RU2119331C1 - Agent for burn wound treatment - Google Patents

Abstract

FIELD: medicine, dermatology. SUBSTANCE: agent has the following components, mas. p. p.: phytoecdisteroids sum 0.01; anhydrous lanolin 20.0; Vaseline 80.0, and 70% alcohol 1.0. Agent can be used in combination with other agents used for thermal damages treatment. Agent is used for treatment of patients with burn wounds. Agent does not show adverse effects but shows the expressed wound-healing, analgetic and antibacterial effects. EFFECT: enhanced effectiveness of an agent, simplified preparing. 3 ex

Description

 The invention relates to medicine, namely to herbal medicine for the treatment of burn wounds, used independently, as well as in combination with anti-inflammatory, antimicrobial, non-specific immunocorrective therapy and physiotherapy.

 The tool has wound healing, analgesic, anti-inflammatory, anabolic activity. It is known to use multicomponent ointments on a hydrophilic basis (levomekol, levosin, etc.), in which an attempt was made to use a number of compatible components in one dosage form, each of which should actively influence one or another factor of the pathogenesis of the wound process [1]. However, these drugs have a limited range of therapeutic effects, cause allergic reactions, which, in turn, requires treatment. In addition, many ointments are imported, difficult to manufacture, and consist of expensive and inaccessible components [2, 3].

 The basis of the invention is the task of creating only a medicinal product for the treatment of burns, which would be highly effective, easy to manufacture even in pharmacies, contained accessible components, applicable in any phase of the wound healing process and had no undesirable side effects.

The problem is solved in that the claimed tool has the following composition, wt. hours:
The amount of phytoecdysteroids - 0.01
Vaseline - 80.0
Anhydrous lanolin - 20.0
Alcohol 70% - 1.0
The sum of ecdysteroids was obtained from the plants of the genera of tar, tar, blister, coronaria, and Lychnis from the family of cloves of the CIS [4]. In each individual case, the sum of phytoecdysteroids consists of several compounds with a predominance of ecdysterone, polypodine B, 22-deoxyecdysterone, etc.

 To prepare the ointment, the amount of phytoecdysteroids was dissolved in 70% alcohol, the solution was thoroughly emulsified with anhydrous lanolin, then petrolatum was added and homogenized.

 The drug is yellowish, without a specific odor, has a neutral reaction. To obtain the ointment, other hydrophilic bases can be used.

 Vitaderm was used against the background of traditional treatment in patients divided into 3 groups depending on the depth of burns. The first group consisted of patients with burns of I - II degree with a lesion area of 2 to 5% (total 13 people), the second group - patients with burns of the IIIB degree with a lesion area of 0.3 to 2% (total 9 people), the third group - patients with burns IIIB - IV degree with a lesion area of 0.1 to 3% (a total of 9 people). Patients age: from 1 - 10 years - 3 people, 20 - 30 years - 8 people, 40 - 50 years - 3 people, 60 years and older - 4 people.

 Inspection Technique.

 The anesthetic effect of the drug was studied using the Billroth method and subjective sensations of patients.

 Anti-inflammatory - visually: during the dressing, the wound was examined, the depth of the lesion was determined, the quantity, color, smell of the wound, swelling, tissue infiltration, quantity, quality, color of granulations were assessed, and the lesion area was specified. The examination ended with taking the material for back examination and determining the sensitivity of microflora to antibiotics.

 The wound healing effect of the drug was evaluated by measuring the area of the wound and the percentage of its reduction in relation to the initial assessment according to L.N. Popova, the term of rejection of the primary scab and complete healing.

 Treatment results.

 The anesthetic effect in all patients was observed 5 to 10 minutes after applying the ointment dressing. The healing time of burns of the II degree was 8.1 days (N 12.1); IIIA degree burns - 17-19 days (N - 36 days).

 After necrectomy of scabs with deep burns, autodermoplasty was performed on 3–5 days in 3 patients with 100% transplant engraftment.

 The invention is illustrated by the following examples (treatment cases taken only "Vitaderm").

 Example 1. Patient P., 58 years old. Delivered by sanitation to the burn department of the OKB on December 1, 1995, from the Central District Hospital, where she was treated for a burn with a flame of the right forearm, person II - IIIB degree ≈6% S from 14.11. on December 1, 1995, household trauma, November 14, 1995 St. localis. A burn of the face was completely epithelized. On the rear of the right forearm, a light brown scab ≈2% S, a granulating wound ≈ 1% S with foci of secondary necrosis, covered with fibrin, purulent compartment. Edge epithelization ≈ 0.3 cm.

 DS. Burn with a flame of a person of the II degree ≈ 2% S, right forearm IIIB degree ≈3% S. Infected granulating wound.

 On December 2, 1995, a chemical scab necrectomy was performed (20% salicylic ointment), and a surgical wound on the forearm wound.

 December 4, 1995, a bandage with Vitaderm ointment was applied to the wound.

 December 6, 1995, dressing: the wound is clean, the granulations are pink, bleeding, and the swelling has decreased. Edge epithelization of 0.6 cm. An ointment dressing is applied.

 12/8/1995, the dressing: marginal epithelization of 1.0 cm, the wound is clean, the granulation is medium-grained, bleeding, the swelling was stopped.

 On December 9, 1995, autodermoplasty was performed with a split perforated flap over the entire surface of the wound.

 12/12/1995, ligation: graft engraftment 100%.

 Example 2. Patient T., 30 years old. Ambulatory treatment. 12/23/1995, in everyday life received a burn of the rear of the right hand with steam. Turned 12/25/1995 to the emergency room OKB. Ligation: on the rear of the right hand are blisters with serous exudate, areas of diepithelized skin. A surgical wound toilet was carried out, an ointment dressing was applied.

 DS. Steam burn of the right hand of I - II degree ≈ 0.4% S.

 12/28/1995, dressing: the wound is clean, there is no edema, active epithelization. The wound was reduced by 75%. Ointment dressing.

 12/30/1995, ligation: complete epithelization of the wound. Discharged to work.

 Example 3. Patient C., 6 years old. He entered the burn department on December 4, 1995. He received burns with hot water on December 4, 1995. Ligation: hyperemia on the left hand, left thigh, left inguinal fold, blisters with serous and hemorrhagic contents, edema, pain in the wound.

 DS. Hot water burn of the hand, thigh, and inguinal region on the left with a total area of ≈ 4.5 - 5% S, II degree - 2% S, IIIA - 2.5% S. Surgical wound toilet was made, ointment dressings were applied.

 December 8, 1995, dressing: second degree burns - epithelialized. Burns IIIA degree clean, swelling, no pain. Wounds were reduced by 30%. Pronounced marginal and islet epithelization. Ointment dressings.

 12/14/1995, the dressing: the wounds are clean, there is no swelling, the epithelization is active. The wound was reduced by 90%.

 12/17/1995, dressing: the wounds were completely epithelized.

 Thus, based on the foregoing, it can be argued that Vitaderm ointment has a pronounced analgesic and decongestant effect; accelerates the epithelization of superficial burns, improves the microcirculation of granulating wounds, activates the marginal and islet epithelization. Reduces treatment time and preparation of granulating wounds for autodermoplasty.

 Adverse effects of ointment treatment have not been identified.

List of references
1. The state register of medicines and medical devices. - M., 1994.

 2. Mashkovsky M. D. Drugs. t. 1 - 2 - M.: Medicine, 1967.

 3. Reference Vidal. Medicines in Russia. - M .: Astra Farm Service, 1995.

 4. Chemistry of natural compounds, 1987, N 1, C. 850 - 852.

Claims (1)

A remedy for the treatment of burn wounds, including an active principle and a base, characterized in that it additionally contains alcohol, as the active principle - the sum of phytoecdysteroids and petrolatum-lanolin base in the ratio of ingredients, parts by weight:
The amount of phytoecdysteroids - 0.01
Anhydrous lanolin - 20.0
Vaseline - 80.0
Alcohol 70% - 1.0e