RU2020117081A - Жидкие стабильные вакцины, содержащие вирус крупного рогатого скота - Google Patents

Жидкие стабильные вакцины, содержащие вирус крупного рогатого скота Download PDF

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RU2020117081A
RU2020117081A RU2020117081A RU2020117081A RU2020117081A RU 2020117081 A RU2020117081 A RU 2020117081A RU 2020117081 A RU2020117081 A RU 2020117081A RU 2020117081 A RU2020117081 A RU 2020117081A RU 2020117081 A RU2020117081 A RU 2020117081A
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live attenuated
liquid stable
combination vaccine
stable combination
bvdv
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RU2759880C2 (ru
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Брэд ЭДДИ
Чжисун ЦЯО
Кевин О`КОННЕЛЛ
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Интервет Интернэшнл Б.В.
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Claims (8)

1. Эффективная жидкая стабильная комбинированная вакцина, способствующая защите крупного рогатого скота от клинического заболевания, которое возникает вследствие инфекции, вызванной вирусом вирусной диареи крупного рогатого скота (BVDV), и/или вирусом инфекционного бычьего ринотрахеита (IBR), и/или вирусом парагриппа типа 3 (PI3), и/или бычьим респираторно-синцитиальным вирусом (BRSV), и/или бычьим респираторным коронавирусом (BRCV), где указанная жидкая стабильная комбинированная вакцина содержит живой ослабленный BVDV, и/или живой ослабленный IBR, и/или живой ослабленный PI3, и/или живой ослабленный BRSV, и/или живой ослабленный BRCV вместе с 10-30% (масса/объем) сорбита, и количеством аминокислоты, выбранным из группы, состоящей из 0,17-0,46 моль аргинина или комбинированного общего 0,2-0,6 моль аргинина и глутаминовой кислоты; и, где жидкая стабильная комбинированная вакцина обладает рН от 6,0 до 8,0.
2. Жидкая стабильная комбинированная вакцина по п.1, в которой живой ослабленный BVDV выбран из группы, состоящей из BVDV1, BVDV2, и BVDV1 с BVDV2.
3. Жидкая стабильная комбинированная вакцина по п.1 или 2, дополнительно содержащая добавку сахара, которая является бесспиртовым сахаром, в которых комбинированное общее количество сахарного спирта и бесспиртового сахара в жидкой стабильной комбинированной вакцине составляет 20-40% (масса/объем).
4. Жидкая стабильная комбинированная вакцина по п.3, в которой бесспиртовой сахар выбран из группы, состоящей из сахарозы и трегалозы.
5. Жидкая стабильная комбинированная вакцина по п.1 или 2, которая дополнительно содержит бактерию.
6. Способ вакцинации крупного рогатого скота для помощи в защите от клинического заболевания, которое возникает вследствие инфекции, вызванной BVDV, и/или IBR, и/или PI3, и/или BRSV, и/или BRCV, включающий введение крупному рогатому скоту жидкой стабильной комбинированной вакцины по любому из пп.1-5.
7. Способ по п.6, в котором вышеупомянутое введение осуществляется путем подкожной инъекции, перорально или интраназально.
8. Способ производства жидкой комбинированной стабильной вакцины по п.1, включающий комбинирование терапевтически эффективного количества живого ослабленного BVDV, и/или живого ослабленного IBR, и/или живого ослабленного PI3, и/или живого ослабленного BRSV, и/или живого ослабленного BRCV вместе с 10-30% (масса/объем) сорбита и количества аминокислоты, выбранным из группы, состоящей из 0,17- 0,46 моль аргинина или комбинированного общего 0,2-0,6 моль аргинина и глутаминовой кислоты; и, где жидкая стабильная комбинированная вакцина обладает рН от 6,0 до 8,0.
RU2020117081A 2013-03-15 2014-03-14 Жидкие стабильные вакцины, содержащие вирус крупного рогатого скота RU2759880C2 (ru)

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US9314519B2 (en) 2012-08-21 2016-04-19 Intervet Inc. Liquid stable virus vaccines
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