RU2056431C1 - Сложные эфиры органических кислот со спиртами 19-нор-стероидов или их соли щелочных металлов, проявляющие прогестомиметическую, антипрогестероновую и антиглюкокортикоидную активность - Google Patents

Сложные эфиры органических кислот со спиртами 19-нор-стероидов или их соли щелочных металлов, проявляющие прогестомиметическую, антипрогестероновую и антиглюкокортикоидную активность Download PDF

Info

Publication number
RU2056431C1
RU2056431C1 SU925011906A SU5011906A RU2056431C1 RU 2056431 C1 RU2056431 C1 RU 2056431C1 SU 925011906 A SU925011906 A SU 925011906A SU 5011906 A SU5011906 A SU 5011906A RU 2056431 C1 RU2056431 C1 RU 2056431C1
Authority
RU
Russia
Prior art keywords
beta
product
water
alpha
phenyl
Prior art date
Application number
SU925011906A
Other languages
English (en)
Russian (ru)
Inventor
Могилевски Мартин
Неделек Люсьен
Ник Франсуа
Филибер Даниель
Original Assignee
Руссель-Юклаф
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Руссель-Юклаф filed Critical Руссель-Юклаф
Application granted granted Critical
Publication of RU2056431C1 publication Critical patent/RU2056431C1/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0096—Alkynyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SU925011906A 1989-08-08 1992-07-07 Сложные эфиры органических кислот со спиртами 19-нор-стероидов или их соли щелочных металлов, проявляющие прогестомиметическую, антипрогестероновую и антиглюкокортикоидную активность RU2056431C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8910648 1989-08-08
FR8910648A FR2650748B1 (fr) 1989-08-08 1989-08-08 Nouveaux esters d'acides organiques avec des alcools derives de 19-nor steroides et leurs sels, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions les renfermant

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
SU4830601 Division

Publications (1)

Publication Number Publication Date
RU2056431C1 true RU2056431C1 (ru) 1996-03-20

Family

ID=9384560

Family Applications (1)

Application Number Title Priority Date Filing Date
SU925011906A RU2056431C1 (ru) 1989-08-08 1992-07-07 Сложные эфиры органических кислот со спиртами 19-нор-стероидов или их соли щелочных металлов, проявляющие прогестомиметическую, антипрогестероновую и антиглюкокортикоидную активность

Country Status (27)

Country Link
EP (1) EP0412907B1 (enExample)
JP (1) JP3056770B2 (enExample)
KR (1) KR910004648A (enExample)
CN (1) CN1036521C (enExample)
AT (1) ATE113958T1 (enExample)
AU (1) AU633604B2 (enExample)
CA (1) CA2022647A1 (enExample)
DE (1) DE69014012T2 (enExample)
DK (1) DK0412907T3 (enExample)
EG (1) EG19423A (enExample)
ES (1) ES2063940T3 (enExample)
FI (1) FI903905A7 (enExample)
FR (1) FR2650748B1 (enExample)
HU (1) HUT55031A (enExample)
IE (1) IE65905B1 (enExample)
IL (1) IL95272A (enExample)
MA (1) MA21925A1 (enExample)
MX (1) MX21771A (enExample)
NO (1) NO177595C (enExample)
NZ (1) NZ234824A (enExample)
OA (1) OA09303A (enExample)
PT (1) PT94935B (enExample)
RU (1) RU2056431C1 (enExample)
TN (1) TNSN90112A1 (enExample)
TW (1) TW201313B (enExample)
YU (1) YU47865B (enExample)
ZA (1) ZA905812B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2659233B1 (fr) * 1990-03-06 1994-01-21 Roussel Uclaf Nouvelle utilisation de composes anti-progestomimetiques chez les animaux d'elevage.
DE4434488A1 (de) * 1994-09-14 1996-03-21 Schering Ag Steroidester und -amide, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
AUPN058895A0 (en) * 1995-01-16 1995-02-09 Garvan Institute Of Medical Research Diagnostic method
US6090798A (en) * 1997-12-19 2000-07-18 Alcon Laboratories, Inc. Treatment of GLC1A glaucoma with glucocorticoid antagonists
DE19915871A1 (de) 1998-04-09 1999-10-21 Unisia Jecs Corp Viskosefluidkupplung
JP2000130165A (ja) 1998-10-30 2000-05-09 Unisia Jecs Corp ファンカップリング装置
JP2001012511A (ja) 1999-06-25 2001-01-16 Unisia Jecs Corp 流体継手
CN110099688A (zh) * 2016-11-17 2019-08-06 赛途公司 骨骼肌肥大诱导物
KR102518275B1 (ko) * 2022-07-27 2023-04-05 주식회사 화성케미칼 재생 네오프렌 원단의 합포 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3347126A1 (de) * 1983-12-22 1985-07-11 Schering AG, 1000 Berlin und 4709 Bergkamen 11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
DE3506785A1 (de) * 1985-02-22 1986-08-28 Schering AG, Berlin und Bergkamen, 1000 Berlin 11ss-n,n-dimethylaminophenyl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
IE60780B1 (en) * 1987-01-23 1994-08-10 Akzo Nv New 11-aryl steroid derivatives
ATE85342T1 (de) * 1987-12-12 1993-02-15 Akzo Nv 11-arylsteroid-derivate.
FR2643638B1 (fr) * 1989-02-24 1991-06-14 Roussel Uclaf Nouveaux 19-nor steroides ayant en position 11beta une chaine carbonee comportant une fonction amide ou carbamate, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
1. Патент ГДР N 264220, кл. C 07J 1/00, 1989. 2. Патент ГДР N 257634, кл. C 07J 1/00, 1988. *

Also Published As

Publication number Publication date
ZA905812B (en) 1991-09-25
HUT55031A (en) 1991-04-29
FI903905A7 (fi) 1991-02-09
NZ234824A (en) 1993-03-26
PT94935A (pt) 1991-04-18
NO903475D0 (no) 1990-08-07
CN1049352A (zh) 1991-02-20
EP0412907A3 (en) 1991-07-24
NO177595C (no) 1995-10-18
MA21925A1 (fr) 1991-04-01
CA2022647A1 (fr) 1991-02-09
YU47865B (sh) 1996-02-19
CN1036521C (zh) 1997-11-26
NO177595B (no) 1995-07-10
TW201313B (enExample) 1993-03-01
TNSN90112A1 (fr) 1991-03-05
FR2650748B1 (fr) 1991-11-08
EP0412907A2 (fr) 1991-02-13
OA09303A (fr) 1992-09-15
AU633604B2 (en) 1993-02-04
MX21771A (es) 1993-10-01
NO903475L (no) 1991-04-11
IE902839A1 (en) 1991-02-27
HU904921D0 (en) 1991-01-28
FI903905A0 (fi) 1990-08-07
YU151390A (sh) 1992-12-21
IL95272A0 (en) 1991-06-30
FR2650748A1 (fr) 1991-02-15
DE69014012D1 (de) 1994-12-15
AU6020890A (en) 1991-02-14
DK0412907T3 (da) 1995-04-03
JPH0377825A (ja) 1991-04-03
JP3056770B2 (ja) 2000-06-26
DE69014012T2 (de) 1995-03-30
EG19423A (en) 1995-02-28
KR910004648A (ko) 1991-03-29
PT94935B (pt) 1997-05-28
ATE113958T1 (de) 1994-11-15
ES2063940T3 (es) 1995-01-16
EP0412907B1 (fr) 1994-11-09
IL95272A (en) 1996-01-31
IE65905B1 (en) 1995-11-29

Similar Documents

Publication Publication Date Title
KR100190775B1 (ko) 11베타-벤즈알독심-에스트라-4,9-디엔유도체, 이의 제조방법 및 이를 함유하는 약제학적 조성물
EP2039701B1 (en) 20-Keto-11Beta-Arylsteroids and their Derivatives having agonist or antagonist hormonal activity
JP2753562B2 (ja) 新規な１１−ベンズアルドキシム−エストラ−ジエン誘導体とその製造方法、及びその化合物を含有する医薬製剤
US5276023A (en) 19-nor-steroid esters
US5576310A (en) 11-benzaldoxime-17β-methoxy-17α-methoxymethyl-estrasdiene derivatives, methods for their production and pharmaceuticals containing such compounds
RU2056431C1 (ru) Сложные эфиры органических кислот со спиртами 19-нор-стероидов или их соли щелочных металлов, проявляющие прогестомиметическую, антипрогестероновую и антиглюкокортикоидную активность
US5705494A (en) Anti-estrogenic activity of IIβ-substituted-19-NOR Steroids
EP1135403B1 (en) 17beta-acyl-17alpha-propynyl-11beta-arylsteroids and their derivatives having agonist or antagonist hormonal properties
RU2041236C1 (ru) Производные омега-фенилалкановых кислот, проявляющие антиглюкокортикоидные, антиандрогенные и антипрогестомиметические свойства
KR0180225B1 (ko) 항프로게스테론양 화합물로 이루어지는 배란 자극용 제약조성물
US6740645B1 (en) 17β-acyl-17α-propynyl-11β-(cyclic amino) aryl steroids and their derivatives having antagonist hormonal properties
US4567000A (en) 11-Difluoromethylene steroids
US5679788A (en) 11 beta-substituted-19 nor-steroids
KR0175687B1 (ko) 11-벤즈알독심-에스트라-디엔 유도체, 이의 제조방법 및 이를 함유하는 약제
NO177594B (no) Nye estere av organiske syrer og alkoholer avledet fra 19-nor-steroider, samt preparater for å hindre befruktning og avbryte svangerskap, inneholdende de nye estere
HRP20000893A2 (en) Novel 17-halogenated 19-nor steroids, method and intermediates for preparing same, use as medicines and pharmaceutical compositions containing same
SI9011513A (sl) Novi estri organskih kisun z alkoholi, izpeljanimi iz 19-nor steroidov, njihove soli, postopek in intermediati za njihovo pripravo ter sestavki, ki jih vsebujejo