RU2018119173A3 - - Google Patents
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- Publication number
- RU2018119173A3 RU2018119173A3 RU2018119173A RU2018119173A RU2018119173A3 RU 2018119173 A3 RU2018119173 A3 RU 2018119173A3 RU 2018119173 A RU2018119173 A RU 2018119173A RU 2018119173 A RU2018119173 A RU 2018119173A RU 2018119173 A3 RU2018119173 A3 RU 2018119173A3
- Authority
- RU
- Russia
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510800975.7 | 2015-11-19 | ||
| CN201510800975 | 2015-11-19 | ||
| PCT/CN2016/104318 WO2017084494A1 (fr) | 2015-11-19 | 2016-11-02 | Dérivé du benzofurane, son procédé de préparation et son utilisation en médecine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2018119173A RU2018119173A (ru) | 2019-12-19 |
| RU2018119173A3 true RU2018119173A3 (fr) | 2020-02-13 |
| RU2727198C2 RU2727198C2 (ru) | 2020-07-21 |
Family
ID=58717310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018119173A RU2727198C2 (ru) | 2015-11-19 | 2016-11-02 | Производное бензофурана, способ его получения и его применение в медицине |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US10759787B2 (fr) |
| EP (1) | EP3378859B1 (fr) |
| JP (1) | JP6828229B2 (fr) |
| KR (1) | KR20180081587A (fr) |
| CN (1) | CN107428742B (fr) |
| AU (1) | AU2016357900B2 (fr) |
| BR (1) | BR112018007876B1 (fr) |
| CA (1) | CA3002436A1 (fr) |
| DK (1) | DK3378859T3 (fr) |
| ES (1) | ES2760510T3 (fr) |
| HK (1) | HK1243414A1 (fr) |
| HR (1) | HRP20192209T1 (fr) |
| HU (1) | HUE047785T2 (fr) |
| LT (1) | LT3378859T (fr) |
| MX (1) | MX2018005019A (fr) |
| PL (1) | PL3378859T3 (fr) |
| PT (1) | PT3378859T (fr) |
| RS (1) | RS59763B1 (fr) |
| RU (1) | RU2727198C2 (fr) |
| SI (1) | SI3378859T1 (fr) |
| TW (1) | TWI718207B (fr) |
| WO (1) | WO2017084494A1 (fr) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10266542B2 (en) | 2017-03-15 | 2019-04-23 | Mirati Therapeutics, Inc. | EZH2 inhibitors |
| TWI810185B (zh) * | 2017-05-18 | 2023-08-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種ｅｚｈ２抑制劑與ｂｔｋ抑制劑聯合在製備治療腫瘤的藥物中的用途 |
| MX2019012967A (es) | 2017-05-18 | 2020-01-20 | Jiangsu Hengrui Medicine Co | Cristal de base libre de derivados benzofurano y metodo de preparacion. |
| EP3708567A4 (fr) * | 2017-11-10 | 2021-07-07 | Jiangsu Hengrui Medicine Co., Ltd. | Procédé de préparation d'un dérivé de benzofurane |
| CA3089639A1 (fr) | 2018-01-31 | 2019-08-08 | Mirati Therapeutics, Inc. | Composes d'imidazo[1,2-c]pyrimidinyle comme inhibiteurs de prc2 |
| CN110179796B (zh) * | 2018-02-23 | 2023-01-24 | 江苏恒瑞医药股份有限公司 | 一种苯并呋喃类衍生物的组合物及制备方法 |
| BR112020021194A2 (pt) * | 2018-04-18 | 2021-03-23 | Constallation Pharmaceuticals, Inc. | moduladores de enzimas modificadoras de metila, composições e usos dos mesmos |
| CN110563722A (zh) * | 2018-06-06 | 2019-12-13 | 上海青煜医药科技有限公司 | 吡啶或哒嗪并环化合物及其应用 |
| CN112512580B (zh) * | 2018-09-29 | 2024-04-16 | 江苏恒瑞医药股份有限公司 | Ezh2抑制剂与免疫检查点抑制剂联合在制备治疗肿瘤的药物中的用途 |
| WO2020192652A1 (fr) | 2019-03-25 | 2020-10-01 | 上海华汇拓医药科技有限公司 | Procédé de préparation de composés amides et son utilisation dans le domaine médical |
| CN113302185B (zh) * | 2019-04-29 | 2024-04-09 | 上海和誉生物医药科技有限公司 | 苯并呋喃-6-甲酰胺衍生物、其制备方法和药学上的应用 |
| CN110003187B (zh) * | 2019-05-10 | 2021-11-05 | 南京工业大学 | 一种多氟烷基取代苯并呋喃类化合物及其制备方法 |
| TW202108578A (zh) * | 2019-05-10 | 2021-03-01 | 大陸商江蘇恒瑞醫藥股份有限公司 | 6-取代氨基苯并呋喃化合物的製備方法 |
| CN112007162B (zh) * | 2019-05-30 | 2023-05-12 | 江苏恒瑞医药股份有限公司 | Ezh2抑制剂与免疫检查点抑制剂、vegfr抑制剂联合在制备治疗肿瘤药物中的用途 |
| CN110172448B (zh) * | 2019-05-30 | 2020-07-28 | 中南大学湘雅二医院 | 一种滑膜肉瘤细胞系hSS-005R及其子代细胞系 |
| TW202114663A (zh) * | 2019-09-30 | 2021-04-16 | 大陸商江蘇恒瑞醫藥股份有限公司 | EZH2抑制劑與含有TGF-β受體的融合蛋白聯合在製備治療腫瘤的藥物中的用途 |
| TW202114670A (zh) * | 2019-09-30 | 2021-04-16 | 大陸商江蘇恒瑞醫藥股份有限公司 | 一種ezh2抑制劑與cdk4/6抑制劑聯合在製備治療腫瘤藥物中的用途 |
| TW202126302A (zh) * | 2019-09-30 | 2021-07-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | Ｅｚｈ２抑制劑與免疫檢查點抑制劑、酪胺酸激酶抑制劑聯合在製備治療腫瘤藥物中的用途 |
| CN112870365A (zh) * | 2019-11-29 | 2021-06-01 | 江苏恒瑞医药股份有限公司 | Ezh2抑制剂和/或parp抑制剂与化疗药物联合在制备治疗肿瘤药物中的用途 |
| IL311097A (en) | 2021-08-30 | 2024-04-01 | Jiangsu Hengrui Pharmaceuticals Co Ltd | Use of an EZH2 inhibitor in the preparation of drugs for the treatment of T-cell lymphoma |
| TW202330509A (zh) * | 2021-10-15 | 2023-08-01 | 大陸商江蘇恒瑞醫藥股份有限公司 | 苯並呋喃衍生物的製備方法 |
| WO2023244917A1 (fr) | 2022-06-13 | 2023-12-21 | Treeline Biosciences, Inc. | Agents dégradant bcl6 hétérobifonctionnels 1,8-naphthyridin-2-one |
| WO2023244918A1 (fr) | 2022-06-13 | 2023-12-21 | Treeline Biosciences, Inc. | Agents de dégradation bifonctionnels de quinolone bcl6 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110275630A1 (en) | 2003-06-02 | 2011-11-10 | Abbott Laboratories | Isoindolinone kinase inhibitors |
| WO2009101022A1 (fr) * | 2008-02-14 | 2009-08-20 | F. Hoffmann-La Roche Ag | Composés hétérocycliques antiviraux |
| WO2011140325A1 (fr) | 2010-05-07 | 2011-11-10 | Glaxosmithkline Llc | Indazoles |
| EP2566327B1 (fr) * | 2010-05-07 | 2017-03-29 | Glaxosmithkline LLC | Indoles |
| EP2566479B1 (fr) | 2010-05-07 | 2014-12-24 | GlaxoSmithKline LLC | Aza-indazoles |
| EP2410171A1 (fr) | 2010-07-23 | 2012-01-25 | Ewt Ip B.V. | Éolienne dotée d'un rotor avec moyeu |
| SG180031A1 (en) | 2010-10-15 | 2012-05-30 | Agency Science Tech & Res | Combination treatment of cancer |
| EP2681216B1 (fr) * | 2011-02-28 | 2017-09-27 | Epizyme, Inc. | Composés hétéroaryles bicycliques substitués condensés en 6,5 |
| TW201733984A (zh) * | 2011-04-13 | 2017-10-01 | 雅酶股份有限公司 | 經取代之苯化合物 |
| JO3438B1 (ar) | 2011-04-13 | 2019-10-20 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
| EP2755962B1 (fr) * | 2011-09-13 | 2017-03-01 | Glaxosmithkline LLC | Azaindazoles |
| CN103987842A (zh) | 2011-09-30 | 2014-08-13 | 葛兰素史密斯克莱有限责任公司 | 治疗癌症的方法 |
| WO2013067300A1 (fr) | 2011-11-04 | 2013-05-10 | Glaxosmithkline Intellectual Property (No. 2) Limited | Méthode de traitement |
| WO2013173441A2 (fr) | 2012-05-16 | 2013-11-21 | Glaxosmithkline Llc | Inhibiteurs d'homologue d'activateur de zeste 2 |
| UA111305C2 (uk) | 2012-12-21 | 2016-04-11 | Пфайзер Інк. | Конденсовані лактами арилу та гетероарилу |
| CN105308038B (zh) | 2013-04-30 | 2018-05-29 | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | Zeste增强子同源物2的抑制剂 |
| US9822103B2 (en) * | 2013-11-22 | 2017-11-21 | Bristol-Myers Squibb Company | Inhibitors of lysine methyl transferase |
| SI3121175T1 (sl) | 2014-03-17 | 2020-07-31 | Daiichi Sankyo Company, Limited | Derivati 1,3-benzodioksola kot EZH1 in/ali EZH2 inhibitorji |
-
2016
- 2016-11-02 DK DK16865671.8T patent/DK3378859T3/da active
- 2016-11-02 US US15/775,958 patent/US10759787B2/en active Active
- 2016-11-02 MX MX2018005019A patent/MX2018005019A/es unknown
- 2016-11-02 PL PL16865671T patent/PL3378859T3/pl unknown
- 2016-11-02 BR BR112018007876-0A patent/BR112018007876B1/pt active IP Right Grant
- 2016-11-02 RU RU2018119173A patent/RU2727198C2/ru active
- 2016-11-02 ES ES16865671T patent/ES2760510T3/es active Active
- 2016-11-02 SI SI201630514T patent/SI3378859T1/sl unknown
- 2016-11-02 CN CN201680013259.7A patent/CN107428742B/zh active Active
- 2016-11-02 JP JP2018523005A patent/JP6828229B2/ja active Active
- 2016-11-02 PT PT168656718T patent/PT3378859T/pt unknown
- 2016-11-02 AU AU2016357900A patent/AU2016357900B2/en active Active
- 2016-11-02 EP EP16865671.8A patent/EP3378859B1/fr active Active
- 2016-11-02 CA CA3002436A patent/CA3002436A1/fr active Pending
- 2016-11-02 HU HUE16865671A patent/HUE047785T2/hu unknown
- 2016-11-02 RS RS20191628A patent/RS59763B1/sr unknown
- 2016-11-02 WO PCT/CN2016/104318 patent/WO2017084494A1/fr active Application Filing
- 2016-11-02 LT LTEP16865671.8T patent/LT3378859T/lt unknown
- 2016-11-02 KR KR1020187016692A patent/KR20180081587A/ko not_active Application Discontinuation
- 2016-11-16 TW TW105137422A patent/TWI718207B/zh active
-
2018
- 2018-03-01 HK HK18102969.3A patent/HK1243414A1/zh unknown
-
2019
- 2019-12-09 HR HRP20192209TT patent/HRP20192209T1/hr unknown
-
2020
- 2020-07-22 US US16/935,407 patent/US11059811B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| SI3378859T1 (sl) | 2020-03-31 |
| PL3378859T3 (pl) | 2020-04-30 |
| AU2016357900B2 (en) | 2020-09-17 |
| HUE047785T2 (hu) | 2020-05-28 |
| CN107428742A (zh) | 2017-12-01 |
| US11059811B2 (en) | 2021-07-13 |
| JP6828229B2 (ja) | 2021-02-10 |
| BR112018007876B1 (pt) | 2023-10-17 |
| LT3378859T (lt) | 2020-01-27 |
| HRP20192209T1 (hr) | 2020-07-24 |
| CA3002436A1 (fr) | 2017-05-26 |
| US20180327394A1 (en) | 2018-11-15 |
| EP3378859A4 (fr) | 2018-09-26 |
| TW201718561A (zh) | 2017-06-01 |
| EP3378859A1 (fr) | 2018-09-26 |
| TWI718207B (zh) | 2021-02-11 |
| MX2018005019A (es) | 2018-06-13 |
| DK3378859T3 (da) | 2020-01-20 |
| RU2727198C2 (ru) | 2020-07-21 |
| KR20180081587A (ko) | 2018-07-16 |
| AU2016357900A1 (en) | 2018-05-24 |
| US20200354349A1 (en) | 2020-11-12 |
| JP2018538257A (ja) | 2018-12-27 |
| PT3378859T (pt) | 2019-12-11 |
| RU2018119173A (ru) | 2019-12-19 |
| WO2017084494A1 (fr) | 2017-05-26 |
| ES2760510T3 (es) | 2020-05-14 |
| BR112018007876A2 (pt) | 2018-10-30 |
| CN107428742B (zh) | 2020-05-08 |
| HK1243414A1 (zh) | 2018-07-13 |
| EP3378859B1 (fr) | 2019-10-30 |
| RS59763B1 (sr) | 2020-02-28 |
| US10759787B2 (en) | 2020-09-01 |