RU2299064C2 - Method for treatment of suppurative wound - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: method involves applying a gauze napkin on wound impregnated with ointment of the following composition, mas. p. p.: ecdysterone, 0.001-0.01 g; pot-marigold flowers 70% alcoholic tincture (1:10), 10.0 g; Saint-John's-wort perforated herb 40% alcoholic tincture (1:10), 10.0 g; polyethylene glycol (PEG)-1500, 50.0 g, and PEG-400, 30.0 g. Method provides stimulating tissues reparation, decreasing inflammation and analgesic effect. Invention can be used in treatment of suppurative wounds.

EFFECT: improved method of treatment.

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Description

The invention relates to medicine, namely to methods for treating purulent wounds of various etiologies, used independently, as well as in conjunction with other methods used for a similar purpose. There are many ways to treat purulent wounds using various drugs, including multicomponent ointments on a hydrophilic basis (levomekol, dimekol, levosin, etc.), in which each of the components affects one or another pathogenesis factor of the wound process. However, the therapeutic spectrum of these drugs is limited; they can cause allergic reactions, which in turn requires treatment [1, 2].

The purpose of the invention: the treatment of purulent wounds of various etiologies by using the original ointment containing ecdysterone. This goal is achieved by the fact that the affected areas are treated with the ointment we created by applying gauze napkins or tamponade turunda, soaked in 0.01-0.001% ointment, having the following composition, in mass parts:

70% alcohol tincture (1:10) of medicinal marigold flowers  10.0 g 40% alcohol tincture (1: 5) Hypericum perforatum herb  10.0 g ecdysterone  0.01-0.001 g PEG-400  30.0 g PEG-1500  50.0 g

We isolated ecdysterone from various species of the genera: tar, Oberna, Lychnis, coronaria, blister, tar and other plants of the clove flora of the Russian Federation.

To prepare the ointment, 50.0 g of PEG-1500 (polyethylene glycol-1500) was melted by heating in a water bath, 30.0 g of PEG-400 was added and the mixture was triturated to obtain a uniform ointment base. To the resulting base mass was added 10.0 g of tincture of marigold flowers and 10.0 g of tincture of St. John's wort with 0.01 g of ecdysterone previously dissolved in it. The mixture was thoroughly homogenized. The ointment is brownish-brown in color, a specific faint odor, a slightly sweet taste, a neutral reaction. To obtain ointments, other hydrophilic and diphilic bases can be used. Ointment - cryosan - was used as monotherapy or against the background of complex therapy in 36 patients at the Ryazan emergency hospital. The control group includes 30 patients. Bandaging was performed on 1, 3, 5, etc. day with gauze napkins. The dynamics of the wound process was evaluated by the following criteria: macroscopic evaluation (the presence and number of granulations, necrosis, epithelization, change in the area of the wound surface); cytological examination of the wound discharge using surface prints (performed on 1, 3, 5 and then after 2 days); in general condition and condition and subjective sensation of patients. In the process, the use of ointments noted an increase in granulations, an increase in the regeneration of the epithelial cover in the experimental group by 64.1% compared with the control group. In the cellular composition of wound detritus with the help of surface prints, an increase was noted in all cases of such cellular elements as fibroblasts, leukocytes, lymphocytes, macrophages in comparison with the control group. Already at the second ligation, epithelization was noted in 53.5% of patients. In general and biochemical blood tests, 58.3% also showed a decrease in signs of inflammation within 5-10 days: normalization of the leukocyte count, a decrease in ESR, in 100% of cases there are no signs of allergic reactions to the drug. Subjectively, patients noted an improvement in the reduction of pain, improving overall health.

The invention is illustrated by the following examples.

Example 1

Patient S., 47 years old. He was admitted to the hospital on January 31, 2004 with complaints of sharp pains, numbness in both hands and fingers, significant swelling, restriction of movements after frostbite.

Frostbite occurred from 29.01 to 30.01, when for several hours in a state of intoxication on the street at an air temperature of -20 ° С. He warmed his hands at home, but on the 2nd day there appeared blisters with serous and hemorrhagic contents.

Objectively: both hands and fingers are sharply swollen, swelling on the right reaches the elbow joint, blisters on the fingers of the hands mainly with hemorrhagic contents, on the hands with serous, finger movements are limited due to edema, sensitivity is reduced. The pulsation of the radial arteries is preserved.

Diagnosis: frostbite of hands 2-3 degrees.

An autopsy of the blisters, necrectomy. Conducted infusion, anti-inflammatory therapy. Local treatment: gauze dressings with 0.01% phytoecdysterone-containing ointment every other day. On the 4th day of inpatient treatment, the swelling of the hands and right forearm disappeared, the foci of frostbite on the hands completely epithelized. On the 12th day, the patient was discharged in satisfactory condition with full restoration of the epidermis of the fingers and restoration of their sensitivity.

Example 2

Patient T., 54 years old. Received June 8, 2004 in the department of purulent surgery with complaints of pain in the right buttock, periodic chills.

From the anamnesis: pain is disturbed for about 1 week, when I independently conducted a course of vitamin therapy in the form of intramuscular injections.

Objectively: in the region of the upper outer quadrant of the right buttock, a sharply hyperemic inflammation focus up to 8 cm in diameter, in the center of which a symptom of fluctuation is determined.

Diagnosis: post-injection abscess of the right buttock.

An autopsy and drainage of the abscess cavity were performed. On the 2nd day at the dressing: perifocal edema and hyperemia decreased, the discharge was serous-necrotic. The abscess cavity was washed daily with 3% hydrogen peroxide solution, tamponade with turunda soaked in 0.01% phytoecdisterone-containing ointment. On the 3rd dressing, the perifocal edema completely slept, the discharge is serous, scanty, the wound surface is covered with scanty granulations; on the 8th: the wound actively granulates, the cavity decreases, secondary sutures are applied. On the 14th day, the sutures were removed, there were no signs of inflammation, the patient was discharged.

Example 3

Patient S., 43 years old. Received November 23, 2003 with complaints of pain and swelling in the left forearm.

From the anamnesis: about 2 weeks ago, bitten by a domestic cat, treated independently - without positive dynamics.

Objectively: on the front surface of the left forearm of cyanotic color, a 15 × 6 cm section with sharp perifocal hyperemia, with foci of expiration of purulent contents. Palpation is sharply painful.

The phlegmon was opened, necrectomy, plugging of the wound surface with potassium permanganate solution. On daily dressings - washing the wound with 3% solution of hydrogen peroxide, applying dressings with 0.01% phytoecdisterone-containing ointment. At the 12th dressing, the wound was completely cleansed, granulated. An autodermoplasty was performed with a split skin graft from the front surface of the left thigh with bandages on the donor and wound site with the same ointment. On the 3rd day, the bandages were removed: on the left forearm, complete engraftment of the transplanted flap, on the donor surface focal granulation. December 15, 2003, in satisfactory condition with a completely restored skin, the patient was discharged.

Thus, the proposed method for the treatment of purulent wounds of various etiologies using cryosan ointment allows to achieve wound healing in a short time with complete restoration of the skin by stimulating tissue repair processes, reducing inflammation, increasing cellular elements, such as fibroblasts, leukocytes, lymphocytes, macrophages and others on the background of a strongly analgesic effect. In no case were undesirable adverse reactions detected.

Information sources

1. Mashkovsky M.D. Medicines, vol. 1, 2. - M .: Medicine, 1987.

2. Reference VIDAL. Medicines in Russia: A Handbook. 10th ed., Revised, isp., Ext. - M.: AstraPharmService, 2004 .-- 1448 p.

3. Darmogray V.N. Ecdysteroids of some plant species of the family. clove // Resource and pharmacological study of the medicinal flora of the USSR: Scientific. tr VNIIF. - M., 1987 .-- T.25. - S.111-113.

Claims (1)

A method for the treatment of purulent wounds, including the application of gauze napkins or tamponade of the affected cavities with turundas soaked in ointment containing PEG-1500, characterized in that the ointment has the following composition, parts by weight: Ecdysterone 0.01-0.001 g 70% Alcohol Tincture (1:10) marigold flowers 10.0 g 40% Alcohol Tincture (1:10) Hypericum perforatum 10.0 g PEG-1500 50.0 g PEG-400 30.0 g where PEG is polyethylene glycol.