RU2017113775A - Применение нейрегулина в профилактике, лечении или отсрочке развития желудочковой аритмии и его композиция - Google Patents
Применение нейрегулина в профилактике, лечении или отсрочке развития желудочковой аритмии и его композиция Download PDFInfo
- Publication number
- RU2017113775A RU2017113775A RU2017113775A RU2017113775A RU2017113775A RU 2017113775 A RU2017113775 A RU 2017113775A RU 2017113775 A RU2017113775 A RU 2017113775A RU 2017113775 A RU2017113775 A RU 2017113775A RU 2017113775 A RU2017113775 A RU 2017113775A
- Authority
- RU
- Russia
- Prior art keywords
- nrg
- ventricular
- pharmaceutical preparation
- composition
- mammal
- Prior art date
Links
- 206010047281 Ventricular arrhythmia Diseases 0.000 title claims 12
- 239000000203 mixture Substances 0.000 title claims 6
- 230000002265 prevention Effects 0.000 title claims 2
- 102000014413 Neuregulin Human genes 0.000 title 1
- 108050003475 Neuregulin Proteins 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 10
- 208000009729 Ventricular Premature Complexes Diseases 0.000 claims 8
- 208000003663 ventricular fibrillation Diseases 0.000 claims 8
- 206010047302 ventricular tachycardia Diseases 0.000 claims 8
- 241000124008 Mammalia Species 0.000 claims 6
- 102100040896 Growth/differentiation factor 15 Human genes 0.000 claims 4
- 101000893549 Homo sapiens Growth/differentiation factor 15 Proteins 0.000 claims 4
- 101000653754 Rattus norvegicus Sphingosine 1-phosphate receptor 5 Proteins 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- ZOXZWYWOECCBSH-UHFFFAOYSA-N 4 Methyl N-ethylcathinone Chemical compound CCNC(C)C(=O)C1=CC=C(C)C=C1 ZOXZWYWOECCBSH-UHFFFAOYSA-N 0.000 claims 2
- 102400000057 Neuregulin-2 Human genes 0.000 claims 2
- 101800000675 Neuregulin-2 Proteins 0.000 claims 2
- 102400000054 Neuregulin-3 Human genes 0.000 claims 2
- 101800000673 Neuregulin-3 Proteins 0.000 claims 2
- 102400000055 Neuregulin-4 Human genes 0.000 claims 2
- 101800002641 Neuregulin-4 Proteins 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102000012740 beta Adrenergic Receptors Human genes 0.000 claims 1
- 108010079452 beta Adrenergic Receptors Proteins 0.000 claims 1
- 239000003087 receptor blocking agent Substances 0.000 claims 1
- 229940125794 sodium channel blocker Drugs 0.000 claims 1
- 239000003195 sodium channel blocking agent Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1883—Neuregulins, e.g.. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410529437.4 | 2014-09-24 | ||
| CN201410529437.4A CN105497876B (zh) | 2014-09-24 | 2014-09-24 | 神经调节蛋白用于预防、治疗或延迟心脏室性心律失常的方法和组合物 |
| PCT/CN2015/088972 WO2016045493A1 (zh) | 2014-09-24 | 2015-09-06 | 神经调节蛋白预防、治疗或延迟室性心律失常的用途及其组合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2017113775A true RU2017113775A (ru) | 2018-10-26 |
| RU2017113775A3 RU2017113775A3 (enExample) | 2019-04-04 |
Family
ID=55580273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017113775A RU2017113775A (ru) | 2014-09-24 | 2015-09-06 | Применение нейрегулина в профилактике, лечении или отсрочке развития желудочковой аритмии и его композиция |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10441633B2 (enExample) |
| EP (1) | EP3199174B1 (enExample) |
| JP (1) | JP2017530127A (enExample) |
| KR (1) | KR20170055492A (enExample) |
| CN (2) | CN105497876B (enExample) |
| AU (1) | AU2015320230B2 (enExample) |
| CA (1) | CA2961813A1 (enExample) |
| RU (1) | RU2017113775A (enExample) |
| WO (1) | WO2016045493A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0620819A2 (pt) | 2005-12-30 | 2011-11-22 | Zensun Shangai Science & Technology Ltd | uso de uma neuregulina (nrg) de liberação prolongada, nrg em uma liberação prolongada de uma dosagem baixa constante, e, composição de liberação prolongada para prevenir, tratar ou retardar uma doença ou distúrbio em um mamìfero |
| JP6096262B2 (ja) | 2009-08-25 | 2017-03-15 | ゼンサン （シャンハイ） サイエンス アンド テクノロジー，シーオー．，エルティーディー． | ニューレグリンに基づく心不全の治療方法 |
| WO2013053076A1 (en) | 2011-10-10 | 2013-04-18 | Zensun （Shanghai）Science & Technology Limited | Compositions and methods for treating heart failure |
| JP6475623B2 (ja) | 2012-10-08 | 2019-02-27 | ゼンスン（シャンハイ）サイエンス アンド テクノロジー カンパニー リミテッド | 糖尿病患者における心不全の治療用組成物 |
| CA2911848A1 (en) | 2013-05-22 | 2014-11-27 | Zensun (Shanghai) Science & Technology, Ltd. | Extended release of neuregulin for treating heart failure |
| CN110946993A (zh) | 2014-01-03 | 2020-04-03 | 上海泽生科技开发股份有限公司 | 纽兰格林制剂的配方 |
| CN105561298A (zh) | 2014-10-17 | 2016-05-11 | 上海泽生科技开发有限公司 | 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物 |
| WO2020037076A1 (en) * | 2018-08-14 | 2020-02-20 | Emory University | Inducing proliferation of cardiomyocytes and therapeutic uses related thereto |
| AR121035A1 (es) | 2019-04-01 | 2022-04-13 | Lilly Co Eli | Compuestos de neuregulina-4 y métodos de uso |
| JP2022547335A (ja) * | 2019-09-16 | 2022-11-11 | ゼンサン （シャンハイ） サイエンス アンド テクノロジー，シーオー．，エルティーディー． | 組換えヒトニューレグリン誘導体及びその使用 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7115554B1 (en) | 1993-05-06 | 2006-10-03 | Acorda Therapeutics, Inc. | Methods of increasing myotube formation or survival or muscle cell mitogenesis differentiation or survival using neuregulin GGF III |
| US5716930A (en) | 1991-04-10 | 1998-02-10 | Ludwig Institute For Cancer Research | Glial growth factors |
| US5530109A (en) | 1991-04-10 | 1996-06-25 | Ludwig Institute For Cancer Research | DNA encoding glial mitogenic factors |
| US5834229A (en) | 1991-05-24 | 1998-11-10 | Genentech, Inc. | Nucleic acids vectors and host cells encoding and expressing heregulin 2-α |
| US5912326A (en) | 1995-09-08 | 1999-06-15 | President And Fellows Of Harvard College | Cerebellum-derived growth factors |
| CA2306228A1 (en) | 1997-10-14 | 1999-04-22 | Cambridge Neuroscience, Inc. | Therapeutic methods comprising use of a neuregulin |
| AUPP785098A0 (en) | 1998-12-21 | 1999-01-21 | Victor Chang Cardiac Research Institute, The | Treatment of heart disease |
| US6635249B1 (en) | 1999-04-23 | 2003-10-21 | Cenes Pharmaceuticals, Inc. | Methods for treating congestive heart failure |
| CN1138785C (zh) | 1999-06-04 | 2004-02-18 | 周明东 | 生长因子神经调节蛋白及其类似物的新应用 |
| AUPQ105799A0 (en) | 1999-06-18 | 1999-07-08 | Victor Chang Cardiac Research Institute, The | Cell growth inhibition |
| WO2003099320A1 (en) | 2002-05-24 | 2003-12-04 | Zensun (Shanghai) Sci-Tech.Ltd | Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy |
| CN1498656A (zh) * | 2002-11-08 | 2004-05-26 | 上海泽生科技开发有限公司 | 神经调节蛋白用于心肌梗死治疗的方法和组合物 |
| AU2006206778A1 (en) | 2005-01-20 | 2006-07-27 | Schuchean Chien | Methods for QT interval control |
| US20070213264A1 (en) | 2005-12-02 | 2007-09-13 | Mingdong Zhou | Neuregulin variants and methods of screening and using thereof |
| BRPI0620819A2 (pt) | 2005-12-30 | 2011-11-22 | Zensun Shangai Science & Technology Ltd | uso de uma neuregulina (nrg) de liberação prolongada, nrg em uma liberação prolongada de uma dosagem baixa constante, e, composição de liberação prolongada para prevenir, tratar ou retardar uma doença ou distúrbio em um mamìfero |
| US9580515B2 (en) | 2006-08-21 | 2017-02-28 | Zensun (Shanghai) Science & Technology, Co., Ltd. | Neukinase, a downstream protein of neuregulin |
| CN101310766B (zh) * | 2007-05-25 | 2014-04-16 | 上海泽生科技开发有限公司 | 神经调节蛋白的新用途 |
| US20090156488A1 (en) | 2007-09-12 | 2009-06-18 | Zensun (Shanghai) Science & Technology Limited | Use of neuregulin for organ preservation |
| US8603817B2 (en) * | 2008-11-03 | 2013-12-10 | University Of Washington | Induction of human embryonic stem cell derived cardiac pacemaker or chamber-type cardiomyocytes by manipulation of neuregulin signaling |
| EP2808339B1 (en) | 2008-11-28 | 2017-02-15 | Zensun (Shanghai) Science & Technology, Co., Ltd. | Neuregulin peptides and their use |
| WO2010060266A1 (en) | 2008-11-28 | 2010-06-03 | Zensun (Shanghai) Science & Technology Limited | Neuregulin and cardiac stem cells |
| CN102470161A (zh) | 2009-06-09 | 2012-05-23 | 上海泽生科技开发有限公司 | 神经调节蛋白用于治疗心力衰竭的有效剂量 |
| WO2010142141A1 (en) | 2009-06-09 | 2010-12-16 | Zensun (Shanghai) Science & Technology Limited | Neuregulin based methods for treating heart failure |
| CN102139095A (zh) | 2010-01-29 | 2011-08-03 | 上海泽生科技开发有限公司 | 神经调节蛋白用于预防、治疗或延迟心脏缺血再灌注损伤的方法和组合物 |
| EP2555788B1 (en) * | 2010-03-24 | 2017-10-11 | Massachusetts Institute of Technology | NEUREGULIN DIMER FOR AN ErbB/HER RECEPTOR FOR USE IN REDUCING CARDIOTOXICITY. |
| US20120028992A1 (en) * | 2010-08-02 | 2012-02-02 | Brown Arthur M | Pharmaceutical compositions for terminating acute episodes of cardiac arrhythmia, restoring sinus rhythm, preventing recurrence of cardiac arrhythmia and/or maintaining normal sinus rhythm in mammals |
| WO2012054718A2 (en) | 2010-10-22 | 2012-04-26 | The General Hospital Corporation | Treating long qt syndrome |
| CN102302552A (zh) * | 2011-08-31 | 2012-01-04 | 朱明军 | 一种治疗心律失常的胶囊及其制备方法 |
| WO2013053076A1 (en) | 2011-10-10 | 2013-04-18 | Zensun （Shanghai）Science & Technology Limited | Compositions and methods for treating heart failure |
| JP6475623B2 (ja) | 2012-10-08 | 2019-02-27 | ゼンスン（シャンハイ）サイエンス アンド テクノロジー カンパニー リミテッド | 糖尿病患者における心不全の治療用組成物 |
| CA2911848A1 (en) | 2013-05-22 | 2014-11-27 | Zensun (Shanghai) Science & Technology, Ltd. | Extended release of neuregulin for treating heart failure |
| SG11201600119PA (en) | 2013-08-01 | 2016-02-26 | Gilead Sciences Inc | Compound and methods for treating long qt syndrome |
| CN104758300A (zh) | 2014-01-02 | 2015-07-08 | 上海泽生科技开发有限公司 | 维生素d及其组合物的抗菌用途 |
| CN110946993A (zh) | 2014-01-03 | 2020-04-03 | 上海泽生科技开发股份有限公司 | 纽兰格林制剂的配方 |
| CN105561298A (zh) | 2014-10-17 | 2016-05-11 | 上海泽生科技开发有限公司 | 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物 |
-
2014
- 2014-09-24 CN CN201410529437.4A patent/CN105497876B/zh active Active
-
2015
- 2015-09-06 JP JP2017516166A patent/JP2017530127A/ja active Pending
- 2015-09-06 US US15/513,939 patent/US10441633B2/en active Active
- 2015-09-06 WO PCT/CN2015/088972 patent/WO2016045493A1/zh not_active Ceased
- 2015-09-06 AU AU2015320230A patent/AU2015320230B2/en active Active
- 2015-09-06 KR KR1020177008203A patent/KR20170055492A/ko not_active Withdrawn
- 2015-09-06 CN CN201580050316.4A patent/CN110337304A/zh active Pending
- 2015-09-06 EP EP15845381.1A patent/EP3199174B1/en not_active Revoked
- 2015-09-06 CA CA2961813A patent/CA2961813A1/en not_active Abandoned
- 2015-09-06 RU RU2017113775A patent/RU2017113775A/ru not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2015320230A1 (en) | 2017-03-30 |
| CN105497876A (zh) | 2016-04-20 |
| EP3199174A1 (en) | 2017-08-02 |
| WO2016045493A1 (zh) | 2016-03-31 |
| CA2961813A1 (en) | 2016-03-31 |
| US10441633B2 (en) | 2019-10-15 |
| EP3199174B1 (en) | 2022-04-13 |
| JP2017530127A (ja) | 2017-10-12 |
| EP3199174A4 (en) | 2018-06-06 |
| CN110337304A (zh) | 2019-10-15 |
| AU2015320230B2 (en) | 2021-06-24 |
| US20170368140A1 (en) | 2017-12-28 |
| RU2017113775A3 (enExample) | 2019-04-04 |
| KR20170055492A (ko) | 2017-05-19 |
| CN105497876B (zh) | 2021-01-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2017113775A (ru) | Применение нейрегулина в профилактике, лечении или отсрочке развития желудочковой аритмии и его композиция | |
| RU2017116973A (ru) | Способы применения и композиции нейрегулинов для предотвращения, лечения или замедления сердечной недостаточности с сохраненной фракцией выброса | |
| EA202092001A1 (ru) | Соединения для лечения болезни гентингтона | |
| JP2017532343A5 (enExample) | ||
| EA201800367A1 (ru) | Способы лечения болезни хантингтона | |
| MX2023003875A (es) | Formulacion de una vacuna peptidica. | |
| UY38986A (es) | Compuestos derivados de 3-(5-metoxi-1-oxoisoindolin-2-il) piperidin-2,6-diona, métodos de usos de los mismos y combinaciones farmacéuticas | |
| EP4233910A3 (en) | Methods of treatment of cholestatic diseases | |
| EP4616914A3 (en) | Polypeptides binding to human complement c5 | |
| WO2016070166A3 (en) | Messenger una molecules and uses thereof | |
| MX2020007060A (es) | Compuestos, composiciones y metodos para tratar enfermedades que involucren tejidos con enfermedades acidas o hipoxicas. | |
| EA201891399A1 (ru) | Бипиразолильные производные, пригодные для лечения аутоиммунных заболеваний | |
| BR112018006866A2 (pt) | compostos agonistas de ppar, composições farmacêuticas e métodos de uso dos mesmos | |
| EA201791535A1 (ru) | Новое соединение 4'-тионуклеозида, а также способ его получения, его фармацевтическая композиция и применение | |
| WO2016014533A3 (en) | Devices and methods for fixation of animal tissue | |
| EP3932418A3 (en) | Peptides for use in promoting transport of glucose | |
| CL2017003097A1 (es) | Composiciones y métodos para el tratamiento de la enfermedad celiaca | |
| EA202190588A1 (ru) | Гетероароматические соединения в качестве ингибиторов ванина | |
| EP4574207A3 (en) | Means and methods for treating copper-related diseases | |
| WO2019032936A8 (en) | LINCONSAMIDE ANTIBIOTICS AND USES THEREOF | |
| WO2016133152A3 (ja) | 蛋白質吸着抑制方法 | |
| MX390418B (es) | Anticuerpos anti proteína similar a angiopoyetina 4 y métodos de uso. | |
| WO2016020882A3 (en) | Angiopoetin-like 4 (angptl4) antibodies and methods of use | |
| WO2019016597A3 (en) | SYNTHETIC PROTEINS AND THEIR THERAPEUTIC USES | |
| WO2018069831A3 (en) | Ligands of the fsh hormone receptor in the diagnosis and treatment of tumors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HZ9A | Changing address for correspondence with an applicant | ||
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20200730 |