RU2021138920A - Офтальмическая композиция - Google Patents
Офтальмическая композиция Download PDFInfo
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- RU2021138920A RU2021138920A RU2021138920A RU2021138920A RU2021138920A RU 2021138920 A RU2021138920 A RU 2021138920A RU 2021138920 A RU2021138920 A RU 2021138920A RU 2021138920 A RU2021138920 A RU 2021138920A RU 2021138920 A RU2021138920 A RU 2021138920A
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- RU
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- composition
- acid
- anionic polymer
- polyquaternium
- mixtures
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/717—Celluloses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/77—Polymers containing oxygen of oxiranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
- A61L12/143—Quaternary ammonium compounds
- A61L12/145—Polymeric quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Ophthalmology & Optometry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (18)
1. Композиция, содержащая:
a. от около 10 ч/млн до около 1000 ч/млн соединения поликватерния, имеющего средневесовую молекулярную массу от около 150 до около 15 000 дальтон;
b. от около 0,001% до около 0,5% анионного полимера, имеющего средневесовую молекулярную массу от около 250 до около 4 000 000 дальтон; и
c. эффективное количество органической кислоты, ее солей или их смесей, так что органическая кислота связывается с соединением поликватерния в молярном отношении, по меньшей мере, 1: 1;
причем композиция по существу не содержит катионных олигомерных соединений и ингибирующих осаждение соединений.
2. Композиция по п. 1, в которой соединение поликватерния имеет средневесовую молекулярную массу от около 200 до около 13 500 дальтон.
3. Композиция по п. 2, в которой соединение поликватерния выбирают из группы, состоящей из поликватерния-1, поликватерния-10, поликватерния-42 или их смесей.
4. Композиция по п. 3, в которой соединение поликватерния представляет собой поликватерний-42.
5. Композиция по п. 1, в которой анионный полимер имеет средневесовую молекулярную массу от около 100 000 до около 3 000 000 дальтон.
6. Композиция по п. 5, в которой анионный полимер выбирают из группы, состоящей из альгинатов; каррагинанов; карбомеров; высокомолекулярной нелинейной полиакриловой кислоты, поперечно-сшитой полиалкениловыми полиэфирами; карбоксиметилцеллюлозы натрия; карбоксиметилцеллюлоз натрия с внутримолекулярными сшивками; геллановой камеди; гиалуроновой кислоты; пектина; ксантановой камеди; сополимера алкилвинилового эфира/малеинового ангидрида и их смесей.
7. Композиция по п. 6, в которой анионный полимер выбирают из группы, состоящей из гиалуроновой кислоты, геллановой камеди, сополимера алкилвинилового эфира/малеинового ангидрида и их смесей.
8. Композиция по п. 7, в которой анионный полимер представляет собой гиалуроновую кислоту.
9. Композиция по п. 7, в которой анионный полимер представляет собой геллановую камедь.
10. Композиция по п. 7, в которой анионный полимер представляет собой сополимер алкилвинилового эфира/малеинового ангидрида.
11. Композиция по п. 10, в которой анионный полимер представляет собой свободную кислоту сополимера алкилвинилового эфира/малеинового ангидрида.
12. Композиция по п. 1, в которой органическую кислоту выбирают из группы, состоящей из карбоновых кислот, дикарбоновых кислот, трикарбоновых кислот и их смесей.
13. Композиция по п. 12, в которой органическая кислота представляет собой карбоновую кислоту.
14. Композиция по п. 13, в которой карбоновую кислоту выбирают из группы, состоящей из муравьиной кислоты, уксусной кислоты, пропионовой кислоты, их солей и их смесей.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462073488P | 2014-10-31 | 2014-10-31 | |
| US62/073,488 | 2014-10-31 | ||
| US14/922,504 | 2015-10-26 | ||
| US14/922,504 US10245324B2 (en) | 2014-10-31 | 2015-10-26 | Ophthalmic composition |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017118578A Division RU2764117C2 (ru) | 2014-10-31 | 2015-10-29 | Офтальмическая композиция |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2021138920A true RU2021138920A (ru) | 2022-01-20 |
Family
ID=54479007
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2021138920A RU2021138920A (ru) | 2014-10-31 | 2015-10-29 | Офтальмическая композиция |
| RU2017118578A RU2764117C2 (ru) | 2014-10-31 | 2015-10-29 | Офтальмическая композиция |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017118578A RU2764117C2 (ru) | 2014-10-31 | 2015-10-29 | Офтальмическая композиция |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10245324B2 (ru) |
| EP (1) | EP3212163A1 (ru) |
| JP (1) | JP6675397B2 (ru) |
| KR (1) | KR102485523B1 (ru) |
| CN (1) | CN107072942A (ru) |
| AU (3) | AU2015339242A1 (ru) |
| BR (1) | BR112017008661A8 (ru) |
| CA (1) | CA2966001C (ru) |
| IL (1) | IL251592B (ru) |
| MX (1) | MX2017005699A (ru) |
| RU (2) | RU2021138920A (ru) |
| TW (1) | TWI746425B (ru) |
| WO (1) | WO2016069845A1 (ru) |
| ZA (1) | ZA201703701B (ru) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115919758A (zh) * | 2022-11-21 | 2023-04-07 | 山东诺明康药物研究院有限公司 | 一种盐酸贝西沙星离子敏感型原位凝胶滴眼液及其制备方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI393567B (zh) | 2005-03-31 | 2013-04-21 | Bausch & Lomb | 治療乾眼之組合物及相關之製造方法及使用方法 |
| TWI434926B (zh) | 2006-12-11 | 2014-04-21 | Alcon Res Ltd | 眼用組成物中聚氧化乙烯-聚氧化丁烯（ｐｅｏ-ｐｂｏ）嵌段共聚物之使用 |
| US8759321B2 (en) | 2007-06-13 | 2014-06-24 | Bausch & Lomb Incorporated | Ophthalmic composition with hyaluronic acid and polymeric biguanide |
| US9096819B2 (en) | 2008-01-31 | 2015-08-04 | Bausch & Lomb Incorporated | Ophthalmic compositions with an amphoteric surfactant and an anionic biopolymer |
| US20110046033A1 (en) | 2008-01-31 | 2011-02-24 | Jinzhong Zhang | Multipurpose Lens Care Solution with Benefits to Corneal Epithelial Barrier Function |
| US8119112B2 (en) | 2008-01-31 | 2012-02-21 | Bausch & Lomb Incorporated | Ophthalmic compositions with an amphoteric surfactant and hyaluronic acid |
| US8840911B2 (en) * | 2008-03-07 | 2014-09-23 | Kimberly-Clark Worldwide, Inc. | Moisturizing hand sanitizer |
| US8163684B2 (en) | 2008-03-26 | 2012-04-24 | Abbott Medical Optics Inc. | Antimicrobials having polyquaternary ammoniums and alcohol-bearing amidoamines and methods for their use |
| US20100286010A1 (en) | 2008-09-03 | 2010-11-11 | Erning Xia | Ophthalmic Compositions with Hyaluronic Acid |
| NL2002214C2 (en) | 2008-11-17 | 2010-05-18 | Louis Johan Wagenaar | Contact lens care solution. |
| US20100178317A1 (en) | 2009-01-09 | 2010-07-15 | Burke Susan E | Lens Care Solutions with Hyaluronic Acid |
| US8349303B1 (en) | 2009-04-29 | 2013-01-08 | Bausch & Lomb Incorporated | Polymeric quaternium compounds |
| EP2255776A1 (en) | 2009-05-26 | 2010-12-01 | PURAC Biochem BV | Cleansing composition |
| US20100086514A1 (en) | 2009-10-01 | 2010-04-08 | Liu X Michael | Contact Lens Care Solutions with a Low Molecular Weight Oligomer |
| US8283463B2 (en) | 2010-02-09 | 2012-10-09 | Bausch & Lomb Incorporated | Sterile hyaluronic acid solutions |
| US20110319502A1 (en) | 2010-06-25 | 2011-12-29 | Coffey Martin J | Compositions and Methods for Enhancing Reduction of Spore-Forming Microorganisms |
| US20120070401A1 (en) | 2010-09-21 | 2012-03-22 | Jinzhong Zhang | Composition and Method for Promoting Wound Healing |
| US9278132B2 (en) | 2012-02-13 | 2016-03-08 | Bausch & Lomb Incorporated | Ophthalmic pharmaceutical compositions and methods of making and using same |
| UA113434C2 (uk) | 2012-05-04 | 2017-01-25 | Алкон Рісерч, Лтд. | Офтальмологічна композиція з поліпшеним захистом від зневоднювання й утриманням |
| US9357771B2 (en) * | 2012-12-17 | 2016-06-07 | Kimberly-Clark Worldwide, Inc. | Foaming sanitizing formulations and products including a quaternary ammonium compound |
-
2015
- 2015-10-26 US US14/922,504 patent/US10245324B2/en active Active
- 2015-10-29 CN CN201580059478.4A patent/CN107072942A/zh active Pending
- 2015-10-29 TW TW104135531A patent/TWI746425B/zh active
- 2015-10-29 KR KR1020177014772A patent/KR102485523B1/ko active IP Right Grant
- 2015-10-29 RU RU2021138920A patent/RU2021138920A/ru unknown
- 2015-10-29 RU RU2017118578A patent/RU2764117C2/ru active
- 2015-10-29 JP JP2017523363A patent/JP6675397B2/ja active Active
- 2015-10-29 MX MX2017005699A patent/MX2017005699A/es active IP Right Grant
- 2015-10-29 AU AU2015339242A patent/AU2015339242A1/en not_active Abandoned
- 2015-10-29 WO PCT/US2015/057959 patent/WO2016069845A1/en active Application Filing
- 2015-10-29 EP EP15791868.1A patent/EP3212163A1/en active Pending
- 2015-10-29 BR BR112017008661A patent/BR112017008661A8/pt not_active Application Discontinuation
- 2015-10-29 CA CA2966001A patent/CA2966001C/en active Active
-
2017
- 2017-04-05 IL IL251592A patent/IL251592B/en unknown
- 2017-05-30 ZA ZA2017/03701A patent/ZA201703701B/en unknown
-
2019
- 2019-02-19 US US16/279,129 patent/US10441658B2/en active Active
- 2019-09-10 US US16/565,983 patent/US10603382B2/en active Active
-
2021
- 2021-01-28 AU AU2021200514A patent/AU2021200514A1/en not_active Abandoned
-
2023
- 2023-03-13 AU AU2023201534A patent/AU2023201534A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR102485523B1 (ko) | 2023-01-09 |
| TW201628657A (zh) | 2016-08-16 |
| KR20170078793A (ko) | 2017-07-07 |
| RU2017118578A3 (ru) | 2019-05-28 |
| AU2023201534A1 (en) | 2023-04-13 |
| IL251592A0 (en) | 2017-06-29 |
| US20170112933A1 (en) | 2017-04-27 |
| RU2764117C2 (ru) | 2022-01-13 |
| RU2017118578A (ru) | 2018-12-04 |
| BR112017008661A2 (pt) | 2017-12-26 |
| IL251592B (en) | 2021-09-30 |
| US20200000923A1 (en) | 2020-01-02 |
| US20190184016A1 (en) | 2019-06-20 |
| CA2966001A1 (en) | 2016-05-06 |
| TWI746425B (zh) | 2021-11-21 |
| BR112017008661A8 (pt) | 2022-08-09 |
| MX2017005699A (es) | 2018-03-23 |
| AU2021200514A1 (en) | 2021-02-25 |
| AU2015339242A1 (en) | 2017-04-27 |
| US20180250408A9 (en) | 2018-09-06 |
| JP6675397B2 (ja) | 2020-04-01 |
| CA2966001C (en) | 2023-02-21 |
| US10603382B2 (en) | 2020-03-31 |
| CN107072942A (zh) | 2017-08-18 |
| US10441658B2 (en) | 2019-10-15 |
| WO2016069845A1 (en) | 2016-05-06 |
| US10245324B2 (en) | 2019-04-02 |
| EP3212163A1 (en) | 2017-09-06 |
| JP2017533216A (ja) | 2017-11-09 |
| ZA201703701B (en) | 2021-05-26 |
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