RU2016133688A - Композиции, содержащие экстракты Curcuma Longa и Echinacea angustifolia, которые являются полезными для уменьшения периферического воспаления и боли - Google Patents
Композиции, содержащие экстракты Curcuma Longa и Echinacea angustifolia, которые являются полезными для уменьшения периферического воспаления и боли Download PDFInfo
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- RU2016133688A RU2016133688A RU2016133688A RU2016133688A RU2016133688A RU 2016133688 A RU2016133688 A RU 2016133688A RU 2016133688 A RU2016133688 A RU 2016133688A RU 2016133688 A RU2016133688 A RU 2016133688A RU 2016133688 A RU2016133688 A RU 2016133688A
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- curcumin
- echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (11)
1. Композиции, по существу состоящие из экстракта Curcuma spp или куркумина и экстракта, выбранного из экстракта Echinacea angustifolia или липофильного экстракта Zanthoxylum bungeanum, смешанных с приемлемыми эксципиентами.
2. Композиции по п. 1, где куркумин образует комплекс с фосфолипидами.
3. Композиции по п. 1, где экстракты Echinacea angustifolia и Zanthoxylum bungeanum получены путем экстрагирования сверхкритическим диоксидом углерода.
4. Композиции по пп. 1-3 для перорального введения.
5. Композиции по п. 4, содержащие в качестве единственных активных ингредиентов куркумин в комплексе с фосфолипидами в количествах, находящихся в диапазоне от 100 до 1000 мг, и экстракт Echinacea в количествах, находящихся в диапазоне от 1 до 20 мг, или, альтернативно, липофильный экстракт Zanthoxylum spp. в количествах, находящихся в диапазоне от 5 до 25 мг, на пероральную стандартную дозу.
6. Композиции по п. 5, содержащие в качестве единственных активных ингредиентов 500 мг куркумина в комплексе с фосфолипидами и 5 мг экстракта Echinacea или, альтернативно, 10 мг липофильного экстракта Zanthoxylum spp., на пероральную стандартную дозу.
7. Композиции по пп. 1-3 для местного введения.
8. Композиции по п. 7, содержащие куркумин в комплексе с фосфолипидами в количествах, находящихся в диапазоне от 0,1% до 0,5% масс./масс., и экстракт Echinacea в количествах, находящихся в диапазоне от 0,05% до 0,5% масс./масс., или липофильный экстракт Zanthoxylum spp.в количествах, находящихся в диапазоне от 0,1 до 1% масс./масс..
9. Композиции по п. 8, содержащие 0,2% масс./масс. куркумина в комплексе с фосфолипидами и 0,2% масс./масс. экстракта Echinacea или, альтернативно, 0,5% масс./масс. липофильнгого экстракта Zanthoxylum spp.
10. Композиции по пп. 1-9 для применения в лечении периферической боли, суставной и мышечной боли, воспалительных, и поверхностных, и глубоких болевых состояний.
11. Композиции по п. 10 для лечения остеоартрита и ревматоидного артрита.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2014A000251 | 2014-02-20 | ||
| ITMI20140251 | 2014-02-20 | ||
| PCT/EP2015/053399 WO2015124616A1 (en) | 2014-02-20 | 2015-02-18 | Compositions containing extracts of curcuma longa and echinacea angustifolia which are useful to reduce peripheral inflammation and pain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2016133688A true RU2016133688A (ru) | 2018-03-23 |
| RU2016133688A3 RU2016133688A3 (ru) | 2018-08-30 |
| RU2677894C2 RU2677894C2 (ru) | 2019-01-22 |
Family
ID=50336467
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016133688A RU2677894C2 (ru) | 2014-02-20 | 2015-02-18 | Композиции, содержащие экстракты Curcuma Longa и Echinacea angustifolia, которые являются полезными для уменьшения периферического воспаления и боли |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US10286028B2 (ru) |
| EP (1) | EP3107555B1 (ru) |
| JP (1) | JP6510544B2 (ru) |
| KR (1) | KR102350519B1 (ru) |
| CN (1) | CN106029082A (ru) |
| AU (1) | AU2015220913B2 (ru) |
| BR (1) | BR112016018973B1 (ru) |
| CA (1) | CA2939976C (ru) |
| DK (1) | DK3107555T3 (ru) |
| ES (1) | ES2804324T3 (ru) |
| HU (1) | HUE051696T2 (ru) |
| IL (1) | IL247314B (ru) |
| MX (1) | MX2016010722A (ru) |
| PL (1) | PL3107555T3 (ru) |
| PT (1) | PT3107555T (ru) |
| RU (1) | RU2677894C2 (ru) |
| SG (1) | SG11201606831PA (ru) |
| SI (1) | SI3107555T1 (ru) |
| WO (1) | WO2015124616A1 (ru) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3150214A1 (en) * | 2015-10-01 | 2017-04-05 | INDENA S.p.A. | Compositions containing extracts of curcuma spp and zingiber officinale which are useful to reduce peripheral inflammation and pain |
| AU2016373576B2 (en) * | 2015-12-16 | 2022-06-02 | Vivek Anand PARACHUR | Tri-molecular complex of natural compounds |
| ITUB20161030A1 (it) | 2016-02-24 | 2017-08-24 | Indena Spa | Composizioni utili nella prevenzione e/o nel trattamento dell’infiammazione e del dolore |
| US10744174B1 (en) * | 2016-03-16 | 2020-08-18 | Robert Alonso | Composition(s) and method(s) for topically treating pain |
| ITUA20164757A1 (it) | 2016-06-29 | 2017-12-29 | Indena Spa | Composizioni utili nella prevenzione e/o nel trattamento dell’infiammazione e del dolore osteoarticolare e del danno cartilagineo |
| JP6987528B2 (ja) * | 2017-05-12 | 2022-01-05 | 小林製薬株式会社 | クルクミノイド含有錠剤 |
| KR102020667B1 (ko) * | 2017-09-29 | 2019-09-10 | 유씨엘 주식회사 | 두피염증 예방 및 완화, 및 탈모방지 효과가 있는 화장료 조성물 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2075187T3 (es) * | 1990-07-05 | 1995-10-01 | Indena Spa | Extractos de equinaceas, un procedimiento para su preparacion y formulaciones que los contienen. |
| US6440448B1 (en) * | 1998-03-16 | 2002-08-27 | Joseph Intelisano | Food supplement/herbal composition for health enhancement |
| ITMI981542A1 (it) * | 1998-07-07 | 2000-01-07 | Indena Spa | Estratti di zanthoxylum bungeanum e loro formulazioni farmaceutiche e cosmetiche |
| JP5032003B2 (ja) | 2005-06-15 | 2012-09-26 | 株式会社琉球バイオリソース開発 | 口腔粘膜用の鎮痛・抗炎症トローチ剤 |
| EP1837030A1 (en) * | 2006-03-09 | 2007-09-26 | INDENA S.p.A. | Phospholipid complexes of curcumin having improved bioavailability |
| ITMI20071136A1 (it) * | 2007-06-04 | 2008-12-05 | Velleja Res Srl | Formulazioni topiche per la prevenzione e il trattamento degli stati infiammatori e/o infettivi dell'aera genitale |
| KR20090047637A (ko) | 2007-11-08 | 2009-05-13 | 재단법인서울대학교산학협력재단 | 커큐민 또는 이의 약학적으로 허용가능한 염을유효성분으로 함유하는 통증 예방 및 치료용 조성물 |
| CN101607068A (zh) * | 2009-07-15 | 2009-12-23 | 中国人民解放军第四军医大学 | 一种治疗肝癌中药前体脂质体注射剂及其制备工艺 |
| IT1401141B1 (it) * | 2010-07-26 | 2013-07-12 | Indena Spa | Formulazioni contenenti estratti di echinacea angustifolia e di zingiber officinale utili nella riduzione dell'infiammazione e del dolore periferico |
-
2015
- 2015-02-18 AU AU2015220913A patent/AU2015220913B2/en active Active
- 2015-02-18 CN CN201580009045.8A patent/CN106029082A/zh active Pending
- 2015-02-18 WO PCT/EP2015/053399 patent/WO2015124616A1/en active Application Filing
- 2015-02-18 SG SG11201606831PA patent/SG11201606831PA/en unknown
- 2015-02-18 RU RU2016133688A patent/RU2677894C2/ru active
- 2015-02-18 BR BR112016018973-6A patent/BR112016018973B1/pt active IP Right Grant
- 2015-02-18 KR KR1020167022484A patent/KR102350519B1/ko active IP Right Grant
- 2015-02-18 SI SI201531247T patent/SI3107555T1/sl unknown
- 2015-02-18 PL PL15709426T patent/PL3107555T3/pl unknown
- 2015-02-18 HU HUE15709426A patent/HUE051696T2/hu unknown
- 2015-02-18 DK DK15709426.9T patent/DK3107555T3/da active
- 2015-02-18 EP EP15709426.9A patent/EP3107555B1/en active Active
- 2015-02-18 CA CA2939976A patent/CA2939976C/en active Active
- 2015-02-18 MX MX2016010722A patent/MX2016010722A/es active IP Right Grant
- 2015-02-18 ES ES15709426T patent/ES2804324T3/es active Active
- 2015-02-18 US US15/118,861 patent/US10286028B2/en active Active
- 2015-02-18 PT PT157094269T patent/PT3107555T/pt unknown
- 2015-02-18 JP JP2016552578A patent/JP6510544B2/ja active Active
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- 2016-08-17 IL IL247314A patent/IL247314B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| RU2677894C2 (ru) | 2019-01-22 |
| SI3107555T1 (sl) | 2020-07-31 |
| AU2015220913B2 (en) | 2020-04-09 |
| IL247314B (en) | 2020-08-31 |
| KR20160113631A (ko) | 2016-09-30 |
| CN106029082A (zh) | 2016-10-12 |
| JP6510544B2 (ja) | 2019-05-08 |
| KR102350519B1 (ko) | 2022-01-14 |
| HUE051696T2 (hu) | 2021-03-29 |
| EP3107555B1 (en) | 2020-06-03 |
| WO2015124616A1 (en) | 2015-08-27 |
| JP2017506241A (ja) | 2017-03-02 |
| ES2804324T3 (es) | 2021-02-05 |
| MX2016010722A (es) | 2016-11-10 |
| US10286028B2 (en) | 2019-05-14 |
| DK3107555T3 (da) | 2020-08-10 |
| PL3107555T3 (pl) | 2020-11-30 |
| SG11201606831PA (en) | 2016-09-29 |
| RU2016133688A3 (ru) | 2018-08-30 |
| EP3107555A1 (en) | 2016-12-28 |
| PT3107555T (pt) | 2020-07-10 |
| IL247314A0 (en) | 2016-09-29 |
| US20170049840A1 (en) | 2017-02-23 |
| AU2015220913A1 (en) | 2016-09-01 |
| CA2939976C (en) | 2023-09-05 |
| CA2939976A1 (en) | 2015-08-27 |
| BR112016018973B1 (pt) | 2021-01-19 |
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