RU2138277C1 - Agent for complex treatment of burn and posttraumatic wounds - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: invention proposes an agent - 2% ointment consisting of a vaseline-base and 40% alcoholic tincture of the plant species at the following composition, mas. p. p.: tatarica or drooping catchfly herb 3; pot-marigold flowers 1 and narrow-leaved willow-herb leaves 1. An ointment shows the expressed analgetic and antiedemic effects, accelerates epithelization of surface burns, improves microcirculation of granulating wounds, activates the edge and insular epithelization, decreases treatment time and preparing granulating wounds to autodermoplastics. Agent can be used both separately and in the complex with other agents. EFFECT: enhanced effectiveness of an agent. 1 cl, 2 ex

Description

 The invention relates to medicine, namely to phytotherapeutic agents for treating skin lesions, used independently, as well as in combination with anti-inflammatory, antimicrobial, non-specific immunocorrection therapy and physiotherapy. The tool has wound healing, analgesic, anti-inflammatory, anabolic activity. It is known to use multicomponent ointments on a hydrophilic basis in which an attempt has been made to use a number of compatible components in one dosage form, each of which should actively influence one or another factor of the pathogenesis of the wound process. Of these, levosin, levomecol, and others should be called (1). These ointments are difficult to manufacture, consist of expensive components, have a narrow spectrum of therapeutic effects and, in some cases, cause allergic reactions. In addition, the basis for scientific approaches to the problem of local treatment of wounds is the concept that the phase of the wound process determines the choice of the "optimal" drug. Prospects for increasing the effectiveness of drug treatment of wounds are determined by the possibility of using a number of compatible substances in one dosage form, each of which should actively influence the pathogenesis of the wound process. Such substances include phytoecdysteroids with high biological activity, including reparative (2). These compounds are part of tar - one of the components of our combination. Other medicinal plants, such as calendula officinalis and narrow-leaved fireweed provide antimicrobial, anti-inflammatory, antispasmodic effect. A synergistic effect on the wound process, good compatibility without chemical interaction between the components of the tincture from this collection made it possible to obtain a high-performance agent.

The basis of the invention is the creation of such a medicine for the treatment of skin lesions, which would be highly effective, easy to manufacture even in a pharmacy, applicable in any phase of the wound healing process and had no undesirable side effects. The problem is solved in that the claimed tool is prepared on the basis of a phytocomposition having the following composition, parts by weight:
3 tarsa or drooping pitches - 3
Flowers of medicinal marigolds - 1
Leaves of narrow-leaved fireweed - 1
To prepare the ointment from this composition, we obtained a 40% alcohol tincture according to the rules of the State Pharmacopoeia (3), followed by the inclusion of tincture in a vaseline-lanolin base (7: 1) and obtaining an ointment. For this, 10 ml of tincture was thoroughly emulsified in 20 g of lanolin, 70 g of vaseline was added and the mixture was homogenized. The drug is yellowish, without a specific smell. To obtain ointments with this tincture, other hydrophilic and diphilic bases can be used. The drug was used against the background of traditional treatment in 42 patients, divided into groups depending on the depth of burns and area of wounds, phase of the wound process. The first group was represented by patients with burns of 1 - 2 degrees and a lesion area of 2 to 5% (13 people). The second group includes patients with degree 3A burns with a lesion area of 0.2 to 2% (9 people). The third group - patients with burns 3B - 4 degrees and post-traumatic with a lesion area of 0.1 to 3% (45 people). Patients age: from 1 - 10 years (5 people), 20 - 40 years (20 people), 40 - 60 years (25 people), older than 30 years (6 people). Local treatment with ointment for superficial burns was carried out in the 1st and 2nd phases of the wound process, deep burns and post-traumatic wounds in the 2nd phase. Before applying ointment dressings, a thorough surgical treatment of wounds of 2–3A degrees was performed, necrectomy for 3B – 4 degrees. Ligation was performed after 2 to 4 days.

 Treatment results: the anesthetic effect in all patients is observed 5 to 10 minutes after application of the ointment dressing. The terms of healing of burns of the 1st - 2nd degree were 8 days (normal 12.1 days). Grade 3A - 17-19 days (normal 31 days). 3B - 4th degree - 20-30 days (depending on the area of the burn). After necrectomy scabs with deep burns on days 5–7, autodermoplasty was performed in 13 patients with 85–100% graft engraftment. The research methods used were: 1) visual analysis of wounds, 2) cytological study of the wound process, 3) study of microcirculation of wounds, 4) histology of skin wounds, 5) comparative analysis of the results of treatment with patented ointment with traditional ointments.

 The invention is illustrated by the following examples.

 Example 1. Patient S., 16 years old. He entered the burn department of the Ryazan OKB September 6, 1996 with a diagnosis of combined injury. Burn volt arc of the left leg, body, buttocks of the 1st - 3A Art. ≈ 40% S (4 tbsp. - 1% S). Burn disease, severe burn shock. Closed fracture of the lower third of the diaphysis of the right thigh. Effective intensive therapy of the 1st and 2nd periods of burn disease was carried out. Dressing burn wounds with moist-drying dressings. September 18, 1996 the operation was performed: open intramedullary osteosynthesis of the right thigh. On September 30, 1996, treatment was started for a deep (4 tbsp.) Left thigh burn with ointment. The wound of the right thigh and the region of the outer ankle with a total area of 1%, the tendon (Achilles) at the bottom of the wound, the granulation is pale, marginal epithelization is not expressed, fibrin plaque, pus. Surgical toilet, ointment dressings. 3.10.96 dressing. The wounds are clean, granulations are pink, fine-grained, bleed, pronounced marginal epithelization, the purulent compartment is scarce. Surgical toilet. Ointment dressings.

 10.10.96 dressing. The wound was made with healthy granulations, the tendon is covered with granulations, pronounced marginal epithelization. The wound was reduced by 50%. Subsequent dressings after 2 to 3 days.

 10/28/96. Complete wound healing. The wound was performed with thin skin without scars.

 Example 2. Patient F., 33 years old. Received August 24, 1996 with a diagnosis of a burn with a volt arch of the face, neck, left shoulder of the 2nd — 3A st. ≈ 7% S, 3B - 4 tbsp. - 1.2 S (shoulder). The treatment is traditional. Chemical necrectomy scab of the left shoulder.

 09/12/96 - a break in treatment due to personal circumstances until 09/30/96.

 09/30/96. dressing: burn wound 1% S, healthy granulation, marginal epithelization is poorly expressed. Surgical toilet, dressing with ointment.

 10/04/96. The wound is clean, granulations are pink, bleed, pronounced marginal epithelization. The area of the wound was reduced by 30%. Subsequent dressing after 2 to 3 days.

 10/10/96. autodermoplasty performed.

 10/14/96. the graft engraftment is 100%.

 10.21.96. complete wound healing.

 Thus, it can be argued that the patented ointment has pronounced analgesic and decongestant effects, accelerates the epithelization of superficial burns, improves microcirculation of granulating wounds, activates marginal and islet epithelization, shortens the treatment time and preparation of granular wounds for autodermoplasty.

List of references
1. The state register of medicines and medical devices. Moscow, 1994.

2. Syrov V.N. Phytoecdysteroids: biological effects in the body of higher animals and prospects for use in medicine. Experiment and wedge. pharmacol. - 1994., - T. 57., - N 5. P. 61 - 66
2. The State Pharmacopoeia of the USSR, - II ed. - M .: Medicine, 1990. - Issue. - 1. - S. 145.

Claims (1)

Means for the complex treatment of burn and post-traumatic wounds, including herbal components and a base, characterized in that the ointment on a petrolatum-lanolin base (7: 2) contains 40% alcohol tincture from a herbal collection of the following composition, parts by weight:
3 tarsa or drooping pitches - 3
Flowers of medicinal marigolds - 1
Leaves of narrow-leaved fireweed - 1