RU2132330C1 - Производные хинолина, способ их получения и противовоспалительное средство - Google Patents

Производные хинолина, способ их получения и противовоспалительное средство Download PDF

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Publication number
RU2132330C1
RU2132330C1 RU94002335A RU94002335A RU2132330C1 RU 2132330 C1 RU2132330 C1 RU 2132330C1 RU 94002335 A RU94002335 A RU 94002335A RU 94002335 A RU94002335 A RU 94002335A RU 2132330 C1 RU2132330 C1 RU 2132330C1
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RU
Russia
Prior art keywords
group
quinoline
dimethoxy
carboxylic acid
triazol
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RU94002335A
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English (en)
Russian (ru)
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RU94002335A (ru
Inventor
Сохда Такеси
Макино Харухико
Баба Ацуо
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Такеда Кемикал Индастриз Лтд.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
RU94002335A 1993-01-28 1994-01-27 Производные хинолина, способ их получения и противовоспалительное средство RU2132330C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP206128/1993 1992-08-20
JP1262893 1993-01-28
JP012628/1993 1993-01-28
JP20612893 1993-08-20

Publications (2)

Publication Number Publication Date
RU94002335A RU94002335A (ru) 1995-11-27
RU2132330C1 true RU2132330C1 (ru) 1999-06-27

Family

ID=26348258

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94002335A RU2132330C1 (ru) 1993-01-28 1994-01-27 Производные хинолина, способ их получения и противовоспалительное средство

Country Status (15)

Country Link
US (3) US5436247A (enExample)
EP (1) EP0608870B1 (enExample)
KR (1) KR100224135B1 (enExample)
CN (1) CN1041520C (enExample)
AT (1) ATE205199T1 (enExample)
AU (1) AU673213B2 (enExample)
CA (1) CA2114300C (enExample)
DE (1) DE69428142T2 (enExample)
FI (1) FI940414A7 (enExample)
HU (1) HU217907B (enExample)
NO (2) NO306992B1 (enExample)
NZ (1) NZ250761A (enExample)
RU (1) RU2132330C1 (enExample)
SG (1) SG50546A1 (enExample)
TW (1) TW256832B (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2183116C1 (ru) * 2001-07-10 2002-06-10 Жаров Олег Владимирович Фармацевтическая композиция, обладающая болеутоляющим, противовоспалительным, антипиретическим и спазмолитическим действием
RU2202545C2 (ru) * 1997-07-05 2003-04-20 Рютгерс ФФТ АГ Способ очистки хинальдина
RU2263674C2 (ru) * 2000-01-17 2005-11-10 Тейдзин Лимитед Бензимидазольное производное, ингибитор человеческой химазы, терапевтический агент и фармацевтическая композиция на его основе
EA008136B1 (ru) * 1997-05-28 2007-04-27 Авентис Фармасьютикалз Инк. ХИНОЛИНОВЫЕ И ХИНОКСАЛИНОВЫЕ СОЕДИНЕНИЯ, ИНГИБИРУЮЩИЕ ТИРОЗИНКИНАЗЫ ТРОМБОЦИТАРНОГО ФАКТОРА РОСТА И/ИЛИ p56
RU2378256C2 (ru) * 2004-11-01 2010-01-10 Ф. Хоффманн-Ля Рош Аг Хинолин в качестве аллостерического энхансера рецепторов гамк-в
EA013076B1 (ru) * 2004-11-12 2010-02-26 Байер Шеринг Фарма Акциенгезельшафт Производные хинолина и изохинолина, замещенные в 5-м положении, способ их получения и их применение в качестве противовоспалительных средств

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW232013B (enExample) * 1992-04-24 1994-10-11 Takeda Pharm Industry Co Ltd
KR100224135B1 (ko) * 1993-01-28 1999-10-15 다께다 구니오 퀴놀린 또는 퀴나졸린 유도체, 그 제조 및 용도
ATE188377T1 (de) * 1993-06-29 2000-01-15 Takeda Chemical Industries Ltd Chinoline oder chinazolin-derivate und deren verwendung zur herstellung eines medikaments für die behandlung von osteoporose
AU1860995A (en) * 1994-03-08 1995-09-25 Takeda Chemical Industries Ltd. Quinoline or quinazoline derivatives as anti-inflammatory agents, in particular for treating arthritis
US5641788A (en) * 1994-06-07 1997-06-24 Takeda Chemical Industries, Ltd. Quinoline derivatives and pharmaceutical composition containing them
WO1996000223A1 (en) * 1994-06-24 1996-01-04 Takeda Chemical Industries, Ltd. Processes for production of quinoline or quinazoline derivatives and intermediates therefor
US5523312A (en) * 1994-09-27 1996-06-04 Sterling Winthrop Inc. Antipicornaviral agents
EP0830133A1 (en) * 1995-04-28 1998-03-25 Takeda Chemical Industries, Ltd. Therapeutic composition for arthritis
DE19610882A1 (de) * 1996-03-20 1997-09-25 Dresden Arzneimittel Neue 1,3,5-trisubstituierte Indazol-Derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO2002051442A1 (en) * 2000-12-26 2002-07-04 Takeda Chemical Industries, Ltd. Concomitant drugs
EP1539751B1 (en) * 2002-07-15 2008-05-07 Scinopharm Taiwan, Ltd. Process for the preparation of imidazo(1,2-a)pyridine-3-acetamides
AU2003277572A1 (en) * 2002-11-06 2004-06-07 Nissan Chemical Industries, Ltd. Process for producing quinolinecarbaldehyde
US20050009817A1 (en) * 2003-04-30 2005-01-13 Jennifer Savoy Substituted heteroaryls
US7937406B2 (en) * 2003-09-11 2011-05-03 Oracle America, Inc. Mechanism for automatically establishing a resource grid
WO2007109274A2 (en) * 2006-03-21 2007-09-27 Alza Corporation Hydratable polymeric ester matrix for drug electrotransport
CA2781865A1 (en) 2009-06-25 2010-12-29 Amgen Inc. Polycyclic derivatives of pyridine and their use in the treatment of (inter alia) rheumatoid arthritis and similar diseases
WO2012068343A1 (en) * 2010-11-17 2012-05-24 Amgen Inc. Quinoline derivatives as pik3 inhibitors
ES2596243T3 (es) * 2012-08-24 2017-01-05 F. Hoffmann-La Roche Ag Nuevos derivados bicíclicos de piridina

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1318148A3 (ru) * 1980-11-11 1987-06-15 Дзе Велкам Фаундейшн Лимитед (Фирма) Способ получени 2,4-диамино-5-(замещенных)пиримидинов
US5084462A (en) * 1988-04-26 1992-01-28 The Du Pont Merck Pharmaceutical Company 4-quinoline carboxylic acid derivatives useful as immunosuppressive agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8307865D0 (en) * 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
GB8827822D0 (en) * 1988-11-29 1988-12-29 Janssen Pharmaceutica Nv (1h-azol-1-ylmethyl)substituted quinoline derivatives
CA2002864C (en) * 1988-11-29 1999-11-16 Eddy J. E. Freyne (1h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
TW232013B (enExample) * 1992-04-24 1994-10-11 Takeda Pharm Industry Co Ltd
KR100224135B1 (ko) * 1993-01-28 1999-10-15 다께다 구니오 퀴놀린 또는 퀴나졸린 유도체, 그 제조 및 용도
WO1996000223A1 (en) * 1994-06-24 1996-01-04 Takeda Chemical Industries, Ltd. Processes for production of quinoline or quinazoline derivatives and intermediates therefor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1318148A3 (ru) * 1980-11-11 1987-06-15 Дзе Велкам Фаундейшн Лимитед (Фирма) Способ получени 2,4-диамино-5-(замещенных)пиримидинов
US5084462A (en) * 1988-04-26 1992-01-28 The Du Pont Merck Pharmaceutical Company 4-quinoline carboxylic acid derivatives useful as immunosuppressive agents

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA008136B1 (ru) * 1997-05-28 2007-04-27 Авентис Фармасьютикалз Инк. ХИНОЛИНОВЫЕ И ХИНОКСАЛИНОВЫЕ СОЕДИНЕНИЯ, ИНГИБИРУЮЩИЕ ТИРОЗИНКИНАЗЫ ТРОМБОЦИТАРНОГО ФАКТОРА РОСТА И/ИЛИ p56
RU2202545C2 (ru) * 1997-07-05 2003-04-20 Рютгерс ФФТ АГ Способ очистки хинальдина
RU2263674C2 (ru) * 2000-01-17 2005-11-10 Тейдзин Лимитед Бензимидазольное производное, ингибитор человеческой химазы, терапевтический агент и фармацевтическая композиция на его основе
RU2183116C1 (ru) * 2001-07-10 2002-06-10 Жаров Олег Владимирович Фармацевтическая композиция, обладающая болеутоляющим, противовоспалительным, антипиретическим и спазмолитическим действием
RU2378256C2 (ru) * 2004-11-01 2010-01-10 Ф. Хоффманн-Ля Рош Аг Хинолин в качестве аллостерического энхансера рецепторов гамк-в
EA013076B1 (ru) * 2004-11-12 2010-02-26 Байер Шеринг Фарма Акциенгезельшафт Производные хинолина и изохинолина, замещенные в 5-м положении, способ их получения и их применение в качестве противовоспалительных средств

Also Published As

Publication number Publication date
DE69428142D1 (de) 2001-10-11
AU673213B2 (en) 1996-10-31
EP0608870A1 (en) 1994-08-03
FI940414L (fi) 1994-07-29
EP0608870B1 (en) 2001-09-05
DE69428142T2 (de) 2002-07-04
KR940018381A (ko) 1994-08-16
FI940414A7 (fi) 1994-07-29
HU217907B (hu) 2000-05-28
CA2114300A1 (en) 1994-07-29
AU5474294A (en) 1994-08-04
US5436247A (en) 1995-07-25
CA2114300C (en) 2000-10-17
CN1041520C (zh) 1999-01-06
TW256832B (enExample) 1995-09-11
HU9400250D0 (en) 1994-05-30
NZ250761A (en) 1995-03-28
NO940245D0 (no) 1994-01-24
KR100224135B1 (ko) 1999-10-15
ATE205199T1 (de) 2001-09-15
CN1105363A (zh) 1995-07-19
NO306992B1 (no) 2000-01-24
US5932592A (en) 1999-08-03
NO940245L (no) 1994-07-29
HUT70194A (en) 1995-09-28
SG50546A1 (en) 1998-07-20
FI940414A0 (fi) 1994-01-27
US5770602A (en) 1998-06-23

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