RU2020121746A - Способ получения роксадустата и его промежуточных соединений - Google Patents
Способ получения роксадустата и его промежуточных соединений Download PDFInfo
- Publication number
- RU2020121746A RU2020121746A RU2020121746A RU2020121746A RU2020121746A RU 2020121746 A RU2020121746 A RU 2020121746A RU 2020121746 A RU2020121746 A RU 2020121746A RU 2020121746 A RU2020121746 A RU 2020121746A RU 2020121746 A RU2020121746 A RU 2020121746A
- Authority
- RU
- Russia
- Prior art keywords
- compound
- formula
- alkyl
- acid
- roxadustat
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201741043126 | 2017-12-01 | ||
| IN201741043126 | 2017-12-01 | ||
| IN201841019627 | 2018-05-25 | ||
| IN201841019627 | 2018-05-25 | ||
| PCT/IB2018/059504 WO2019106621A1 (en) | 2017-12-01 | 2018-11-30 | Process for the preparation of roxadustat and its intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2020121746A true RU2020121746A (ru) | 2022-01-04 |
Family
ID=66664380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2020121746A RU2020121746A (ru) | 2017-12-01 | 2018-11-30 | Способ получения роксадустата и его промежуточных соединений |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20200299242A1 (https=) |
| EP (1) | EP3717456A4 (https=) |
| JP (1) | JP2021504440A (https=) |
| CN (1) | CN111566090A (https=) |
| BR (1) | BR112020011040A2 (https=) |
| CA (1) | CA3083672A1 (https=) |
| RU (1) | RU2020121746A (https=) |
| WO (1) | WO2019106621A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2842856C1 (ru) * | 2023-06-27 | 2025-07-02 | ЦЗЯНСУ Оушен Юниверсити | Синтетический способ для промежуточного продукта роксадустата |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2709493C1 (ru) * | 2019-08-01 | 2019-12-18 | Марат Феликсович Фазылов | Способ получения роксадустата |
| US20220340532A1 (en) | 2019-08-07 | 2022-10-27 | Teva Pharmaceuticals International Gmbh | Processes for the preparation of roxadustat and intermediates thereof |
| CN115144480B (zh) * | 2021-03-31 | 2023-11-28 | 成都倍特药业股份有限公司 | 一种从罗沙司他中间体中检测吗啉和/或四甲基甲烷二胺的方法 |
| CN113248432B (zh) * | 2021-04-25 | 2022-12-13 | 南京正济医药研究有限公司 | 高收率制备罗沙司他中间体的新方法 |
| CN116903532A (zh) * | 2023-06-02 | 2023-10-20 | 珠海优润医药科技有限公司 | 一种罗沙司他的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2528232C (en) * | 2003-06-06 | 2010-05-25 | Fibrogen, Inc. | Novel nitrogen-containing heteroaryl compounds and their use in increasing endogenous erythropoietin |
| US9206134B2 (en) * | 2011-07-22 | 2015-12-08 | Beijing Betta Pharmaceuticals Co. Ltd. | Polymorphic forms of compounds as prolyl hydroxylase inhibitor, and uses thereof |
| EP2872487B1 (en) * | 2012-07-16 | 2017-04-26 | Fibrogen, Inc. | Process for making isoquinoline compounds |
| CN104892509B (zh) * | 2015-06-04 | 2018-03-09 | 苏州明锐医药科技有限公司 | 诺得司他的制备方法 |
| CN106478504B (zh) * | 2016-09-29 | 2020-04-21 | 上海勋和医药科技有限公司 | 制备Roxadustat中间体的方法 |
| CN108383787A (zh) * | 2017-11-05 | 2018-08-10 | 王兆举 | 诺得司他的制备方法 |
| CN108424388B (zh) * | 2018-04-19 | 2020-08-21 | 杭州科巢生物科技有限公司 | 一种慢性贫血药物的制备方法 |
-
2018
- 2018-11-30 CA CA3083672A patent/CA3083672A1/en active Pending
- 2018-11-30 CN CN201880076576.2A patent/CN111566090A/zh active Pending
- 2018-11-30 EP EP18884511.9A patent/EP3717456A4/en not_active Withdrawn
- 2018-11-30 RU RU2020121746A patent/RU2020121746A/ru unknown
- 2018-11-30 BR BR112020011040-0A patent/BR112020011040A2/pt not_active Application Discontinuation
- 2018-11-30 US US16/768,523 patent/US20200299242A1/en not_active Abandoned
- 2018-11-30 WO PCT/IB2018/059504 patent/WO2019106621A1/en not_active Ceased
- 2018-11-30 JP JP2020529736A patent/JP2021504440A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2842856C1 (ru) * | 2023-06-27 | 2025-07-02 | ЦЗЯНСУ Оушен Юниверсити | Синтетический способ для промежуточного продукта роксадустата |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2021504440A (ja) | 2021-02-15 |
| CN111566090A (zh) | 2020-08-21 |
| WO2019106621A1 (en) | 2019-06-06 |
| CA3083672A1 (en) | 2019-06-06 |
| EP3717456A4 (en) | 2021-09-15 |
| EP3717456A1 (en) | 2020-10-07 |
| US20200299242A1 (en) | 2020-09-24 |
| BR112020011040A2 (pt) | 2020-11-17 |
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