RU2019126152A - Однодоменные антитела, направленные против внутриклеточных антигенов - Google Patents
Однодоменные антитела, направленные против внутриклеточных антигенов Download PDFInfo
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- RU2019126152A RU2019126152A RU2019126152A RU2019126152A RU2019126152A RU 2019126152 A RU2019126152 A RU 2019126152A RU 2019126152 A RU2019126152 A RU 2019126152A RU 2019126152 A RU2019126152 A RU 2019126152A RU 2019126152 A RU2019126152 A RU 2019126152A
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- 108010003723 Single-Domain Antibodies Proteins 0.000 title claims 3
- 238000000034 method Methods 0.000 claims 8
- 101710127861 Membrane-associated protein VP24 Proteins 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 238000004458 analytical method Methods 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 238000002965 ELISA Methods 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 241001529936 Murinae Species 0.000 claims 2
- 230000001900 immune effect Effects 0.000 claims 2
- 239000012491 analyte Substances 0.000 claims 1
- 230000000840 anti-viral effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003889 eye drop Substances 0.000 claims 1
- 229940012356 eye drops Drugs 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 238000004811 liquid chromatography Methods 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 239000007922 nasal spray Substances 0.000 claims 1
- 229940097496 nasal spray Drugs 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
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- A—HUMAN NECESSITIES
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C07K16/1002—Coronaviridae
- C07K16/1003—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2 or Covid-19]
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- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
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- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
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- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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Claims (16)
1. Однодоменное антитело (sdAb) к Эбола VP24.
2. Однодоменное антитело (sdAb) к Эбола VP24, содержащее аминокислотную последовательность, представленную в SEQ ID NO: 55.
3. Способ лечения заболевания, предотвращения развития заболевания или предотвращения рецидива заболевания у субъекта с применением sdAb к Эбола VP24 по пп. 1 или 2, который включает введение эффективного количества sdAb к Эбола VP24 субъекту, нуждающемуся в этом.
4. Способ по п. 3, отличающийся тем, что субъектом является млекопитающее.
5. Способ по п. 4, отличающийся тем, что млекопитающим яаляется человек.
6. Способ по п. 3, отличающийся тем, что sdAb к Эбола VP24 вводят в комбинации с одним или более соединениями.
7. Способ по п. 6, отличающийся тем, что одно или более соединений представляет собой противовирусное соединение.
8. Способ по п. 2, отличающийся тем, что введение эффективного количества sdAb к Эбола VP24 субъекту, нуждающемуся в этом, включает внутривенное введение, внутримышечное введение, пероральный прием, ректальное введение, энтеральное введение, парентеральное введение, внутриглазное введение, подкожное введение, трансдермальное введение, введение в виде глазных капель, введение в виде назального спрея, введение путем ингаляции или распыления, местное введение и введение в качестве имплантируемого лекарственного средства.
9. Выделенный полипептид, содержащий аминокислотную последовательность, представленную в SEQ ID NO: 55.
10. Антитело к полипептиду по п. 9.
11. Способ измерения уровней sdAb к Эбола VP24 в образце от субъекта, включающий этапы, на которых:
a) создают мышиное моноклональное антитело, направленное против одного или более доменов полипептида, содержащего аминокислотную последовательность, представленную в SEQ ID NO: 55;
b) получают образец от субъекта;
c) проводят количественный иммунологический анализ с мышиным моноклональным антителом и образцом для определения количества sdAb у субъекта; и
d) определяют количество sdAb у субъекта.
12. Способ по п. 11, отличающийся тем, что количественный иммунологический анализ включает иммуноферментный анализ (ИФА), анализ специфического мечения аналита и повторного захвата (SALRA), жидкостную хроматографию, масс-спектрометрию, сортировку клеток на проточном цитометре, или их комбинацию.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US201562249868P | 2015-11-02 | 2015-11-02 | |
US62/249,868 | 2015-11-02 |
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RU2018120245A Division RU2741110C2 (ru) | 2015-11-02 | 2016-11-02 | Однодоменные антитела, направленные против внутриклеточных антигенов |
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RU2019126152A true RU2019126152A (ru) | 2019-12-04 |
RU2019126152A3 RU2019126152A3 (ru) | 2020-05-13 |
RU2742247C2 RU2742247C2 (ru) | 2021-02-04 |
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RU2019126220A RU2742248C2 (ru) | 2015-11-02 | 2016-11-02 | Однодоменные антитела, направленные против внутриклеточных антигенов |
RU2019126152A RU2742247C2 (ru) | 2015-11-02 | 2016-11-02 | Однодоменные антитела, направленные против внутриклеточных антигенов |
RU2018120245A RU2741110C2 (ru) | 2015-11-02 | 2016-11-02 | Однодоменные антитела, направленные против внутриклеточных антигенов |
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Country Status (14)
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US (4) | US10369223B2 (ru) |
EP (1) | EP3371215A4 (ru) |
JP (2) | JP6918005B2 (ru) |
KR (1) | KR20180069064A (ru) |
CN (2) | CN113512112A (ru) |
AR (1) | AR106556A1 (ru) |
AU (1) | AU2016349876B2 (ru) |
BR (1) | BR112018008840B1 (ru) |
CA (1) | CA3002239A1 (ru) |
IL (1) | IL258742B (ru) |
MX (1) | MX2018005154A (ru) |
RU (3) | RU2742248C2 (ru) |
TW (1) | TWI746473B (ru) |
WO (1) | WO2017079314A2 (ru) |
Families Citing this family (6)
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US20170267784A1 (en) | 2014-10-23 | 2017-09-21 | Singh Molecular Medicine, Llc | Single domain antibodies directed against intracellular antigens |
CN113557246B (zh) * | 2019-07-24 | 2023-09-01 | 韩国基础科学支援研究院 | 靶向αvβ3整联蛋白的单域抗体 |
CN111234019B (zh) * | 2020-01-16 | 2022-06-24 | 佛山汉腾生物科技有限公司 | 抗ctla-4纳米抗体、药物组合物及其应用 |
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