RU2018112710A - Способы размножения мезенхимальных стволовых клеток (MSC) для применения в трансплантации - Google Patents
Способы размножения мезенхимальных стволовых клеток (MSC) для применения в трансплантации Download PDFInfo
- Publication number
- RU2018112710A RU2018112710A RU2018112710A RU2018112710A RU2018112710A RU 2018112710 A RU2018112710 A RU 2018112710A RU 2018112710 A RU2018112710 A RU 2018112710A RU 2018112710 A RU2018112710 A RU 2018112710A RU 2018112710 A RU2018112710 A RU 2018112710A
- Authority
- RU
- Russia
- Prior art keywords
- apoptosis
- cells
- inducing agent
- stem cells
- mesenchymal stem
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 15
- 210000002901 mesenchymal stem cell Anatomy 0.000 title claims 10
- 238000002054 transplantation Methods 0.000 title claims 2
- 230000006907 apoptotic process Effects 0.000 claims 14
- 210000004027 cell Anatomy 0.000 claims 13
- 239000003795 chemical substances by application Substances 0.000 claims 13
- 230000001939 inductive effect Effects 0.000 claims 13
- 238000011534 incubation Methods 0.000 claims 6
- 239000002609 medium Substances 0.000 claims 6
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 4
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 4
- 102100031988 Tumor necrosis factor ligand superfamily member 6 Human genes 0.000 claims 4
- 108050002568 Tumor necrosis factor ligand superfamily member 6 Proteins 0.000 claims 4
- 239000001963 growth medium Substances 0.000 claims 3
- 230000001902 propagating effect Effects 0.000 claims 3
- 102100024598 Tumor necrosis factor ligand superfamily member 10 Human genes 0.000 claims 2
- 101710097160 Tumor necrosis factor ligand superfamily member 10 Proteins 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 238000002955 isolation Methods 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000015212 Fas Ligand Protein Human genes 0.000 claims 1
- 108010039471 Fas Ligand Protein Proteins 0.000 claims 1
- 206010054094 Tumour necrosis Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 210000000577 adipose tissue Anatomy 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000000411 inducer Substances 0.000 claims 1
- 238000007443 liposuction Methods 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/25—Tumour necrosing factors [TNF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/48—Regulators of apoptosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562222853P | 2015-09-24 | 2015-09-24 | |
| US62/222,853 | 2015-09-24 | ||
| PCT/IL2016/051053 WO2017051421A1 (en) | 2015-09-24 | 2016-09-22 | Methods for propagating mesenchymal stem cells (msc) for use in transplantation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2018112710A true RU2018112710A (ru) | 2019-10-24 |
Family
ID=57121465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018112710A RU2018112710A (ru) | 2015-09-24 | 2016-09-22 | Способы размножения мезенхимальных стволовых клеток (MSC) для применения в трансплантации |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11578306B2 (https=) |
| EP (1) | EP3353286A1 (https=) |
| JP (1) | JP7011827B2 (https=) |
| KR (1) | KR20180050750A (https=) |
| CN (1) | CN108138142A (https=) |
| AU (1) | AU2016327285A1 (https=) |
| CA (1) | CA2999140A1 (https=) |
| IL (1) | IL258267B (https=) |
| RU (1) | RU2018112710A (https=) |
| WO (1) | WO2017051421A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201604304D0 (en) * | 2016-03-14 | 2016-04-27 | Tigenix S A U | Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease |
| CA3081768A1 (en) * | 2017-11-06 | 2019-05-09 | King's College London | Therapeutic substances, their preparation and diagnostic procedure |
| AU2019264974A1 (en) * | 2018-05-08 | 2020-10-29 | Cellect Biotherapeutics Ltd. | Methods for expanding adipose-derived stem cells |
| CN113943705B (zh) * | 2021-11-01 | 2023-09-19 | 北京大学口腔医学院 | 一种凋亡微囊泡及其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL68218A (en) | 1983-03-23 | 1985-12-31 | Univ Ramot | Compositions for cartilage repair comprising embryonal chondrocytes |
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5851832A (en) | 1991-07-08 | 1998-12-22 | Neurospheres, Ltd. | In vitro growth and proliferation of multipotent neural stem cells and their progeny |
| US5736396A (en) | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
| EP0893493A3 (de) | 1997-07-21 | 2002-12-04 | Aventis Pharma Deutschland GmbH | Genetisch veränderte Zellen und deren Verwendung in der Prophylaxe oder Therapie von Erkrankungen |
| CA2653881C (en) * | 2006-05-31 | 2016-08-23 | Styx Llc | Methods of selecting stem cells and uses thereof |
| CN105530946A (zh) * | 2013-09-11 | 2016-04-27 | 南加利福尼亚大学 | 具有高度表达的fas配体的干细胞组合物 |
-
2016
- 2016-09-22 EP EP16778893.4A patent/EP3353286A1/en not_active Withdrawn
- 2016-09-22 AU AU2016327285A patent/AU2016327285A1/en not_active Abandoned
- 2016-09-22 JP JP2018515293A patent/JP7011827B2/ja not_active Expired - Fee Related
- 2016-09-22 RU RU2018112710A patent/RU2018112710A/ru not_active Application Discontinuation
- 2016-09-22 CA CA2999140A patent/CA2999140A1/en not_active Abandoned
- 2016-09-22 KR KR1020187011049A patent/KR20180050750A/ko not_active Withdrawn
- 2016-09-22 WO PCT/IL2016/051053 patent/WO2017051421A1/en not_active Ceased
- 2016-09-22 CN CN201680061134.1A patent/CN108138142A/zh active Pending
- 2016-09-22 US US15/762,956 patent/US11578306B2/en active Active
-
2018
- 2018-03-21 IL IL258267A patent/IL258267B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2999140A1 (en) | 2017-03-30 |
| EP3353286A1 (en) | 2018-08-01 |
| JP2018528782A (ja) | 2018-10-04 |
| WO2017051421A1 (en) | 2017-03-30 |
| AU2016327285A1 (en) | 2018-04-12 |
| JP7011827B2 (ja) | 2022-02-10 |
| IL258267A (en) | 2018-05-31 |
| IL258267B (en) | 2022-05-01 |
| CN108138142A (zh) | 2018-06-08 |
| KR20180050750A (ko) | 2018-05-15 |
| US20180340144A1 (en) | 2018-11-29 |
| US11578306B2 (en) | 2023-02-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20190923 |