CN105497876B - 神经调节蛋白用于预防、治疗或延迟心脏室性心律失常的方法和组合物 - Google Patents

神经调节蛋白用于预防、治疗或延迟心脏室性心律失常的方法和组合物 Download PDF

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CN105497876B
CN105497876B CN201410529437.4A CN201410529437A CN105497876B CN 105497876 B CN105497876 B CN 105497876B CN 201410529437 A CN201410529437 A CN 201410529437A CN 105497876 B CN105497876 B CN 105497876B
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ventricular
neuregulin
incidence
arrhythmia
heart
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CN105497876A (zh
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周明东
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Zensun Shanghai Science and Technology Ltd
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Zensun Shanghai Science and Technology Ltd
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Priority to CN201410529437.4A priority Critical patent/CN105497876B/zh
Priority to US15/513,939 priority patent/US10441633B2/en
Priority to JP2017516166A priority patent/JP2017530127A/ja
Priority to KR1020177008203A priority patent/KR20170055492A/ko
Priority to RU2017113775A priority patent/RU2017113775A/ru
Priority to EP15845381.1A priority patent/EP3199174B1/en
Priority to AU2015320230A priority patent/AU2015320230B2/en
Priority to PCT/CN2015/088972 priority patent/WO2016045493A1/zh
Priority to CN201580050316.4A priority patent/CN110337304A/zh
Priority to CA2961813A priority patent/CA2961813A1/en
Publication of CN105497876A publication Critical patent/CN105497876A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1883—Neuregulins, e.g.. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
CN201410529437.4A 2014-09-24 2014-09-24 神经调节蛋白用于预防、治疗或延迟心脏室性心律失常的方法和组合物 Active CN105497876B (zh)

Priority Applications (10)

Application Number Priority Date Filing Date Title
CN201410529437.4A CN105497876B (zh) 2014-09-24 2014-09-24 神经调节蛋白用于预防、治疗或延迟心脏室性心律失常的方法和组合物
AU2015320230A AU2015320230B2 (en) 2014-09-24 2015-09-06 Uses of neuregulin in preventing, treating or delaying ventricular arrhythmia, and composition thereof
CN201580050316.4A CN110337304A (zh) 2014-09-24 2015-09-06 神经调节蛋白预防、治疗或延迟室性心律失常的用途及其组合物
KR1020177008203A KR20170055492A (ko) 2014-09-24 2015-09-06 심실 부정맥의 예방, 치료 또는 지연에 있어서의 뉴레귤린의 용도 및 그의 조성물
RU2017113775A RU2017113775A (ru) 2014-09-24 2015-09-06 Применение нейрегулина в профилактике, лечении или отсрочке развития желудочковой аритмии и его композиция
EP15845381.1A EP3199174B1 (en) 2014-09-24 2015-09-06 Uses of neuregulin in preventing, treating or delaying ventricular arrhythmia
US15/513,939 US10441633B2 (en) 2014-09-24 2015-09-06 Uses of neuregulin in preventing, treating or delaying ventricular arrhythmia, and composition thereof
PCT/CN2015/088972 WO2016045493A1 (zh) 2014-09-24 2015-09-06 神经调节蛋白预防、治疗或延迟室性心律失常的用途及其组合物
JP2017516166A JP2017530127A (ja) 2014-09-24 2015-09-06 心室性不整脈の予防、治療、又は遅延におけるニューレグリンの使用、及びその組成物
CA2961813A CA2961813A1 (en) 2014-09-24 2015-09-06 Uses of neuregulin in preventing, treating or delaying ventricular arrhythmia, and composition thereof

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CN201410529437.4A CN105497876B (zh) 2014-09-24 2014-09-24 神经调节蛋白用于预防、治疗或延迟心脏室性心律失常的方法和组合物

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CN105497876A CN105497876A (zh) 2016-04-20
CN105497876B true CN105497876B (zh) 2021-01-15

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CN201410529437.4A Active CN105497876B (zh) 2014-09-24 2014-09-24 神经调节蛋白用于预防、治疗或延迟心脏室性心律失常的方法和组合物
CN201580050316.4A Pending CN110337304A (zh) 2014-09-24 2015-09-06 神经调节蛋白预防、治疗或延迟室性心律失常的用途及其组合物

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US (1) US10441633B2 (enExample)
EP (1) EP3199174B1 (enExample)
JP (1) JP2017530127A (enExample)
KR (1) KR20170055492A (enExample)
CN (2) CN105497876B (enExample)
AU (1) AU2015320230B2 (enExample)
CA (1) CA2961813A1 (enExample)
RU (1) RU2017113775A (enExample)
WO (1) WO2016045493A1 (enExample)

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JP6096262B2 (ja) 2009-08-25 2017-03-15 ゼンサン （シャンハイ） サイエンス アンド テクノロジー，シーオー．，エルティーディー． ニューレグリンに基づく心不全の治療方法
WO2013053076A1 (en) 2011-10-10 2013-04-18 Zensun （Shanghai）Science & Technology Limited Compositions and methods for treating heart failure
JP6475623B2 (ja) 2012-10-08 2019-02-27 ゼンスン（シャンハイ）サイエンス アンド テクノロジー カンパニー リミテッド 糖尿病患者における心不全の治療用組成物
CA2911848A1 (en) 2013-05-22 2014-11-27 Zensun (Shanghai) Science & Technology, Ltd. Extended release of neuregulin for treating heart failure
CN110946993A (zh) 2014-01-03 2020-04-03 上海泽生科技开发股份有限公司 纽兰格林制剂的配方
CN105561298A (zh) 2014-10-17 2016-05-11 上海泽生科技开发有限公司 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物
WO2020037076A1 (en) * 2018-08-14 2020-02-20 Emory University Inducing proliferation of cardiomyocytes and therapeutic uses related thereto
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JP2022547335A (ja) * 2019-09-16 2022-11-11 ゼンサン （シャンハイ） サイエンス アンド テクノロジー，シーオー．，エルティーディー． 組換えヒトニューレグリン誘導体及びその使用

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Publication number Publication date
AU2015320230A1 (en) 2017-03-30
CN105497876A (zh) 2016-04-20
EP3199174A1 (en) 2017-08-02
WO2016045493A1 (zh) 2016-03-31
CA2961813A1 (en) 2016-03-31
US10441633B2 (en) 2019-10-15
EP3199174B1 (en) 2022-04-13
RU2017113775A (ru) 2018-10-26
JP2017530127A (ja) 2017-10-12
EP3199174A4 (en) 2018-06-06
CN110337304A (zh) 2019-10-15
AU2015320230B2 (en) 2021-06-24
US20170368140A1 (en) 2017-12-28
RU2017113775A3 (enExample) 2019-04-04
KR20170055492A (ko) 2017-05-19

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