RU2128170C1 - Производные индолин-2-она и промежуточные продукты для их получения - Google Patents

Производные индолин-2-она и промежуточные продукты для их получения Download PDF

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RU2128170C1
RU2128170C1 RU95120168A RU95120168A RU2128170C1 RU 2128170 C1 RU2128170 C1 RU 2128170C1 RU 95120168 A RU95120168 A RU 95120168A RU 95120168 A RU95120168 A RU 95120168A RU 2128170 C1 RU2128170 C1 RU 2128170C1
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group
substituted
indolin
methylphenyl
ureido
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RU95120168A
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English (en)
Russian (ru)
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RU95120168A (ru
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Есаки Тору
Емура Такаси
Хосино Ейити
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Чугаи Сейяку Кабусики Кайся
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
RU95120168A 1993-02-17 1994-02-17 Производные индолин-2-она и промежуточные продукты для их получения RU2128170C1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP67297/1993 1993-02-17
JP6729793 1993-02-17
JP167262/1993 1993-05-31
JP16726293 1993-05-31
PCT/JP1994/000235 WO1994019322A1 (en) 1993-02-17 1994-02-17 Indolin-2-one derivative

Publications (2)

Publication Number Publication Date
RU95120168A RU95120168A (ru) 1997-09-27
RU2128170C1 true RU2128170C1 (ru) 1999-03-27

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RU95120168A RU2128170C1 (ru) 1993-02-17 1994-02-17 Производные индолин-2-она и промежуточные продукты для их получения

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US (5) US5952511A (US06559137-20030506-C00039.png)
EP (1) EP0685463B1 (US06559137-20030506-C00039.png)
JP (1) JP3419539B2 (US06559137-20030506-C00039.png)
KR (1) KR100226310B1 (US06559137-20030506-C00039.png)
CN (1) CN1046268C (US06559137-20030506-C00039.png)
AT (1) ATE217864T1 (US06559137-20030506-C00039.png)
AU (1) AU6044894A (US06559137-20030506-C00039.png)
CA (1) CA2156287C (US06559137-20030506-C00039.png)
CZ (1) CZ290504B6 (US06559137-20030506-C00039.png)
DE (1) DE69430664T2 (US06559137-20030506-C00039.png)
ES (1) ES2176236T3 (US06559137-20030506-C00039.png)
FI (1) FI112652B (US06559137-20030506-C00039.png)
HU (1) HUT74105A (US06559137-20030506-C00039.png)
MY (1) MY128102A (US06559137-20030506-C00039.png)
NO (1) NO305201B1 (US06559137-20030506-C00039.png)
PL (1) PL176710B1 (US06559137-20030506-C00039.png)
RU (1) RU2128170C1 (US06559137-20030506-C00039.png)
TW (1) TW281669B (US06559137-20030506-C00039.png)
WO (1) WO1994019322A1 (US06559137-20030506-C00039.png)

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IS2334B (is) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
US5723490A (en) * 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
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DK0731091T3 (da) * 1993-11-26 2002-04-15 Tanabe Seiyaku Co 2-oxoindolin-derivater som cholecystokininreceptor-antagonister
AU699483B2 (en) * 1994-03-07 1998-12-03 Vertex Pharmaceuticals Incorporated Sulphonamide derivatives as aspartyl protease inhibitors
US5691372A (en) * 1995-04-19 1997-11-25 Vertex Pharmaceuticals Incorporated Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease
US6004957A (en) * 1995-06-07 1999-12-21 Vertex Pharmaceuticals, Incorporated Sulfonamide inhibitors of aspartyl protease
AU2233097A (en) * 1996-03-11 1997-10-01 Chugai Seiyaku Kabushiki Kaisha Process for the preparation of optically active indole compounds
WO1998002419A1 (fr) * 1996-07-12 1998-01-22 Chugai Seiyaku Kabushiki Kaisha Inhibiteurs de proliferation de cellules cancereuses
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
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JP2002531498A (ja) * 1998-12-04 2002-09-24 ニューロサーチ、アクティーゼルスカブ イオンチャネル活性剤としてのイサチン誘導体の使用方法
US6605623B1 (en) 1998-12-18 2003-08-12 Bristol-Myers Squibb Pharma Co. N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
DE60016384T2 (de) 1999-01-29 2005-12-01 Chugai Seiyaku K.K. Chondrogonese promotoren und indolin-2-on derivate
WO2000064872A1 (en) * 1999-04-23 2000-11-02 Vertex Pharmaceuticals Incorporated INHIBITORS OF c-JUN N-TERMINAL KINASES (JNK)
US6391907B1 (en) 1999-05-04 2002-05-21 American Home Products Corporation Indoline derivatives
KR20100035666A (ko) * 1999-11-23 2010-04-05 메틸진 인크. 히스톤 디아세틸라제의 억제제
WO2001066142A1 (fr) * 2000-03-10 2001-09-13 Chugai Seiyaku Kabushiki Kaisha Preparations pour chondrogenese
US7612065B2 (en) 2000-04-21 2009-11-03 Vertex Pharmaceuticals Incorporated Inhibitors of c-JUN N-terminal kinases (JNK)
CA2413274A1 (en) * 2000-06-21 2001-12-27 George V. Delucca N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
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Also Published As

Publication number Publication date
AU6044894A (en) 1994-09-14
FI953866A (fi) 1995-08-16
WO1994019322A1 (en) 1994-09-01
MY128102A (en) 2007-01-31
NO953235D0 (no) 1995-08-17
CA2156287A1 (en) 1994-09-01
CA2156287C (en) 2005-12-27
PL176710B1 (pl) 1999-07-30
FI953866A0 (fi) 1995-08-16
ES2176236T3 (es) 2002-12-01
US6031111A (en) 2000-02-29
JP3419539B2 (ja) 2003-06-23
PL310168A1 (en) 1995-11-27
EP0685463A4 (US06559137-20030506-C00039.png) 1996-01-03
TW281669B (US06559137-20030506-C00039.png) 1996-07-21
DE69430664D1 (de) 2002-06-27
CN1117727A (zh) 1996-02-28
KR100226310B1 (ko) 1999-10-15
JPH0748349A (ja) 1995-02-21
DE69430664T2 (de) 2003-01-30
US5952511A (en) 1999-09-14
NO953235L (no) 1995-10-09
US6207836B1 (en) 2001-03-27
US6114536A (en) 2000-09-05
HUT74105A (en) 1996-11-28
FI112652B (fi) 2003-12-31
CZ209695A3 (en) 1995-12-13
EP0685463B1 (en) 2002-05-22
ATE217864T1 (de) 2002-06-15
HU9502415D0 (en) 1996-05-28
EP0685463A1 (en) 1995-12-06
NO305201B1 (no) 1999-04-19
US6127544A (en) 2000-10-03
KR960701011A (ko) 1996-02-24
CZ290504B6 (cs) 2002-08-14
CN1046268C (zh) 1999-11-10

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Effective date: 20070218