ES2167312T3 - Profarmacos para antagonistas de la colecistoquinina. - Google Patents
Profarmacos para antagonistas de la colecistoquinina.Info
- Publication number
- ES2167312T3 ES2167312T3 ES91918120T ES91918120T ES2167312T3 ES 2167312 T3 ES2167312 T3 ES 2167312T3 ES 91918120 T ES91918120 T ES 91918120T ES 91918120 T ES91918120 T ES 91918120T ES 2167312 T3 ES2167312 T3 ES 2167312T3
- Authority
- ES
- Spain
- Prior art keywords
- agents
- drugs
- useful
- treatment
- new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000005557 antagonist Substances 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 238000011282 treatment Methods 0.000 abstract 4
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 abstract 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 abstract 1
- -1 DIAPEZAM Chemical compound 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010033664 Panic attack Diseases 0.000 abstract 1
- 108010043958 Peptoids Proteins 0.000 abstract 1
- IMMPMHKLUUZKAZ-WMZOPIPTSA-N Trp-Phe Chemical class C([C@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)N)C(O)=O)C1=CC=CC=C1 IMMPMHKLUUZKAZ-WMZOPIPTSA-N 0.000 abstract 1
- 229960001948 caffeine Drugs 0.000 abstract 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 229960003920 cocaine Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 210000004211 gastric acid Anatomy 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229960002715 nicotine Drugs 0.000 abstract 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 208000019906 panic disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 210000002784 stomach Anatomy 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE PRESENTAN NUEVAS PRO-DROGAS PARA NUEVOS DIPEPTOIDES NO NATURALES DE DERIVADOS TRP-PHE SUSTITUIDOS EN (ALFA) UTILES COMO AGENTES EN EL TRATAMIENTO DE LA OBESIDAD, LA HIPERSECRECION DE ACIDO GASTRICO EN EL ESTOMAGO, LOS TUMORES DEPENDIENTES DE LAS GASTRINA O COMO ANTISICOTICOS. ADEMAS, LOS DIPEPTOIDES SON AGENTES ANSIOLITICOS Y AGENTES ANTIULCEROSOS. LOS PEPTOIDES SON AGENTES UTILES PARA PREVENIR LA RESPUESTA A LA SUSPENSION DE TRATAMIENTOS CRONICOS O CON EL USO DE LA NICOTINA, EL DIAPEZAM, EL ALCOHOL, LA COCAINA, LA CAFEINA O LOS OPIACEOS. LAS PRO-DROGAS SON TAMBIEN UTILES EN EL TRATAMIENTO Y/O PREVENCION DE ATAQUES DE PANICO. TAMBIEN SE PRESENTAN COMPOSICIONES FARMACEUTICAS Y METODOS DE TRATAMIENTO QUE USAN LAS PRO-DROGAS ASI COMO PROCESOS PARA SU PREPARACION Y NUEVOS PRODUCTOS INTERMEDIOS UTILES EN SU PREPARACION. ADEMAS, UNA CARACTERISTICA ADICIONAL DE LA INVENCION ES EL USO DE LOS COMPUESTOS DE PRO-DROGAS EN COMPOSICIONES PARA DIAGNOSTICO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57631590A | 1990-08-31 | 1990-08-31 | |
US07/726,653 US5340825A (en) | 1990-08-31 | 1991-07-12 | Pro drugs for CCK antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2167312T3 true ES2167312T3 (es) | 2002-05-16 |
Family
ID=27076930
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91918120T Expired - Lifetime ES2167312T3 (es) | 1990-08-31 | 1991-08-29 | Profarmacos para antagonistas de la colecistoquinina. |
Country Status (14)
Country | Link |
---|---|
US (2) | US5554643A (es) |
EP (1) | EP0546108B1 (es) |
JP (1) | JP3356431B2 (es) |
AT (1) | ATE208400T1 (es) |
AU (1) | AU649077B2 (es) |
CA (1) | CA2088980C (es) |
DE (1) | DE69132805T2 (es) |
DK (1) | DK0546108T3 (es) |
ES (1) | ES2167312T3 (es) |
IE (1) | IE913079A1 (es) |
NO (1) | NO300324B1 (es) |
NZ (1) | NZ239591A (es) |
PT (1) | PT98831B (es) |
WO (1) | WO1992004038A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2167312T3 (es) * | 1990-08-31 | 2002-05-16 | Warner Lambert Co | Profarmacos para antagonistas de la colecistoquinina. |
AU665562B2 (en) * | 1991-07-12 | 1996-01-11 | Warner-Lambert Company | Cholecystokinin antagonists useful in the treatment of panic attacks |
US5217957A (en) * | 1991-08-20 | 1993-06-08 | Warner-Lambert Company | Cholecystokinin antagonists useful for treating depression |
US5380872A (en) * | 1992-07-14 | 1995-01-10 | Glaxo Inc. | Modulators of cholecystokinin |
NZ255721A (en) * | 1992-08-13 | 1997-06-24 | Warner Lambert Co | Hetarylmethoxy carbonyl substituted tryptophan amides, esters, analogues and pharmaceutical compositions thereof |
TW281669B (es) * | 1993-02-17 | 1996-07-21 | Chugai Pharmaceutical Co Ltd | |
US6403577B1 (en) | 1993-11-17 | 2002-06-11 | Eli Lilly And Company | Hexamethyleneiminyl tachykinin receptor antagonists |
US6869957B1 (en) | 1993-11-17 | 2005-03-22 | Eli Lilly And Company | Non-peptide tachykinin receptor antagonists |
US6129685A (en) * | 1994-02-09 | 2000-10-10 | The University Of Iowa Research Foundation | Stereotactic hypothalamic obesity probe |
US7077822B1 (en) | 1994-02-09 | 2006-07-18 | The University Of Iowa Research Foundation | Stereotactic hypothalamic obesity probe |
CA2152765A1 (en) | 1994-06-30 | 1995-12-31 | Jeroen Elisabeth-Joseph Knops | Methods for treating a physiological disorder associated with beta amyloid peptide |
US7109326B2 (en) * | 1997-04-15 | 2006-09-19 | Genentech, Inc. | Halo-alkoxycarbonyl prodrugs |
US8278355B2 (en) | 2006-09-12 | 2012-10-02 | Therexcell Pharma Inc. | Isovaline for treatment of pain |
WO2017158621A1 (en) * | 2016-03-14 | 2017-09-21 | Sphaera Pharma Pvt. Ltd. | Trigonelline based compounds |
WO2020070557A1 (en) * | 2018-10-02 | 2020-04-09 | Q Biomed Inc. | Modified therapeutic agent analogs of mefenamic acid |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2364659A1 (fr) * | 1976-09-21 | 1978-04-14 | Commissariat Energie Atomique | Medicament antagoniste de l'action de la gastrine et des polypeptides apparentes |
US4757151A (en) * | 1985-11-14 | 1988-07-12 | Warner-Lambert Company | 2-substituted-[2-substituted-amino]-N-arylalkyl-3-[indol-3-yl] |
EP0442878A4 (en) * | 1988-04-05 | 1991-10-23 | Abbott Laboratories | Derivatives of tryptophan as cck antagonists |
US4997950A (en) * | 1989-04-20 | 1991-03-05 | Richard Finbar Murphy | Novel C-terminal gastrin antagonists |
US5278316A (en) * | 1989-06-29 | 1994-01-11 | Warner-Lambert Company | N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp-Phe- and phenethylamine derivatives |
NZ234264A (en) * | 1989-06-29 | 1993-05-26 | Warner Lambert Co | N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe- and phenethylamine derivatives, and pharmaceutical compositions |
ES2167312T3 (es) * | 1990-08-31 | 2002-05-16 | Warner Lambert Co | Profarmacos para antagonistas de la colecistoquinina. |
-
1991
- 1991-08-29 ES ES91918120T patent/ES2167312T3/es not_active Expired - Lifetime
- 1991-08-29 CA CA002088980A patent/CA2088980C/en not_active Expired - Fee Related
- 1991-08-29 DE DE69132805T patent/DE69132805T2/de not_active Expired - Fee Related
- 1991-08-29 EP EP91918120A patent/EP0546108B1/en not_active Expired - Lifetime
- 1991-08-29 WO PCT/US1991/006178 patent/WO1992004038A1/en active IP Right Grant
- 1991-08-29 DK DK91918120T patent/DK0546108T3/da active
- 1991-08-29 JP JP51666591A patent/JP3356431B2/ja not_active Expired - Fee Related
- 1991-08-29 NZ NZ23959191A patent/NZ239591A/en unknown
- 1991-08-29 AU AU87250/91A patent/AU649077B2/en not_active Ceased
- 1991-08-29 AT AT91918120T patent/ATE208400T1/de not_active IP Right Cessation
- 1991-08-30 PT PT98831A patent/PT98831B/pt not_active IP Right Cessation
- 1991-08-30 IE IE307991A patent/IE913079A1/en not_active Application Discontinuation
-
1993
- 1993-02-26 NO NO930710A patent/NO300324B1/no not_active IP Right Cessation
-
1994
- 1994-04-13 US US08/227,211 patent/US5554643A/en not_active Expired - Fee Related
-
1996
- 1996-06-10 US US08/661,254 patent/US5726200A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69132805T2 (de) | 2002-10-24 |
NO930710D0 (no) | 1993-02-26 |
NZ239591A (en) | 1994-07-26 |
JP3356431B2 (ja) | 2002-12-16 |
PT98831A (pt) | 1992-08-31 |
PT98831B (pt) | 1999-02-26 |
JPH06501007A (ja) | 1994-01-27 |
ATE208400T1 (de) | 2001-11-15 |
US5726200A (en) | 1998-03-10 |
CA2088980C (en) | 2002-04-16 |
EP0546108A1 (en) | 1993-06-16 |
IE913079A1 (en) | 1992-03-11 |
NO930710L (no) | 1993-04-21 |
EP0546108B1 (en) | 2001-11-07 |
WO1992004038A1 (en) | 1992-03-19 |
NO300324B1 (no) | 1997-05-12 |
CA2088980A1 (en) | 1992-03-01 |
EP0546108A4 (en) | 1993-09-22 |
DE69132805D1 (de) | 2001-12-13 |
US5554643A (en) | 1996-09-10 |
DK0546108T3 (da) | 2002-02-18 |
AU8725091A (en) | 1992-03-30 |
AU649077B2 (en) | 1994-05-12 |
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