Способ получени 4 @ -эпи-9-дезоксо-9 а-метил-9а-аза-9а-гомоэритромицина А
EP0292352A2 (fr) * 1987-05-06 1988-11-23 Adir Et Compagnie Nouveaux dérivés macrolides, leur procédé de préparation et les compositions pharmaceutiques les contenant
EP0345627A2 (en) * 1988-06-07 1989-12-13 Abbott Laboratories 9-R-azacyclic erythromycin antibiotics
EP0507595A1 (en) * 1991-04-05 1992-10-07 Merck & Co. Inc. 8A-aza-8A-homoerythromycin lactams

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EP0627442A4 (en) * 1992-01-31 1995-01-11 Nippon Shinyaku Co Ltd DERIVATIVE OF A LEWIS TYPE SUGAR CHAIN.
US5444050A (en) * 1994-04-29 1995-08-22 Texas Biotechnology Corporation Binding of E-selectin or P-selectin to sialyl Lewisx or sialyl-Lewisa
US5498775A (en) * 1994-11-07 1996-03-12 American Home Products Corporation Polyanionic benzylglycosides as inhibitors of smooth muscle cell proliferation

Patent Citations (4)

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SU1272996A3 (ru) * 1982-11-15 1986-11-23 Пфайзер Инк.(Фирма) Способ получени 4 @ -эпи-9-дезоксо-9 а-метил-9а-аза-9а-гомоэритромицина А
EP0292352A2 (fr) * 1987-05-06 1988-11-23 Adir Et Compagnie Nouveaux dérivés macrolides, leur procédé de préparation et les compositions pharmaceutiques les contenant
EP0345627A2 (en) * 1988-06-07 1989-12-13 Abbott Laboratories 9-R-azacyclic erythromycin antibiotics
EP0507595A1 (en) * 1991-04-05 1992-10-07 Merck & Co. Inc. 8A-aza-8A-homoerythromycin lactams

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2386631C2 (ru) * 2004-07-27 2010-04-20 Чугаи Сейяку Кабусики Кайся Новое производное глюцитола, его пролекарство и его соль и содержащий их терапевтический агент для лечения диабета
RU2428979C2 (ru) * 2005-09-20 2011-09-20 Ревотар Биофармасьютикалз Аг Новые производные нитрокатехола, обладающие активностью в качестве лигандов селектина

Also Published As

Publication number Publication date
ES2146886T3 (es) 2000-08-16
AU704596B2 (en) 1999-04-29
AU6292396A (en) 1997-01-30
HU224590B1 (hu) 2005-11-28
JP4046351B2 (ja) 2008-02-13
HUP9802602A2 (hu) 1999-02-01
PL185372B1 (pl) 2003-04-30
DE69608804T2 (de) 2000-11-02
DE69608804D1 (de) 2000-07-13
GR3034289T3 (en) 2000-12-29
CZ407597A3 (cs) 1998-07-15
NO310623B1 (no) 2001-07-30
CA2221991C (en) 2007-09-18
NO976074D0 (no) 1997-12-23
FI974618A7 (fi) 1997-12-23
CZ290072B6 (cs) 2002-05-15
PL324330A1 (en) 1998-05-25
DK0840606T3 (da) 2000-08-07
JPH11508885A (ja) 1999-08-03
EP0840606A4 (cg-RX-API-DMAC10.html) 1998-05-13
UA52607C2 (uk) 2003-01-15
NO976074L (no) 1998-03-02
EP0840606B1 (en) 2000-06-07
FI974618A0 (fi) 1997-12-23
HUP9802602A3 (en) 1999-08-30
CN1149082C (zh) 2004-05-12
PT840606E (pt) 2000-11-30
FI974618L (fi) 1997-12-23
WO1997001335A1 (en) 1997-01-16
EP0840606A1 (en) 1998-05-13
ATE193647T1 (de) 2000-06-15
CA2221991A1 (en) 1997-01-16
BR9608873A (pt) 1999-07-06
KR100438136B1 (ko) 2004-08-25
CN1196678A (zh) 1998-10-21
KR19990028441A (ko) 1999-04-15

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Effective date: 20130627